Clinical trial of autologous adipose-derived mesenchymal stromal cells (ASC) in the treatment of mild to moderate osteoarthritis

Project Information

ADIPOA2

Grant agreement ID: 643809

DOI

10.3030/643809

Project closed

EC signature date 1 December 2014

Start date 1 January 2015

End date 31 December 2019

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost

€ 5 999 000,00

EU contribution

€ 5 999 000,00

Coordinated by

UNIVERSITY OF GALWAY
Ireland

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (1)

Patient Information Templates

Templates for Informed Consent Forms and Information Sheets in all clinical-trial-site languages.

Other (1)

Website

Website (updated throughout the project)

Publications

Peer reviewed articles (14)

From osteoarthritic synovium to synovial-derived cells characterization: synovial macrophages are key effector cells

Author(s): Cattini, Luca; Silvestri, Ylenia; Gambari, Laura; Filardo, Giuseppe; Paolella, Francesca; Gabusi, Elena; Fleury-Cappellesso, Sandrine; Manferdini, Cristina; Lisignoli, Gina
Published in: Arthritis Research & Therapy, Issue 1, 2016, ISSN 1478-6362
Publisher: BioMed Central
DOI: 10.1186/s13075-016-0983-4

Therapeutic application of mesenchymal stem cells in osteoarthritis

Author(s): Maxime Ruiz, Stella Cosenza, Marie Maumus, Christian Jorgensen, Danièle Noël
Published in: Expert Opinion on Biological Therapy, Issue 16/1, 2015, Page(s) 33-42, ISSN 1471-2598
Publisher: Ashley Publications Ltd.
DOI: 10.1517/14712598.2016.1093108

Deregulation and therapeutic potential of microRNAs in arthritic diseases

Author(s): Rita Vicente, Danièle Noël, Yves-Marie Pers, Florence Apparailly, Christian Jorgensen
Published in: Nature Reviews Rheumatology, Issue 12/4, 2015, Page(s) 211-220, ISSN 1759-4790
Publisher: Nature Publishing Group
DOI: 10.1038/nrrheum.2015.162

Adipose Mesenchymal Stem Cells Isolated after Manual or Water-jet-Assisted Liposuction Display Similar Properties

Author(s): Claire Bony, Mailys Cren, Sophie Domergue, Karine Toupet, Christian Jorgensen, Danièle Noël
Published in: Frontiers in Immunology, Issue 6, 2016, ISSN 1664-3224
Publisher: Frontiers Research Foundation
DOI: 10.3389/fimmu.2015.00655

Mesenchymal stem cells for the management of inflammation in osteoarthritis: state of the art and perspectives

Author(s): Y.-M. Pers, M. Ruiz, D. Noël, C. Jorgensen
Published in: Osteoarthritis and Cartilage, Issue 23/11, 2015, Page(s) 2027-2035, ISSN 1063-4584
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.joca.2015.07.004

Adipose stromal cells mediated switching of the pro-inflammatory profile of M1-like macrophages is facilitated by PGE2: in vitro evaluation

Author(s): C. Manferdini, F. Paolella, E. Gabusi, L. Gambari, A. Piacentini, G. Filardo, S. Fleury-Cappellesso, A. Barbero, M. Murphy, G. Lisignoli
Published in: Osteoarthritis and Cartilage, Issue 25/7, 2017, Page(s) 1161-1171, ISSN 1063-4584
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.joca.2017.01.011

Pathogenic or Therapeutic Extracellular Vesicles in Rheumatic Diseases: Role of Mesenchymal Stem Cell-Derived Vesicles

Author(s): Stella Cosenza, Maxime Ruiz, Marie Maumus, Christian Jorgensen, Danièle Noël
Published in: International Journal of Molecular Sciences, Issue 18/12, 2017, Page(s) 889, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms18040889

Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis

Author(s): Stella Cosenza, Karine Toupet, Marie Maumus, Patricia Luz-Crawford, Olivier Blanc-Brude, Christian Jorgensen, Danièle Noël
Published in: Theranostics, Issue 8/5, 2018, Page(s) 1399-1410, ISSN 1838-7640
Publisher: Ivyspring International Publisher
DOI: 10.7150/thno.21072

Thrombospondin-1 Partly Mediates the Cartilage Protective Effect of Adipose-Derived Mesenchymal Stem Cells in Osteoarthritis

Author(s): Marie Maumus, Cristina Manferdini, Karine Toupet, Paul Chuchana, Louis Casteilla, Mélanie Gachet, Christian Jorgensen, Gina Lisignoli, Danièle Noël
Published in: Frontiers in Immunology, Issue 8, 2017, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2017.01638

Treatment efficacy of adipose-derived stem cells in experimental osteoarthritis is driven by high synovial activation and reflected by S100A8/A9 serum levels

Author(s): R.F. Schelbergen, S. van Dalen, M. ter Huurne, J. Roth, T. Vogl, D. Noël, C. Jorgensen, W.B. van den Berg, F.A. van de Loo, A.B. Blom, P.L.E.M. van Lent
Published in: Osteoarthritis and Cartilage, Issue 22/8, 2014, Page(s) 1158-1166, ISSN 1063-4584
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.joca.2014.05.022

IL-1β-Mediated Activation of Adipose-Derived Mesenchymal Stromal Cells Results in PMN Reallocation and Enhanced Phagocytosis: A Possible Mechanism for the Reduction of Osteoarthritis Pathology

Author(s): Stephanie C. M. van Dalen, Arjen B. Blom, Birgitte Walgreen, Annet W. Slöetjes, Monique M. A. Helsen, Edwin J. W. Geven, Menno ter Huurne, Thomas Vogl, Johannes Roth, Fons A. J. van de Loo, Marije I. Koenders, Louis Casteilla, Peter M. van der Kraan, Martijn H. J. van den Bosch, Peter L. E. M. van Lent
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2019.01075

TGFBI secreted by mesenchymal stromal cells ameliorates osteoarthritis and is detected in extracellular vesicles

Author(s): Maxime Ruiz, Karine Toupet, Marie Maumus, Pauline Rozier, Christian Jorgensen, Danièle Noël
Published in: Biomaterials, Issue 226, 2020, Page(s) 119544, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2019.119544

Osteoarthritic Milieu Affects Adipose‐Derived Mesenchymal Stromal Cells

Author(s): Cristina Manferdini, Francesca Paolella, Elena Gabusi, Luca Cattini, Markus Rojewski, Hubert Schrezenmeier, Olga Addimanda, Riccardo Meliconi, Gina Lisignoli
Published in: Journal of Orthopaedic Research, 2019, ISSN 0736-0266
Publisher: Elsevier BV
DOI: 10.1002/jor.24446

Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis

Author(s): Stella Cosenza, Maxime Ruiz, Karine Toupet, Christian Jorgensen, Danièle Noël
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-15376-8