Clinical trial of autologous adipose-derived mesenchymal stromal cells (ASC) in the treatment of mild to moderate osteoarthritis

Resultado final

Templates for Informed Consent Forms and Information Sheets in all clinical-trial-site languages.

Website (updated throughout the project)

Publicaciones

From osteoarthritic synovium to synovial-derived cells characterization: synovial macrophages are key effector cells

Autores: Cattini, Luca; Silvestri, Ylenia; Gambari, Laura; Filardo, Giuseppe; Paolella, Francesca; Gabusi, Elena; Fleury-Cappellesso, Sandrine; Manferdini, Cristina; Lisignoli, Gina
Publicado en: Arthritis Research & Therapy, Edición 1, 2016, ISSN 1478-6362
Editor: BioMed Central
DOI: 10.1186/s13075-016-0983-4

Therapeutic application of mesenchymal stem cells in osteoarthritis

Autores: Maxime Ruiz, Stella Cosenza, Marie Maumus, Christian Jorgensen, Danièle Noël
Publicado en: Expert Opinion on Biological Therapy, Edición 16/1, 2015, Página(s) 33-42, ISSN 1471-2598
Editor: Ashley Publications Ltd.
DOI: 10.1517/14712598.2016.1093108

Deregulation and therapeutic potential of microRNAs in arthritic diseases

Autores: Rita Vicente, Danièle Noël, Yves-Marie Pers, Florence Apparailly, Christian Jorgensen
Publicado en: Nature Reviews Rheumatology, Edición 12/4, 2015, Página(s) 211-220, ISSN 1759-4790
Editor: Nature Publishing Group
DOI: 10.1038/nrrheum.2015.162

Adipose Mesenchymal Stem Cells Isolated after Manual or Water-jet-Assisted Liposuction Display Similar Properties

Autores: Claire Bony, Mailys Cren, Sophie Domergue, Karine Toupet, Christian Jorgensen, Danièle Noël
Publicado en: Frontiers in Immunology, Edición 6, 2016, ISSN 1664-3224
Editor: Frontiers Research Foundation
DOI: 10.3389/fimmu.2015.00655

Mesenchymal stem cells for the management of inflammation in osteoarthritis: state of the art and perspectives

Autores: Y.-M. Pers, M. Ruiz, D. Noël, C. Jorgensen
Publicado en: Osteoarthritis and Cartilage, Edición 23/11, 2015, Página(s) 2027-2035, ISSN 1063-4584
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.joca.2015.07.004

Adipose stromal cells mediated switching of the pro-inflammatory profile of M1-like macrophages is facilitated by PGE2: in vitro evaluation

Autores: C. Manferdini, F. Paolella, E. Gabusi, L. Gambari, A. Piacentini, G. Filardo, S. Fleury-Cappellesso, A. Barbero, M. Murphy, G. Lisignoli
Publicado en: Osteoarthritis and Cartilage, Edición 25/7, 2017, Página(s) 1161-1171, ISSN 1063-4584
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.joca.2017.01.011

Pathogenic or Therapeutic Extracellular Vesicles in Rheumatic Diseases: Role of Mesenchymal Stem Cell-Derived Vesicles

Autores: Stella Cosenza, Maxime Ruiz, Marie Maumus, Christian Jorgensen, Danièle Noël
Publicado en: International Journal of Molecular Sciences, Edición 18/12, 2017, Página(s) 889, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms18040889

Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis

Autores: Stella Cosenza, Karine Toupet, Marie Maumus, Patricia Luz-Crawford, Olivier Blanc-Brude, Christian Jorgensen, Danièle Noël
Publicado en: Theranostics, Edición 8/5, 2018, Página(s) 1399-1410, ISSN 1838-7640
Editor: Ivyspring International Publisher
DOI: 10.7150/thno.21072

Thrombospondin-1 Partly Mediates the Cartilage Protective Effect of Adipose-Derived Mesenchymal Stem Cells in Osteoarthritis

Autores: Marie Maumus, Cristina Manferdini, Karine Toupet, Paul Chuchana, Louis Casteilla, Mélanie Gachet, Christian Jorgensen, Gina Lisignoli, Danièle Noël
Publicado en: Frontiers in Immunology, Edición 8, 2017, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2017.01638

Treatment efficacy of adipose-derived stem cells in experimental osteoarthritis is driven by high synovial activation and reflected by S100A8/A9 serum levels

Autores: R.F. Schelbergen, S. van Dalen, M. ter Huurne, J. Roth, T. Vogl, D. Noël, C. Jorgensen, W.B. van den Berg, F.A. van de Loo, A.B. Blom, P.L.E.M. van Lent
Publicado en: Osteoarthritis and Cartilage, Edición 22/8, 2014, Página(s) 1158-1166, ISSN 1063-4584
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.joca.2014.05.022

IL-1β-Mediated Activation of Adipose-Derived Mesenchymal Stromal Cells Results in PMN Reallocation and Enhanced Phagocytosis: A Possible Mechanism for the Reduction of Osteoarthritis Pathology

Autores: Stephanie C. M. van Dalen, Arjen B. Blom, Birgitte Walgreen, Annet W. Slöetjes, Monique M. A. Helsen, Edwin J. W. Geven, Menno ter Huurne, Thomas Vogl, Johannes Roth, Fons A. J. van de Loo, Marije I. Koenders, Louis Casteilla, Peter M. van der Kraan, Martijn H. J. van den Bosch, Peter L. E. M. van Lent
Publicado en: Frontiers in Immunology, Edición 10, 2019, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2019.01075

TGFBI secreted by mesenchymal stromal cells ameliorates osteoarthritis and is detected in extracellular vesicles

Autores: Maxime Ruiz, Karine Toupet, Marie Maumus, Pauline Rozier, Christian Jorgensen, Danièle Noël
Publicado en: Biomaterials, Edición 226, 2020, Página(s) 119544, ISSN 0142-9612
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2019.119544

Osteoarthritic Milieu Affects Adipose‐Derived Mesenchymal Stromal Cells

Autores: Cristina Manferdini, Francesca Paolella, Elena Gabusi, Luca Cattini, Markus Rojewski, Hubert Schrezenmeier, Olga Addimanda, Riccardo Meliconi, Gina Lisignoli
Publicado en: Journal of Orthopaedic Research, 2019, ISSN 0736-0266
Editor: Elsevier BV
DOI: 10.1002/jor.24446

Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis

Autores: Stella Cosenza, Maxime Ruiz, Karine Toupet, Christian Jorgensen, Danièle Noël
Publicado en: Scientific Reports, Edición 7/1, 2017, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-017-15376-8

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