Clinical trial of autologous adipose-derived mesenchymal stromal cells (ASC) in the treatment of mild to moderate osteoarthritis

Risultati finali

Templates for Informed Consent Forms and Information Sheets in all clinical-trial-site languages.

Website (updated throughout the project)

Pubblicazioni

From osteoarthritic synovium to synovial-derived cells characterization: synovial macrophages are key effector cells

Autori: Cattini, Luca; Silvestri, Ylenia; Gambari, Laura; Filardo, Giuseppe; Paolella, Francesca; Gabusi, Elena; Fleury-Cappellesso, Sandrine; Manferdini, Cristina; Lisignoli, Gina
Pubblicato in: Arthritis Research & Therapy, Numero 1, 2016, ISSN 1478-6362
Editore: BioMed Central
DOI: 10.1186/s13075-016-0983-4

Therapeutic application of mesenchymal stem cells in osteoarthritis

Autori: Maxime Ruiz, Stella Cosenza, Marie Maumus, Christian Jorgensen, Danièle Noël
Pubblicato in: Expert Opinion on Biological Therapy, Numero 16/1, 2015, Pagina/e 33-42, ISSN 1471-2598
Editore: Ashley Publications Ltd.
DOI: 10.1517/14712598.2016.1093108

Deregulation and therapeutic potential of microRNAs in arthritic diseases

Autori: Rita Vicente, Danièle Noël, Yves-Marie Pers, Florence Apparailly, Christian Jorgensen
Pubblicato in: Nature Reviews Rheumatology, Numero 12/4, 2015, Pagina/e 211-220, ISSN 1759-4790
Editore: Nature Publishing Group
DOI: 10.1038/nrrheum.2015.162

Adipose Mesenchymal Stem Cells Isolated after Manual or Water-jet-Assisted Liposuction Display Similar Properties

Autori: Claire Bony, Mailys Cren, Sophie Domergue, Karine Toupet, Christian Jorgensen, Danièle Noël
Pubblicato in: Frontiers in Immunology, Numero 6, 2016, ISSN 1664-3224
Editore: Frontiers Research Foundation
DOI: 10.3389/fimmu.2015.00655

Mesenchymal stem cells for the management of inflammation in osteoarthritis: state of the art and perspectives

Autori: Y.-M. Pers, M. Ruiz, D. Noël, C. Jorgensen
Pubblicato in: Osteoarthritis and Cartilage, Numero 23/11, 2015, Pagina/e 2027-2035, ISSN 1063-4584
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.joca.2015.07.004

Adipose stromal cells mediated switching of the pro-inflammatory profile of M1-like macrophages is facilitated by PGE2: in vitro evaluation

Autori: C. Manferdini, F. Paolella, E. Gabusi, L. Gambari, A. Piacentini, G. Filardo, S. Fleury-Cappellesso, A. Barbero, M. Murphy, G. Lisignoli
Pubblicato in: Osteoarthritis and Cartilage, Numero 25/7, 2017, Pagina/e 1161-1171, ISSN 1063-4584
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.joca.2017.01.011

Pathogenic or Therapeutic Extracellular Vesicles in Rheumatic Diseases: Role of Mesenchymal Stem Cell-Derived Vesicles

Autori: Stella Cosenza, Maxime Ruiz, Marie Maumus, Christian Jorgensen, Danièle Noël
Pubblicato in: International Journal of Molecular Sciences, Numero 18/12, 2017, Pagina/e 889, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms18040889

Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis

Autori: Stella Cosenza, Karine Toupet, Marie Maumus, Patricia Luz-Crawford, Olivier Blanc-Brude, Christian Jorgensen, Danièle Noël
Pubblicato in: Theranostics, Numero 8/5, 2018, Pagina/e 1399-1410, ISSN 1838-7640
Editore: Ivyspring International Publisher
DOI: 10.7150/thno.21072

Thrombospondin-1 Partly Mediates the Cartilage Protective Effect of Adipose-Derived Mesenchymal Stem Cells in Osteoarthritis

Autori: Marie Maumus, Cristina Manferdini, Karine Toupet, Paul Chuchana, Louis Casteilla, Mélanie Gachet, Christian Jorgensen, Gina Lisignoli, Danièle Noël
Pubblicato in: Frontiers in Immunology, Numero 8, 2017, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2017.01638

Treatment efficacy of adipose-derived stem cells in experimental osteoarthritis is driven by high synovial activation and reflected by S100A8/A9 serum levels

Autori: R.F. Schelbergen, S. van Dalen, M. ter Huurne, J. Roth, T. Vogl, D. Noël, C. Jorgensen, W.B. van den Berg, F.A. van de Loo, A.B. Blom, P.L.E.M. van Lent
Pubblicato in: Osteoarthritis and Cartilage, Numero 22/8, 2014, Pagina/e 1158-1166, ISSN 1063-4584
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.joca.2014.05.022

IL-1β-Mediated Activation of Adipose-Derived Mesenchymal Stromal Cells Results in PMN Reallocation and Enhanced Phagocytosis: A Possible Mechanism for the Reduction of Osteoarthritis Pathology

Autori: Stephanie C. M. van Dalen, Arjen B. Blom, Birgitte Walgreen, Annet W. Slöetjes, Monique M. A. Helsen, Edwin J. W. Geven, Menno ter Huurne, Thomas Vogl, Johannes Roth, Fons A. J. van de Loo, Marije I. Koenders, Louis Casteilla, Peter M. van der Kraan, Martijn H. J. van den Bosch, Peter L. E. M. van Lent
Pubblicato in: Frontiers in Immunology, Numero 10, 2019, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2019.01075

TGFBI secreted by mesenchymal stromal cells ameliorates osteoarthritis and is detected in extracellular vesicles

Autori: Maxime Ruiz, Karine Toupet, Marie Maumus, Pauline Rozier, Christian Jorgensen, Danièle Noël
Pubblicato in: Biomaterials, Numero 226, 2020, Pagina/e 119544, ISSN 0142-9612
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2019.119544

Osteoarthritic Milieu Affects Adipose‐Derived Mesenchymal Stromal Cells

Autori: Cristina Manferdini, Francesca Paolella, Elena Gabusi, Luca Cattini, Markus Rojewski, Hubert Schrezenmeier, Olga Addimanda, Riccardo Meliconi, Gina Lisignoli
Pubblicato in: Journal of Orthopaedic Research, 2019, ISSN 0736-0266
Editore: Elsevier BV
DOI: 10.1002/jor.24446

Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis

Autori: Stella Cosenza, Maxime Ruiz, Karine Toupet, Christian Jorgensen, Danièle Noël
Pubblicato in: Scientific Reports, Numero 7/1, 2017, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-017-15376-8

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