Clinical trial of autologous adipose-derived mesenchymal stromal cells (ASC) in the treatment of mild to moderate osteoarthritis

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Templates for Informed Consent Forms and Information Sheets in all clinical-trial-site languages.

Website (updated throughout the project)

Publications

From osteoarthritic synovium to synovial-derived cells characterization: synovial macrophages are key effector cells

Auteurs: Cattini, Luca; Silvestri, Ylenia; Gambari, Laura; Filardo, Giuseppe; Paolella, Francesca; Gabusi, Elena; Fleury-Cappellesso, Sandrine; Manferdini, Cristina; Lisignoli, Gina
Publié dans: Arthritis Research & Therapy, Numéro 1, 2016, ISSN 1478-6362
Éditeur: BioMed Central
DOI: 10.1186/s13075-016-0983-4

Therapeutic application of mesenchymal stem cells in osteoarthritis

Auteurs: Maxime Ruiz, Stella Cosenza, Marie Maumus, Christian Jorgensen, Danièle Noël
Publié dans: Expert Opinion on Biological Therapy, Numéro 16/1, 2015, Page(s) 33-42, ISSN 1471-2598
Éditeur: Ashley Publications Ltd.
DOI: 10.1517/14712598.2016.1093108

Deregulation and therapeutic potential of microRNAs in arthritic diseases

Auteurs: Rita Vicente, Danièle Noël, Yves-Marie Pers, Florence Apparailly, Christian Jorgensen
Publié dans: Nature Reviews Rheumatology, Numéro 12/4, 2015, Page(s) 211-220, ISSN 1759-4790
Éditeur: Nature Publishing Group
DOI: 10.1038/nrrheum.2015.162

Adipose Mesenchymal Stem Cells Isolated after Manual or Water-jet-Assisted Liposuction Display Similar Properties

Auteurs: Claire Bony, Mailys Cren, Sophie Domergue, Karine Toupet, Christian Jorgensen, Danièle Noël
Publié dans: Frontiers in Immunology, Numéro 6, 2016, ISSN 1664-3224
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fimmu.2015.00655

Mesenchymal stem cells for the management of inflammation in osteoarthritis: state of the art and perspectives

Auteurs: Y.-M. Pers, M. Ruiz, D. Noël, C. Jorgensen
Publié dans: Osteoarthritis and Cartilage, Numéro 23/11, 2015, Page(s) 2027-2035, ISSN 1063-4584
Éditeur: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.joca.2015.07.004

Adipose stromal cells mediated switching of the pro-inflammatory profile of M1-like macrophages is facilitated by PGE2: in vitro evaluation

Auteurs: C. Manferdini, F. Paolella, E. Gabusi, L. Gambari, A. Piacentini, G. Filardo, S. Fleury-Cappellesso, A. Barbero, M. Murphy, G. Lisignoli
Publié dans: Osteoarthritis and Cartilage, Numéro 25/7, 2017, Page(s) 1161-1171, ISSN 1063-4584
Éditeur: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.joca.2017.01.011

Pathogenic or Therapeutic Extracellular Vesicles in Rheumatic Diseases: Role of Mesenchymal Stem Cell-Derived Vesicles

Auteurs: Stella Cosenza, Maxime Ruiz, Marie Maumus, Christian Jorgensen, Danièle Noël
Publié dans: International Journal of Molecular Sciences, Numéro 18/12, 2017, Page(s) 889, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms18040889

Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis

Auteurs: Stella Cosenza, Karine Toupet, Marie Maumus, Patricia Luz-Crawford, Olivier Blanc-Brude, Christian Jorgensen, Danièle Noël
Publié dans: Theranostics, Numéro 8/5, 2018, Page(s) 1399-1410, ISSN 1838-7640
Éditeur: Ivyspring International Publisher
DOI: 10.7150/thno.21072

Thrombospondin-1 Partly Mediates the Cartilage Protective Effect of Adipose-Derived Mesenchymal Stem Cells in Osteoarthritis

Auteurs: Marie Maumus, Cristina Manferdini, Karine Toupet, Paul Chuchana, Louis Casteilla, Mélanie Gachet, Christian Jorgensen, Gina Lisignoli, Danièle Noël
Publié dans: Frontiers in Immunology, Numéro 8, 2017, ISSN 1664-3224
Éditeur: Frontiers
DOI: 10.3389/fimmu.2017.01638

Treatment efficacy of adipose-derived stem cells in experimental osteoarthritis is driven by high synovial activation and reflected by S100A8/A9 serum levels

Auteurs: R.F. Schelbergen, S. van Dalen, M. ter Huurne, J. Roth, T. Vogl, D. Noël, C. Jorgensen, W.B. van den Berg, F.A. van de Loo, A.B. Blom, P.L.E.M. van Lent
Publié dans: Osteoarthritis and Cartilage, Numéro 22/8, 2014, Page(s) 1158-1166, ISSN 1063-4584
Éditeur: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.joca.2014.05.022

IL-1β-Mediated Activation of Adipose-Derived Mesenchymal Stromal Cells Results in PMN Reallocation and Enhanced Phagocytosis: A Possible Mechanism for the Reduction of Osteoarthritis Pathology

Auteurs: Stephanie C. M. van Dalen, Arjen B. Blom, Birgitte Walgreen, Annet W. Slöetjes, Monique M. A. Helsen, Edwin J. W. Geven, Menno ter Huurne, Thomas Vogl, Johannes Roth, Fons A. J. van de Loo, Marije I. Koenders, Louis Casteilla, Peter M. van der Kraan, Martijn H. J. van den Bosch, Peter L. E. M. van Lent
Publié dans: Frontiers in Immunology, Numéro 10, 2019, ISSN 1664-3224
Éditeur: Frontiers
DOI: 10.3389/fimmu.2019.01075

TGFBI secreted by mesenchymal stromal cells ameliorates osteoarthritis and is detected in extracellular vesicles

Auteurs: Maxime Ruiz, Karine Toupet, Marie Maumus, Pauline Rozier, Christian Jorgensen, Danièle Noël
Publié dans: Biomaterials, Numéro 226, 2020, Page(s) 119544, ISSN 0142-9612
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2019.119544

Osteoarthritic Milieu Affects Adipose‐Derived Mesenchymal Stromal Cells

Auteurs: Cristina Manferdini, Francesca Paolella, Elena Gabusi, Luca Cattini, Markus Rojewski, Hubert Schrezenmeier, Olga Addimanda, Riccardo Meliconi, Gina Lisignoli
Publié dans: Journal of Orthopaedic Research, 2019, ISSN 0736-0266
Éditeur: Elsevier BV
DOI: 10.1002/jor.24446

Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis

Auteurs: Stella Cosenza, Maxime Ruiz, Karine Toupet, Christian Jorgensen, Danièle Noël
Publié dans: Scientific Reports, Numéro 7/1, 2017, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-017-15376-8

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