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Regenerative treatment of complete Traumatic Spinal Cord injury with a surgical implantation of a biodegradable device with FGF1 and nerve grafts

Obiettivo

Today there is no regenerative therapy available for treatment of complete spinal cord injuries (SCI). BioArctic Neuroscience develops a novel treatment of complete SCI. The method is based on the regeneration of functional nerves in the injured spinal cord. Nerve grafts are transplanted into the injured spinal cord, by using a biodegradable device, loaded with a growth factor and nerve grafts (these three components are abbreviated SC0806). Efficacy and safety of the treatment has been demonstrated in an in vivo model of SCI. The therapy has been designated Orphan Drug status in Europe and in USA. Ethical approval to commence into clinical trial in Sweden was recently granted.
The proposed project is the first clinical trial of the treatment of complete spinal cord injury. Following surgery at the Karolinska University Hospital, patients will receive rehabilitation in their home countries, with state of the art robotics equipment, at clinics in Denmark, Finland and Sweden.

This clinical study will be the first in-human trial with this new treatment concept. Several interim analyses are included in the study design to secure the safety of the patients. This is a single dose study in up to 3 sequences (A, B and C) in 27 subjects with complete traumatic SCI. In the first sequence (A), 6 subjects will be randomized to a surgical procedure where SC0806 will be implanted at the spinal cord, and receive robotics assisted walking training for 18 months, and 3 subjects will be randomized to specific walking training only. For safety reasons, the first three subjects will be operated on and implanted with at least 1 month in between. If efficacy is demonstrated, control subjects from (A) and (B) and (C) will later be given the opportunity to receive treatment with SC0806.The proposed project spans a period of 42 months and will start nov 2014 with screening, inclusion and treatment of patients in Sweden.

Invito a presentare proposte

H2020-PHC-2014-2015

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Bando secondario

H2020-PHC-2014-single-stage

Meccanismo di finanziamento

RIA - Research and Innovation action

Coordinatore

BIOARCTIC AB
Contribution nette de l'UE
€ 652 987,00
Indirizzo
Warfvinges Vag 35
112 51 Stockholm
Svezia

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Regione
Östra Sverige Stockholm Stockholms län
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Altri finanziamenti
€ 6 148 311,50

Partecipanti (7)

REHAB STATION STOCKHOLM AKTIEBOLAG
Svezia
Contribution nette de l'UE
€ 1 511 125,00
Indirizzo
Frosundaviks Alle 13
16 970 Solna

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Regione
Östra Sverige Stockholm Stockholms län
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Altri finanziamenti
€ 377 781,25
REGION MIDTJYLLAND

Partecipazione conclusa

Danimarca
Contribution nette de l'UE
€ 0,00
Indirizzo
Skottenborg 26
8800 Viborg
Regione
Danmark Midtjylland Vestjylland
Tipo di attività
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Altri finanziamenti
€ 0,00
KIINTEISTO OY Laitilan Terveyskoti
Finlandia
Contribution nette de l'UE
€ 1 125 742,00
Indirizzo
Sairaalantie 8
23800 Laitila

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Regione
Manner-Suomi Etelä-Suomi Varsinais-Suomi
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Altri finanziamenti
€ 281 435,50
REGION HOVEDSTADEN

Partecipazione conclusa

Danimarca
Contribution nette de l'UE
€ 0,00
Indirizzo
Kongens Vaenge 2
3400 Hillerod
Regione
Danmark Hovedstaden Nordsjælland
Tipo di attività
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Altri finanziamenti
€ 0,00
REGION STOCKHOLM
Svezia
Contribution nette de l'UE
€ 1 451 217,00
Indirizzo
Hantverkargatan 45
104 22 Stockholm

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Regione
Östra Sverige Stockholm Stockholms län
Tipo di attività
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Altri finanziamenti
€ 362 804,25
SIHTASUTUS HAAPSALU NEUROLOOGILINE REHABILITATSIOONIKESKUS
Estonia
Contribution nette de l'UE
€ 687 931,00
Indirizzo
Sadama 16
90502 Haapsalu

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Regione
Eesti Eesti Lääne-Eesti
Tipo di attività
Other
Altri finanziamenti
€ 171 982,75
HELSE BERGEN HF
Norvegia
Contribution nette de l'UE
€ 968 075,00
Indirizzo
Jonas Lies Vei 65
5021 Bergen

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Regione
Norge Vestlandet Vestland
Tipo di attività
Higher or Secondary Education Establishments
Altri finanziamenti
€ 242 018,75