AEGLE (Ancient Greek: Αἴγλη) – An analytics framework for integrated and personalized healthcare services in Europe | AEGLE | Project | Results | H2020 | CORDIS

Deliverables

AEGLE's third integrated prototype

Certification for the AEGLE product

AEGLE final prototype (product)

This deliverable will be the amalgamation of AEGLE project results combining technical, business and ethical aspects aiming to support other big-data efforts in the field of health.

Business and HTA framework

Business and HTA framework for AEGLE project

AEGLE final strategy, business evaluation and feasibility analysis

Report on AEGLE's final strategy, business evaluation and feasibility analysis

Market Research Report

Market and Research for the AEGLE Start-Up

AEGLE Legal Framework

Legal assessment for adressing the issues concerning the use of big-data in healthcare

Final system design

Final system design report

Project's Stationary

AEGLEs stationary

Project’s Promotional material

AEGLE's promotional Material

Project's Website

AEGLEs official website

Final components for local, cloud-level BigData Analytics and Applications

Publications

Antigen Selection Shapes the T-cell Repertoire in Chronic Lymphocytic Leukemia

Author(s): A. Vardi, A. Agathangelidis, E. Stalika, M. Karypidou, A. Siorenta, A. Anagnostopoulos, R. Rosenquist, A. Hadzidimitriou, P. Ghia, L.-A. Sutton, K. Stamatopoulos
Published in: Clinical Cancer Research, Issue 22/1, 2016, Page(s) 167-174, ISSN 1078-0432
Publisher: American Association for Cancer Research
DOI: 10.1158/1078-0432.CCR-14-3017

An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors

Author(s): V. Bikos, M. Karypidou, E. Stalika, P. Baliakas, A. Xochelli, L.-A. Sutton, G. Papadopoulos, A. Agathangelidis, E. Papadopoulou, Z. Davis, P. Algara, G. Kanellis, A. Traverse-Glehen, M. Mollejo, A. Anagnostopoulos, M. Ponzoni, D. Gonzalez, S. Pospisilova, E. Matutes, M. A. Piris, T. Papadaki, P. Ghia, R. Rosenquist, D. Oscier, N. Darzentas, D. Tzovaras, C. Belessi, A. Hadzidimitriou, K. Stamatopou
Published in: Clinical Cancer Research, Issue 22/8, 2016, Page(s) 2032-2040, ISSN 1078-0432
Publisher: American Association for Cancer Research
DOI: 10.1158/1078-0432.CCR-15-1170

Prognostic indices in chronic lymphocytic leukaemia: where do we stand how do we proceed?

Author(s): P. Baliakas, M. Mattsson, K. Stamatopoulos, R. Rosenquist
Published in: Journal of Internal Medicine, Issue 279/4, 2016, Page(s) 347-357, ISSN 0954-6820
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/joim.12455

A Customizable Framework for Application Implementation onto 3-D FPGAs

Author(s): Kostas Siozios, Dimitrios Soudris
Published in: IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems, 2016, Page(s) 1-1, ISSN 0278-0070
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/TCAD.2016.2529421

Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations

Author(s): V. Ljungstrom, D. Cortese, E. Young, T. Pandzic, L. Mansouri, K. Plevova, S. Ntoufa, P. Baliakas, R. Clifford, L.-A. Sutton, S. J. Blakemore, N. Stavroyianni, A. Agathangelidis, D. Rossi, M. Hoglund, J. Kotaskova, G. Juliusson, C. Belessi, N. Chiorazzi, P. Panagiotidis, A. W. Langerak, K. E. Smedby, D. Oscier, G. Gaidano, A. Schuh, F. Davi, C. Pott, J. C. Strefford, L. Trentin, S. Pospisilova, P.
Published in: Blood, Issue 127/8, 2016, Page(s) 1007-1016, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood-2015-10-674572

A Systematic Methodology for Optimization of Applications Utilizing Concurrent Data Structures

Author(s): Lazaros Papadopoulos, Ivan Walulya, Philippas Tsigas, Dimitris Soudris
Published in: IEEE Transactions on Computers, 2015, Page(s) 1-1, ISSN 0018-9340
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/TC.2015.2479604

Innovation in the prognostication of chronic lymphocytic leukemia: how far beyond TP53 gene analysis can we go?

Author(s): S. Pospisilova, L.-A. Sutton, J. Malcikova, E. Tausch, D. Rossi, E. Montserrat, C. Moreno, K. Stamatopoulos, G. Gaidano, R. Rosenquist, P. Ghia
Published in: Haematologica, Issue 101/3, 2016, Page(s) 263-265, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2015.139246

A critique of the regulation of data science in healthcare research in the European Union

Author(s): John M. M. Rumbold, Barbara K. Pierscionek
Published in: BMC Medical Ethics, Issue 18/1, 2017, ISSN 1472-6939
Publisher: BioMed Central
DOI: 10.1186/s12910-017-0184-y

The Effect of the General Data Protection Regulation on Medical Research

Author(s): John Mark Michael Rumbold, Barbara Pierscionek
Published in: Journal of Medical Internet Research, Issue 19/2, 2017, Page(s) e47, ISSN 1438-8871
Publisher: Journal of medical Internet Research
DOI: 10.2196/jmir.7108

Reply to Why patients shouldn't “own” their medical records

Author(s): John Rumbold; Barbara Pierscionek
Published in: Nature Biotechnology, Issue 34/6, 2016, Page(s) 586-587, ISSN 1087-0156
Publisher: Nature Publishing Group
DOI: 10.1038/nbt.3615

EGR2 mutations define a new clinically aggressive subgroup of chronic lymphocytic leukemia

Author(s): E Young, D Noerenberg, L Mansouri, V Ljungström, M Frick, L-A Sutton, S J Blakemore, J Galan-Sousa, K Plevova, P Baliakas, D Rossi, R Clifford, D Roos-Weil, V Navrkalova, B Dörken, C A Schmitt, K E Smedby, G Juliusson, B Giacopelli, J S Blachly, C Belessi, P Panagiotidis, N Chiorazzi, F Davi, A W Langerak, D Oscier, A Schuh, G Gaidano, P Ghia, W Xu, L Fan, O A Bernard, F Nguyen-Khac, L Rassenti,
Published in: Leukemia, Issue 31/7, 2016, Page(s) 1547-1554, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/leu.2016.359

Different spectra of recurrent gene mutations in subsets of chronic lymphocytic leukemia harboring stereotyped B-cell receptors

Author(s): L.-A. Sutton, E. Young, P. Baliakas, A. Hadzidimitriou, T. Moysiadis, K. Plevova, D. Rossi, J. Kminkova, E. Stalika, L. B. Pedersen, J. Malcikova, A. Agathangelidis, Z. Davis, L. Mansouri, L. Scarfo, M. Boudjoghra, A. Navarro, A. F. Muggen, X.-J. Yan, F. Nguyen-Khac, M. Larrayoz, P. Panagiotidis, N. Chiorazzi, C. U. Niemann, C. Belessi, E. Campo, J. C. Strefford, A. W. Langerak, D. Oscier, G. Gaid
Published in: Haematologica, Issue 101/8, 2016, Page(s) 959-967, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2016.141812

"ATM mutations in major stereotyped subsets of chronic lymphocytic leukemia: enrichment in subset #2 is associated with markedly short telomeres"

Author(s): V. Navrkalova, E. Young, P. Baliakas, L. Radova, L.-A. Sutton, K. Plevova, L. Mansouri, V. Ljungstrom, S. Ntoufa, Z. Davis, G. Juliusson, K. E. Smedby, C. Belessi, P. Panagiotidis, T. Touloumenidou, F. Davi, A. W. Langerak, P. Ghia, J. C. Strefford, D. Oscier, J. Mayer, K. Stamatopoulos, S. Pospisilova, R. Rosenquist, M. Trbusek
Published in: Haematologica, Issue 101/9, 2016, Page(s) e369-e373, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2016.142968

Additional trisomies amongst patients with chronic lymphocytic leukemia carrying trisomy 12: the accompanying chromosome makes a difference

Author(s): P. Baliakas, A. Puiggros, A. Xochelli, L.-A. Sutton, F. Nguyen-Khac, A. Gardiner, K. Plevova, E. Minga, A. Hadzidimitriou, R. Walewska, H. McCarthy, M. Ortega, R. Collado, T. Gonzalez, I. Granada, E. Luno, J. Kota kova, T. Moysiadis, Z. Davis, N. Stavroyianni, A. Anagnostopoulos, J. C. Strefford, S. Pospisilova, F. Davi, A. Athanasiadou, R. Rosenquist, D. Oscier, B. Espinet, K. Stamatopoulos
Published in: Haematologica, Issue 101/7, 2016, Page(s) e299-e302, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2015.140202

Clusters of ineffective efforts during mechanical ventilation: impact on outcome

Author(s): Katerina Vaporidi, Dimitris Babalis, Achilleas Chytas, Emmanuel Lilitsis, Eumorfia Kondili, Vasilis Amargianitakis, Ioanna Chouvarda, Nicos Maglaveras, Dimitris Georgopoulos
Published in: Intensive Care Medicine, Issue 43/2, 2017, Page(s) 184-191, ISSN 0342-4642
Publisher: Springer Verlag
DOI: 10.1007/s00134-016-4593-z

Design-Efficient Approximate Multiplication Circuits Through Partial Product Perforation

Author(s): Georgios Zervakis, Kostas Tsoumanis, Sotirios Xydis, Dimitrios Soudris, Kiamal Pekmestzi
Published in: IEEE Transactions on Very Large Scale Integration (VLSI) Systems, Issue 24/10, 2016, Page(s) 3105-3117, ISSN 1063-8210
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/TVLSI.2016.2535398

Integrating multiple immunogenetic data sources for feature extraction and mining somatic hypermutation patterns: the case of “towards analysis” in chronic lymphocytic leukaemia

Author(s): Ioannis Kavakiotis, Aliki Xochelli, Andreas Agathangelidis, Grigorios Tsoumakas, Nicos Maglaveras, Kostas Stamatopoulos, Anastasia Hadzidimitriou, Ioannis Vlahavas, Ioanna Chouvarda
Published in: BMC Bioinformatics, Issue 17/S5, 2016, ISSN 1471-2105
Publisher: BioMed Central
DOI: 10.1186/s12859-016-1044-3

Antigen receptor stereotypy in chronic lymphocytic leukemia

Author(s): K Stamatopoulos, A Agathangelidis, R Rosenquist, P Ghia
Published in: Leukemia, Issue 31/2, 2016, Page(s) 282-291, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/leu.2016.322

SoftRM

Author(s): Vasileios Tsoutsouras, Dimosthenis Masouros, Sotirios Xydis, Dimitrios Soudris
Published in: ACM Transactions on Embedded Computing Systems, Issue 16/5s, 2017, Page(s) 1-19, ISSN 1539-9087
Publisher: Association for Computing Machinary, Inc.
DOI: 10.1145/3126562

Immunoglobulin genes in chronic lymphocytic leukemia: key to understanding the disease and improving risk stratification

Author(s): Lesley-Ann Sutton, Anastasia Hadzidimitriou, Panagiotis Baliakas, Andreas Agathangelidis, Anton W. Langerak, Stephan Stilgenbauer, Sarka Pospisilova, Zadie Davis, Francesco Forconi, Frederic Davi, Paolo Ghia, Richard Rosenquist, Kostas Stamatopoulos
Published in: Haematologica, Issue 102/6, 2017, Page(s) 968-971, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2017.165605

NF-κB activation in chronic lymphocytic leukemia: A point of convergence of external triggers and intrinsic lesions

Author(s): Larry Mansouri, Nikos Papakonstantinou, Stavroula Ntoufa, Kostas Stamatopoulos, Richard Rosenquist
Published in: Seminars in Cancer Biology, Issue 39, 2016, Page(s) 40-48, ISSN 1044-579X
Publisher: Academic Press
DOI: 10.1016/j.semcancer.2016.07.005

Clinical impact of recurrently mutated genes on lymphoma diagnostics: state-of-the-art and beyond

Author(s): R. Rosenquist, A. Rosenwald, M.-Q. Du, G. Gaidano, P. Groenen, A. Wotherspoon, P. Ghia, P. Gaulard, E. Campo, K. Stamatopoulos
Published in: Haematologica, Issue 101/9, 2016, Page(s) 1002-1009, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2015.134510

Reconfigurable Computing for Analytics Acceleration of Big Bio-Data: The AEGLE Approach

Author(s): Andreas Raptopoulos, Sotirios Xydis, Dimitrios Soudris
Published in: Applied Reconfigurable Computing, 2015, Page(s) 531-541, ISBN 978-3-319-16214-0
Publisher: Springer International Publishing
DOI: 10.1007/978-3-319-16214-0_49

Machine Learning and Data Mining Methods in Diabetes Research

Author(s): Ioannis Kavakiotis, Olga Tsave, Athanasios Salifoglou, Nicos Maglaveras, Ioannis Vlahavas, Ioanna Chouvarda
Published in: Computational and Structural Biotechnology Journal, Issue 15, 2017, Page(s) 104-116, ISSN 2001-0370
Publisher: Computational and Structural Biotechnology Journal
DOI: 10.1016/j.csbj.2016.12.005

Does your electronic butler owe you a duty of confidentiality?

Author(s): John Rumbold, Barbara Pierscionek
Published in: Computer Law Review International, Issue 18/2, 2017, ISSN 2194-4164
Publisher: Computer Law Review International
DOI: 10.9785/cri-2017-0206

Performance-power exploration of software-defined big data analytics: The AEGLE cloud backend

Author(s): Georgios Zervakis, Sotirios Xydis, Dimitrios Soudris
Published in: 2016 International Conference on Embedded Computer Systems: Architectures, Modeling and Simulation (SAMOS), 2016, Page(s) 312-319, ISBN 978-1-5090-3076-7
Publisher: IEEE
DOI: 10.1109/SAMOS.2016.7818364

Distributed QoS management for internet of things under resource constraints

Author(s): Farzad Samie, Vasileios Tsoutsouras, Sotirios Xydis, Lars Bauer, Dimitrios Soudris, Jörg Henkel
Published in: Proceedings of the Eleventh IEEE/ACM/IFIP International Conference on Hardware/Software Codesign and System Synthesis - CODES '16, 2016, Page(s) 1-10, ISBN 9781-450344838
Publisher: ACM Press
DOI: 10.1145/2968456.2974005

Computation offloading and resource allocation for low-power IoT edge devices

Author(s): Farzad Samie, Vasileios Tsoutsouras, Lars Bauer, Sotirios Xydis, Dimitrios Soudris, Jorg Henkel
Published in: 2016 IEEE 3rd World Forum on Internet of Things (WF-IoT), 2016, Page(s) 7-12, ISBN 978-1-5090-4130-5
Publisher: IEEE
DOI: 10.1109/WF-IoT.2016.7845499

Dataflow Acceleration of scikit-learn Gaussian Process Regression

Author(s): Michail Doukas, Sotirios Xydis, Dimitrios Soudris
Published in: Proceedings of the 8th Workshop and 6th Workshop on Parallel Programming and Run-Time Management Techniques for Many-core Architectures and Design Tools and Architectures for Multicore Embedded Computing Platforms - PARMA-DITAM '17, 2017, Page(s) 1-6, ISBN 9781-450348775
Publisher: ACM Press
DOI: 10.1145/3029580.3029587

Novel Methods for Correcting Next Generation Sequencing Errors in the β Chain of T Cell Receptors

Author(s): Chrysi Panopoulou, Christos Maramis, Nicos Maglaveras, Ioanna Chouvarda
Published in: 2016, Page(s) 529-534
Publisher: Springer International Publishing
DOI: 10.1007/978-3-319-32703-7_103

Ineffective Efforts in ICU Assisted Ventilation: Feature Extraction and Analysis Platform

Author(s): Achilleas Chytas, Katerina Vaporidi, Dimitris Babalis, Dimitris Georgopoulos, Nicos Maglaveras, Ioanna Chouvarda
Published in: 2016, Page(s) 642-650
Publisher: Springer International Publishing
DOI: 10.1007/978-3-319-44944-9_57

AEGLE's Cloud Infrastructure for Resource Monitoring and Containerized Accelerated Analytics

Author(s): Konstantina Koliogeorgi, Dimosthenis Masouros, Georgios Zervakis, Sotirios Xydis, Tobias Becker, Georgi Gaydadjiev, Dimitrios Soudris
Published in: 2017 IEEE Computer Society Annual Symposium on VLSI (ISVLSI), 2017, Page(s) 362-367, ISBN 978-1-5090-6762-6
Publisher: IEEE
DOI: 10.1109/ISVLSI.2017.70

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AEGLE (Ancient Greek: Αἴγλη) – An analytics framework for integrated and personalized healthcare services in Europe

Deliverables

Publications

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