AEGLE (Ancient Greek: Αἴγλη) – An analytics framework for integrated and personalized healthcare services in Europe

Información del proyecto

AEGLE

Identificador del acuerdo de subvención: 644906

DOI

10.3030/644906

Proyecto cerrado

Fecha de la firma de la CE 12 Diciembre 2014

Fecha de inicio 1 Marzo 2015

Fecha de finalización 31 Agosto 2018

Financiado con arreglo a

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT)

Coste total

€ 6 079 642,50

Aportación de la UE

€ 5 230 698,75

Coordinado por

EXODUS ANONYMOS ETAIREIA PLIROFORIKIS
Greece

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Demonstrators, pilots, prototypes (3)

AEGLE third prototype

AEGLE's third integrated prototype

AEGLE Certification

Certification for the AEGLE product

AEGLE product

AEGLE final prototype (product)

Open Research Data Pilot (1)

AEGLE Best Practices

This deliverable will be the amalgamation of AEGLE project results combining technical, business and ethical aspects aiming to support other big-data efforts in the field of health.

Documents, reports (5)

Business and HTA framework

Business and HTA framework for AEGLE project

AEGLE final strategy, business evaluation and feasibility analysis

Report on AEGLE's final strategy, business evaluation and feasibility analysis

Market Research Report

Market and Research for the AEGLE Start-Up

AEGLE Legal Framework

Legal assessment for adressing the issues concerning the use of big-data in healthcare

Final system design

Final system design report

Websites, patent fillings, videos etc. (3)

Project's Stationary

AEGLEs stationary

Project’s Promotional material

AEGLE's promotional Material

Project's Website

AEGLEs official website

Other (1)

Final components for local, cloud-level BigData Analytics and Applications

Publicaciones

Peer reviewed articles (22)

Antigen Selection Shapes the T-cell Repertoire in Chronic Lymphocytic Leukemia

Autores: A. Vardi, A. Agathangelidis, E. Stalika, M. Karypidou, A. Siorenta, A. Anagnostopoulos, R. Rosenquist, A. Hadzidimitriou, P. Ghia, L.-A. Sutton, K. Stamatopoulos
Publicado en: Clinical Cancer Research, Edición 22/1, 2016, Página(s) 167-174, ISSN 1078-0432
Editor: American Association for Cancer Research
DOI: 10.1158/1078-0432.CCR-14-3017

An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors

Autores: V. Bikos, M. Karypidou, E. Stalika, P. Baliakas, A. Xochelli, L.-A. Sutton, G. Papadopoulos, A. Agathangelidis, E. Papadopoulou, Z. Davis, P. Algara, G. Kanellis, A. Traverse-Glehen, M. Mollejo, A. Anagnostopoulos, M. Ponzoni, D. Gonzalez, S. Pospisilova, E. Matutes, M. A. Piris, T. Papadaki, P. Ghia, R. Rosenquist, D. Oscier, N. Darzentas, D. Tzovaras, C. Belessi, A. Hadzidimitriou, K. Stamatopou
Publicado en: Clinical Cancer Research, Edición 22/8, 2016, Página(s) 2032-2040, ISSN 1078-0432
Editor: American Association for Cancer Research
DOI: 10.1158/1078-0432.CCR-15-1170

Prognostic indices in chronic lymphocytic leukaemia: where do we stand how do we proceed?

Autores: P. Baliakas, M. Mattsson, K. Stamatopoulos, R. Rosenquist
Publicado en: Journal of Internal Medicine, Edición 279/4, 2016, Página(s) 347-357, ISSN 0954-6820
Editor: Blackwell Publishing Inc.
DOI: 10.1111/joim.12455

A Customizable Framework for Application Implementation onto 3-D FPGAs

Autores: Kostas Siozios, Dimitrios Soudris
Publicado en: IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems, 2016, Página(s) 1-1, ISSN 0278-0070
Editor: Institute of Electrical and Electronics Engineers
DOI: 10.1109/TCAD.2016.2529421

Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations

Autores: V. Ljungstrom, D. Cortese, E. Young, T. Pandzic, L. Mansouri, K. Plevova, S. Ntoufa, P. Baliakas, R. Clifford, L.-A. Sutton, S. J. Blakemore, N. Stavroyianni, A. Agathangelidis, D. Rossi, M. Hoglund, J. Kotaskova, G. Juliusson, C. Belessi, N. Chiorazzi, P. Panagiotidis, A. W. Langerak, K. E. Smedby, D. Oscier, G. Gaidano, A. Schuh, F. Davi, C. Pott, J. C. Strefford, L. Trentin, S. Pospisilova, P.
Publicado en: Blood, Edición 127/8, 2016, Página(s) 1007-1016, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood-2015-10-674572

A Systematic Methodology for Optimization of Applications Utilizing Concurrent Data Structures

Autores: Lazaros Papadopoulos, Ivan Walulya, Philippas Tsigas, Dimitris Soudris
Publicado en: IEEE Transactions on Computers, 2015, Página(s) 1-1, ISSN 0018-9340
Editor: Institute of Electrical and Electronics Engineers
DOI: 10.1109/TC.2015.2479604

Innovation in the prognostication of chronic lymphocytic leukemia: how far beyond TP53 gene analysis can we go?

Autores: S. Pospisilova, L.-A. Sutton, J. Malcikova, E. Tausch, D. Rossi, E. Montserrat, C. Moreno, K. Stamatopoulos, G. Gaidano, R. Rosenquist, P. Ghia
Publicado en: Haematologica, Edición 101/3, 2016, Página(s) 263-265, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2015.139246

A critique of the regulation of data science in healthcare research in the European Union

Autores: John M. M. Rumbold, Barbara K. Pierscionek
Publicado en: BMC Medical Ethics, Edición 18/1, 2017, ISSN 1472-6939
Editor: BioMed Central
DOI: 10.1186/s12910-017-0184-y

The Effect of the General Data Protection Regulation on Medical Research

Autores: John Mark Michael Rumbold, Barbara Pierscionek
Publicado en: Journal of Medical Internet Research, Edición 19/2, 2017, Página(s) e47, ISSN 1438-8871
Editor: Journal of medical Internet Research
DOI: 10.2196/jmir.7108

Reply to Why patients shouldn't “own” their medical records

Autores: John Rumbold; Barbara Pierscionek
Publicado en: Nature Biotechnology, Edición 34/6, 2016, Página(s) 586-587, ISSN 1087-0156
Editor: Nature Publishing Group
DOI: 10.1038/nbt.3615

EGR2 mutations define a new clinically aggressive subgroup of chronic lymphocytic leukemia

Autores: E Young, D Noerenberg, L Mansouri, V Ljungström, M Frick, L-A Sutton, S J Blakemore, J Galan-Sousa, K Plevova, P Baliakas, D Rossi, R Clifford, D Roos-Weil, V Navrkalova, B Dörken, C A Schmitt, K E Smedby, G Juliusson, B Giacopelli, J S Blachly, C Belessi, P Panagiotidis, N Chiorazzi, F Davi, A W Langerak, D Oscier, A Schuh, G Gaidano, P Ghia, W Xu, L Fan, O A Bernard, F Nguyen-Khac, L Rassenti,
Publicado en: Leukemia, Edición 31/7, 2016, Página(s) 1547-1554, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/leu.2016.359

Different spectra of recurrent gene mutations in subsets of chronic lymphocytic leukemia harboring stereotyped B-cell receptors

Autores: L.-A. Sutton, E. Young, P. Baliakas, A. Hadzidimitriou, T. Moysiadis, K. Plevova, D. Rossi, J. Kminkova, E. Stalika, L. B. Pedersen, J. Malcikova, A. Agathangelidis, Z. Davis, L. Mansouri, L. Scarfo, M. Boudjoghra, A. Navarro, A. F. Muggen, X.-J. Yan, F. Nguyen-Khac, M. Larrayoz, P. Panagiotidis, N. Chiorazzi, C. U. Niemann, C. Belessi, E. Campo, J. C. Strefford, A. W. Langerak, D. Oscier, G. Gaid
Publicado en: Haematologica, Edición 101/8, 2016, Página(s) 959-967, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2016.141812

"ATM mutations in major stereotyped subsets of chronic lymphocytic leukemia: enrichment in subset #2 is associated with markedly short telomeres"

Autores: V. Navrkalova, E. Young, P. Baliakas, L. Radova, L.-A. Sutton, K. Plevova, L. Mansouri, V. Ljungstrom, S. Ntoufa, Z. Davis, G. Juliusson, K. E. Smedby, C. Belessi, P. Panagiotidis, T. Touloumenidou, F. Davi, A. W. Langerak, P. Ghia, J. C. Strefford, D. Oscier, J. Mayer, K. Stamatopoulos, S. Pospisilova, R. Rosenquist, M. Trbusek
Publicado en: Haematologica, Edición 101/9, 2016, Página(s) e369-e373, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2016.142968

Additional trisomies amongst patients with chronic lymphocytic leukemia carrying trisomy 12: the accompanying chromosome makes a difference

Autores: P. Baliakas, A. Puiggros, A. Xochelli, L.-A. Sutton, F. Nguyen-Khac, A. Gardiner, K. Plevova, E. Minga, A. Hadzidimitriou, R. Walewska, H. McCarthy, M. Ortega, R. Collado, T. Gonzalez, I. Granada, E. Luno, J. Kota kova, T. Moysiadis, Z. Davis, N. Stavroyianni, A. Anagnostopoulos, J. C. Strefford, S. Pospisilova, F. Davi, A. Athanasiadou, R. Rosenquist, D. Oscier, B. Espinet, K. Stamatopoulos
Publicado en: Haematologica, Edición 101/7, 2016, Página(s) e299-e302, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2015.140202

Clusters of ineffective efforts during mechanical ventilation: impact on outcome

Autores: Katerina Vaporidi, Dimitris Babalis, Achilleas Chytas, Emmanuel Lilitsis, Eumorfia Kondili, Vasilis Amargianitakis, Ioanna Chouvarda, Nicos Maglaveras, Dimitris Georgopoulos
Publicado en: Intensive Care Medicine, Edición 43/2, 2017, Página(s) 184-191, ISSN 0342-4642
Editor: Springer Verlag
DOI: 10.1007/s00134-016-4593-z

Design-Efficient Approximate Multiplication Circuits Through Partial Product Perforation

Autores: Georgios Zervakis, Kostas Tsoumanis, Sotirios Xydis, Dimitrios Soudris, Kiamal Pekmestzi
Publicado en: IEEE Transactions on Very Large Scale Integration (VLSI) Systems, Edición 24/10, 2016, Página(s) 3105-3117, ISSN 1063-8210
Editor: Institute of Electrical and Electronics Engineers
DOI: 10.1109/TVLSI.2016.2535398

Integrating multiple immunogenetic data sources for feature extraction and mining somatic hypermutation patterns: the case of “towards analysis” in chronic lymphocytic leukaemia

Autores: Ioannis Kavakiotis, Aliki Xochelli, Andreas Agathangelidis, Grigorios Tsoumakas, Nicos Maglaveras, Kostas Stamatopoulos, Anastasia Hadzidimitriou, Ioannis Vlahavas, Ioanna Chouvarda
Publicado en: BMC Bioinformatics, Edición 17/S5, 2016, ISSN 1471-2105
Editor: BioMed Central
DOI: 10.1186/s12859-016-1044-3

Antigen receptor stereotypy in chronic lymphocytic leukemia

Autores: K Stamatopoulos, A Agathangelidis, R Rosenquist, P Ghia
Publicado en: Leukemia, Edición 31/2, 2016, Página(s) 282-291, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/leu.2016.322

SoftRM

Autores: Vasileios Tsoutsouras, Dimosthenis Masouros, Sotirios Xydis, Dimitrios Soudris
Publicado en: ACM Transactions on Embedded Computing Systems, Edición 16/5s, 2017, Página(s) 1-19, ISSN 1539-9087
Editor: Association for Computing Machinary, Inc.
DOI: 10.1145/3126562

Immunoglobulin genes in chronic lymphocytic leukemia: key to understanding the disease and improving risk stratification

Autores: Lesley-Ann Sutton, Anastasia Hadzidimitriou, Panagiotis Baliakas, Andreas Agathangelidis, Anton W. Langerak, Stephan Stilgenbauer, Sarka Pospisilova, Zadie Davis, Francesco Forconi, Frederic Davi, Paolo Ghia, Richard Rosenquist, Kostas Stamatopoulos
Publicado en: Haematologica, Edición 102/6, 2017, Página(s) 968-971, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2017.165605

NF-κB activation in chronic lymphocytic leukemia: A point of convergence of external triggers and intrinsic lesions

Autores: Larry Mansouri, Nikos Papakonstantinou, Stavroula Ntoufa, Kostas Stamatopoulos, Richard Rosenquist
Publicado en: Seminars in Cancer Biology, Edición 39, 2016, Página(s) 40-48, ISSN 1044-579X
Editor: Academic Press
DOI: 10.1016/j.semcancer.2016.07.005

Clinical impact of recurrently mutated genes on lymphoma diagnostics: state-of-the-art and beyond

Autores: R. Rosenquist, A. Rosenwald, M.-Q. Du, G. Gaidano, P. Groenen, A. Wotherspoon, P. Ghia, P. Gaulard, E. Campo, K. Stamatopoulos
Publicado en: Haematologica, Edición 101/9, 2016, Página(s) 1002-1009, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2015.134510

Book chapters (1)

Reconfigurable Computing for Analytics Acceleration of Big Bio-Data: The AEGLE Approach

Autores: Andreas Raptopoulos, Sotirios Xydis, Dimitrios Soudris
Publicado en: Applied Reconfigurable Computing, 2015, Página(s) 531-541, ISBN 978-3-319-16214-0
Editor: Springer International Publishing
DOI: 10.1007/978-3-319-16214-0_49

Non-peer reviewed articles (2)

Machine Learning and Data Mining Methods in Diabetes Research

Autores: Ioannis Kavakiotis, Olga Tsave, Athanasios Salifoglou, Nicos Maglaveras, Ioannis Vlahavas, Ioanna Chouvarda
Publicado en: Computational and Structural Biotechnology Journal, Edición 15, 2017, Página(s) 104-116, ISSN 2001-0370
Editor: Computational and Structural Biotechnology Journal
DOI: 10.1016/j.csbj.2016.12.005

Does your electronic butler owe you a duty of confidentiality?

Autores: John Rumbold, Barbara Pierscionek
Publicado en: Computer Law Review International, Edición 18/2, 2017, ISSN 2194-4164
Editor: Computer Law Review International
DOI: 10.9785/cri-2017-0206

Conference proceedings (7)

Performance-power exploration of software-defined big data analytics: The AEGLE cloud backend

Autores: Georgios Zervakis, Sotirios Xydis, Dimitrios Soudris
Publicado en: 2016 International Conference on Embedded Computer Systems: Architectures, Modeling and Simulation (SAMOS), 2016, Página(s) 312-319, ISBN 978-1-5090-3076-7
Editor: IEEE
DOI: 10.1109/SAMOS.2016.7818364

Distributed QoS management for internet of things under resource constraints

Autores: Farzad Samie, Vasileios Tsoutsouras, Sotirios Xydis, Lars Bauer, Dimitrios Soudris, Jörg Henkel
Publicado en: Proceedings of the Eleventh IEEE/ACM/IFIP International Conference on Hardware/Software Codesign and System Synthesis - CODES '16, 2016, Página(s) 1-10, ISBN 9781-450344838
Editor: ACM Press
DOI: 10.1145/2968456.2974005

Computation offloading and resource allocation for low-power IoT edge devices

Autores: Farzad Samie, Vasileios Tsoutsouras, Lars Bauer, Sotirios Xydis, Dimitrios Soudris, Jorg Henkel
Publicado en: 2016 IEEE 3rd World Forum on Internet of Things (WF-IoT), 2016, Página(s) 7-12, ISBN 978-1-5090-4130-5
Editor: IEEE
DOI: 10.1109/WF-IoT.2016.7845499

Dataflow Acceleration of scikit-learn Gaussian Process Regression

Autores: Michail Doukas, Sotirios Xydis, Dimitrios Soudris
Publicado en: Proceedings of the 8th Workshop and 6th Workshop on Parallel Programming and Run-Time Management Techniques for Many-core Architectures and Design Tools and Architectures for Multicore Embedded Computing Platforms - PARMA-DITAM '17, 2017, Página(s) 1-6, ISBN 9781-450348775
Editor: ACM Press
DOI: 10.1145/3029580.3029587

Novel Methods for Correcting Next Generation Sequencing Errors in the β Chain of T Cell Receptors

Autores: Chrysi Panopoulou, Christos Maramis, Nicos Maglaveras, Ioanna Chouvarda
Publicado en: 2016, Página(s) 529-534
Editor: Springer International Publishing
DOI: 10.1007/978-3-319-32703-7_103

Ineffective Efforts in ICU Assisted Ventilation: Feature Extraction and Analysis Platform

Autores: Achilleas Chytas, Katerina Vaporidi, Dimitris Babalis, Dimitris Georgopoulos, Nicos Maglaveras, Ioanna Chouvarda
Publicado en: 2016, Página(s) 642-650
Editor: Springer International Publishing
DOI: 10.1007/978-3-319-44944-9_57

AEGLE's Cloud Infrastructure for Resource Monitoring and Containerized Accelerated Analytics

Autores: Konstantina Koliogeorgi, Dimosthenis Masouros, Georgios Zervakis, Sotirios Xydis, Tobias Becker, Georgi Gaydadjiev, Dimitrios Soudris
Publicado en: 2017 IEEE Computer Society Annual Symposium on VLSI (ISVLSI), 2017, Página(s) 362-367, ISBN 978-1-5090-6762-6
Editor: IEEE
DOI: 10.1109/ISVLSI.2017.70