AEGLE (Ancient Greek: Αἴγλη) – An analytics framework for integrated and personalized healthcare services in Europe | AEGLE | Project | Results | H2020 | CORDIS

Livrables

AEGLE's third integrated prototype

Certification for the AEGLE product

AEGLE final prototype (product)

This deliverable will be the amalgamation of AEGLE project results combining technical, business and ethical aspects aiming to support other big-data efforts in the field of health.

Business and HTA framework

Business and HTA framework for AEGLE project

AEGLE final strategy, business evaluation and feasibility analysis

Report on AEGLE's final strategy, business evaluation and feasibility analysis

Market Research Report

Market and Research for the AEGLE Start-Up

AEGLE Legal Framework

Legal assessment for adressing the issues concerning the use of big-data in healthcare

Final system design

Final system design report

Project's Stationary

AEGLEs stationary

Project’s Promotional material

AEGLE's promotional Material

Project's Website

AEGLEs official website

Final components for local, cloud-level BigData Analytics and Applications

Publications

Antigen Selection Shapes the T-cell Repertoire in Chronic Lymphocytic Leukemia

Auteurs: A. Vardi, A. Agathangelidis, E. Stalika, M. Karypidou, A. Siorenta, A. Anagnostopoulos, R. Rosenquist, A. Hadzidimitriou, P. Ghia, L.-A. Sutton, K. Stamatopoulos
Publié dans: Clinical Cancer Research, Numéro 22/1, 2016, Page(s) 167-174, ISSN 1078-0432
Éditeur: American Association for Cancer Research
DOI: 10.1158/1078-0432.CCR-14-3017

An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors

Auteurs: V. Bikos, M. Karypidou, E. Stalika, P. Baliakas, A. Xochelli, L.-A. Sutton, G. Papadopoulos, A. Agathangelidis, E. Papadopoulou, Z. Davis, P. Algara, G. Kanellis, A. Traverse-Glehen, M. Mollejo, A. Anagnostopoulos, M. Ponzoni, D. Gonzalez, S. Pospisilova, E. Matutes, M. A. Piris, T. Papadaki, P. Ghia, R. Rosenquist, D. Oscier, N. Darzentas, D. Tzovaras, C. Belessi, A. Hadzidimitriou, K. Stamatopou
Publié dans: Clinical Cancer Research, Numéro 22/8, 2016, Page(s) 2032-2040, ISSN 1078-0432
Éditeur: American Association for Cancer Research
DOI: 10.1158/1078-0432.CCR-15-1170

Prognostic indices in chronic lymphocytic leukaemia: where do we stand how do we proceed?

Auteurs: P. Baliakas, M. Mattsson, K. Stamatopoulos, R. Rosenquist
Publié dans: Journal of Internal Medicine, Numéro 279/4, 2016, Page(s) 347-357, ISSN 0954-6820
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/joim.12455

A Customizable Framework for Application Implementation onto 3-D FPGAs

Auteurs: Kostas Siozios, Dimitrios Soudris
Publié dans: IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems, 2016, Page(s) 1-1, ISSN 0278-0070
Éditeur: Institute of Electrical and Electronics Engineers
DOI: 10.1109/TCAD.2016.2529421

Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations

Auteurs: V. Ljungstrom, D. Cortese, E. Young, T. Pandzic, L. Mansouri, K. Plevova, S. Ntoufa, P. Baliakas, R. Clifford, L.-A. Sutton, S. J. Blakemore, N. Stavroyianni, A. Agathangelidis, D. Rossi, M. Hoglund, J. Kotaskova, G. Juliusson, C. Belessi, N. Chiorazzi, P. Panagiotidis, A. W. Langerak, K. E. Smedby, D. Oscier, G. Gaidano, A. Schuh, F. Davi, C. Pott, J. C. Strefford, L. Trentin, S. Pospisilova, P.
Publié dans: Blood, Numéro 127/8, 2016, Page(s) 1007-1016, ISSN 0006-4971
Éditeur: American Society of Hematology
DOI: 10.1182/blood-2015-10-674572

A Systematic Methodology for Optimization of Applications Utilizing Concurrent Data Structures

Auteurs: Lazaros Papadopoulos, Ivan Walulya, Philippas Tsigas, Dimitris Soudris
Publié dans: IEEE Transactions on Computers, 2015, Page(s) 1-1, ISSN 0018-9340
Éditeur: Institute of Electrical and Electronics Engineers
DOI: 10.1109/TC.2015.2479604

Innovation in the prognostication of chronic lymphocytic leukemia: how far beyond TP53 gene analysis can we go?

Auteurs: S. Pospisilova, L.-A. Sutton, J. Malcikova, E. Tausch, D. Rossi, E. Montserrat, C. Moreno, K. Stamatopoulos, G. Gaidano, R. Rosenquist, P. Ghia
Publié dans: Haematologica, Numéro 101/3, 2016, Page(s) 263-265, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
DOI: 10.3324/haematol.2015.139246

A critique of the regulation of data science in healthcare research in the European Union

Auteurs: John M. M. Rumbold, Barbara K. Pierscionek
Publié dans: BMC Medical Ethics, Numéro 18/1, 2017, ISSN 1472-6939
Éditeur: BioMed Central
DOI: 10.1186/s12910-017-0184-y

The Effect of the General Data Protection Regulation on Medical Research

Auteurs: John Mark Michael Rumbold, Barbara Pierscionek
Publié dans: Journal of Medical Internet Research, Numéro 19/2, 2017, Page(s) e47, ISSN 1438-8871
Éditeur: Journal of medical Internet Research
DOI: 10.2196/jmir.7108

Reply to Why patients shouldn't “own” their medical records

Auteurs: John Rumbold; Barbara Pierscionek
Publié dans: Nature Biotechnology, Numéro 34/6, 2016, Page(s) 586-587, ISSN 1087-0156
Éditeur: Nature Publishing Group
DOI: 10.1038/nbt.3615

EGR2 mutations define a new clinically aggressive subgroup of chronic lymphocytic leukemia

Auteurs: E Young, D Noerenberg, L Mansouri, V Ljungström, M Frick, L-A Sutton, S J Blakemore, J Galan-Sousa, K Plevova, P Baliakas, D Rossi, R Clifford, D Roos-Weil, V Navrkalova, B Dörken, C A Schmitt, K E Smedby, G Juliusson, B Giacopelli, J S Blachly, C Belessi, P Panagiotidis, N Chiorazzi, F Davi, A W Langerak, D Oscier, A Schuh, G Gaidano, P Ghia, W Xu, L Fan, O A Bernard, F Nguyen-Khac, L Rassenti,
Publié dans: Leukemia, Numéro 31/7, 2016, Page(s) 1547-1554, ISSN 0887-6924
Éditeur: Nature Publishing Group
DOI: 10.1038/leu.2016.359

Different spectra of recurrent gene mutations in subsets of chronic lymphocytic leukemia harboring stereotyped B-cell receptors

Auteurs: L.-A. Sutton, E. Young, P. Baliakas, A. Hadzidimitriou, T. Moysiadis, K. Plevova, D. Rossi, J. Kminkova, E. Stalika, L. B. Pedersen, J. Malcikova, A. Agathangelidis, Z. Davis, L. Mansouri, L. Scarfo, M. Boudjoghra, A. Navarro, A. F. Muggen, X.-J. Yan, F. Nguyen-Khac, M. Larrayoz, P. Panagiotidis, N. Chiorazzi, C. U. Niemann, C. Belessi, E. Campo, J. C. Strefford, A. W. Langerak, D. Oscier, G. Gaid
Publié dans: Haematologica, Numéro 101/8, 2016, Page(s) 959-967, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
DOI: 10.3324/haematol.2016.141812

"ATM mutations in major stereotyped subsets of chronic lymphocytic leukemia: enrichment in subset #2 is associated with markedly short telomeres"

Auteurs: V. Navrkalova, E. Young, P. Baliakas, L. Radova, L.-A. Sutton, K. Plevova, L. Mansouri, V. Ljungstrom, S. Ntoufa, Z. Davis, G. Juliusson, K. E. Smedby, C. Belessi, P. Panagiotidis, T. Touloumenidou, F. Davi, A. W. Langerak, P. Ghia, J. C. Strefford, D. Oscier, J. Mayer, K. Stamatopoulos, S. Pospisilova, R. Rosenquist, M. Trbusek
Publié dans: Haematologica, Numéro 101/9, 2016, Page(s) e369-e373, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
DOI: 10.3324/haematol.2016.142968

Additional trisomies amongst patients with chronic lymphocytic leukemia carrying trisomy 12: the accompanying chromosome makes a difference

Auteurs: P. Baliakas, A. Puiggros, A. Xochelli, L.-A. Sutton, F. Nguyen-Khac, A. Gardiner, K. Plevova, E. Minga, A. Hadzidimitriou, R. Walewska, H. McCarthy, M. Ortega, R. Collado, T. Gonzalez, I. Granada, E. Luno, J. Kota kova, T. Moysiadis, Z. Davis, N. Stavroyianni, A. Anagnostopoulos, J. C. Strefford, S. Pospisilova, F. Davi, A. Athanasiadou, R. Rosenquist, D. Oscier, B. Espinet, K. Stamatopoulos
Publié dans: Haematologica, Numéro 101/7, 2016, Page(s) e299-e302, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
DOI: 10.3324/haematol.2015.140202

Clusters of ineffective efforts during mechanical ventilation: impact on outcome

Auteurs: Katerina Vaporidi, Dimitris Babalis, Achilleas Chytas, Emmanuel Lilitsis, Eumorfia Kondili, Vasilis Amargianitakis, Ioanna Chouvarda, Nicos Maglaveras, Dimitris Georgopoulos
Publié dans: Intensive Care Medicine, Numéro 43/2, 2017, Page(s) 184-191, ISSN 0342-4642
Éditeur: Springer Verlag
DOI: 10.1007/s00134-016-4593-z

Design-Efficient Approximate Multiplication Circuits Through Partial Product Perforation

Auteurs: Georgios Zervakis, Kostas Tsoumanis, Sotirios Xydis, Dimitrios Soudris, Kiamal Pekmestzi
Publié dans: IEEE Transactions on Very Large Scale Integration (VLSI) Systems, Numéro 24/10, 2016, Page(s) 3105-3117, ISSN 1063-8210
Éditeur: Institute of Electrical and Electronics Engineers
DOI: 10.1109/TVLSI.2016.2535398

Integrating multiple immunogenetic data sources for feature extraction and mining somatic hypermutation patterns: the case of “towards analysis” in chronic lymphocytic leukaemia

Auteurs: Ioannis Kavakiotis, Aliki Xochelli, Andreas Agathangelidis, Grigorios Tsoumakas, Nicos Maglaveras, Kostas Stamatopoulos, Anastasia Hadzidimitriou, Ioannis Vlahavas, Ioanna Chouvarda
Publié dans: BMC Bioinformatics, Numéro 17/S5, 2016, ISSN 1471-2105
Éditeur: BioMed Central
DOI: 10.1186/s12859-016-1044-3

Antigen receptor stereotypy in chronic lymphocytic leukemia

Auteurs: K Stamatopoulos, A Agathangelidis, R Rosenquist, P Ghia
Publié dans: Leukemia, Numéro 31/2, 2016, Page(s) 282-291, ISSN 0887-6924
Éditeur: Nature Publishing Group
DOI: 10.1038/leu.2016.322

SoftRM

Auteurs: Vasileios Tsoutsouras, Dimosthenis Masouros, Sotirios Xydis, Dimitrios Soudris
Publié dans: ACM Transactions on Embedded Computing Systems, Numéro 16/5s, 2017, Page(s) 1-19, ISSN 1539-9087
Éditeur: Association for Computing Machinary, Inc.
DOI: 10.1145/3126562

Immunoglobulin genes in chronic lymphocytic leukemia: key to understanding the disease and improving risk stratification

Auteurs: Lesley-Ann Sutton, Anastasia Hadzidimitriou, Panagiotis Baliakas, Andreas Agathangelidis, Anton W. Langerak, Stephan Stilgenbauer, Sarka Pospisilova, Zadie Davis, Francesco Forconi, Frederic Davi, Paolo Ghia, Richard Rosenquist, Kostas Stamatopoulos
Publié dans: Haematologica, Numéro 102/6, 2017, Page(s) 968-971, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
DOI: 10.3324/haematol.2017.165605

NF-κB activation in chronic lymphocytic leukemia: A point of convergence of external triggers and intrinsic lesions

Auteurs: Larry Mansouri, Nikos Papakonstantinou, Stavroula Ntoufa, Kostas Stamatopoulos, Richard Rosenquist
Publié dans: Seminars in Cancer Biology, Numéro 39, 2016, Page(s) 40-48, ISSN 1044-579X
Éditeur: Academic Press
DOI: 10.1016/j.semcancer.2016.07.005

Clinical impact of recurrently mutated genes on lymphoma diagnostics: state-of-the-art and beyond

Auteurs: R. Rosenquist, A. Rosenwald, M.-Q. Du, G. Gaidano, P. Groenen, A. Wotherspoon, P. Ghia, P. Gaulard, E. Campo, K. Stamatopoulos
Publié dans: Haematologica, Numéro 101/9, 2016, Page(s) 1002-1009, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
DOI: 10.3324/haematol.2015.134510

Reconfigurable Computing for Analytics Acceleration of Big Bio-Data: The AEGLE Approach

Auteurs: Andreas Raptopoulos, Sotirios Xydis, Dimitrios Soudris
Publié dans: Applied Reconfigurable Computing, 2015, Page(s) 531-541, ISBN 978-3-319-16214-0
Éditeur: Springer International Publishing
DOI: 10.1007/978-3-319-16214-0_49

Machine Learning and Data Mining Methods in Diabetes Research

Auteurs: Ioannis Kavakiotis, Olga Tsave, Athanasios Salifoglou, Nicos Maglaveras, Ioannis Vlahavas, Ioanna Chouvarda
Publié dans: Computational and Structural Biotechnology Journal, Numéro 15, 2017, Page(s) 104-116, ISSN 2001-0370
Éditeur: Computational and Structural Biotechnology Journal
DOI: 10.1016/j.csbj.2016.12.005

Does your electronic butler owe you a duty of confidentiality?

Auteurs: John Rumbold, Barbara Pierscionek
Publié dans: Computer Law Review International, Numéro 18/2, 2017, ISSN 2194-4164
Éditeur: Computer Law Review International
DOI: 10.9785/cri-2017-0206

Performance-power exploration of software-defined big data analytics: The AEGLE cloud backend

Auteurs: Georgios Zervakis, Sotirios Xydis, Dimitrios Soudris
Publié dans: 2016 International Conference on Embedded Computer Systems: Architectures, Modeling and Simulation (SAMOS), 2016, Page(s) 312-319, ISBN 978-1-5090-3076-7
Éditeur: IEEE
DOI: 10.1109/SAMOS.2016.7818364

Distributed QoS management for internet of things under resource constraints

Auteurs: Farzad Samie, Vasileios Tsoutsouras, Sotirios Xydis, Lars Bauer, Dimitrios Soudris, Jörg Henkel
Publié dans: Proceedings of the Eleventh IEEE/ACM/IFIP International Conference on Hardware/Software Codesign and System Synthesis - CODES '16, 2016, Page(s) 1-10, ISBN 9781-450344838
Éditeur: ACM Press
DOI: 10.1145/2968456.2974005

Computation offloading and resource allocation for low-power IoT edge devices

Auteurs: Farzad Samie, Vasileios Tsoutsouras, Lars Bauer, Sotirios Xydis, Dimitrios Soudris, Jorg Henkel
Publié dans: 2016 IEEE 3rd World Forum on Internet of Things (WF-IoT), 2016, Page(s) 7-12, ISBN 978-1-5090-4130-5
Éditeur: IEEE
DOI: 10.1109/WF-IoT.2016.7845499

Dataflow Acceleration of scikit-learn Gaussian Process Regression

Auteurs: Michail Doukas, Sotirios Xydis, Dimitrios Soudris
Publié dans: Proceedings of the 8th Workshop and 6th Workshop on Parallel Programming and Run-Time Management Techniques for Many-core Architectures and Design Tools and Architectures for Multicore Embedded Computing Platforms - PARMA-DITAM '17, 2017, Page(s) 1-6, ISBN 9781-450348775
Éditeur: ACM Press
DOI: 10.1145/3029580.3029587

Novel Methods for Correcting Next Generation Sequencing Errors in the β Chain of T Cell Receptors

Auteurs: Chrysi Panopoulou, Christos Maramis, Nicos Maglaveras, Ioanna Chouvarda
Publié dans: 2016, Page(s) 529-534
Éditeur: Springer International Publishing
DOI: 10.1007/978-3-319-32703-7_103

Ineffective Efforts in ICU Assisted Ventilation: Feature Extraction and Analysis Platform

Auteurs: Achilleas Chytas, Katerina Vaporidi, Dimitris Babalis, Dimitris Georgopoulos, Nicos Maglaveras, Ioanna Chouvarda
Publié dans: 2016, Page(s) 642-650
Éditeur: Springer International Publishing
DOI: 10.1007/978-3-319-44944-9_57

AEGLE's Cloud Infrastructure for Resource Monitoring and Containerized Accelerated Analytics

Auteurs: Konstantina Koliogeorgi, Dimosthenis Masouros, Georgios Zervakis, Sotirios Xydis, Tobias Becker, Georgi Gaydadjiev, Dimitrios Soudris
Publié dans: 2017 IEEE Computer Society Annual Symposium on VLSI (ISVLSI), 2017, Page(s) 362-367, ISBN 978-1-5090-6762-6
Éditeur: IEEE
DOI: 10.1109/ISVLSI.2017.70

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AEGLE (Ancient Greek: Αἴγλη) – An analytics framework for integrated and personalized healthcare services in Europe

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