Systematic discovery of functional elements in RNA virus genomes: an Encyclopedia of RNA Virus Elements

Información del proyecto

ERVE

Identificador del acuerdo de subvención: 646891

DOI

10.3030/646891

Proyecto cerrado

Fecha de la firma de la CE 17 Agosto 2015

Fecha de inicio 1 Septiembre 2015

Fecha de finalización 31 Agosto 2021

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 780 000,00

Aportación de la UE

€ 1 780 000,00

Coordinado por

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (31)

Discovery of three RNA viruses using ant transcriptomic datasets

Autores: Eleni Kleanthous, Ingrida Olendraite, Nina I. Lukhovitskaya, Andrew E. Firth
Publicado en: Archives of Virology, Edición 164/2, 2019, Página(s) 643-647, ISSN 0304-8608
Editor: Springer Verlag
DOI: 10.1007/s00705-018-4093-2

A case for a negative-strand coding sequence in a group of positive-sense RNA viruses.

Autores: Dinan, Adam M; Lukhovitskaya, Nina; Olendraite, Ingrida; Firth, Andrew
Publicado en: Virus Evolution, Edición 1, 2020, Página(s) veaa007, ISSN 2057-1577
Editor: Oxford Academic
DOI: 10.1093/ve/veaa007

Detection of novel and recognized RNA viruses in mosquitoes from the Yucatan Peninsula of Mexico using metagenomics and characterization of their in vitro host ranges

Autores: Jermilia Charles, Chandra S. Tangudu, Stefanie L. Hurt, Charlotte Tumescheit, Andrew E. Firth, Julian E. Garcia-Rejon, Carlos Machain-Williams, Bradley J. Blitvich
Publicado en: Journal of General Virology, Edición 99/12, 2018, Página(s) 1729-1738, ISSN 0022-1317
Editor: Society for General Microbiology
DOI: 10.1099/jgv.0.001165

Programmed −2/−1 Ribosomal Frameshifting in Simarteriviruses: an Evolutionarily Conserved Mechanism

Autores: Yanhua Li, Andrew E. Firth, Ian Brierley, Yingyun Cai, Sawsan Napthine, Tao Wang, Xingyu Yan, Jens H. Kuhn, Ying Fang
Publicado en: Journal of Virology, Edición 93/16, 2019, Página(s) e00370-19, ISSN 0022-538X
Editor: American Society for Microbiology
DOI: 10.1128/JVI.00370-19

Hybrid Gene Origination Creates Human-Virus Chimeric Proteins during Infection

Autores: Jessica Sook Yuin Ho, Matthew Angel, Yixuan Ma, Elizabeth Sloan, Guojun Wang, Carles Martinez-Romero, Marta Alenquer, Vladimir Roudko, Liliane Chung, Simin Zheng, Max Chang, Yesai Fstkchyan, Sara Clohisey, Adam M. Dinan, James Gibbs, Robert Gifford, Rong Shen, Quan Gu, Nerea Irigoyen, Laura Campisi, Cheng Huang, Nan Zhao, Joshua D. Jones, Ingeborg van Knippenberg, Zeyu Zhu, Natasha Moshkina, Léa
Publicado en: Cell, Edición 181/7, 2020, Página(s) 1502-1517.e23, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2020.05.035

Propensity of a picornavirus polymerase to slip on potyvirus-derived transcriptional slippage sites

Autores: Hazel Stewart, Allan Olspert, Benjamin G. Butt, Andrew E. Firth
Publicado en: Journal of General Virology, Edición 100/2, 2019, Página(s) 199-205, ISSN 0022-1317
Editor: Society for General Microbiology
DOI: 10.1099/jgv.0.001189

Targeting the Conserved Stem Loop 2 Motif in the SARS-CoV-2 Genome

Autores: Lulla V, Wandel MP, Bandyra KJ, Ulferts R, Wu M, Dendooven T, Yang X, Doyle N, Oerum S, Beale R, O'Rourke SM, Randow F, Maier HJ, Scott W, Ding Y, Firth AE, Bloznelyte K, Luisi BF
Publicado en: Journal of Virology, Edición 95, 2021, Página(s) e0066321, ISSN 0022-538X
Editor: American Society for Microbiology
DOI: 10.1128/jvi.00663-21

A hidden gene in astroviruses encodes a viroporin

Autores: Valeria Lulla, Andrew E. Firth
Publicado en: Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-17906-x

Enterovirus Competition Assay to Assess Replication Fitness

Autores: Valeria Lulla, Andrew Firth
Publicado en: BIO-PROTOCOL, Edición 9/10, 2019, ISSN 2331-8325
Editor: bio-protocol
DOI: 10.21769/bioprotoc.3233

Complete genome sequences of two insect-specific flaviviruses

Autores: Jermilia Charles, Chandra S. Tangudu, Andrew E. Firth, Bradley J. Blitvich
Publicado en: Archives of Virology, Edición 162/12, 2017, Página(s) 3913-3917, ISSN 0304-8608
Editor: Springer Verlag
DOI: 10.1007/s00705-017-3552-5

ASXL gain-of-function truncation mutants: defective and dysregulated forms of a natural ribosomal frameshifting product?

Autores: Adam M. Dinan, John F. Atkins, Andrew E. Firth
Publicado en: Biology Direct, Edición 12/1, 2017, ISSN 1745-6150
Editor: BioMed Central
DOI: 10.1186/s13062-017-0195-0

A Review of Flaviviruses that Have No Known Arthropod Vector

Autores: Bradley Blitvich, Andrew Firth
Publicado en: Viruses, Edición 9/6, 2017, Página(s) 154, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v9060154

Avoidance of reporter assay distortions from fused dual reporters

Autores: Gary Loughran, Michael T. Howard, Andrew E. Firth, John F. Atkins
Publicado en: RNA, Edición 23/8, 2017, Página(s) 1285-1289, ISSN 1355-8382
Editor: Cold Spring Harbor Laboratory Press
DOI: 10.1261/rna.061051.117

Ribosome profiling of the retrovirus murine leukemia virus

Autores: Nerea Irigoyen, Adam M. Dinan, Ian Brierley, Andrew E. Firth
Publicado en: Retrovirology, Edición 15/1, 2018, ISSN 1742-4690
Editor: BioMed Central
DOI: 10.1186/s12977-018-0394-5

Protein-directed ribosomal frameshifting temporally regulates gene expression

Autores: Sawsan Napthine, Roger Ling, Leanne K. Finch, Joshua D. Jones, Susanne Bell, Ian Brierley, Andrew E. Firth
Publicado en: Nature Communications, Edición 8, 2017, Página(s) 15582, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/ncomms15582

An analysis by metabolic labelling of the encephalomyocarditis virus ribosomal frameshifting efficiency and stimulators

Autores: Roger Ling, Andrew E. Firth
Publicado en: Journal of General Virology, Edición 98/8, 2017, Página(s) 2100-2105, ISSN 0022-1317
Editor: Society for General Microbiology
DOI: 10.1099/jgv.0.000888

Polycipiviridae: a proposed new family of polycistronic picorna-like RNA viruses

Autores: Ingrida Olendraite, Nina I. Lukhovitskaya, Sanford D. Porter, Steven M. Valles, Andrew E. Firth
Publicado en: Journal of General Virology, Edición 98/9, 2017, Página(s) 2368-2378, ISSN 0022-1317
Editor: Society for General Microbiology
DOI: 10.1099/jgv.0.000902

Transcriptional and Translational Landscape of Equine Torovirus

Autores: Hazel Stewart, Katherine Brown, Adam M. Dinan, Nerea Irigoyen, Eric J. Snijder, Andrew E. Firth
Publicado en: Journal of Virology, Edición 92/17, 2018, ISSN 0022-538X
Editor: American Society for Microbiology
DOI: 10.1128/JVI.00589-18

Isolation and characterization of Nylanderia fulva virus 1, a positive-sense, single-stranded RNA virus infecting the tawny crazy ant, Nylanderia fulva

Autores: Steven M. Valles, David H. Oi, James J. Becnel, James K. Wetterer, John S. LaPolla, Andrew E. Firth
Publicado en: Virology, Edición 496, 2016, Página(s) 244-254, ISSN 0042-6822
Editor: Academic Press
DOI: 10.1016/j.virol.2016.06.014

Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use

Autores: John F. Atkins, Gary Loughran, Pramod R. Bhatt, Andrew E. Firth, Pavel V. Baranov
Publicado en: Nucleic Acids Research, 2016, Página(s) gkw530, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkw530

High-Resolution Analysis of Coronavirus Gene Expression by RNA Sequencing and Ribosome Profiling

Autores: Nerea Irigoyen, Andrew E. Firth, Joshua D. Jones, Betty Y.-W. Chung, Stuart G. Siddell, Ian Brierley
Publicado en: PLOS Pathogens, Edición 12/2, 2016, Página(s) e1005473, ISSN 1553-7374
Editor: Public Library of Science
DOI: 10.1371/journal.ppat.1005473

Mutational analysis of the Potyviridae transcriptional slippage site utilized for expression of the P3N-PIPO and P1N-PISPO proteins

Autores: Allan Olspert, John P. Carr, Andrew E. Firth
Publicado en: Nucleic Acids Research, Edición 44/16, 2016, Página(s) 7618-7629, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkw441

Characterization of the stimulators of protein-directed ribosomal frameshifting in Theiler's murine encephalomyelitis virus

Autores: Sawsan Napthine, Susanne Bell, Chris H Hill, Ian Brierley, Andrew E Firth
Publicado en: Nucleic Acids Research, Edición 47/15, 2019, Página(s) 8207-8223, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkz503

Discovery of a novel Tymoviridae-like virus in mosquitoes from Mexico

Autores: Jermilia Charles, Chandra S. Tangudu, Stefanie L. Hurt, Charlotte Tumescheit, Andrew E. Firth, Julian E. Garcia-Rejon, Carlos Machain-Williams, Bradley J. Blitvich
Publicado en: Archives of Virology, Edición 164/2, 2019, Página(s) 649-652, ISSN 0304-8608
Editor: Springer Verlag
DOI: 10.1007/s00705-018-4098-x

Manipulation of the unfolded protein response: A pharmacological strategy against coronavirus infection

Autores: Echavarría-Consuegra L, Cook GM, Busnadiego I, Lefèvre C, Keep S, Brown K, Doyle N, Dowgier G, Franaszek K, Moore NA, Siddell SG, Bickerton E, Hale BG, Firth AE, Brierley I, Irigoyen N
Publicado en: PLoS Pathogens, Edición 17, 2021, Página(s) e1009644, ISSN 1553-7374
Editor: Public Library of Science
DOI: 10.1371/journal.ppat.1009644

A putative new SARS-CoV protein, 3c, encoded in an ORF overlapping ORF3a

Autores: Andrew E. Firth
Publicado en: Journal of General Virology, 2020, ISSN 0022-1317
Editor: Society for General Microbiology
DOI: 10.1099/jgv.0.001469

An upstream protein-coding region in enteroviruses modulates virus infection in gut epithelial cells

Autores: Valeria Lulla, Adam M. Dinan, Myra Hosmillo, Yasmin Chaudhry, Lee Sherry, Nerea Irigoyen, Komal M. Nayak, Nicola J. Stonehouse, Matthias Zilbauer, Ian Goodfellow, Andrew E. Firth
Publicado en: Nature Microbiology, Edición 4/2, 2019, Página(s) 280-292, ISSN 2058-5276
Editor: Nature Research
DOI: 10.1038/s41564-018-0297-1

C6orf203 is an RNA-binding protein involved in mitochondrial protein synthesis

Autores: Shreekara Gopalakrishna, Sarah F Pearce, Adam M Dinan, Florian A Schober, Miriam Cipullo, Henrik Spåhr, Anas Khawaja, Camilla Maffezzini, Christoph Freyer, Anna Wredenberg, Ilian Atanassov, Andrew E Firth, Joanna Rorbach
Publicado en: Nucleic Acids Research, Edición 47/17, 2019, Página(s) 9386-9399, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkz684

Comparative Analysis of Gene Expression in Virulent and Attenuated Strains of Infectious Bronchitis Virus at Subcodon Resolution

Autores: Adam M. Dinan, Sarah Keep, Erica Bickerton, Paul Britton, Andrew E. Firth, Ian Brierley
Publicado en: Journal of Virology, Edición 93/18, 2019, ISSN 0022-538X
Editor: American Society for Microbiology
DOI: 10.1128/JVI.00714-19

Investigating molecular mechanisms of 2A-stimulated ribosomal pausing and frameshifting in Theilovirus

Autores: Hill CH, Cook GM, Napthine S, Kibe A, Brown K, Caliskan N, Firth AE, Graham SC, Brierley I
Publicado en: Nucleic Acids Research, Edición 49, 2021, Página(s) 11938-11958, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkab969

Structural and molecular basis for Cardiovirus 2A protein as a viral gene expression switch

Autores: Hill CH, Pekarek L, Napthine S, Kibe A, Firth AE, Graham SC, Caliskan N, Brierley I
Publicado en: Nature Communications, Edición 12, 2021, Página(s) 7166, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-27400-7