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The molecular genetic architecture of educational attainment and its significance for cognitive health

Veröffentlichungen

Genetic Fortune: Winning or Losing Education, Income, and Health

Autoren: Hyeokmoon Kweon, Casper A.P. Burik, Richard Karlsson Linnér, Ronald de Vlaming, Aysu Okbay, Daphne Martschenko, Kathryn Paige Harden, Thomas A. DiPrete, Philipp D. Koellinger
Veröffentlicht in: Tinbergen Discussion Paper, 20-053/V, 2020
Herausgeber: Tinbergen Institute

Equivalence of LD-Score Regression and Individual-Level-Data Methods

Autoren: de Vlaming, Ronald; Johannesson, Magnus; Magnusson, Patrik K.E.; Ikram, M. Arfan; Visscher, Peter M.
Veröffentlicht in: BioRxiv, 2017
Herausgeber: BioRxiv
DOI: 10.1101/211821

Genetic Underpinnings of Risky Behavior Relate to Altered Neuroanatomy

Autoren: Hare, Todd A; Aydogan, G; Daviet, R; Linnér, R Karlsson; Kable, J W; Kranzler, H R; Wetherill, R R; Ruff, C C; Koellinger, P D; Nave, G
Veröffentlicht in: Aydogan, G; Daviet, R; Linnér, R Karlsson; Hare, Todd A; Kable, J W; Kranzler, H R; Wetherill, R R; Ruff, C C; Koellinger, P D; Nave, G (2019). Genetic underpinnings of risky behavior relate to altered neuroanatomy. bioRxiv 862417, Cold Spring Harbor Laboratory., 2019
Herausgeber: BioRxiv
DOI: 10.1101/862417

Multimodal brain imaging study of 19,825 participants reveals adverse effects of moderate drinking

Autoren: Daviet, Remi; Aydogan, Gökhan; Jagannathan, Kanchana; Spilka, Nathaniel; Koellinger, Philipp; Kranzler, Henry R.; Nave, Gideon; Wetherill, Reagan R.
Veröffentlicht in: BioRxiv, 2020
Herausgeber: BioRxiv
DOI: 10.1101/2020.03.27.011791

Genetic risk scores of disease and mortality capture differences in longevity, economic behavior, and insurance outcomes

Autoren: Karlsson Linner, Richard; Koellinger, Philipp D
Veröffentlicht in: MedRxiv, 2020
Herausgeber: MedRxiv
DOI: 10.1101/2020.03.30.20047290

Genomic analysis of diet composition finds novel loci and associations with health and lifestyle

Autoren: S. Fleur W. Meddens, Ronald de Vlaming, Peter Bowers, Casper A. P. Burik, Richard Karlsson Linnér, Chanwook Lee, Aysu Okbay, Patrick Turley, Cornelius A. Rietveld, Mark Alan Fontana, Mohsen Ghanbari, Fumiaki Imamura, George McMahon, Peter J. van der Most, Trudy Voortman, Kaitlin H. Wade, Emma L. Anderson, Kim V. E. Braun, Pauline M. Emmett, Tonũ Esko, Juan R. Gonzalez, Jessica C. Kiefte-de Jong,
Veröffentlicht in: Molecular Psychiatry, 11 May 2020, 2020, ISSN 1359-4184
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41380-020-0697-5

Using genetics for social science

Autoren: K. Paige Harden, Philipp D. Koellinger
Veröffentlicht in: Nature Human Behaviour, 4/6, 2020, Page(s) 567-576, ISSN 2397-3374
Herausgeber: Springer Nature
DOI: 10.1038/s41562-020-0862-5

An epigenome-wide association study meta-analysis of educational attainment

Autoren: R Karlsson Linnér, R E Marioni, C A Rietveld, A J Simpkin, N M Davies, K Watanabe, N J Armstrong, K Auro, C Baumbach, M J Bonder, J Buchwald, G Fiorito, K Ismail, S Iurato, A Joensuu, P Karell, S Kasela, J Lahti, A F McRae, P R Mandaviya, I Seppälä, Y Wang, L Baglietto, E B Binder, S E Harris, A M Hodge, S Horvath, M Hurme, M Johannesson, A Latvala, K A Mather, S E Medland, A Metspalu, L Milani
Veröffentlicht in: Molecular Psychiatry, 22/12, 2017, Page(s) 1680-1690, ISSN 1359-4184
Herausgeber: Nature Publishing Group
DOI: 10.1038/mp.2017.210

Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence

Autoren: Suzanne Sniekers, Sven Stringer, Kyoko Watanabe, Philip R Jansen, Jonathan R I Coleman, Eva Krapohl, Erdogan Taskesen, Anke R Hammerschlag, Aysu Okbay, Delilah Zabaneh, Najaf Amin, Gerome Breen, David Cesarini, Christopher F Chabris, William G Iacono, M Arfan Ikram, Magnus Johannesson, Philipp Koellinger, James J Lee, Patrik K E Magnusson, Matt McGue, Mike B Miller, William E R Ollier, Antony Payt
Veröffentlicht in: Nature Genetics, 49/7, 2017, Page(s) 1107-1112, ISSN 1061-4036
Herausgeber: Nature Publishing Group
DOI: 10.1038/ng.3869

Education and coronary heart disease: mendelian randomisation study

Autoren: Taavi Tillmann, Julien Vaucher, Aysu Okbay, Hynek Pikhart, Anne Peasey, Ruzena Kubinova, Andrzej Pajak, Abdonas Tamosiunas, Sofia Malyutina, Fernando Pires Hartwig, Krista Fischer, Giovanni Veronesi, Tom Palmer, Jack Bowden, George Davey Smith, Martin Bobak, Michael V Holmes
Veröffentlicht in: BMJ, 358, 2017, Page(s) j3542, ISSN 0959-8138
Herausgeber: British Medical Association
DOI: 10.1136/bmj.j3542

Genetic Heterogeneity in Depressive Symptoms Following the Death of a Spouse: Polygenic Score Analysis of the U.S. Health and Retirement Study

Autoren: Benjamin W. Domingue, Hexuan Liu, Aysu Okbay, Daniel W. Belsky
Veröffentlicht in: American Journal of Psychiatry, 174/10, 2017, Page(s) 963-970, ISSN 0002-953X
Herausgeber: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.2017.16111209

Multi-trait analysis of genome-wide association summary statistics using MTAG

Autoren: Patrick Turley, Raymond K. Walters, Omeed Maghzian, Aysu Okbay, James J. Lee, Mark Alan Fontana, Tuan Anh Nguyen-Viet, Robbee Wedow, Meghan Zacher, Nicholas A. Furlotte, Patrik Magnusson, Sven Oskarsson, Magnus Johannesson, Peter M. Visscher, David Laibson, David Cesarini, Benjamin M. Neale, Daniel J. Benjamin
Veröffentlicht in: Nature Genetics, 50/2, 2018, Page(s) 229-237, ISSN 1061-4036
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41588-017-0009-4

Signatures of negative selection in the genetic architecture of human complex traits

Autoren: Jian Zeng, Ronald de Vlaming, Yang Wu, Matthew R. Robinson, Luke R. Lloyd-Jones, Loic Yengo, Chloe X. Yap, Angli Xue, Julia Sidorenko, Allan F. McRae, Joseph E. Powell, Grant W. Montgomery, Andres Metspalu, Tonu Esko, Greg Gibson, Naomi R. Wray, Peter M. Visscher, Jian Yang
Veröffentlicht in: Nature Genetics, 50/5, 2018, Page(s) 746-753, ISSN 1061-4036
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41588-018-0101-4

Genome-wide association study results for educational attainment aid in identifying genetic heterogeneity of schizophrenia

Autoren: V. Bansal, M. Mitjans, C. A. P. Burik, R. K. Linnér, A. Okbay, C. A. Rietveld, M. Begemann, S. Bonn, S. Ripke, R. de Vlaming, M. G. Nivard, H. Ehrenreich, P. D. Koellinger
Veröffentlicht in: Nature Communications, 9/1, 2018, ISSN 2041-1723
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41467-018-05510-z

Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

Autoren: Daniel J Weiner, Emilie M Wigdor, Stephan Ripke, Raymond K Walters, Jack A Kosmicki, Jakob Grove, Kaitlin E Samocha, Jacqueline I Goldstein, Aysu Okbay, Jonas Bybjerg-Grauholm, Thomas Werge, David M Hougaard, Jacob Taylor, Marie Bækvad-Hansen, Ashley Dumont, Christine Hansen, Thomas F Hansen, Daniel Howrigan, Manuel Mattheisen, Jennifer Moran, Ole Mors, Merete Nordentoft, Bent Nørgaard-Pedersen,
Veröffentlicht in: Nature Genetics, 49/7, 2017, Page(s) 978-985, ISSN 1061-4036
Herausgeber: Nature Publishing Group
DOI: 10.1038/ng.3863

Genetic Instrumental Variable (GIV) Regression: Explaining Socioeconomic And Health Outcomes In Non-Experimental Data

Autoren: Burik, Casper; Diprete, Thomas; Burik, Casper; Koellinger, Philipp; Koellinger, Philipp
Veröffentlicht in: PNAS, 115(22), 2018, Page(s) E4970-E4979, ISSN 0027-8424
Herausgeber: National Academy of Sciences
DOI: 10.1101/134197

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

Autoren: James J. Lee, Robbee Wedow, Aysu Okbay, Edward Kong, Omeed Maghzian, Meghan Zacher, Tuan Anh Nguyen-Viet, Peter Bowers, Julia Sidorenko, Richard Karlsson Linnér, Mark Alan Fontana, Tushar Kundu, Chanwook Lee, Hui Li, Ruoxi Li, Rebecca Royer, Pascal N. Timshel, Raymond K. Walters, Emily A. Willoughby, Loïc Yengo, Maris Alver, Yanchun Bao, David W. Clark, Felix R. Day, Nicholas A. Furlotte, Peter
Veröffentlicht in: Nature Genetics, 50/8, 2018, Page(s) 1112-1121, ISSN 1061-4036
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41588-018-0147-3

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

Autoren: Aysu Okbay, Bart M L Baselmans, Jan-Emmanuel De Neve, Patrick Turley, Michel G Nivard, Mark Alan Fontana, S Fleur W Meddens, Richard Karlsson Linnér, Cornelius A Rietveld, Jaime Derringer, Jacob Gratten, James J Lee, Jimmy Z Liu, Ronald de Vlaming, Tarunveer S Ahluwalia, Jadwiga Buchwald, Alana Cavadino, Alexis C Frazier-Wood, Nicholas A Furlotte, Victoria Garfield, Marie Henrike Geisel, Juan R G
Veröffentlicht in: Nature Genetics, 48/6, 2016, Page(s) 624-633, ISSN 1061-4036
Herausgeber: Nature Publishing Group
DOI: 10.1038/ng.3552

Genome-wide association study identifies 74 loci associated with educational attainment

Autoren: Aysu Okbay, Jonathan P. Beauchamp, Mark Alan Fontana, James J. Lee, Tune H. Pers, Cornelius A. Rietveld, Patrick Turley, Guo-Bo Chen, Valur Emilsson, S. Fleur W. Meddens, Sven Oskarsson, Joseph K. Pickrell, Kevin Thom, Pascal Timshel, Ronald de Vlaming, Abdel Abdellaoui, Tarunveer S. Ahluwalia, Jonas Bacelis, Clemens Baumbach, Gyda Bjornsdottir, Johannes H. Brandsma, Maria Pina Concas, Jaime Derri
Veröffentlicht in: Nature, 533/7604, 2016, Page(s) 539-542, ISSN 0028-0836
Herausgeber: Nature Publishing Group
DOI: 10.1038/nature17671

Meta-GWAS Accuracy and Power (MetaGAP) Calculator Shows that Hiding Heritability Is Partially Due to Imperfect Genetic Correlations across Studies

Autoren: Ronald de Vlaming, Aysu Okbay, Cornelius A. Rietveld, Magnus Johannesson, Patrik K. E. Magnusson, André G. Uitterlinden, Frank J. A. van Rooij, Albert Hofman, Patrick J. F. Groenen, A. Roy Thurik, Philipp D. Koellinger
Veröffentlicht in: PLOS Genetics, 13/1, 2017, Page(s) e1006495, ISSN 1553-7404
Herausgeber: PLOS Genetics
DOI: 10.1371/journal.pgen.1006495

Genome-wide analysis identifies 12 loci influencing human reproductive behavior

Autoren: Nicola Barban, Rick Jansen, Ronald de Vlaming, Ahmad Vaez, Jornt J Mandemakers, Felix C Tropf, Xia Shen, James F Wilson, Daniel I Chasman, Ilja M Nolte, Vinicius Tragante, Sander W van der Laan, John R B Perry, Augustine Kong, Tarunveer S Ahluwalia, Eva Albrecht, Laura Yerges-Armstrong, Gil Atzmon, Kirsi Auro, Kristin Ayers, Andrew Bakshi, Danny Ben-Avraham, Klaus Berger, Aviv Bergman, Lars Bertra
Veröffentlicht in: Nature Genetics, 48/12, 2016, Page(s) 1462-1472, ISSN 1061-4036
Herausgeber: Nature Publishing Group
DOI: 10.1038/ng.3698

Are bigger brains smarter? Evidence from a large-scale preregistered study

Autoren: Gideon Nave, Wi Hoon Jung, Richard Karlsson Linnér, Joseph W. Kable, and Philipp D. Koellinger
Veröffentlicht in: Psychological Science, 30 (1), 2019, Page(s) 43-54, ISSN 0956-7976
Herausgeber: SAGE Publications
DOI: 10.1177/09567976188084

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

Autoren: Richard Karlsson Linnér, Pietro Biroli, Edward Kong, S. Fleur W. Meddens, Robbee Wedow, Mark Alan Fontana, Maël Lebreton, Stephen P. Tino, Abdel Abdellaoui, Anke R. Hammerschlag, Michel G. Nivard, Aysu Okbay, Cornelius A. Rietveld, Pascal N. Timshel, Maciej Trzaskowski, Ronald de Vlaming, Christian L. Zünd, Yanchun Bao, Laura Buzdugan, Ann H. Caplin, Chia-Yen Chen, Peter Eibich, Pierre Fontanil
Veröffentlicht in: Nature Genetics, 51/2, 2019, Page(s) 245-257, ISSN 1061-4036
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41588-018-0309-3

Genomic structural equation modelling provides insights into the multivariate genetic architecture of complex traits

Autoren: Andrew D. Grotzinger, Mijke Rhemtulla, Ronald de Vlaming, Stuart J. Ritchie, Travis T. Mallard, W. David Hill, Hill F. Ip, Riccardo E. Marioni, Andrew M. McIntosh, Ian J. Deary, Philipp D. Koellinger, K. Paige Harden, Michel G. Nivard, Elliot M. Tucker-Drob
Veröffentlicht in: Nature Human Behaviour, 3/5, 2019, Page(s) 513-525, ISSN 2397-3374
Herausgeber: Springer Nature
DOI: 10.1038/s41562-019-0566-x

Mendelian randomization: the challenge of unobserved environmental confounds

Autoren: Philipp D Koellinger, Ronald de Vlaming
Veröffentlicht in: International Journal of Epidemiology, 48/3, 2019, Page(s) 665-671, ISSN 0300-5771
Herausgeber: Oxford University Press
DOI: 10.1093/ije/dyz138

Using nature to understand nurture

Autoren: Philipp D. Koellinger, K. Paige Harden
Veröffentlicht in: Science, 359/6374, 2018, Page(s) 386-387, ISSN 0036-8075
Herausgeber: American Association for the Advancement of Science
DOI: 10.1126/science.aar6429