The molecular genetic architecture of educational attainment and its significance for cognitive health

Informazioni relative al progetto

EdGe

ID dell’accordo di sovvenzione: 647648

DOI

10.3030/647648

Progetto chiuso

Data della firma CE 18 Agosto 2015

Data di avvio 1 Settembre 2015

Data di completamento 31 Agosto 2020

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 870 135,00

Contributo UE

€ 1 870 135,00

Coordinato da

STICHTING VU
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Other (5)

Genetic Fortune: Winning or Losing Education, Income, and Health

Autori: Hyeokmoon Kweon, Casper A.P. Burik, Richard Karlsson Linnér, Ronald de Vlaming, Aysu Okbay, Daphne Martschenko, Kathryn Paige Harden, Thomas A. DiPrete, Philipp D. Koellinger
Pubblicato in: Tinbergen Discussion Paper, Numero 20-053/V, 2020
Editore: Tinbergen Institute

Equivalence of LD-Score Regression and Individual-Level-Data Methods

Autori: de Vlaming, Ronald; Johannesson, Magnus; Magnusson, Patrik K.E.; Ikram, M. Arfan; Visscher, Peter M.
Pubblicato in: BioRxiv, 2017
Editore: BioRxiv
DOI: 10.1101/211821

Genetic Underpinnings of Risky Behavior Relate to Altered Neuroanatomy

Autori: Hare, Todd A; Aydogan, G; Daviet, R; Linnér, R Karlsson; Kable, J W; Kranzler, H R; Wetherill, R R; Ruff, C C; Koellinger, P D; Nave, G
Pubblicato in: Aydogan, G; Daviet, R; Linnér, R Karlsson; Hare, Todd A; Kable, J W; Kranzler, H R; Wetherill, R R; Ruff, C C; Koellinger, P D; Nave, G (2019). Genetic underpinnings of risky behavior relate to altered neuroanatomy. bioRxiv 862417, Cold Spring Harbor Laboratory., 2019
Editore: BioRxiv
DOI: 10.1101/862417

Multimodal brain imaging study of 19,825 participants reveals adverse effects of moderate drinking

Autori: Daviet, Remi; Aydogan, Gökhan; Jagannathan, Kanchana; Spilka, Nathaniel; Koellinger, Philipp; Kranzler, Henry R.; Nave, Gideon; Wetherill, Reagan R.
Pubblicato in: BioRxiv, 2020
Editore: BioRxiv
DOI: 10.1101/2020.03.27.011791

Genetic risk scores of disease and mortality capture differences in longevity, economic behavior, and insurance outcomes

Autori: Karlsson Linner, Richard; Koellinger, Philipp D
Pubblicato in: MedRxiv, 2020
Editore: MedRxiv
DOI: 10.1101/2020.03.30.20047290

Peer reviewed articles (20)

Genomic analysis of diet composition finds novel loci and associations with health and lifestyle

Autori: S. Fleur W. Meddens, Ronald de Vlaming, Peter Bowers, Casper A. P. Burik, Richard Karlsson Linnér, Chanwook Lee, Aysu Okbay, Patrick Turley, Cornelius A. Rietveld, Mark Alan Fontana, Mohsen Ghanbari, Fumiaki Imamura, George McMahon, Peter J. van der Most, Trudy Voortman, Kaitlin H. Wade, Emma L. Anderson, Kim V. E. Braun, Pauline M. Emmett, Tonũ Esko, Juan R. Gonzalez, Jessica C. Kiefte-de Jong,
Pubblicato in: Molecular Psychiatry, Numero 11 May 2020, 2020, ISSN 1359-4184
Editore: Nature Publishing Group
DOI: 10.1038/s41380-020-0697-5

Using genetics for social science

Autori: K. Paige Harden, Philipp D. Koellinger
Pubblicato in: Nature Human Behaviour, Numero 4/6, 2020, Pagina/e 567-576, ISSN 2397-3374
Editore: Springer Nature
DOI: 10.1038/s41562-020-0862-5

An epigenome-wide association study meta-analysis of educational attainment

Autori: R Karlsson Linnér, R E Marioni, C A Rietveld, A J Simpkin, N M Davies, K Watanabe, N J Armstrong, K Auro, C Baumbach, M J Bonder, J Buchwald, G Fiorito, K Ismail, S Iurato, A Joensuu, P Karell, S Kasela, J Lahti, A F McRae, P R Mandaviya, I Seppälä, Y Wang, L Baglietto, E B Binder, S E Harris, A M Hodge, S Horvath, M Hurme, M Johannesson, A Latvala, K A Mather, S E Medland, A Metspalu, L Milani
Pubblicato in: Molecular Psychiatry, Numero 22/12, 2017, Pagina/e 1680-1690, ISSN 1359-4184
Editore: Nature Publishing Group
DOI: 10.1038/mp.2017.210

Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence

Autori: Suzanne Sniekers, Sven Stringer, Kyoko Watanabe, Philip R Jansen, Jonathan R I Coleman, Eva Krapohl, Erdogan Taskesen, Anke R Hammerschlag, Aysu Okbay, Delilah Zabaneh, Najaf Amin, Gerome Breen, David Cesarini, Christopher F Chabris, William G Iacono, M Arfan Ikram, Magnus Johannesson, Philipp Koellinger, James J Lee, Patrik K E Magnusson, Matt McGue, Mike B Miller, William E R Ollier, Antony Payt
Pubblicato in: Nature Genetics, Numero 49/7, 2017, Pagina/e 1107-1112, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/ng.3869

Education and coronary heart disease: mendelian randomisation study

Autori: Taavi Tillmann, Julien Vaucher, Aysu Okbay, Hynek Pikhart, Anne Peasey, Ruzena Kubinova, Andrzej Pajak, Abdonas Tamosiunas, Sofia Malyutina, Fernando Pires Hartwig, Krista Fischer, Giovanni Veronesi, Tom Palmer, Jack Bowden, George Davey Smith, Martin Bobak, Michael V Holmes
Pubblicato in: BMJ, Numero 358, 2017, Pagina/e j3542, ISSN 0959-8138
Editore: British Medical Association
DOI: 10.1136/bmj.j3542

Genetic Heterogeneity in Depressive Symptoms Following the Death of a Spouse: Polygenic Score Analysis of the U.S. Health and Retirement Study

Autori: Benjamin W. Domingue, Hexuan Liu, Aysu Okbay, Daniel W. Belsky
Pubblicato in: American Journal of Psychiatry, Numero 174/10, 2017, Pagina/e 963-970, ISSN 0002-953X
Editore: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.2017.16111209

Multi-trait analysis of genome-wide association summary statistics using MTAG

Autori: Patrick Turley, Raymond K. Walters, Omeed Maghzian, Aysu Okbay, James J. Lee, Mark Alan Fontana, Tuan Anh Nguyen-Viet, Robbee Wedow, Meghan Zacher, Nicholas A. Furlotte, Patrik Magnusson, Sven Oskarsson, Magnus Johannesson, Peter M. Visscher, David Laibson, David Cesarini, Benjamin M. Neale, Daniel J. Benjamin
Pubblicato in: Nature Genetics, Numero 50/2, 2018, Pagina/e 229-237, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-017-0009-4

Signatures of negative selection in the genetic architecture of human complex traits

Autori: Jian Zeng, Ronald de Vlaming, Yang Wu, Matthew R. Robinson, Luke R. Lloyd-Jones, Loic Yengo, Chloe X. Yap, Angli Xue, Julia Sidorenko, Allan F. McRae, Joseph E. Powell, Grant W. Montgomery, Andres Metspalu, Tonu Esko, Greg Gibson, Naomi R. Wray, Peter M. Visscher, Jian Yang
Pubblicato in: Nature Genetics, Numero 50/5, 2018, Pagina/e 746-753, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-018-0101-4

Genome-wide association study results for educational attainment aid in identifying genetic heterogeneity of schizophrenia

Autori: V. Bansal, M. Mitjans, C. A. P. Burik, R. K. Linnér, A. Okbay, C. A. Rietveld, M. Begemann, S. Bonn, S. Ripke, R. de Vlaming, M. G. Nivard, H. Ehrenreich, P. D. Koellinger
Pubblicato in: Nature Communications, Numero 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-018-05510-z

Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

Autori: Daniel J Weiner, Emilie M Wigdor, Stephan Ripke, Raymond K Walters, Jack A Kosmicki, Jakob Grove, Kaitlin E Samocha, Jacqueline I Goldstein, Aysu Okbay, Jonas Bybjerg-Grauholm, Thomas Werge, David M Hougaard, Jacob Taylor, Marie Bækvad-Hansen, Ashley Dumont, Christine Hansen, Thomas F Hansen, Daniel Howrigan, Manuel Mattheisen, Jennifer Moran, Ole Mors, Merete Nordentoft, Bent Nørgaard-Pedersen,
Pubblicato in: Nature Genetics, Numero 49/7, 2017, Pagina/e 978-985, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/ng.3863

Genetic Instrumental Variable (GIV) Regression: Explaining Socioeconomic And Health Outcomes In Non-Experimental Data

Autori: Burik, Casper; Diprete, Thomas; Burik, Casper; Koellinger, Philipp; Koellinger, Philipp
Pubblicato in: PNAS, Numero 115(22), 2018, Pagina/e E4970-E4979, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1101/134197

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

Autori: James J. Lee, Robbee Wedow, Aysu Okbay, Edward Kong, Omeed Maghzian, Meghan Zacher, Tuan Anh Nguyen-Viet, Peter Bowers, Julia Sidorenko, Richard Karlsson Linnér, Mark Alan Fontana, Tushar Kundu, Chanwook Lee, Hui Li, Ruoxi Li, Rebecca Royer, Pascal N. Timshel, Raymond K. Walters, Emily A. Willoughby, Loïc Yengo, Maris Alver, Yanchun Bao, David W. Clark, Felix R. Day, Nicholas A. Furlotte, Peter
Pubblicato in: Nature Genetics, Numero 50/8, 2018, Pagina/e 1112-1121, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-018-0147-3

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

Autori: Aysu Okbay, Bart M L Baselmans, Jan-Emmanuel De Neve, Patrick Turley, Michel G Nivard, Mark Alan Fontana, S Fleur W Meddens, Richard Karlsson Linnér, Cornelius A Rietveld, Jaime Derringer, Jacob Gratten, James J Lee, Jimmy Z Liu, Ronald de Vlaming, Tarunveer S Ahluwalia, Jadwiga Buchwald, Alana Cavadino, Alexis C Frazier-Wood, Nicholas A Furlotte, Victoria Garfield, Marie Henrike Geisel, Juan R G
Pubblicato in: Nature Genetics, Numero 48/6, 2016, Pagina/e 624-633, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/ng.3552

Genome-wide association study identifies 74 loci associated with educational attainment

Autori: Aysu Okbay, Jonathan P. Beauchamp, Mark Alan Fontana, James J. Lee, Tune H. Pers, Cornelius A. Rietveld, Patrick Turley, Guo-Bo Chen, Valur Emilsson, S. Fleur W. Meddens, Sven Oskarsson, Joseph K. Pickrell, Kevin Thom, Pascal Timshel, Ronald de Vlaming, Abdel Abdellaoui, Tarunveer S. Ahluwalia, Jonas Bacelis, Clemens Baumbach, Gyda Bjornsdottir, Johannes H. Brandsma, Maria Pina Concas, Jaime Derri
Pubblicato in: Nature, Numero 533/7604, 2016, Pagina/e 539-542, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/nature17671

Meta-GWAS Accuracy and Power (MetaGAP) Calculator Shows that Hiding Heritability Is Partially Due to Imperfect Genetic Correlations across Studies

Autori: Ronald de Vlaming, Aysu Okbay, Cornelius A. Rietveld, Magnus Johannesson, Patrik K. E. Magnusson, André G. Uitterlinden, Frank J. A. van Rooij, Albert Hofman, Patrick J. F. Groenen, A. Roy Thurik, Philipp D. Koellinger
Pubblicato in: PLOS Genetics, Numero 13/1, 2017, Pagina/e e1006495, ISSN 1553-7404
Editore: PLOS Genetics
DOI: 10.1371/journal.pgen.1006495

Genome-wide analysis identifies 12 loci influencing human reproductive behavior

Autori: Nicola Barban, Rick Jansen, Ronald de Vlaming, Ahmad Vaez, Jornt J Mandemakers, Felix C Tropf, Xia Shen, James F Wilson, Daniel I Chasman, Ilja M Nolte, Vinicius Tragante, Sander W van der Laan, John R B Perry, Augustine Kong, Tarunveer S Ahluwalia, Eva Albrecht, Laura Yerges-Armstrong, Gil Atzmon, Kirsi Auro, Kristin Ayers, Andrew Bakshi, Danny Ben-Avraham, Klaus Berger, Aviv Bergman, Lars Bertra
Pubblicato in: Nature Genetics, Numero 48/12, 2016, Pagina/e 1462-1472, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/ng.3698

Are bigger brains smarter? Evidence from a large-scale preregistered study

Autori: Gideon Nave, Wi Hoon Jung, Richard Karlsson Linnér, Joseph W. Kable, and Philipp D. Koellinger
Pubblicato in: Psychological Science, Numero 30 (1), 2019, Pagina/e 43-54, ISSN 0956-7976
Editore: SAGE Publications
DOI: 10.1177/09567976188084

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

Autori: Richard Karlsson Linnér, Pietro Biroli, Edward Kong, S. Fleur W. Meddens, Robbee Wedow, Mark Alan Fontana, Maël Lebreton, Stephen P. Tino, Abdel Abdellaoui, Anke R. Hammerschlag, Michel G. Nivard, Aysu Okbay, Cornelius A. Rietveld, Pascal N. Timshel, Maciej Trzaskowski, Ronald de Vlaming, Christian L. Zünd, Yanchun Bao, Laura Buzdugan, Ann H. Caplin, Chia-Yen Chen, Peter Eibich, Pierre Fontanil
Pubblicato in: Nature Genetics, Numero 51/2, 2019, Pagina/e 245-257, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-018-0309-3

Genomic structural equation modelling provides insights into the multivariate genetic architecture of complex traits

Autori: Andrew D. Grotzinger, Mijke Rhemtulla, Ronald de Vlaming, Stuart J. Ritchie, Travis T. Mallard, W. David Hill, Hill F. Ip, Riccardo E. Marioni, Andrew M. McIntosh, Ian J. Deary, Philipp D. Koellinger, K. Paige Harden, Michel G. Nivard, Elliot M. Tucker-Drob
Pubblicato in: Nature Human Behaviour, Numero 3/5, 2019, Pagina/e 513-525, ISSN 2397-3374
Editore: Springer Nature
DOI: 10.1038/s41562-019-0566-x

Mendelian randomization: the challenge of unobserved environmental confounds

Autori: Philipp D Koellinger, Ronald de Vlaming
Pubblicato in: International Journal of Epidemiology, Numero 48/3, 2019, Pagina/e 665-671, ISSN 0300-5771
Editore: Oxford University Press
DOI: 10.1093/ije/dyz138

Non-peer reviewed articles (1)

Using nature to understand nurture

Autori: Philipp D. Koellinger, K. Paige Harden
Pubblicato in: Science, Numero 359/6374, 2018, Pagina/e 386-387, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.aar6429