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Infrastructure for NMR, EM and X-rays for translational research

Livrables

Second report on the interaction with industrial parties

Report on the interaction with industrial parties (EMBL-GR)

Delivery of 370 days of access as High-end Data Acquisition to SONNMRLSF at UU

Delivery of 370 days of access as High-end Data Acquisition to SONNMRLSF at UU

Second report on outreach activities

Second report on outreach activities

Start of TA to HT integrated fragment screening in Grenoble

Start of TA to HT integrated fragment screening in Grenoble (EMBL-GR)

Secondary screening of a set of derivatives around an initial hit making use of the EU-OPENSCREEN library

Secondary screening of a set of derivatives around an initial hit making use of the EU-OPENSCREEN library

Delivery of 145 days of access to NMR at CEITEC

Delivery of 145 days of access to NMR at CEITEC

Reports on feasibility studies on the promising translational targets

Reports on feasibility studies on the promising translational targets

Setup for lower background for diffraction data on membrane proteins

Setup for lower background for diffraction data on membrane proteins

Delivery of 100 days of access as Enhanced Support to SONNMRLSF at UU

Delivery of 100 days of access as Enhanced Support to SONNMRLSF at UU

At least two articles for the general public

At least two articles for the general public

Report on Coordination activities with Virtual Research Environments

Report on Coordination activities with Virtual Research Environments

Storage and queuing facilities at ESRF

Storage and queuing facilities at ESRF

120 samples through “Structural Audit”

120 samples through “Structural Audit”

Report on novel biophysical methods

Report on novel biophysical methods

Hiring a Project Manager

Hiring a Project Manager

Protocols and tools for using ssNMR to study protein complexes associated with cellular compartments

Protocols and tools for using ssNMR to study protein complexes associated with cellular compartments

Report on Coordination activities with PDBe and Elixir

Report on Coordination activities with PDBe and Elixir

Delivery of 120 samples through the Structural Audit procedure at NKI

Delivery of 120 samples through the Structural Audit procedure at NKI

Report on a model for future structural biology access in Europe

Report on a model for future structural biology access in Europe

Delivery of 305 days of High-End Data Acquisition to NMR at BMRZ

Delivery of 305 days of High-End Data Acquisition to NMR at BMRZ

TA access to HT crystallization and crystal mounting

TA access to HT crystallization and crystal mounting (EMBL-GR)

Delivery of 75 days of access to Cryo-EM at CSIC

Delivery of 75 days of access to Cryo-EM at CSIC

First report on the interaction with industrial parties

Report on the interaction with industrial parties (EMBL-GR)

Report on financial sustainability

Report on financial sustainability

Delivery of 2389 hours of access to Beam MX at Diamond

Delivery of 2389 hours of access to Beam MX at Diamond

Second report on conferences and meetings with iNEXT representation

Second report on conferences and meetings with iNEXT representation (EMBL-HH)

Report on the organization of TDC workshops

Report on the organization of TDC workshops

Access to NMR probe(s) optimized for the investigation of membrane proteins (binding studies/,screening)

Access to NMR probe(s) optimized for the investigation of membrane proteins (binding studies/,screening)

Start of TA to integrated screening for focused libraries at EMBL-GR/ESRF

Start of TA to integrated screening for focused libraries at EMBL-GR/ESRF

Workflow for EM-based determination of membrane protein structures

Workflow for EM-based determination of membrane protein structures (EMBL-HD)

Delivery of 78 days of full service ‘Protein to XTAL’at EMBL-HH

Delivery of 78 days of full service ‘Protein to XTAL’at EMBL-HH

Data management system for ligand and fragment screening, extending ISPyB

Data management system for ligand and fragment screening, extending ISPyB

Protocols for membrane protein structure determination by solid-state NMR

Protocols for membrane protein structure determination by solid-state NMR

Protocols for correlative fluorescent labeling of proteins in vitro and in situ

Protocols for correlative fluorescent labeling of proteins in vitro and in situ

Delivery of 130 days of access to cryo-EM at CEITEC

Delivery of 130 days of access to cryo-EM at CEITEC

Second summary report on networking activities

Second summary report on networking activities (EMBL-HH)

Draft sustainability plan

Draft sustainability plan

Report on the attendance to EMBO and FEBS meetings

Report on the attendance to EMBO, FEBS and similar meetings

Automatic EM Image Processing workflow in the absence of structural flexibility

Automatic EM Image Processing workflow in the absence of structural flexibility

Automation of the on-line SEC setups at the partner SAXS beamlines

Automation of the on-line SEC setups at the partner SAXS beamlines

First summary report on networking activities

First summary report on networking activities (EMBL-HH)

Integrated submission system operational

Integrated submission system operational

Protocols and tools for protein interactions in mammalian cells by NMR

Protocols and tools for protein interactions in mammalian cells by NMR

Delivery of 144 days of access to Titan KRIO cyro-EM at NeCEN

Delivery of 144 days of access to Titan KRIO cyro-EM at NeCEN

Delivery of 76 days of full service ‘Protein to SAXS at EMBL-HH

Delivery of 76 days of full service ‘Protein to SAXS at EMBL-HH

Delivery of 192 supervised access days to EMCF at EMBL-HD

Delivery of 192 supervised access days to EMCF at EMBL-HD

Protocols for data acquisition for correlative CLEXM

Protocols for data acquisition for correlative CLEXM

Storage and queuing facilities at Diamond

Storage and queuing facilities at Diamond

Delivery of 5450 supervised access hours to ALMF at EMBL-HD

Delivery of 5450 supervised access hours to ALMF at EMBL-HD

Report on comparative analysis of data models in all disciplines and strategy for integration

Report on comparative analysis of data models in all disciplines and strategy for integration

Delivery of 110 days of access to NMR at RALF-NMR

Delivery of 110 days of access to NMR at RALF-NMR

Delivery of 36 days of accessto Integrated fragment screening by MX at EMBL-GR

Delivery of 36 days of accessto Integrated fragment screening by MX at EMBL-GR

Report on the organization of annual user meetings

Report on the organization of annual user meetings

Delivery of 1555 hours of access to MX beamtime at EMBL-HH

Delivery of 1555 hours of access to MX beamtime at EMBL-HH

Delivery of 14 days of access to Integrated compound screening (focused libraries) by MX at EMBL-GR

Delivery of 14 days of access to Integrated compound screening (focused libraries) by MX at EMBL-GR

Protocols for RNA sample optimization and DNA/RNA delivery into bacterial and mammalian cells. for in-cell NMR studies

Protocols for RNA sample optimization and DNA/RNA delivery into bacterial and mammalian cells. for in-cell NMR studies

Access to an integrated miniaturized HT-SEC-SAXS set-up

Access to an integrated miniaturized HT-SEC-SAXS set-up (EMBL-HH)

Management Guidelines

Management Guidelines

Delivery of 70 days of access to Integrated Macromolecular Crystallography service at EMBL-GR

Delivery of 70 days of access to Integrated Macromolecular Crystallography service at EMBL-GR

Optimized protocols for reconstitution of membrane proteins

Optimized protocols for reconstitution of membrane proteins (EMBL-HH)

Automated SAXS pipeline for membrane proteins, integrated into ISPyB

Automated SAXS pipeline for membrane proteins, integrated into ISPyB (EMBL-HH)

Automated pipelines for NMR-based structure determination accessible online

Automated pipelines for NMR-based structure determination accessible online

Delivery of 10 days of Structural Audit to NMR at BMRZ

Delivery of 10 days of Structural Audit to NMR at BMRZ

Delivery of 2720 hours of access to Beam MX/SAXS at SOLEIL

Delivery of 2720 hours of access to Beam MX/SAXS at SOLEIL

Start of TA to HT integrated fragment screening at Diamond

Start of TA to HT integrated fragment screening at Diamond

Fully automatic screening, large scale X-ray data collection pipelines

Fully automatic screening, large scale X-ray data collection pipelines

Start of TA access to HT fragment screening by NMR

Start of TA access to HT fragment screening by NMR

Delivery of 10 days of access as Structural Audit to SONNMRLSF at UU

Delivery of 10 days of access as Structural Audit to SONNMRLSF at UU

Delivery of 100 days of Enhanced Support to NMR at BMRZ

Delivery of 100 days of Enhanced Support to NMR at BMRZ

Delivery of 212 days of access to NMR at FVB-FMP

Delivery of 212 days of access to NMR at FVB-FMP

Report on demands of the user community

Report on demands of the user community

Representation on RI bodies or Committees

Representation on RI bodies or Committees

Protocols for preparing ssNMR samples in bacterial and mammalian cell fractions and cells

Protocols for preparing ssNMR samples in bacterial and mammalian cell fractions and cells

15 structure validation projects through biophysics facility

15 structure validation projects through biophysics facility

Characterization of 120 “SAXS x-audit” samples at EMBL-HH

Characterization of 120 “SAXS x-audit” samples at EMBL-HH

Delivery of 346 days of High-End Data Acquisition to NMR at CERM/CIRMMP

Delivery of 346 days of High-End Data Acquisition to NMR at CERM/CIRMMP

SONICC-based centring of membrane protein crystals

SONICC-based centring of membrane protein crystals

CRIMS support for ligand and fragment screening

CRIMS support for ligand and fragment screening (EMBL-GR)

Data management system for a EM workflows, extending ISPyB

Data management system for a EM workflows, extending ISPyB

Fragment library distributed to partners

Fragment library distributed to partners

Delivery of 775 hours of access to SAXS beamtime at EMBL-HH

Delivery of 775 hours of access to SAXS beamtime at EMBL-HH

Summary report on networking activities with industry

Summary report on networking activities with industry (EMBL-GR)

First report on outreach activities

First report on outreach activities

First report on conferences and meetings with iNEXT representation

First report on conferences and meetings with iNEXT representation (EMBL-HH)

Delivery of access for 60 mail-in SAXS sessions at Diamond

Delivery of access for 60 mail-in SAXS sessions at Diamond

Delivery of 30 samples analysed for Structural Audit at CSIC

Delivery of 30 samples analysed for Structural Audit at CSIC

Optimized workflows for ligand screening by NMR

Optimized workflows for ligand screening by NMR

Best practice workflows for cryo electron tomography specimen preparation

Best practice workflows for cryo electron tomography specimen preparation

Fluorophore knock in cell lines for structural studies

Fluorophore knock in cell lines for structural studies (EMBL-HD)

Protocols for cooperation with ESFRI BMS RIs

Protocols for cooperation with ESFRI BMS RIs

5 integrated structure validation projects through combined access in biophysics and imaging

5 integrated structure validation projects through combined access in biophysics and imaging

Delivery of access to 10 screening campaigns at Diamond

Delivery of access to 10 screening campaigns at Diamond

Delivery of 20 projects for biophysical characterisation at NKI

Delivery of 20 projects for biophysical characterisation at NKI

Delivery of 10 days of Structural Audit to NMR at CERM/CIRMMP

Delivery of 10 days of Structural Audit to NMR at CERM/CIRMMP

Delivery of 750 hours of access to the BioMAX beamline at MAXIV

Delivery of 750 hours of access to the BioMAX beamline at MAXIV

Delivery of 100 days of Enhanced Support to NMR at CERM/CIRMMP

Delivery of 100 days of Enhanced Support to NMR at CERM/CIRMMP

15 structure validation projects through advanced imaging facility

15 structure validation projects through advanced imaging facility

Delivery of 110 days of access to cryo-EM at Diamond

Delivery of 110 days of access to cryo-EM at Diamond

Publications

Design of coiled-coil protein-origami cages that self-assemble in vitro and in vivo

Auteurs: Ajasja Ljubetič, Fabio Lapenta, Helena Gradišar, Igor Drobnak, Jana Aupič, Žiga Strmšek, Duško Lainšček, Iva Hafner-Bratkovič, Andreja Majerle, Nuša Krivec, Mojca Benčina, Tomaž Pisanski, Tanja Ćirković Veličković, Adam Round, José María Carazo, Roberto Melero, Roman Jerala
Publié dans: Nature Biotechnology, Issue 35(11), 2017, Page(s) 1094-1101, ISSN 1087-0156
DOI: 10.1038/nbt.3994

Structural Basis for Polyproline-Mediated Ribosome Stalling and Rescue by the Translation Elongation Factor EF-P

Auteurs: Paul Huter, Stefan Arenz, Lars V. Bock, Michael Graf, Jan Ole Frister, Andre Heuer, Lauri Peil, Agata L. Starosta, Ingo Wohlgemuth, Frank Peske, Jiří Nováček, Otto Berninghausen, Helmut Grubmüller, Tanel Tenson, Roland Beckmann, Marina V. Rodnina, Andrea C. Vaiana, Daniel N. Wilson
Publié dans: Molecular Cell, Issue 68/3, 2017, Page(s) 515-527.e6, ISSN 1097-2765
DOI: 10.1016/j.molcel.2017.10.014

Characterization of the Conjugation Pattern in Large Polysaccharide-Protein Conjugates by NMR Spectroscopy

Auteurs: Stefano Giuntini, Evita Balducci, Linda Cerofolini, Enrico Ravera, Marco Fragai, Francesco Berti, Claudio Luchinat
Publié dans: Angewandte Chemie International Edition, Issue 56/47, 2017, Page(s) 14997-15001, ISSN 1433-7851
DOI: 10.1002/anie.201709274

Structural Snapshots of α-1,3-Galactosyltransferase with Native Substrates: Insight into the Catalytic Mechanism of Retaining Glycosyltransferases

Auteurs: David Albesa-Jové, M. Ángela Sainz-Polo, Alberto Marina, Marcelo E. Guerin
Publié dans: Angewandte Chemie International Edition, Issue 56/47, 2017, Page(s) 14853-14857, ISSN 1433-7851
DOI: 10.1002/anie.201707922

Enhanced Pru p 3 IgE-binding activity by selective free fatty acid-interaction

Auteurs: Pawel Dubiela, Roberta Aina, Dominika Polak, Sabine Geiselhart, Piotr Humeniuk, Barbara Bohle, Stefano Alessandri, Rebecca Del Conte, Francesca Cantini, Tomasz Borowski, Merima Bublin, Karin Hoffmann-Sommergruber
Publié dans: Journal of Allergy and Clinical Immunology, Issue 140/6, 2017, Page(s) 1728-1731.e10, ISSN 0091-6749
DOI: 10.1016/j.jaci.2017.06.016

Impact of Azidohomoalanine Incorporation on Protein Structure and Ligand Binding

Auteurs: Florian Lehner, Denis Kudlinzki, Christian Richter, Henrike M. Müller-Werkmeister, Katharina B. Eberl, Jens Bredenbeck, Harald Schwalbe, Robert Silvers
Publié dans: ChemBioChem, Issue 18/23, 2017, Page(s) 2340-2350, ISSN 1439-4227
DOI: 10.1002/cbic.201700437

A molecular chaperone activity of CCS restores the maturation of SOD1 fALS mutants

Auteurs: Enrico Luchinat, Letizia Barbieri, Lucia Banci
Publié dans: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
DOI: 10.1038/s41598-017-17815-y

Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors

Auteurs: Pau Martin-Malpartida, Marta Batet, Zuzanna Kaczmarska, Regina Freier, Tiago Gomes, Eric Aragón, Yilong Zou, Qiong Wang, Qiaoran Xi, Lidia Ruiz, Angela Vea, José A. Márquez, Joan Massagué, Maria J. Macias
Publié dans: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
DOI: 10.1038/s41467-017-02054-6

Structure of outer membrane protein G in lipid bilayers

Auteurs: Joren S. Retel, Andrew J. Nieuwkoop, Matthias Hiller, Victoria A. Higman, Emeline Barbet-Massin, Jan Stanek, Loren B. Andreas, W. Trent Franks, Barth-Jan van Rossum, Kutti R. Vinothkumar, Lieselotte Handel, Gregorio Giuseppe de Palma, Benjamin Bardiaux, Guido Pintacuda, Lyndon Emsley, Werner Kühlbrandt, Hartmut Oschkinat
Publié dans: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
DOI: 10.1038/s41467-017-02228-2

Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase

Auteurs: Sina Reckel, Charlotte Gehin, Delphine Tardivon, Sandrine Georgeon, Tim Kükenshöner, Frank Löhr, Akiko Koide, Lena Buchner, Alejandro Panjkovich, Aline Reynaud, Sara Pinho, Barbara Gerig, Dmitri Svergun, Florence Pojer, Peter Güntert, Volker Dötsch, Shohei Koide, Anne-Claude Gavin, Oliver Hantschel
Publié dans: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
DOI: 10.1038/s41467-017-02313-6

Atomic structural details of a protein grafted onto gold nanoparticles

Auteurs: Stefano Giuntini, Linda Cerofolini, Enrico Ravera, Marco Fragai, Claudio Luchinat
Publié dans: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
DOI: 10.1038/s41598-017-18109-z

Molecular mechanism for the subversion of the retromer coat by the Legionella effector RidL

Auteurs: Miguel Romano-Moreno, Adriana L. Rojas, Chad D. Williamson, David C. Gershlick, María Lucas, Michail N. Isupov, Juan S. Bonifacino, Matthias P. Machner, Aitor Hierro
Publié dans: Proceedings of the National Academy of Sciences, Issue 114/52, 2017, Page(s) E11151-E11160, ISSN 0027-8424
DOI: 10.1073/pnas.1715361115

Long-range paramagnetic NMR data can provide a closer look on metal coordination in metalloproteins

Auteurs: Linda Cerofolini, Tommaso Staderini, Stefano Giuntini, Enrico Ravera, Marco Fragai, Giacomo Parigi, Roberta Pierattelli, Claudio Luchinat
Publié dans: JBIC Journal of Biological Inorganic Chemistry, Issue 23/1, 2018, Page(s) 71-80, ISSN 0949-8257
DOI: 10.1007/s00775-017-1511-y

Intracellular metal binding and redox behavior of human DJ-1

Auteurs: Letizia Barbieri, Enrico Luchinat, Lucia Banci
Publié dans: JBIC Journal of Biological Inorganic Chemistry, Issue 23/1, 2018, Page(s) 61-69, ISSN 0949-8257
DOI: 10.1007/s00775-017-1509-5

Dynamic control of RSK complexes by phosphoswitch-based regulation

Auteurs: Gergő Gógl, Beáta Biri-Kovács, Ádám L. Póti, Henrietta Vadászi, Bálint Szeder, Andrea Bodor, Gitta Schlosser, András Ács, Lilla Turiák, László Buday, Anita Alexa, László Nyitray, Attila Reményi
Publié dans: The FEBS Journal, Issue 285/1, 2018, Page(s) 46-71, ISSN 1742-464X
DOI: 10.1111/febs.14311

Combined 1H-Detected Solid-State NMR Spectroscopy and Electron Cryotomography to Study Membrane Proteins across Resolutions in Native Environments

Auteurs: Baker LA, Sinnige T, Schellenberger P, de Keyzer J, Siebert CA, Driessen AJM, Baldus M, Grünewald K
Publié dans: Structure, Issue 26/1, 2018, Page(s) 161-170.e3, ISSN 0969-2126

Structural basis of RNA polymerase III transcription initiation

Auteurs: Guillermo Abascal-Palacios, Ewan Phillip Ramsay, Fabienne Beuron, Edward Morris, Alessandro Vannini
Publié dans: Nature, Issue 553/7688, 2018, Page(s) 301-306, ISSN 0028-0836
DOI: 10.1038/nature25441

1 H NMR Spectroscopy of [FeFe] Hydrogenase: Insight into the Electronic Structure of the Active Site

Auteurs: Sigrun Rumpel, Enrico Ravera, Constanze Sommer, Edward Reijerse, Christophe Farès, Claudio Luchinat, Wolfgang Lubitz
Publié dans: Journal of the American Chemical Society, Issue 140/1, 2017, Page(s) 131-134, ISSN 0002-7863
DOI: 10.1021/jacs.7b11196

Structural plasticity of the N-terminal capping helix of the TPR domain of kinesin light chain

Auteurs: The Quyen Nguyen, Mélanie Chenon, Fernando Vilela, Christophe Velours, Magali Aumont-Nicaise, Jessica Andreani, Paloma F. Varela, Paola Llinas, Julie Ménétrey
Publié dans: PLOS ONE, Issue October 16, 2017, 2017, Page(s) 1-20, ISSN 1932-6203
DOI: 10.1371/journal.pone.0186354.s004

Saposin Lipid Nanoparticles: A Highly Versatile and Modular Tool for Membrane Protein Research

Auteurs: Flayhan A, Mertens HDT, Ural-Blimke Y, Martinez Molledo M, Svergun DI, Löw C
Publié dans: Structure, Issue 26, 2018, Page(s) 345-355, ISSN 0969-2126
DOI: 10.1016/j.str.2018.01.007

CHROMIXS: automatic and interactive analysis of chromatography-coupled small-angle X-ray scattering data

Auteurs: Alejandro Panjkovich, Dmitri I Svergun
Publié dans: Bioinformatics, Issue 28 December 2017, 2017, Page(s) 1-3, ISSN 1367-4803
DOI: 10.1093/bioinformatics/btx846

Automated harvesting and processing of protein crystals through laser photoablation

Auteurs: Ulrich Zander, Guillaume Hoffmann, Irina Cornaciu, Jean-Pierre Marquette, Gergely Papp, Christophe Landret, Gaël Seroul, Jérémy Sinoir, Martin Röwer, Frank Felisaz, Sonia Rodriguez-Puente, Vincent Mariaule, Peter Murphy, Magali Mathieu, Florent Cipriani, José Antonio Márquez
Publié dans: Acta Crystallographica Section D Structural Biology, Issue 72/4, 2016, Page(s) 454-466, ISSN 2059-7983
DOI: 10.1107/S2059798316000954

RavN is a member of a previously unrecognized group of Legionella pneumophila E3 ubiquitin ligases

Auteurs: Yi-Han Lin, María Lucas, Timothy R. Evans, Guillermo Abascal-Palacios, Alexandra G. Doms, Nicole A. Beauchene, Adriana L. Rojas, Aitor Hierro, Matthias P. Machner
Publié dans: PLOS Pathogens, Issue 14/2, 2018, Page(s) e1006897, ISSN 1553-7374
DOI: 10.1371/journal.ppat.1006897

An allosteric binding site of the α7 nicotinic acetylcholine receptor revealed in a humanized acetylcholine-binding protein

Auteurs: Florian Delbart, Marijke Brams, Fabian Gruss, Sam Noppen, Steve Peigneur, Sandro Boland, Patrick Chaltin, Jose Brandao-Neto, Frank von Delft, Wouter G. Touw, Robbie P. Joosten, Sandra Liekens, Jan Tytgat, Chris Ulens
Publié dans: Journal of Biological Chemistry, Issue 293/7, 2018, Page(s) 2534-2545, ISSN 0021-9258
DOI: 10.1074/jbc.M117.815316

Evaluation of the Stability of DNA i-Motifs in the Nuclei of Living Mammalian Cells

Auteurs: Simon Dzatko, Michaela Krafcikova, Robert Hänsel-Hertsch, Tomas Fessl, Radovan Fiala, Tomas Loja, Daniel Krafcik, Jean-Louis Mergny, Silvie Foldynova-Trantirkova, Lukas Trantirek
Publié dans: Angewandte Chemie International Edition, Issue 57/8, 2018, Page(s) 2165-2169, ISSN 1433-7851
DOI: 10.1002/anie.201712284

A family of unconventional deubiquitinases with modular chain specificity determinants

Auteurs: Thomas Hermanns, Christian Pichlo, Ilka Woiwode, Karsten Klopffleisch, Katharina F. Witting, Huib Ovaa, Ulrich Baumann, Kay Hofmann
Publié dans: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
DOI: 10.1038/s41467-018-03148-5

Multi-channel in situ dynamic light scattering instrumentation enhancing biological small-angle X-ray scattering experiments at the PETRA III beamline P12

Auteurs: Sven Falke, Karsten Dierks, Clement Blanchet, Melissa Graewert, Florent Cipriani, Rob Meijers, Dmitri Svergun, Christian Betzel
Publié dans: Journal of Synchrotron Radiation, Issue 25/2, 2018, Page(s) 361-372, ISSN 1600-5775
DOI: 10.1107/S1600577517017568

Homology-based hydrogen bond information improves crystallographic structures in the PDB

Auteurs: Bart van Beusekom, Wouter G. Touw, Mahidhar Tatineni, Sandeep Somani, Gunaretnam Rajagopal, Jinquan Luo, Gary L. Gilliland, Anastassis Perrakis, Robbie P. Joosten
Publié dans: Protein Science, Issue 27/3, 2018, Page(s) 798-808, ISSN 0961-8368
DOI: 10.1002/pro.3353

Solution NMR structure of yeast Rcf1, a protein involved in respiratory supercomplex formation

Auteurs: Shu Zhou, Pontus Pettersson, Jingjing Huang, Johannes Sjöholm, Dan Sjöstrand, Régis Pomès, Martin Högbom, Peter Brzezinski, Lena Mäler, Pia Ädelroth
Publié dans: Proceedings of the National Academy of Sciences, Issue 115/12, 2018, Page(s) 3048-3053, ISSN 0027-8424
DOI: 10.1073/pnas.1712061115

Multispecific Substrate Recognition in a Proton-Dependent Oligopeptide Transporter.

Auteurs: Martinez Molledo M, Quistgaard EM, Flayhan A, Pieprzyk J, Löw C
Publié dans: Structure, Issue Mar 6;26(3), 2018, Page(s) 467-476, ISSN 0969-2126

A multidisciplinary study of 3-(β- d -glucopyranosyl)-5-substituted-1,2,4-triazole derivatives as glycogen phosphorylase inhibitors: Computation, synthesis, crystallography and kinetics reveal new potent inhibitors

Auteurs: Sándor Kun, Jaida Begum, Efthimios Kyriakis, Evgenia C.V. Stamati, Thomas A. Barkas, Eszter Szennyes, Éva Bokor, Katalin E. Szabó, George A. Stravodimos, Ádám Sipos, Tibor Docsa, Pál Gergely, Colin Moffatt, Myrto S. Patraskaki, Maria C. Kokolaki, Alkistis Gkerdi, Vassiliki T. Skamnaki, Demetres D. Leonidas, László Somsák, Joseph M. Hayes
Publié dans: European Journal of Medicinal Chemistry, Issue 147, 2018, Page(s) 266-278, ISSN 0223-5234
DOI: 10.1016/j.ejmech.2018.01.095

Structural model of human dUTPase in complex with a novel proteinaceous inhibitor

Auteurs: Kinga Nyíri, Haydyn D. T. Mertens, Borbála Tihanyi, Gergely N. Nagy, Bianka Kőhegyi, Judit Matejka, Matthew J. Harris, Judit E. Szabó, Veronika Papp-Kádár, Veronika Németh-Pongrácz, Olivér Ozohanics, Károly Vékey, Dmitri I. Svergun, Antoni J. Borysik, Beáta G. Vértessy
Publié dans: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
DOI: 10.1038/s41598-018-22145-8

Structures of Teneurin adhesion receptors reveal an ancient fold for cell-cell interaction

Auteurs: Verity A. Jackson, Dimphna H. Meijer, Maria Carrasquero, Laura S. van Bezouwen, Edward D. Lowe, Colin Kleanthous, Bert J. C. Janssen, Elena Seiradake
Publié dans: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
DOI: 10.1038/s41467-018-03460-0

Structural changes of TasA in biofilm formation of Bacillus subtilis

Auteurs: Anne Diehl, Yvette Roske, Linda Ball, Anup Chowdhury, Matthias Hiller, Noel Molière, Regina Kramer, Daniel Stöppler, Catherine L. Worth, Brigitte Schlegel, Martina Leidert, Nils Cremer, Natalja Erdmann, Daniel Lopez, Heike Stephanowitz, Eberhard Krause, Barth-Jan van Rossum, Peter Schmieder, Udo Heinemann, Kürşad Turgay, Ümit Akbey, Hartmut Oschkinat
Publié dans: Proceedings of the National Academy of Sciences, Issue 115/13, 2018, Page(s) 3237-3242, ISSN 0027-8424
DOI: 10.1073/pnas.1718102115

1H, 13C, and 15N chemical shift assignments of a G-quadruplex forming sequence within the KRAS proto-oncogene promoter region

Auteurs: Julien Marquevielle, M. V. Vasantha Kumar, Jean-Louis Mergny, Gilmar F. Salgado
Publié dans: Biomolecular NMR Assignments, Issue 12/1, 2018, Page(s) 123-127, ISSN 1874-2718
DOI: 10.1007/s12104-017-9793-0

A General Small-Angle X-ray Scattering-Based Screening Protocol Validated for Protein–RNA Interactions

Auteurs: Po-chia Chen, Pawel Masiewicz, Vladimir Rybin, Dmitri Svergun, Janosch Hennig
Publié dans: ACS Combinatorial Science, Issue 20/4, 2018, Page(s) 197-202, ISSN 2156-8952
DOI: 10.1021/acscombsci.8b00007

Structural characterization of the intrinsically disordered domain of Mycobacterium tuberculosis protein tyrosine kinase A

Auteurs: Anna Niesteruk, Marie Hutchison, Sridhar Sreeramulu, Hendrik R.A. Jonker, Christian Richter, Rupert Abele, Christoph Bock, Harald Schwalbe
Publié dans: FEBS Letters, Issue 592/7, 2018, Page(s) 1233-1245, ISSN 0014-5793
DOI: 10.1002/1873-3468.13022

RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex

Auteurs: Fabrizio Martino, Mohinder Pal, Hugo Muñoz-Hernández, Carlos F. Rodríguez, Rafael Núñez-Ramírez, David Gil-Carton, Gianluca Degliesposti, J. Mark Skehel, S. Mark Roe, Chrisostomos Prodromou, Laurence H. Pearl, Oscar Llorca
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The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation

Auteurs: Michael J. Capper, Gareth S. A. Wright, Letizia Barbieri, Enrico Luchinat, Eleonora Mercatelli, Luke McAlary, Justin J. Yerbury, Paul M. O’Neill, Svetlana V. Antonyuk, Lucia Banci, S. Samar Hasnain
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Functional interaction of low-homology FRPs from different cyanobacteria with Synechocystis OCP

Auteurs: Yury B. Slonimskiy, Eugene G. Maksimov, Evgeny P. Lukashev, Marcus Moldenhauer, Cy M. Jeffries, Dmitri I. Svergun, Thomas Friedrich, Nikolai N. Sluchanko
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Integrated beamline control and data acquisition for small-angle X-ray scattering at the P12 BioSAXS beamline at PETRAIII storage ring DESY

Auteurs: Nelly R. Hajizadeh, Daniel Franke, Dmitri I. Svergun
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Consensus Bayesian assessment of protein molecular mass from solution X-ray scattering data

Auteurs: Nelly R. Hajizadeh, Daniel Franke, Cy M. Jeffries, Dmitri I. Svergun
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Structure of the hexagonal surface layer on Caulobacter crescentus cells

Auteurs: Tanmay A. M. Bharat, Danguole Kureisaite-Ciziene, Gail G. Hardy, Ellen W. Yu, Jessica M. Devant, Wim J. H. Hagen, Yves V. Brun, John A. G. Briggs, Jan Löwe
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The structure of FIV reverse transcriptase and its implications for non-nucleoside inhibitor resistance

Auteurs: Meytal Galilee, Akram Alian
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NMR-Based Plasma Metabolomics at Set Intervals in Newborn Dairy Calves with Severe Sepsis

Auteurs: Abdullah Basoglu, Ismail Sen, Gaia Meoni, Leonardo Tenori, Amir Naseri
Publié dans: Mediators of Inflammation, Issue 2018, 2018, Page(s) 1-12, ISSN 0962-9351
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iNEXT: a European facility network to stimulate translational structural biology

Auteurs: iNEXT Consortium
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Complete assignment of Ala, Ile, Leu, Met and Val methyl groups of human blood group A and B glycosyltransferases using lanthanide-induced pseudocontact shifts and methyl–methyl NOESY

Auteurs: Friedemann Flügge, Thomas Peters
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Engineering l -asparaginase for spontaneous formation of calcium phosphate bioinspired microreactors

Auteurs: Alexandra Louka, Irina Matlahov, Stefano Giuntini, Linda Cerofolini, Andrea Cavallo, Serena Pillozzi, Enrico Ravera, Marco Fragai, Annarosa Arcangeli, Ayyalusamy Ramamoorthy, Gil Goobes, Claudio Luchinat
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Structural basis for the recognition of complex-type N-glycans by Endoglycosidase S

Auteurs: Beatriz Trastoy, Erik Klontz, Jared Orwenyo, Alberto Marina, Lai-Xi Wang, Eric J. Sundberg, Marcelo E. Guerin
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Targeting RNA structure in SMN2 reverses spinal muscular atrophy molecular phenotypes

Auteurs: Amparo Garcia-Lopez, Francesca Tessaro, Hendrik R. A. Jonker, Anna Wacker, Christian Richter, Arnaud Comte, Nikolaos Berntenis, Roland Schmucki, Klas Hatje, Olivier Petermann, Gianpaolo Chiriano, Remo Perozzo, Daniel Sciarra, Piotr Konieczny, Ignacio Faustino, Guy Fournet, Modesto Orozco, Ruben Artero, Friedrich Metzger, Martin Ebeling, Peter Goekjian, Benoît Joseph, Harald Schwalbe, Leonardo Sca
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Crystal structure of thebaine 6-O-demethylase from the morphine biosynthesis pathway

Auteurs: Anna Kluza, Ewa Niedzialkowska, Katarzyna Kurpiewska, Zuzanna Wojdyla, Matthew Quesne, Ewa Kot, Przemyslaw J. Porebski, Tomasz Borowski
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Enabling STD-NMR fragment screening using stabilized native GPCR: A case study of adenosine receptor

Auteurs: Sébastien Igonet, Claire Raingeval, Erika Cecon, Maja Pučić-Baković, Gordan Lauc, Olivier Cala, Maciej Baranowski, Javier Perez, Ralf Jockers, Isabelle Krimm, Anass Jawhari
Publié dans: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
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Generation and validation of homozygous fluorescent knock-in cells using CRISPR–Cas9 genome editing

Auteurs: Birgit Koch, Bianca Nijmeijer, Moritz Kueblbeck, Yin Cai, Nike Walther, Jan Ellenberg
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Quantitative mapping of fluorescently tagged cellular proteins using FCS-calibrated four-dimensional imaging

Auteurs: Antonio Z Politi, Yin Cai, Nike Walther, M Julius Hossain, Birgit Koch, Malte Wachsmuth, Jan Ellenberg
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Insights into catalysis and function of phosphoribosyl-linked serine ubiquitination

Auteurs: Sissy Kalayil, Sagar Bhogaraju, Florian Bonn, Donghyuk Shin, Yaobin Liu, Ninghai Gan, Jérôme Basquin, Paolo Grumati, Zhao-Qing Luo, Ivan Dikic
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Correlative microscopy for structural microbiology

Auteurs: Stuart C Howes, Roman I Koning, Abraham J Koster
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Advances in the cellular structural biology of nucleic acids

Auteurs: Ilektra-Chara Giassa, Jan Rynes, Tomas Fessl, Silvie Foldynova-Trantirkova, Lukas Trantirek
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Machine Learning Methods for X-Ray Scattering Data Analysis from Biomacromolecular Solutions

Auteurs: Daniel Franke, Cy M. Jeffries, Dmitri I. Svergun
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Biophysical and structural characterization of the putative nickel chaperone CooT from Carboxydothermus hydrogenoformans

Auteurs: M. Alfano, J. Pérard, R. Miras, P. Catty, C. Cavazza
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Influence of pH on structure and stability of the sweet protein MNEI

Auteurs: Roberta Spadaccini, Serena Leone, Michele Fortunato Rega, Christian Richter, Delia Picone
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Cross-membranes orchestrate compartmentalization and morphogenesis in Streptomyces

Auteurs: Katherine Celler, Roman I. Koning, Joost Willemse, Abraham J. Koster, Gilles P. van Wezel
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Subcompartmentalization by cross-membranes during early growth of Streptomyces hyphae

Auteurs: Paula Yagüe, Joost Willemse, Roman I. Koning, Beatriz Rioseras, María T. López-García, Nathaly Gonzalez-Quiñonez, Carmen Lopez-Iglesias, Pavel V. Shliaha, Adelina Rogowska-Wrzesinska, Abraham J. Koster, Ole N. Jensen, Gilles P. van Wezel, Ángel Manteca
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Structural Characterization of the Interaction of the Fibroblast Growth Factor Receptor with a Small Molecule Allosteric Inhibitor

Auteurs: Franziska Kappert, Sridhar Sreeramulu, Hendrik R. A. Jonker, Christian Richter, Vladimir V. Rogov, Ewgenij Proschak, Bruno Hargittay, Krishna Saxena, Harald Schwalbe
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Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis

Auteurs: Carlos Sacristan, Misbha Ud Din Ahmad, Jenny Keller, Job Fermie, Vincent Groenewold, Eelco Tromer, Alexander Fish, Roberto Melero, José María Carazo, Judith Klumperman, Andrea Musacchio, Anastassis Perrakis, Geert JPL Kops
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Direct shape determination of intermediates in evolving macromolecular solutions from small-angle scattering data

Auteurs: Petr V. Konarev, Dmitri I. Svergun
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Smaller capillaries improve the small-angle X-ray scattering signal and sample consumption for biomacromolecular solutions

Auteurs: Martin A. Schroer, Clement E. Blanchet, Andrey Yu. Gruzinov, Melissa A. Gräwert, Martha E. Brennich, Nelly R. Hajizadeh, Cy M. Jeffries, Dmitri I. Svergun
Publié dans: Journal of Synchrotron Radiation, Issue 25/4, 2018, Page(s) 1113-1122, ISSN 1600-5775
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Paradoxically, Most Flexible Ligand Binds Most Entropy-Favored: Intriguing Impact of Ligand Flexibility and Solvation on Drug–Kinase Binding

Auteurs: Barbara Wienen-Schmidt, Hendrik R. A. Jonker, Tobias Wulsdorf, Hans-Dieter Gerber, Krishna Saxena, Denis Kudlinzki, Sridhar Sreeramulu, Giacomo Parigi, Claudio Luchinat, Andreas Heine, Harald Schwalbe, Gerhard Klebe
Publié dans: Journal of Medicinal Chemistry, Issue 61/14, 2018, Page(s) 5922-5933, ISSN 0022-2623
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The domain architecture of PtkA, the first tyrosine kinase from Mycobacterium tuberculosis , differs from the conventional kinase architecture

Auteurs: Anna Niesteruk, Hendrik R. A. Jonker, Christian Richter, Verena Linhard, Sridhar Sreeramulu, Harald Schwalbe
Publié dans: Journal of Biological Chemistry, Issue 293/30, 2018, Page(s) 11823-11836, ISSN 0021-9258
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Visualization of translation termination intermediates trapped by the Apidaecin 137 peptide during RF3-mediated recycling of RF1

Auteurs: Michael Graf, Paul Huter, Cristina Maracci, Miroslav Peterek, Marina V. Rodnina, Daniel N. Wilson
Publié dans: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
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Recognition of Complex Core-Fucosylated N-Glycans by a Mini Lectin

Auteurs: Aurore Cabanettes, Lukas Perkams, Carolina Spies, Carlo Unverzagt, Annabelle Varrot
Publié dans: Angewandte Chemie International Edition, Issue 57/32, 2018, Page(s) 10178-10181, ISSN 1433-7851
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1H-detected solid-state NMR of proteins entrapped in bioinspired silica: a new tool for biomaterials characterization

Auteurs: Enrico Ravera, Linda Cerofolini, Tommaso Martelli, Alexandra Louka, Marco Fragai, Claudio Luchinat
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Aromatic Cluster Sensor of Protein Folding: Near-UV Electronic Circular Dichroism Bands Assigned to Fold Compactness

Auteurs: Viktor Farkas, Imre Jákli, Gábor K. Tóth, András Perczel
Publié dans: Chemistry - A European Journal, Issue 22/39, 2016, Page(s) 13871-13883, ISSN 0947-6539
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Emergence of a Homo sapiens-specific gene family and chromosome 16p11.2 CNV susceptibility

Auteurs: Xander Nuttle, Giuliana Giannuzzi, Michael H. Duyzend, Joshua G. Schraiber, Iñigo Narvaiza, Peter H. Sudmant, Osnat Penn, Giorgia Chiatante, Maika Malig, John Huddleston, Chris Benner, Francesca Camponeschi, Simone Ciofi-Baffoni, Holly A. F. Stessman, Maria C. N. Marchetto, Laura Denman, Lana Harshman, Carl Baker, Archana Raja, Kelsi Penewit, Nicolette Janke, W. Joyce Tang, Mario Ventura, Lucia B
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Mitochondrial Bol1 and Bol3 function as assembly factors for specific iron-sulfur proteins

Auteurs: Marta A Uzarska, Veronica Nasta, Benjamin D Weiler, Farah Spantgar, Simone Ciofi-Baffoni, Maria Rosaria Saviello, Leonardo Gonnelli, Ulrich Mühlenhoff, Lucia Banci, Roland Lill
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Plasma metabolomics in calves with acute bronchopneumonia

Auteurs: Abdullah Basoglu, Nuri Baspinar, Leonardo Tenori, Alessia Vignoli, Ramazan Yildiz
Publié dans: Metabolomics, Issue 12/8, 2016, ISSN 1573-3882
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EGFR Dynamics Change during Activation in Native Membranes as Revealed by NMR

Auteurs: Mohammed Kaplan, Siddarth Narasimhan, Cecilia de Heus, Deni Mance, Sander van Doorn, Klaartje Houben, Dušan Popov-Čeleketić, Reinier Damman, Eugene A. Katrukha, Purvi Jain, Willie J.C. Geerts, Albert J.R. Heck, Gert E. Folkers, Lukas C. Kapitein, Simone Lemeer, Paul M.P. van Bergen en Henegouwen, Marc Baldus
Publié dans: Cell, Issue 167, 2016, ISSN 0092-8674
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Structural analysis of a signal peptide inside the ribosome tunnel by DNP MAS NMR

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Resolution of ab initio shapes determined from small-angle scattering

Auteurs: Anne T. Tuukkanen, Gerard J. Kleywegt, Dmitri I. Svergun
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Studying assembly of the BAM complex in native membranes by cellular solid-state NMR spectroscopy

Auteurs: Cecilia Pinto, Deni Mance, Manon Julien, Mark Daniels, Markus Weingarth, Marc Baldus
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Experimental and computational framework for a dynamic protein atlas of human cell division

Auteurs: Yin Cai, M. Julius Hossain, Jean-Karim Hériché, Antonio Z. Politi, Nike Walther, Birgit Koch, Malte Wachsmuth, Bianca Nijmeijer, Moritz Kueblbeck, Marina Martinic-Kavur, Rene Ladurner, Stephanie Alexander, Jan-Michael Peters, Jan Ellenberg
Publié dans: Nature, Issue 561/7723, 2018, Page(s) 411-415, ISSN 0028-0836
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Formation of the β-barrel assembly machinery complex in lipid bilayers as seen by solid-state NMR

Auteurs: Cecilia Pinto, Deni Mance, Tessa Sinnige, Mark Daniëls, Markus Weingarth, Marc Baldus
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Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR

Auteurs: Daniel Stöppler, Alex Macpherson, Susanne Smith-Penzel, Nicolas Basse, Fabien Lecomte, Hervé Deboves, Richard D. Taylor, Tim Norman, John Porter, Lorna C. Waters, Marta Westwood, Ben Cossins, Katharine Cain, James White, Robert Griffin, Christine Prosser, Sebastian Kelm, Amy H. Sullivan, David Fox, Mark D. Carr, Alistair Henry, Richard Taylor, Beat H. Meier, Hartmut Oschkinat, Alastair D. Lawson
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Structural basis for antibiotic resistance mediated by the Bacillus subtilis ABCF ATPase VmlR

Auteurs: Caillan Crowe-McAuliffe, Michael Graf, Paul Huter, Hiraku Takada, Maha Abdelshahid, Jiří Nováček, Victoriia Murina, Gemma C. Atkinson, Vasili Hauryliuk, Daniel N. Wilson
Publié dans: Proceedings of the National Academy of Sciences, Issue 115/36, 2018, Page(s) 8978-8983, ISSN 0027-8424
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Multivalency regulates activity in an intrinsically disordered transcription factor

Auteurs: Sarah Clark, Janette B Myers, Ashleigh King, Radovan Fiala, Jiri Novacek, Grant Pearce, Jörg Heierhorst, Steve L Reichow, Elisar J Barbar
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Urease Inhibition in the Presence of N -( n -Butyl)thiophosphoric Triamide, a Suicide Substrate: Structure and Kinetics

Auteurs: Luca Mazzei, Michele Cianci, Umberto Contaldo, Francesco Musiani, Stefano Ciurli
Publié dans: Biochemistry, Issue 56/40, 2017, Page(s) 5391-5404, ISSN 0006-2960
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Structural and functional studies of the metalloregulator Fur identify a promoter-binding mechanism and its role in Francisella tularensis virulence

Auteurs: J. Pérard, S. Nader, M. Levert, L. Arnaud, P. Carpentier, C. Siebert, F. Blanquet, C. Cavazza, P. Renesto, D. Schneider, M. Maurin, J. Coves, S. Crouzy, I. Michaud-Soret
Publié dans: Communications Biology, Issue 1/1, 2018, ISSN 2399-3642
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OCP–FRP protein complex topologies suggest a mechanism for controlling high light tolerance in cyanobacteria

Auteurs: Nikolai N. Sluchanko, Yury B. Slonimskiy, Evgeny A. Shirshin, Marcus Moldenhauer, Thomas Friedrich, Eugene G. Maksimov
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The Regulation of Axon Diameter: From Axonal Circumferential Contractility to Activity-Dependent Axon Swelling

Auteurs: Ana Rita Costa, Rita Pinto-Costa, Sara Castro Sousa, Mónica Mendes Sousa
Publié dans: Frontiers in Molecular Neuroscience, Issue 11, 2018, ISSN 1662-5099
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Rapid access to RNA resonances by proton-detected solid-state NMR at >100 kHz MAS

Auteurs: Alexander Marchanka, Jan Stanek, Guido Pintacuda, Teresa Carlomagno
Publié dans: Chemical Communications, Issue 54/65, 2018, Page(s) 8972-8975, ISSN 1359-7345
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Architecture of the complete oxygen-sensing FixL-FixJ two-component signal transduction system

Auteurs: Gareth S. A. Wright, Akane Saeki, Takaaki Hikima, Yoko Nishizono, Tamao Hisano, Misaki Kamaya, Kohei Nukina, Hideo Nishitani, Hiro Nakamura, Masaki Yamamoto, Svetlana V. Antonyuk, S. Samar Hasnain, Yoshitsugu Shiro, Hitomi Sawai
Publié dans: Science Signaling, Issue 11/525, 2018, Page(s) eaaq0825, ISSN 1937-9145
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Disordered Peptides Looking for Their Native Environment: Structural Basis of CB1 Endocannabinoid Receptor Binding to Pepcans

Auteurs: Alessandro Emendato, Remo Guerrini, Erika Marzola, Hans Wienk, Rolf Boelens, Serena Leone, Delia Picone
Publié dans: Frontiers in Molecular Biosciences, Issue 5, 2018, ISSN 2296-889X
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NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family

Auteurs: Alix Tröster, Stephanie Heinzlmeir, Benedict-Tilman Berger, Santosh L. Gande, Krishna Saxena, Sridhar Sreeramulu, Verena Linhard, Amir H. Nasiri, Michael Bolte, Susanne Müller, Bernhard Kuster, Guillaume Médard, Denis Kudlinzki, Harald Schwalbe
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Structural basis of RNA polymerase I stalling at UV light-induced DNA damage

Auteurs: Marta Sanz-Murillo, Jun Xu, Georgiy A. Belogurov, Olga Calvo, David Gil-Carton, María Moreno-Morcillo, Dong Wang, Carlos Fernández-Tornero
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On the Implication of Water on Fragment-to-Ligand Growth in Kinase Binding Thermodynamics

Auteurs: Barbara Wienen-Schmidt, Tobias Wulsdorf, Hendrik R. A. Jonker, Krishna Saxena, Denis Kudlinzki, Verena Linhard, Sridhar Sreeramulu, Andreas Heine, Harald Schwalbe, Gerhard Klebe
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Structure of Type-I Mycobacterium tuberculosis fatty acid synthase at 3.3 Å resolution

Auteurs: Nadav Elad, Szilvia Baron, Yoav Peleg, Shira Albeck, Jacob Grunwald, Gal Raviv, Zippora Shakked, Oren Zimhony, Ron Diskin
Publié dans: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
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Homology-based loop modeling yields more complete crystallographic protein structures

Auteurs: Bart van Beusekom, Krista Joosten, Maarten L. Hekkelman, Robbie P. Joosten, Anastassis Perrakis
Publié dans: IUCrJ, Issue 5/5, 2018, Page(s) 585-594, ISSN 2052-2525
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Comment on “Innovative scattering analysis shows that hydrophobic disordered proteins are expanded in water”

Auteurs: Gustavo Fuertes, Niccolo Banterle, Kiersten M. Ruff, Aritra Chowdhury, Rohit V. Pappu, Dmitri I. Svergun, Edward A. Lemke
Publié dans: Science, Issue 361/6405, 2018, Page(s) eaau8230, ISSN 0036-8075
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Tripeptide binding in a proton-dependent oligopeptide transporter

Auteurs: Maria Martinez Molledo, Esben M. Quistgaard, Christian Löw
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Structural and biochemical characterization of the Cutibacterium acnes exo-β-1,4-mannosidase that targets the N-glycan core of host glycoproteins

Auteurs: Tom Reichenbach, Dayanand Kalyani, Rosaria Gandini, Olov Svartström, Henrik Aspeborg, Christina Divne
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Multivariate Control of Transcript to Protein Variability in Single Mammalian Cells

Auteurs: Doris Popovic, Birgit Koch, Moritz Kueblbeck, Jan Ellenberg, Lucas Pelkmans
Publié dans: Cell Systems, Issue 7/4, 2018, Page(s) 398-411.e6, ISSN 2405-4712
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Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction

Auteurs: Wout Oosterheert, Laura S. van Bezouwen, Remco N. P. Rodenburg, Joke Granneman, Friedrich Förster, Andrea Mattevi, Piet Gros
Publié dans: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
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Subtomogram averaging of COPII assemblies reveals how coat organization dictates membrane shape

Auteurs: Joshua Hutchings, Viktoriya Stancheva, Elizabeth A. Miller, Giulia Zanetti
Publié dans: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
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Molecular Recognition of a Thomsen-Friedenreich Antigen Mimetic Targeting Human Galectin-3

Auteurs: Sabrina Santarsia, Ana Sofia Grosso, Filipa Trovão, Jesús Jiménez-Barbero, Ana Luísa Carvalho, Cristina Nativi, Filipa Marcelo
Publié dans: ChemMedChem, Issue 13/19, 2018, Page(s) 2030-2036, ISSN 1860-7179
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The first single particle analysis Map Challenge: A summary of the assessments

Auteurs: J. Bernard Heymann, Roberto Marabini, Mohsen Kazemi, Carlos Oscar S. Sorzano, Maya Holmdahl, Joshua H. Mendez, Scott M. Stagg, Slavica Jonic, Eugene Palovcak, Jean-Paul Armache, Jianhua Zhao, Yifan Cheng, Grigore Pintilie, Wah Chiu, Ardan Patwardhan, Jose-Maria Carazo
Publié dans: Journal of Structural Biology, Issue 204/2, 2018, Page(s) 291-300, ISSN 1047-8477
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Recombinant production of A1S_0222 from Acinetobacter baumannii ATCC 17978 and confirmation of its DNA-(adenine N6)-methyltransferase activity

Auteurs: Ulrike Blaschke, Beneditta Suwono, Sachli Zafari, Ingo Ebersberger, Evelyn Skiebe, Cy M. Jeffries, Dmitri I. Svergun, Gottfried Wilharm
Publié dans: Protein Expression and Purification, Issue 151, 2018, Page(s) 78-85, ISSN 1046-5928
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IBA57 Recruits ISCA2 to Form a [2Fe-2S] Cluster-Mediated Complex

Auteurs: Spyridon Gourdoupis, Veronica Nasta, Vito Calderone, Simone Ciofi-Baffoni, Lucia Banci
Publié dans: Journal of the American Chemical Society, Issue 140/43, 2018, Page(s) 14401-14412, ISSN 0002-7863
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DNA recognition by Arabidopsis transcription factors ABI3 and NGA1

Auteurs: Giedrius Sasnauskas, Elena Manakova, Kęstutis Lapėnas, Kotryna Kauneckaitė, Virginijus Siksnys
Publié dans: The FEBS Journal, Issue 285/21, 2018, Page(s) 4041-4059, ISSN 1742-464X
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Probing the Architecture of a Multi-PDZ Domain Protein: Structure of PDZK1 in Solution

Auteurs: Hajizadeh NR, Pieprzyk J, Skopintsev P, Flayhan A, Svergun DI, Löw C
Publié dans: Structure, Issue 26/11, 2018, Page(s) 1522-1533.e5, ISSN 0969-2126
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Structure of Mutant Hepatitis B Core Protein Capsids with Premature Secretion Phenotype

Auteurs: Bettina Böttcher, Michael Nassal
Publié dans: Journal of Molecular Biology, Issue 430/24, 2018, Page(s) 4941-4954, ISSN 0022-2836
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Map challenge: Analysis using a pair comparison method based on Fourier shell correlation

Auteurs: R. Marabini, M. Kazemi, C.O.S. Sorzano, J.M. Carazo
Publié dans: Journal of Structural Biology, Issue 204/3, 2018, Page(s) 527-542, ISSN 1047-8477
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A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity

Auteurs: Marta Compte, Seandean Lykke Harwood, Ines G. Muñoz, Rocio Navarro, Manuela Zonca, Gema Perez-Chacon, Ainhoa Erce-Llamazares, Nekane Merino, Antonio Tapia-Galisteo, Angel M. Cuesta, Kasper Mikkelsen, Eduardo Caleiras, Natalia Nuñez-Prado, M. Angela Aznar, Simon Lykkemark, Jorge Martínez-Torrecuadrada, Ignacio Melero, Francisco J. Blanco, Jorge Bernardino de la Serna, Juan M. Zapata, Laura Sanz,
Publié dans: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
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Function and Interactions of ERCC1-XPF in DNA Damage Response

Auteurs: Maryam Faridounnia, Gert Folkers, Rolf Boelens
Publié dans: Molecules, Issue 23/12, 2018, Page(s) 3205, ISSN 1420-3049
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Assessing protein conformational landscapes: integration of DEER data in Maximum Occurrence analysis

Auteurs: Lucia Gigli, Witold Andrałojć, Arina Dalaloyan, Giacomo Parigi, Enrico Ravera, Daniella Goldfarb, Claudio Luchinat
Publié dans: Physical Chemistry Chemical Physics, Issue 20/43, 2018, Page(s) 27429-27438, ISSN 1463-9076
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Local and Global Dynamics in Intrinsically Disordered Synuclein

Auteurs: Nasrollah Rezaei-Ghaleh, Giacomo Parigi, Andrea Soranno, Andrea Holla, Stefan Becker, Benjamin Schuler, Claudio Luchinat, Markus Zweckstetter
Publié dans: Angewandte Chemie International Edition, Issue 57/46, 2018, Page(s) 15262-15266, ISSN 1433-7851
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Essential but sparse collagen hydroxylysyl post-translational modifications detected by DNP NMR

Auteurs: Wing Ying Chow, Rui Li, Ieva Goldberga, David G. Reid, Rakesh Rajan, Jonathan Clark, Hartmut Oschkinat, Melinda J. Duer, Robert Hayward, Catherine M. Shanahan
Publié dans: Chemical Communications, Issue 54/89, 2018, Page(s) 12570-12573, ISSN 1359-7345
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Using Scipion for stream image processing at Cryo-EM facilities

Auteurs: J. Gómez-Blanco, J.M. de la Rosa-Trevín, R. Marabini, L. del Cano, A. Jiménez, M. Martínez, R. Melero, T. Majtner, D. Maluenda, J. Mota, Y. Rancel, E Ramírez-Aportela, J.L. Vilas, M. Carroni, S. Fleischmann, E. Lindahl, A.W. Ashton, M. Basham, D.K. Clare, K. Savage, C.A. Siebert, G.G. Sharov, C.O.S. Sorzano, P. Conesa, J.M. Carazo
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Allosteric Inhibition of a Mammalian Lectin

Auteurs: Jonas Aretz, Upendra R. Anumala, Felix F. Fuchsberger, Narges Molavi, Nandor Ziebart, Hengxi Zhang, Marc Nazaré, Christoph Rademacher
Publié dans: Journal of the American Chemical Society, Issue 140/44, 2018, Page(s) 14915-14925, ISSN 0002-7863
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β 2 -Type Amyloidlike Fibrils of Poly- l -glutamic Acid Convert into Long, Highly Ordered Helices upon Dissolution in Dimethyl Sulfoxide

Auteurs: Sylwia Berbeć, Robert Dec, Dmitry Molodenskiy, Beata Wielgus-Kutrowska, Christian Johannessen, Agnieszka Hernik-Magoń, Fernando Tobias, Agnieszka Bzowska, Grzegorz Ścibisz, Timothy A. Keiderling, Dmitri Svergun, Wojciech Dzwolak
Publié dans: The Journal of Physical Chemistry B, Issue 122/50, 2018, Page(s) 11895-11905, ISSN 1520-6106
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Biochemical and structural studies reveal differences and commonalities among cap-snatching endonucleases from segmented negative-strand RNA viruses

Auteurs: Tobias Holm, Janine-Denise Kopicki, Carola Busch, Silke Olschewski, Maria Rosenthal, Charlotte Uetrecht, Stephan Günther, Sophia Reindl
Publié dans: Journal of Biological Chemistry, Issue 293/51, 2018, Page(s) 19686-19698, ISSN 0021-9258
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Protein Glycosylation through Sulfur Fluoride Exchange (SuFEx) Chemistry: The Key Role of a Fluorosulfate Thiolactoside

Auteurs: Alberto Marra, Jiajia Dong, Tiancheng Ma, Stefano Giuntini, Elisa Crescenzo, Linda Cerofolini, Marco Martinucci, Claudio Luchinat, Marco Fragai, Cristina Nativi, Alessandro Dondoni
Publié dans: Chemistry - A European Journal, Issue 24/71, 2018, Page(s) 18981-18987, ISSN 0947-6539
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Effects of Boron Supplementation on Peripartum Dairy Cows' Health.

Auteurs: Abdullah Basoglu, Nuri Baspinar, Leonardo Tenori, Alessia Vignoli, Erdem Gulersoy
Publié dans: Biological Trace Element Research, 2017, ISSN 0163-4984
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Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR

Auteurs: Simon Erlendsson, Kamil Gotfryd, Flemming Hofmann, Larsen Jonas, Sigurd Mortensen, Michel-Andreas Geiger, Barth-Jan van Rossum, Hartmut Oschkinat, Ulrik Gether, Kaare Teilum, Claus J Loland
Publié dans: eLife, 2017, ISSN 2050-084X
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Cryo-EM structure of the spinach chloroplast ribosome reveals the location of plastid-specific ribosomal proteins and extensions

Auteurs: Michael Graf, Stefan Arenz, Paul Huter, Alexandra Dönhöfer, Jiří Nováček, Daniel N. Wilson
Publié dans: Nucleic Acids Research, 2017, Page(s) gkw1272, ISSN 0305-1048
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Structural Mechanism for Cargo Recognition by the Retromer Complex

Auteurs: Marıa Lucas, David C. Gershlick, Ander Vidaurrazaga, Adriana L. Rojas, Juan S. Bonifacino, Aitor Hierro
Publié dans: Cell, 2016, ISSN 0092-8674
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Structure determination of a major facilitator peptide transporter: Inward facing PepTSt from Streptococcus thermophilus crystallized in space group P3121

Auteurs: Esben M. Quistgaard, Maria Martinez Molledo, Christian Löw
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[4Fe-4S] Cluster Assembly in Mitochondria and Its Impairment by Copper

Auteurs: Diego Brancaccio, Angelo Gallo, Mario Piccioli, Ettore Novellino, Simone Ciofi-Baffoni, Lucia Banci
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Gelified Biofluids for High-Resolution Magic Angle Spinning 1H NMR Analysis: The Case of Urine

Auteurs: Panteleimon G. Takis, Leonardo Tenori, Enrico Ravera, Claudio Luchinat
Publié dans: Analytical Chemistry, 2017, ISSN 0003-2700
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Three-Dimensional Structure of Full-Length NtrX, an Unusual Member of the NtrC Family of Response Regulators

Auteurs: Ignacio Fernández, Irina Cornaciu, Mariela del Carmen Carrica, Emiko Uchikawa, Guillaume Hoffmann, Rodrigo Sieira, José Antonio Márquez, Fernando A. Goldbaum
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Decision-Making in Cascade Complexes Harboring crRNAs of Altered Length

Auteurs: Inga Songailiene, Marius Rutkauskas, Tomas Sinkunas, Elena Manakova, Sabine Wittig, Carla Schmidt, Virginijus Siksnys, Ralf Seidel
Publié dans: Cell Reports, Issue 28/12, 2019, Page(s) 3157-3166.e4, ISSN 2211-1247
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Engineered Carbonic Anhydrase VI-Mimic Enzyme Switched the Structure and Affinities of Inhibitors

Auteurs: Justina Kazokaitė, Visvaldas Kairys, Joana Smirnovienė, Alexey Smirnov, Elena Manakova, Martti Tolvanen, Seppo Parkkila, Daumantas Matulis
Publié dans: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
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Cryo-EM structure of pleconaril-resistant rhinovirus-B5 complexed to the antiviral OBR-5-340 reveals unexpected binding site

Auteurs: Jiri Wald, Marion Pasin, Martina Richter, Christin Walther, Neann Mathai, Johannes Kirchmair, Vadim A. Makarov, Nikolaus Goessweiner-Mohr, Thomas C. Marlovits, Irene Zanella, Antonio Real-Hohn, Nuria Verdaguer, Dieter Blaas, Michaela Schmidtke
Publié dans: Proceedings of the National Academy of Sciences, Issue 116/38, 2019, Page(s) 19109-19115, ISSN 0027-8424
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What are the methodological and theoretical prospects for paramagnetic NMR in structural biology? A glimpse into the crystal ball

Auteurs: Enrico Ravera, Giacomo Parigi, Claudio Luchinat
Publié dans: Journal of Magnetic Resonance, Issue 306, 2019, Page(s) 173-179, ISSN 1090-7807
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Atomic structure of the Epstein-Barr virus portal

Auteurs: Cristina Machón, Montserrat Fàbrega-Ferrer, Daming Zhou, Ana Cuervo, José L. Carrascosa, David I. Stuart, Miquel Coll
Publié dans: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
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Monitoring DNA–Ligand Interactions in Living Human Cells Using NMR Spectroscopy

Auteurs: Michaela Krafcikova, Simon Dzatko, Coralie Caron, Anton Granzhan, Radovan Fiala, Tomas Loja, Marie-Paule Teulade-Fichou, Tomas Fessl, Robert Hänsel-Hertsch, Jean-Louis Mergny, Silvie Foldynova-Trantirkova, Lukas Trantirek
Publié dans: Journal of the American Chemical Society, Issue 141/34, 2019, Page(s) 13281-13285, ISSN 0002-7863
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Crystal structures of cholera toxin in complex with fucosylated receptors point to importance of secondary binding site

Auteurs: Joel B. Heim, Vesna Hodnik, Julie E. Heggelund, Gregor Anderluh, Ute Krengel
Publié dans: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
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Detection of nucleic acids and other low abundance components in native bone and osteosarcoma extracellular matrix by isotope enrichment and DNP-enhanced NMR

Auteurs: Ieva Goldberga, Rui Li, Wing Ying Chow, David G. Reid, Ulyana Bashtanova, Rakesh Rajan, Anna Puszkarska, Hartmut Oschkinat, Melinda J. Duer
Publié dans: RSC Advances, Issue 9/46, 2019, Page(s) 26686-26690, ISSN 2046-2069
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Molecular determinants of the mechanism and substrate specificity of Clostridium difficile proline-proline endopeptidase-1

Auteurs: Christian Pichlo, Linda Juetten, Fabian Wojtalla, Magdalena Schacherl, Dolores Diaz, Ulrich Baumann
Publié dans: Journal of Biological Chemistry, Issue 294/30, 2019, Page(s) 11525-11535, ISSN 0021-9258
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Structures of T7 bacteriophage portal and tail suggest a viral DNA retention and ejection mechanism

Auteurs: Ana Cuervo, Montserrat Fàbrega-Ferrer, Cristina Machón, José Javier Conesa, Francisco J. Fernández, Rosa Pérez-Luque, Mar Pérez-Ruiz, Joan Pous, M. Cristina Vega, José L. Carrascosa, Miquel Coll
Publié dans: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
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Validation of electron microscopy initial models via small angle X-ray scattering curves

Auteurs: Amaya Jiménez, Slavica Jonic, Tomas Majtner, Joaquín Otón, Jose Luis Vilas, David Maluenda, Javier Mota, Erney Ramírez-Aportela, Marta Martínez, Yaiza Rancel, Joan Segura, Ruben Sánchez-García, Roberto Melero, Laura del Cano, Pablo Conesa, Lars Skjaerven, Roberto Marabini, Jose M Carazo, Carlos Oscar S Sorzano
Publié dans: Bioinformatics, Issue 35/14, 2018, Page(s) 2427-2433, ISSN 1367-4803
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Integrative Approaches in Structural Biology: A More Complete Picture from the Combination of Individual Techniques

Auteurs: Linda Cerofolini, Marco Fragai, Enrico Ravera, Christoph A. Diebolder, Ludovic Renault, Vito Calderone
Publié dans: Biomolecules, Issue 9/8, 2019, Page(s) 370, ISSN 2218-273X
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Structural Basis of Transcription: RNA Polymerase Backtracking and Its Reactivation

Auteurs: Mo’men Abdelkareem, Charlotte Saint-André, Maria Takacs, Gabor Papai, Corinne Crucifix, Xieyang Guo, Julio Ortiz, Albert Weixlbaumer
Publié dans: Molecular Cell, Issue 75/2, 2019, Page(s) 298-309.e4, ISSN 1097-2765
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Molecular tuning of farnesoid X receptor partial agonism

Auteurs: Daniel Merk, Sridhar Sreeramulu, Denis Kudlinzki, Krishna Saxena, Verena Linhard, Santosh L. Gande, Fabian Hiller, Christina Lamers, Ewa Nilsson, Anna Aagaard, Lisa Wissler, Niek Dekker, Krister Bamberg, Manfred Schubert-Zsilavecz, Harald Schwalbe
Publié dans: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
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High-throughput stability screening for detergent-solubilized membrane proteins

Auteurs: Vadim Kotov, Kim Bartels, Katharina Veith, Inokentijs Josts, Udaya K. Tiruttani Subhramanyam, Christian Günther, Jörg Labahn, Thomas C. Marlovits, Isabel Moraes, Henning Tidow, Christian Löw, Maria M. Garcia-Alai
Publié dans: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
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DNP-Supported Solid-State NMR Spectroscopy of Proteins Inside Mammalian Cells

Auteurs: Siddarth Narasimhan, Stephan Scherpe, Alessandra Lucini Paioni, Johan van der Zwan, Gert E. Folkers, Huib Ovaa, Marc Baldus
Publié dans: Angewandte Chemie International Edition, Issue 58/37, 2019, Page(s) 12969-12973, ISSN 1433-7851
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Joint X-ray/NMR structure refinement of multidomain/multisubunit systems

Auteurs: Azzurra Carlon, Enrico Ravera, Giacomo Parigi, Garib N. Murshudov, Claudio Luchinat
Publié dans: Journal of Biomolecular NMR, Issue 73/6-7, 2019, Page(s) 265-278, ISSN 0925-2738
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High-throughput peptide-MHC complex generation and kinetic screenings of TCRs with peptide-receptive HLA-A*02:01 molecules

Auteurs: Andreas Moritz, Raghavendra Anjanappa, Claudia Wagner, Sebastian Bunk, Martin Hofmann, Gabriele Pszolla, Ankur Saikia, Maria Garcia-Alai, Rob Meijers, Hans-Georg Rammensee, Sebastian Springer, Dominik Maurer
Publié dans: Science Immunology, Issue 4/37, 2019, Page(s) eaav0860, ISSN 2470-9468
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Empty peptide-receptive MHC class I molecules for efficient detection of antigen-specific T cells

Auteurs: Sunil Kumar Saini, Tripti Tamhane, Raghavendra Anjanappa, Ankur Saikia, Sofie Ramskov, Marco Donia, Inge Marie Svane, Søren Nyboe Jakobsen, Maria Garcia-Alai, Martin Zacharias, Rob Meijers, Sebastian Springer, Sine Reker Hadrup
Publié dans: Science Immunology, Issue 4/37, 2019, Page(s) eaau9039, ISSN 2470-9468
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Absolute quantification of cohesin, CTCF and their regulators in human cells

Auteurs: Johann Holzmann, Antonio Z Politi, Kota Nagasaka, Merle Hantsche-Grininger, Nike Walther, Birgit Koch, Johannes Fuchs, Gerhard Dürnberger, Wen Tang, Rene Ladurner, Roman R Stocsits, Georg A Busslinger, Béla Novák, Karl Mechtler, Iain Finley Davidson, Jan Ellenberg, Jan-Michael Peters
Publié dans: eLife, Issue 8, 2019, ISSN 2050-084X
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A novel druggable interprotomer pocket in the capsid of rhino- and enteroviruses

Auteurs: Rana Abdelnabi, James A. Geraets, Yipeng Ma, Carmen Mirabelli, Justin W. Flatt, Aušra Domanska, Leen Delang, Dirk Jochmans, Timiri Ajay Kumar, Venkatesan Jayaprakash, Barij Nayan Sinha, Pieter Leyssen, Sarah J. Butcher, Johan Neyts
Publié dans: PLOS Biology, Issue 17/6, 2019, Page(s) e3000281, ISSN 1545-7885
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Determining cellular CTCF and cohesin abundances to constrain 3D genome models

Auteurs: Claudia Cattoglio, Iryna Pustova, Nike Walther, Jaclyn J Ho, Merle Hantsche-Grininger, Carla J Inouye, M Julius Hossain, Gina M Dailey, Jan Ellenberg, Xavier Darzacq, Robert Tjian, Anders S Hansen
Publié dans: eLife, Issue 8, 2019, ISSN 2050-084X
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Neuropathy-related mutations alter the membrane binding properties of the human myelin protein P0 cytoplasmic tail

Auteurs: Arne Raasakka, Salla Ruskamo, Robert Barker, Oda C. Krokengen, Guro H. Vatne, Cecilie K. Kristiansen, Erik I. Hallin, Maximilian W. A. Skoda, Ulrich Bergmann, Hanna Wacklin-Knecht, Nykola C. Jones, Søren V. Hoffmann, Petri Kursula
Publié dans: PLOS ONE, Issue 14/6, 2019, Page(s) e0216833, ISSN 1932-6203
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An Emerin LEM-Domain Mutation Impairs Cell Response to Mechanical Stress

Auteurs: Nada Essawy, Camille Samson, Ambre Petitalot, Sophie Moog, Anne Bigot, Isaline Herrada, Agathe Marcelot, Ana-Andreea Arteni, Catherine Coirault, Sophie Zinn-Justin
Publié dans: Cells, Issue 8/6, 2019, Page(s) 570, ISSN 2073-4409
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Protective Dps–DNA co‐crystallization in stressed cells: an in vitro structural study by small‐angle X‐ray scattering and cryo‐electron tomography

Auteurs: Liubov A. Dadinova, Yurii M. Chesnokov, Roman A. Kamyshinsky, Ivan A. Orlov, Maxim V. Petoukhov, Andrey A. Mozhaev, Ekaterina Yu. Soshinskaya, Vassili N. Lazarev, Valentin A. Manuvera, Anton S. Orekhov, Alexander L. Vasiliev, Eleonora V. Shtykova
Publié dans: FEBS Letters, Issue 593/12, 2019, Page(s) 1360-1371, ISSN 0014-5793
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The structure of a membrane adenylyl cyclase bound to an activated stimulatory G protein

Auteurs: Chao Qi, Simona Sorrentino, Ohad Medalia, Volodymyr M. Korkhov
Publié dans: Science, Issue 364/6438, 2019, Page(s) 389-394, ISSN 0036-8075
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Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor

Auteurs: Albert Escobedo, Busra Topal, Micha B. A. Kunze, Juan Aranda, Giulio Chiesa, Daniele Mungianu, Ganeko Bernardo-Seisdedos, Bahareh Eftekharzadeh, Margarida Gairí, Roberta Pierattelli, Isabella C. Felli, Tammo Diercks, Oscar Millet, Jesús García, Modesto Orozco, Ramon Crehuet, Kresten Lindorff-Larsen, Xavier Salvatella
Publié dans: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
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A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex

Auteurs: Chiara Marabelli, Biagina Marrocco, Simona Pilotto, Sagar Chittori, Sarah Picaud, Sara Marchese, Giuseppe Ciossani, Federico Forneris, Panagis Filippakopoulos, Guy Schoehn, Daniela Rhodes, Sriram Subramaniam, Andrea Mattevi
Publié dans: Cell Reports, Issue 27/2, 2019, Page(s) 387-399.e7, ISSN 2211-1247
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Structural characterization of a protein adsorbed on aluminum hydroxide adjuvant in vaccine formulation

Auteurs: Linda Cerofolini, Stefano Giuntini, Enrico Ravera, Claudio Luchinat, Francesco Berti, Marco Fragai
Publié dans: npj Vaccines, Issue 4/1, 2019, ISSN 2059-0105
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The carbon monoxide dehydrogenase accessory protein CooJ is a histidine-rich multidomain dimer containing an unexpected Ni(II)-binding site

Auteurs: Marila Alfano, Julien Pérard, Philippe Carpentier, Christian Basset, Barbara Zambelli, Jennifer Timm, Serge Crouzy, Stefano Ciurli, Christine Cavazza
Publié dans: Journal of Biological Chemistry, Issue 294/19, 2019, Page(s) 7601-7614, ISSN 0021-9258
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Structural Basis for the Action of an All-Purpose Transcription Anti-termination Factor

Auteurs: Ferdinand Krupp, Nelly Said, Yong-Heng Huang, Bernhard Loll, Jörg Bürger, Thorsten Mielke, Christian M.T. Spahn, Markus C. Wahl
Publié dans: Molecular Cell, Issue 74/1, 2019, Page(s) 143-157.e5, ISSN 1097-2765
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High-Resolution Crystal Structure of Endoplasmic Reticulum Aminopeptidase 1 with Bound Phosphinic Transition-State Analogue Inhibitor

Auteurs: Petros Giastas, Margarete Neu, Paul Rowland, Efstratios Stratikos
Publié dans: ACS Medicinal Chemistry Letters, Issue 10/5, 2019, Page(s) 708-713, ISSN 1948-5875
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New insights into the tetrameric family of the Fur metalloregulators

Auteurs: S. Nader, J. Pérard, P. Carpentier, L. Arnaud, S. Crouzy, I. Michaud-Soret
Publié dans: BioMetals, Issue 32/3, 2019, Page(s) 501-519, ISSN 0966-0844
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MXCuBE2 : the dawn of MXCuBE Collaboration

Auteurs: Marcus Oscarsson, Antonia Beteva, David Flot, Elspeth Gordon, Matias Guijarro, Gordon Leonard, Sean McSweeney, Stephanie Monaco, Christoph Mueller-Dieckmann, Max Nanao, Didier Nurizzo, Alexander N. Popov, David von Stetten, Olof Svensson, Vicente Rey-Bakaikoa, Idrissou Chado, Leonard M. G. Chavas, Laurent Gadea, Patrick Gourhant, Tatiana Isabet, Pierre Legrand, Martin Savko, Serena Sirigu, William
Publié dans: Journal of Synchrotron Radiation, Issue 26/2, 2019, Page(s) 393-405, ISSN 1600-5775
DOI: 10.1107/s1600577519001267

Cryo-EM fibril structures from systemic AA amyloidosis reveal the species complementarity of pathological amyloids

Auteurs: Falk Liberta, Sarah Loerch, Matthies Rennegarbe, Angelika Schierhorn, Per Westermark, Gunilla T. Westermark, Bouke P. C. Hazenberg, Nikolaus Grigorieff, Marcus Fändrich, Matthias Schmidt
Publié dans: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
DOI: 10.1038/s41467-019-09033-z

Cryo-EM structure of a light chain-derived amyloid fibril from a patient with systemic AL amyloidosis

Auteurs: Lynn Radamaker, Yin-Hsi Lin, Karthikeyan Annamalai, Stefanie Huhn, Ute Hegenbart, Stefan O. Schönland, Günter Fritz, Matthias Schmidt, Marcus Fändrich
Publié dans: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
DOI: 10.1038/s41467-019-09032-0

Structure of Prototypic Peptide Transporter DtpA from E. coli in Complex with Valganciclovir Provides Insights into Drug Binding of Human PepT1

Auteurs: Yonca Ural-Blimke, Ali Flayhan, Jan Strauss, Vasileios Rantos, Kim Bartels, Rolf Nielsen, Els Pardon, Jan Steyaert, Jan Kosinski, Esben M. Quistgaard, Christian Löw
Publié dans: Journal of the American Chemical Society, Issue 141/6, 2019, Page(s) 2404-2412, ISSN 0002-7863
DOI: 10.1021/jacs.8b11343

Design, Synthesis and Biological Evaluation of Isoxazole-Based CK1 Inhibitors Modified with Chiral Pyrrolidine Scaffolds

Auteurs: Andreas Luxenburger, Dorian Schmidt, Chiara Ianes, Christian Pichlo, Marc Krüger, Thorsten von Drathen, Elena Brunstein, Graeme Gainsford, Ulrich Baumann, Uwe Knippschild, Christian Peifer
Publié dans: Molecules, Issue 24/5, 2019, Page(s) 873, ISSN 1420-3049
DOI: 10.3390/molecules24050873

A post-translational modification of human Norovirus capsid protein attenuates glycan binding

Auteurs: Alvaro Mallagaray, Robert Creutznacher, Jasmin Dülfer, Philipp H. O. Mayer, Lena Lisbeth Grimm, Jose Maria Orduña, Esben Trabjerg, Thilo Stehle, Kasper D. Rand, Bärbel S. Blaum, Charlotte Uetrecht, Thomas Peters
Publié dans: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
DOI: 10.1038/s41467-019-09251-5

Impact of lipid binding on the tertiary structure and allergenic potential of Jug r 3, the non-specific lipid transfer protein from walnut

Auteurs: Pawel Dubiela, Rebecca Del Conte, Francesca Cantini, Tomasz Borowski, Roberta Aina, Christian Radauer, Merima Bublin, Karin Hoffmann-Sommergruber, Stefano Alessandri
Publié dans: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
DOI: 10.1038/s41598-019-38563-1

A framework for tracer-based metabolism in mammalian cells by NMR

Auteurs: Raquel Saborano, Zuhal Eraslan, Jennie Roberts, Farhat L. Khanim, Patricia F. Lalor, Michelle A. C. Reed, Ulrich L. Günther
Publié dans: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
DOI: 10.1038/s41598-018-37525-3

Building and rebuilding N-glycans in protein structure models

Auteurs: Bart van Beusekom, Natasja Wezel, Maarten L. Hekkelman, Anastassis Perrakis, Paul Emsley, Robbie P. Joosten
Publié dans: Acta Crystallographica Section D Structural Biology, Issue 75/4, 2019, Page(s) 416-425, ISSN 2059-7983
DOI: 10.1107/s2059798319003875

Structural basis for assembly of vertical single β-barrel viruses

Auteurs: Isaac Santos-Pérez, Diego Charro, David Gil-Carton, Mikel Azkargorta, Felix Elortza, Dennis H. Bamford, Hanna M. Oksanen, Nicola G. A. Abrescia
Publié dans: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
DOI: 10.1038/s41467-019-08927-2

Real-Time Insights into Biological Events: In-Cell Processes and Protein-Ligand Interactions

Auteurs: Linda Cerofolini, Stefano Giuntini, Letizia Barbieri, Matteo Pennestri, Anna Codina, Marco Fragai, Lucia Banci, Enrico Luchinat, Enrico Ravera
Publié dans: Biophysical Journal, Issue 116/2, 2019, Page(s) 239-247, ISSN 0006-3495
DOI: 10.1016/j.bpj.2018.11.3132

Cadmium effects on superoxide dismutase 1 in human cells revealed by NMR

Auteurs: Panagis Polykretis, Francesca Cencetti, Chiara Donati, Enrico Luchinat, Lucia Banci
Publié dans: Redox Biology, Issue 21, 2019, Page(s) 101102, ISSN 2213-2317
DOI: 10.1016/j.redox.2019.101102

A 2.8-Angstrom-Resolution Cryo-Electron Microscopy Structure of Human Parechovirus 3 in Complex with Fab from a Neutralizing Antibody

Auteurs: Aušra Domanska, Justin W. Flatt, Joonas J. J. Jukonen, James A. Geraets, Sarah J. Butcher
Publié dans: Journal of Virology, Issue 93/4, 2019, ISSN 0022-538X
DOI: 10.1128/jvi.01597-18

Regulation of Human Hsc70 ATPase and Chaperone Activities by Apg2: Role of the Acidic Subdomain

Auteurs: Yovana Cabrera, Leire Dublang, José Angel Fernández-Higuero, David Albesa-Jové, Maria Lucas, Ana Rosa Viguera, Marcelo E. Guerin, Jose M.G. Vilar, Arturo Muga, Fernando Moro
Publié dans: Journal of Molecular Biology, Issue 431/2, 2019, Page(s) 444-461, ISSN 0022-2836
DOI: 10.1016/j.jmb.2018.11.026

Utilization of Staphylococcal Immune Evasion Protein Sbi as a Novel Vaccine Adjuvant

Auteurs: Yi Yang, Catherine R. Back, Melissa A. Gräwert, Ayla A. Wahid, Harriet Denton, Rebecca Kildani, Joshua Paulin, Kristin Wörner, Wolgang Kaiser, Dmitri I. Svergun, Asel Sartbaeva, Andrew G. Watts, Kevin J. Marchbank, Jean M. H. van den Elsen
Publié dans: Frontiers in Immunology, Issue 9, 2019, ISSN 1664-3224
DOI: 10.3389/fimmu.2018.03139

Survey of the analysis of continuous conformational variability of biological macromolecules by electron microscopy

Auteurs: C. O. S. Sorzano, A. Jiménez, J. Mota, J. L. Vilas, D. Maluenda, M. Martínez, E. Ramírez-Aportela, T. Majtner, J. Segura, R. Sánchez-García, Y. Rancel, L. del Caño, P. Conesa, R. Melero, S. Jonic, J. Vargas, F. Cazals, Z. Freyberg, J. Krieger, I. Bahar, R. Marabini, J. M. Carazo
Publié dans: Acta Crystallographica Section F Structural Biology Communications, Issue 75/1, 2019, Page(s) 19-32, ISSN 2053-230X
DOI: 10.1107/s2053230x18015108

Metal cofactors trafficking and assembly in the cell: a molecular view

Auteurs: Francesca Camponeschi, Lucia Banci
Publié dans: Pure and Applied Chemistry, Issue 91/2, 2019, Page(s) 231-245, ISSN 0033-4545
DOI: 10.1515/pac-2018-0720

Conformational switch in the ribosomal protein S1 guides unfolding of structured RNAs for translation initiation

Auteurs: Nusrat Shahin Qureshi, Jasleen Kaur Bains, Sridhar Sreeramulu, Harald Schwalbe, Boris Fürtig
Publié dans: Nucleic Acids Research, 2018, ISSN 0305-1048
DOI: 10.1093/nar/gky746

Correlative cryo super-resolution light and electron microscopy on mammalian cells using fluorescent proteins

Auteurs: Maarten W. Tuijtel, Abraham J. Koster, Stefan Jakobs, Frank G. A. Faas, Thomas H. Sharp
Publié dans: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
DOI: 10.1038/s41598-018-37728-8

GM130 and p115 play a key role in the organisation of the early secretory pathway during skeletal muscle differentiation

Auteurs: Emiliana Giacomello, Paolo Ronchi, Rainer Pepperkok
Publié dans: Journal of Cell Science, Issue 132/2, 2019, Page(s) jcs222083, ISSN 0021-9533
DOI: 10.1242/jcs.222083

Shedding Light on the Interaction of Human Anti-Apoptotic Bcl-2 Protein with Ligands through Biophysical and in Silico Studies

Auteurs: Joao Ramos, Jayaraman Muthukumaran, Filipe Freire, João Paquete-Ferreira, Ana Otrelo-Cardoso, Dmitri Svergun, Alejandro Panjkovich, Teresa Santos-Silva
Publié dans: International Journal of Molecular Sciences, Issue 20/4, 2019, Page(s) 860, ISSN 1422-0067
DOI: 10.3390/ijms20040860

NMR Characterization of Long‐Range Contacts in Intrinsically Disordered Proteins from Paramagnetic Relaxation Enhancement in 13 C Direct‐Detection Experiments

Auteurs: Borja Mateos, Robert Konrat, Roberta Pierattelli, Isabella C. Felli
Publié dans: ChemBioChem, Issue 20/3, 2018, Page(s) 335-339, ISSN 1439-4227
DOI: 10.1002/cbic.201800539

3DBIONOTES v3.0: crossing molecular and structural biology data with genomic variations

Auteurs: Joan Segura, Ruben Sanchez-Garcia, C O S Sorzano, J M Carazo
Publié dans: Bioinformatics, Issue 35/18, 2019, Page(s) 3512-3513, ISSN 1367-4803
DOI: 10.1093/bioinformatics/btz118

DeepRes : a new deep-learning- and aspect-based local resolution method for electron-microscopy maps

Auteurs: Erney Ramírez-Aportela, Javier Mota, Pablo Conesa, Jose Maria Carazo, Carlos Oscar S. Sorzano
Publié dans: IUCrJ, Issue 6/6, 2019, ISSN 2052-2525
DOI: 10.1107/s2052252519011692

Automatic local resolution-based sharpening of cryo-EM maps

Auteurs: Erney Ramírez-Aportela, Jose Luis Vilas, Alisa Glukhova, Roberto Melero, Pablo Conesa, Marta Martínez, David Maluenda, Javier Mota, Amaya Jiménez, Javier Vargas, Roberto Marabini, Patrick M Sexton, Jose Maria Carazo, Carlos Oscar S Sorzano
Publié dans: Bioinformatics, 2019, ISSN 1367-4803
DOI: 10.1093/bioinformatics/btz671

Advances in image processing for single-particle analysis by electron cryomicroscopy and challenges ahead

Auteurs: J.L. Vilas, N. Tabassum, J. Mota, D. Maluenda, A. Jiménez-Moreno, T. Majtner, J.M. Carazo, S.T. Acton, C.O.S. Sorzano
Publié dans: Current Opinion in Structural Biology, Issue 52, 2018, Page(s) 127-145, ISSN 0959-440X
DOI: 10.1016/j.sbi.2018.11.004

Correction: Structural plasticity of the N-terminal capping helix of the TPR domain of kinesin light chain

Auteurs: The Quyen Nguyen, Mélanie Chenon, Fernando Vilela, Christophe Velours, Magali Aumont-Nicaise, Jessica Andreani, Paloma F. Varela, Paola Llinas, Julie Ménétrey
Publié dans: PLOS ONE, Issue 13/5, 2018, Page(s) e0197193, ISSN 1932-6203
DOI: 10.1371/journal.pone.0197193

Advances in cryo-electron tomography for biology and medicine

Auteurs: Roman I. Koning, Abraham J. Koster, Thomas H. Sharp
Publié dans: Annals of Anatomy - Anatomischer Anzeiger, Issue 217, 2018, Page(s) 82-96, ISSN 0940-9602
DOI: 10.1016/j.aanat.2018.02.004

NMR Study of Rcf2 Reveals an Unusual Dimeric Topology in Detergent Micelles

Auteurs: Shu Zhou, Pontus Pettersson, Peter Brzezinski, Pia Ädelroth, Lena Mäler
Publié dans: ChemBioChem, Issue 19/5, 2018, Page(s) 444-447, ISSN 1439-4227
DOI: 10.1002/cbic.201700664

XTEND: Extending the depth of field in cryo soft X-ray tomography

Auteurs: Joaquín Otón, Eva Pereiro, José J. Conesa, Francisco J. Chichón, Daniel Luque, Javier M. Rodríguez, Ana J. Pérez-Berná, Carlos Oscar S. Sorzano, Joanna Klukowska, Gabor T. Herman, Javier Vargas, Roberto Marabini, José L. Carrascosa, José M. Carazo
Publié dans: Scientific Reports, Issue 7, 2017, Page(s) 45808, ISSN 2045-2322
DOI: 10.1038/srep45808

Solution NMR Structure of a Ligand/Hybrid-2-G-Quadruplex Complex Reveals Rearrangements that Affect Ligand Binding

Auteurs: Julia Wirmer-Bartoschek, Lars Erik Bendel, Hendrik R. A. Jonker, J. Tassilo Grün, Francesco Papi, Carla Bazzicalupi, Luigi Messori, Paola Gratteri, Harald Schwalbe
Publié dans: Angewandte Chemie International Edition, 2017, ISSN 1433-7851
DOI: 10.1002/anie.201702135

ATSAS 2.8 : a comprehensive data analysis suite for small-angle scattering from macromolecular solutions

Auteurs: D. Franke, M. V. Petoukhov, P. V. Konarev, A. Panjkovich, A. Tuukkanen, H. D. T. Mertens, A. G. Kikhney, N. R. Hajizadeh, J. M. Franklin, C. M. Jeffries, D. I. Svergun
Publié dans: Journal of Applied Crystallography, Issue 50/4, 2017, ISSN 1600-5767
DOI: 10.1107/S1600576717007786

Crabrolin, a natural antimicrobial peptide: structural properties

Auteurs: Massimiliano Aschi, Argante Bozzi, Carla Luzi, Nadia Bouchemal, Marco Sette
Publié dans: Journal of Peptide Science, Issue June 5, 2017, ISSN 1075-2617
DOI: 10.1002/psc.3013

Mistakes in translation: Reflections on mechanism

Auteurs: Yizhou Liu, Joshua S. Sharp, Duc H-T. Do, Richard A. Kahn, Harald Schwalbe, Florian Buhr, James H. Prestegard
Publié dans: PLOS ONE, Issue 12/6, 2017, Page(s) e0180566, ISSN 1932-6203
DOI: 10.1371/journal.pone.0180566

Structural insights into the molecular function of human [2Fe-2S] BOLA1-GRX5 and [2Fe-2S] BOLA3-GRX5 complexes

Auteurs: Veronica Nasta, Andrea Giachetti, Simone Ciofi-Baffoni, Lucia Banci
Publié dans: Biochimica et Biophysica Acta (BBA) - General Subjects, Issue 1861/8, 2017, Page(s) 2119-2131, ISSN 0304-4165
DOI: 10.1016/j.bbagen.2017.05.005

A Spring-Loaded Mechanism Governs the Clamp-like Dynamics of the Skp Chaperone

Auteurs: Daniel A. Holdbrook, Björn M. Burmann, Roland G. Huber, Maxim V. Petoukhov, Dmitri I. Svergun, Sebastian Hiller, Peter J. Bond
Publié dans: Structure, Issue 25/7, 2017, Page(s) 1079-1088.e3, ISSN 0969-2126
DOI: 10.1016/j.str.2017.05.018

Paramagnetic Properties of a Crystalline Iron–Sulfur Protein by Magic-Angle Spinning NMR Spectroscopy

Auteurs: Andrea Bertarello, Tobias Schubeis, Carmelo Fuccio, Enrico Ravera, Marco Fragai, Giacomo Parigi, Lyndon Emsley, Guido Pintacuda, Claudio Luchinat
Publié dans: Inorganic Chemistry, Issue 56/11, 2017, Page(s) 6624-6629, ISSN 0020-1669
DOI: 10.1021/acs.inorgchem.7b00674

Combining NMR and small angle X-ray scattering for the study of biomolecular structure and dynamics

Auteurs: Haydyn D.T. Mertens, Dmitri I. Svergun
Publié dans: Archives of Biochemistry and Biophysics, Issue 628, 2017, Page(s) 33-41, ISSN 0003-9861
DOI: 10.1016/j.abb.2017.05.005

Anthranilate phosphoribosyltransferase from the hyperthermophilic archaeon Thermococcus kodakarensis shows maximum activity with zinc and forms a unique dimeric structure

Auteurs: Sumera Perveen, Naeem Rashid, Xiao-Feng Tang, Tadayuki Imanaka, Anastassios C. Papageorgiou
Publié dans: FEBS Open Bio, Issue 7/8, 2017, Page(s) 1217-1230, ISSN 2211-5463
DOI: 10.1002/2211-5463.12264

A Novel Approach to Data Collection for Difficult Structures: Data Management for Large Numbers of Crystals with the BLEND Software

Auteurs: Anastasia Mylona, Stephen Carr, Pierre Aller, Isabel Moraes, Richard Treisman, Gwyndaf Evans, James Foadi
Publié dans: Crystals, Issue 7/8, 2017, Page(s) 242, ISSN 2073-4352
DOI: 10.3390/cryst7080242

Anamorsin/Ndor1 Complex Reduces [2Fe–2S]-MitoNEET via a Transient Protein–Protein Interaction

Auteurs: Francesca Camponeschi, Simone Ciofi-Baffoni, Lucia Banci
Publié dans: Journal of the American Chemical Society, Issue 139/28, 2017, Page(s) 9479-9482, ISSN 0002-7863
DOI: 10.1021/jacs.7b05003

An antimicrobial peptide that inhibits translation by trapping release factors on the ribosome

Auteurs: Tanja Florin, Cristina Maracci, Michael Graf, Prajwal Karki, Dorota Klepacki, Otto Berninghausen, Roland Beckmann, Nora Vázquez-Laslop, Daniel N Wilson, Marina V Rodnina, Alexander S Mankin
Publié dans: Nature Structural & Molecular Biology, Issue 24/9, 2017, Page(s) 752-757, ISSN 1545-9993
DOI: 10.1038/nsmb.3439

Lipid-like Peptides can Stabilize Integral Membrane Proteins for Biophysical and Structural Studies

Auteurs: Katharina Veith, Maria Martinez Molledo, Yasser Almeida Hernandez, Inokentijs Josts, Julius Nitsche, Christian Löw, Henning Tidow
Publié dans: ChemBioChem, Issue 18/17, 2017, Page(s) 1735-1742, ISSN 1439-4227
DOI: 10.1002/cbic.201700235

Evaluation of 15N-detected H–N correlation experiments on increasingly large RNAs

Auteurs: Robbin Schnieders, Christian Richter, Sven Warhaut, Vanessa de Jesus, Sara Keyhani, Elke Duchardt-Ferner, Heiko Keller, Jens Wöhnert, Lars T. Kuhn, Alexander L. Breeze, Wolfgang Bermel, Harald Schwalbe, Boris Fürtig
Publié dans: Journal of Biomolecular NMR, Issue 69/1, 2017, Page(s) 31-44, ISSN 0925-2738
DOI: 10.1007/s10858-017-0132-7

An effective introduction to structural crystallography using 1D Gaussian atoms

Auteurs: Emily Smith, Gwyndaf Evans, James Foadi
Publié dans: European Journal of Physics, Issue 38/6, 2017, Page(s) 065501, ISSN 0143-0807
DOI: 10.1088/1361-6404/aa8188

Saposin-Lipoprotein Scaffolds for Structure Determination of Membrane Transporters

Auteurs: Joseph A. Lyons, Andreas Bøggild, Poul Nissen, Jens Frauenfeld
Publié dans: Methods in Enzymology, Issue 19/07/2017, 2017, Page(s) 85-99
DOI: 10.1016/bs.mie.2017.06.035

Ensemble de données

Dataset for: Tripeptide binding in a Proton-Dependent Oligopeptide Transporter

Auteurs: Molledo, Maria Martinez; Quistgaard, Esben M; Löw, Christian
Publié dans: Wiley

CCDC 1830721: Experimental Crystal Structure Determination

Auteurs: Tröster, Alix; Heinzlmeir, Stephanie; Berger, Benedict-Tilman; Gande, Santosh L.; Saxena, Krishna; Sreeramulu, Sridhar; Linhard, Verena; Nasiri, Amir H.; Bolte, Michael; Müller, Susanne; Kuster, Bernhard; Médard, Guillaume; Kudlinzki, Denis; Schwalbe, Harald
Publié dans: Cambridge Crystallographic Data Centre

Dataset supporting "Essential but sparse collagen hydroxylysyl post-translational modifications detected by DNP NMR"

Auteurs: Reid, David; Reid, David
Publié dans: Apollo - University of Cambridge Repository

CCDC 1589043: Experimental Crystal Structure Determination

Auteurs: Luxenburger, Andreas; Schmidt, Dorian; Von Drahten, Thorsten; Ianes, Chiara; Krüger, Marc; Pichlo, Christian; Brunstein, Elena; Gainsford, Graeme J.; Baumann, Ulrich; Knippschild, Uwe; Peifer, Christian
Publié dans: Cambridge Crystallographic Data Centre

CCDC 1830722: Experimental Crystal Structure Determination

Auteurs: Tröster, Alix; Heinzlmeir, Stephanie; Berger, Benedict-Tilman; Gande, Santosh L.; Saxena, Krishna; Sreeramulu, Sridhar; Linhard, Verena; Nasiri, Amir H.; Bolte, Michael; Müller, Susanne; Kuster, Bernhard; Médard, Guillaume; Kudlinzki, Denis; Schwalbe, Harald
Publié dans: Cambridge Crystallographic Data Centre