Network Analysis of Musculoskeletal Evolution and Modularity during the Fin-to-Limb Transition

Projektinformationen

LIMB NETWORKS

ID Finanzhilfevereinbarung: 654155

DOI 10.3030/654155

Abgeschlossenes Projekt

EK-Unterschriftsdatum 24 Februar 2015

Startdatum 15 August 2015

Enddatum 14 August 2018

Finanziert unter

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Gesamtkosten € 251 857,80

EU-Beitrag € 251 857,80

Koordiniert durch

THE ROYAL VETERINARY COLLEGE
United Kingdom

Ziel

The fin-to-limb transition was a major milestone in the history of life that shaped the morphology and remarkable biodiversity of land vertebrates. A central question in vertebrate evolution is how the various anatomical parts of limbs evolved semi-autonomously (modularity) while still growing and adapting in coordination (integration). The main goal of this project is to unravel (i) the evolutionary changes in modularity of the musculoskeletal system that occurred during the evolution from fins to limbs and (ii) how these newly acquired modular organizations facilitated the evolution of different morphologies for the forelimb and hindlimb. To this end, we will evaluate the modularity of limbs and the strength of topological integration among modules by using an innovative approach–anatomical network analysis–¬¬based on the topological relations that anatomical parts establish among them; these anatomical relations are embodied in network models and quantified globally using sophisticated algorithms from Graph Theory. We propose a multidisciplinary combination, for the first time, of (i) new data on fin/limb muscle anatomy in extant species, (ii) reconstruction of muscle attachments in extinct forms, and (iii) the use of innovative tools such as Anatomical Network Analysis to identify morphological modules and quantify their integration within a phylogenetic context. The results of this unique and transformative project have the potential to revolutionize our understanding of limb evolution during the fin-limb transition. The training in gross anatomy, imaging techniques, and reconstruction of muscles in fossils by the leading researchers involved in this project will foster the development of the candidate Fellow as an independent and innovative frontline researcher in theoretical, evolutionary, and comparative biology in the EU.

Wissenschaftliches Gebiet

• medical and health sciences › basic medicine › anatomy and morphology
• engineering and technology › medical engineering › diagnostic imaging › computed tomography
• natural sciences › biological sciences › evolutionary biology
• natural sciences › biological sciences › ecology › ecosystems
• natural sciences › mathematics › pure mathematics › discrete mathematics › graph theory

Programm/Programme

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Thema/Themen

• MSCA-IF-2014-GF - Marie Skłodowska-Curie Individual Fellowships (IF-GF)

Aufforderung zur Vorschlagseinreichung

H2020-MSCA-IF-2014

Finanzierungsplan

MSCA-IF-GF - Global Fellowships

Koordinator

THE ROYAL VETERINARY COLLEGE

• Netto-EU-Beitrag: € 251 857,80
• Adresse: ROYAL COLLEGE STREET ; NW1 OTU London ; Vereinigtes Königreich
• Region: London › Outer London — West and North West › Barnet
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: € 251 857,80

Partner (1)

Partner

Partnerorganisationen tragen zur Umsetzung der Aktion bei, unterzeichnen jedoch nicht die Finanzhilfevereinbarung.

howard university

Vereinigte Staaten

• Netto-EU-Beitrag: € 0,00
• Adresse: Howard University College of Medicine, 2400 Sixth Street, NW ; 20059 Washington
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: € 160 130,40