Obiettivo
In the coming decade a significant number of the 500.000.000 European (EU/EEA) citizens will have their genome determined routinely. This will be complemented with much cheaper (currently ~20 Euro per measurement) acquisition of the metabolome of biofluids (e.g. urine, saliva, blood plasma) which will link the genotype with metabolome data that captures the highly dynamic phenome and exposome of patients. Having such low cost solutions will enable, for the first time, the development of a truly personalised and evidence-based medicine founded on hard scientific measurements. The exposome includes the metabolic information resulting from all the external influences on the human organism such as age, behavioural factors like exercise and nutrition or other environmental factors.
Considering that the amount of data generated by molecular phenotyping exceeds the data volume of personal genomes by at least an order of magnitude, the collection of such information will pose dramatic demands on biomedical data management and compute capabilities in Europe. For example, a single typical National Phenome Centre, managing only around 100,000 human samples per year, can generate more than 2 Petabytes of data during this period alone. A scale-up to sizable portions of the European population over time will require data analysis services capable to work on exabyte-scale amounts of biomedical phenotyping data, for which no viable solution exists at the moment.
The PhenoMeNal project will develop and deploy an integrated, secure, permanent, on-demand service-driven, privacy-compliant and sustainable e-infrastructure for the processing, analysis and information-mining of the massive amount of medical molecular phenotyping and genotyping data that will be generated by metabolomics applications now entering research and clinic.
Campo scientifico
- natural sciencescomputer and information sciencessoftware
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomics
- natural sciencesphysical sciencesastronomy
- natural sciencesbiological sciencesgeneticsgenomes
- natural sciencescomputer and information sciencesdata sciencedata processing
Programma(i)
Invito a presentare proposte
Vedi altri progetti per questo bandoBando secondario
H2020-EINFRA-2014-2
Meccanismo di finanziamento
RIA - Research and Innovation actionCoordinatore
69117 Heidelberg
Germania
Mostra sulla mappa
Partecipanti (14)
SW7 2AZ LONDON
Mostra sulla mappa
06120 Halle
Mostra sulla mappa
08007 Barcelona
Mostra sulla mappa
B15 2TT Birmingham
Mostra sulla mappa
50121 FIRENZE
Mostra sulla mappa
Soggetto giuridico diverso da un subappaltatore che è affiliato o legalmente collegato a un partecipante. Il soggetto svolge le attività secondo le condizioni stabilite nell’accordo di sovvenzione, fornisce beni o servizi per l’azione, ma non ha sottoscritto l’accordo di sovvenzione. Una terza parte rispetta le regole applicabili al suo partecipante correlato ai sensi dell’accordo di sovvenzione per quanto riguarda l’ammissibilità dei costi e il controllo delle spese.
50121 Florence
Mostra sulla mappa
2311 EZ Leiden
Mostra sulla mappa
OX1 2JD Oxford
Mostra sulla mappa
751 05 Uppsala
Mostra sulla mappa
8010 Graz
Mostra sulla mappa
75015 PARIS 15
Mostra sulla mappa
75007 Paris
Mostra sulla mappa
1206 Geneve
Mostra sulla mappa
09050 Pula Cagliari
Mostra sulla mappa