"The specific objectives of this project were:
- Reconstruction of the 3D heart anatomy from CMR recordings. Starting from clinical CMR recordings, we have developed an automatic pipeline for the reconstruction of the heart anatomy. Several techniques and methodologies have been employed in this complex task.
- Evaluation of microstructural tissue properties from CMR. Diffusion Tensor Imaging (DTI) allowed as to characterize the muscle microstructure measuring, among others, the orientation of the cardiac fibers and the degree of arrangement of the myocytes.
- Atlas-based reconstruction of a personalized torso. We tackle the challenging problem of reconstructing the body surface from standard clinical MRI scans with the use of statistical shape models.
- Simulation of patient-specific EP and their assessment on ECG end ECM recordings. Electrophysiological simulations were performed on subject-specific personalized models including anatomical, microstructural, and functional information from CMR data. We evaluated, on these virtual models, how the different physiological and structural parameters affect ECG signatures.
Overview of the results and their exploitation and dissemination.
- Dutta, Minchole, Zacur, Quinnc, Taggartd, Rodriguez, ""Early afterdepolarizations promote transmural reentry in ischemic human ventricles with reduced repolarization reserve"", Progress in Biophysics and Molecular Biology, 120:1-3, 2016.
- Villard, Zacur, Dall'Armellina, Grau, ""Correction of slice misalignment in multi-breath-hold cardiac MRI scans"", MICCAI Workshop on Statistical Atlases and Computational Models of the Heart (STACOM), Athens (Greece), Oct 2016.
- Villard, Carapella, Ariga, Grau, Zacur, ""Cardiac mesh reconstruction from sparse, heterogeneous contours"", Medical Image Understanding and Analysis (MIUA), Edinburgh (Scotland), Jul 2017.
- Zacur, Minchole, Villard, Carapella, Ariga, Rodriguez, Grau, ""MRI-based heart and torso personalization for computer modeling and simulation of cardiac electrophysiology"", MICCAI Workshop on Bio-Imaging and Visualization for Patient-Customized Simulations (BIVPCS), Quebec (Canada), Sep 2017.
- Villard, Grau, Zacur, ""Surface Mesh Reconstruction from Cardiac MRI Contours"", accepted in Journal of Imaging.
- Zacur, Grau, ""Parametric interpolation of PCA by geodesic regression"", submitted to IEEE Transactions on Pattern Analysis and Machine Intelligence.
- Zacur, Minchole, Villard, Carapella, Ariga, Rodriguez, Grau, ""MRI-based heart and torso personalization"", prepared to be submitted to Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization.
- Minchole, Zacur, Grau, Rodriguez, ""Dependency of the QRS complex with the MRI-based heart/torso geometries in computer models"", in preparation.
- Levrero-Florencio, Zacur, Minchole, Aguado-Sierra, Vazquez, Rodriguez, ""Patient-specific modelling of ventricular electro-mechanics: mathematical background, parameter estimation and image-based validation"", prepared to be submitted to Frontiers in Physiology.
Invited talks:
- British Heart Foundation Centre of Research Excellence annual symposium, September 2016.
- First international conference on Big Data on Biomedical Sciences, Xi'an, China, July 2017.
- Oxford imaging festival, Oxford, September 2017.
Exploitation and dissemination of results from secondary collaborations.
- Varela, Bisbal, Zacur, Berruezo, Aslandi, Mont, Lamata, ""Novel computational analysis of left atrial anatomy improves prediction of atrial fibrillation recurrence after ablation"", Frontiers in Physiology, 8:68, 2017.
- Warriner, Jackson, Zacur, Sammut, Sheridan, Hose, Lawford, Razavi, Niederer, Rinaldi, Lamata, ""An asymmetric wall-thickening pattern predicts response to Cardiac Resynchronization Therapy"", submitted to JACC: Cardiovascular Imaging.
"
