Development of pyrrolizidine alkaloid detection methods for the assessment of food contamination and impact on human and animal health

Projektinformationen

PATOX

ID Finanzhilfevereinbarung: 658520

DOI

10.3030/658520

Das Projekt endete am 18 Januar 2016

EK-Unterschriftsdatum 14 April 2015

Startdatum 18 Januar 2016

Enddatum 17 Januar 2018

Finanziert unter

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Gesamtkosten

€ 183 454,80

EU-Beitrag

€ 183 454,80

Koordiniert durch

THE QUEEN'S UNIVERSITY OF BELFAST
United Kingdom

Periodic Reporting for period 1 - PATOX (Development of pyrrolizidine alkaloid detection methods for the assessment of food contamination and impact on human and animal health)

Berichtszeitraum: 2016-01-18 bis 2018-01-17

Zusammenfassung vom Kontext und den Gesamtzielen des Projekts

Pyrrolizidine alkaloids are more than 600 individual compounds that are hazardous for animals and humans if ingested. The 3% of the flowering plants produce these type of molecules and grow as weeds in agricultural production systems throughout the world where they can contaminate commonly consumed foods (eg. grain, milk, meat, eggs, honey, pollen). Chronic exposure to low concentrations of these alkaloids can be the cause of progressive, chronic disease (hepatic damage, vascular obstructive disease, and cancer) that may be difficult to attribute to their presence in food. The 2007 statement from the European Food Safety Authority calls to generate more quantitative data sets on pyrrolizidine alkaloids levels in milk and honey, and to determine which PA plants and/or marker PA need to be considered relevant in animal feed. In the same direction, this Authority pointed in 2011 that toxicological data for pyrrolizidine alkaloids commonly found in honey was needed. Even though some countries have regulated the concentration of pyrrolizidine alkaloids in herbs used in traditional medicines, a general European legislation regulating the concentrations of these alkaloids in food is still pending. The present project propose the use of state of the art technology (UPLC-Qtof-MS, antibody microarrays) to better understand the distribution of pyrrolizidine alkaloids producing plants in relation to food content, and determine the incidence of exposure to these molecules in humans and animals. The results will impact several levels of society, the scientific results will provide science legal advisors with solid data to better inform law makers in the regulation of pyrrolizidine alkaloids in food, society will gain knowledge on the exposure to this type of molecules and on hazardous dietary habits, and food industry will benefit through the introduction of practices to avoid pyrrolizidine alkaloids containing components in food.

Arbeit, die ab Beginn des Projekts bis zum Ende des durch den Bericht erfassten Berichtszeitraums geleistet wurde, und die wichtigsten bis dahin erzielten Ergebnisse

The project never started because the fellow finally chose to do not undertake this fellowship.
The project was terminated on 18/01/2016.

Fortschritte, die über den aktuellen Stand der Technik hinausgehen und voraussichtliche potenzielle Auswirkungen (einschließlich der bis dato erzielten sozioökonomischen Auswirkungen und weiter gefassten gesellschaftlichen Auswirkungen des Projekts)

The project never started because the fellow finally chose to do not undertake this fellowship.
The project was terminated on 18/01/2016.

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