Exploring the role of TFEB in exosome biology and in novel approaches for treatment of lysosomal diseases

Informazioni relative al progetto

REBuILD

ID dell’accordo di sovvenzione: 661271

DOI

10.3030/661271

Progetto chiuso

Data della firma CE 4 Maggio 2015

Data di avvio 1 Gennaio 2016

Data di completamento 31 Gennaio 2018

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 180 277,20

Contributo UE

€ 180 277,20

Coordinato da

FONDAZIONE TELETHON ETS
Italy

Periodic Reporting for period 1 - REBuILD (Exploring the role of TFEB in exosome biology and in novel approaches for treatment of lysosomal diseases)

Periodo di rendicontazione: 2016-01-01 al 2017-12-31

Sintesi del contesto e degli obiettivi generali del progetto

Cell-to-cell communication is a fundamental biological mechanism that allows the adaptation of any organism to environmental changes. Cells sense and respond to environmental cues, such as nutrient availability and stress, via the activation of important signaling molecules, whose activity is crucial to ensure the correct biological responses to constantly changing external demands. Importantly, these mechanisms are often de-regulated in several human diseases, ranging from metabolic disorders to cancer. Despite their relevance, the mechanisms by which cells sense and signal environmental and nutritional inputs is poorly understood. The main goal of this project is to get a deeper molecular understanding on these processes and on their relevance to disease.

Lavoro eseguito dall’inizio del progetto fino alla fine del periodo coperto dalla relazione e principali risultati finora ottenuti

Cell-to-cell communication represents an essential process for the coordination of cell functions and the environmental adaptation of multicellular organisms. Primary mediators of such communication are represented by small cellular vesicles released by most cell types known as exosomes.
This project has extended our knowledge on the molecular mechanisms controlling exosome biogenesis and secretion. Furthermore, this project has provided new important data identifying the mechanism by which cells sense and signal nutrient availability in physiological and pathological conditions.

Progressi oltre lo stato dell’arte e potenziale impatto previsto (incluso l’impatto socioeconomico e le implicazioni sociali più ampie del progetto fino ad ora)

De-regulation of the mechanisms responsible for nutrient sensing and cell-to-cell communication has been associated to multiple human diseases, including metabolic disorders and cancer. The data generated in this project have profoundly advanced our understanding on the cellular events that modulate such processes. This will have a major impact on both basic and translational science, as it identifies key therapeutic targets for metabolic disease conditions.

TFEB at a glance