Topological organization of vertebrate regulatory landscapes: The Hox genes paradigm

Project Information

RegulHox

Grant agreement ID: 667156

DOI

10.3030/667156

Project closed

EC signature date 26 June 2015

Start date 1 September 2015

End date 28 February 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 499 628,00

EU contribution

€ 2 499 628,00

Coordinated by

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (10)

Control of Hoxd gene transcription in the mammary bud by hijacking a preexisting regulatory landscape

Author(s): Ruben Schep, Anamaria Necsulea, Eddie Rodríguez-Carballo, Isabel Guerreiro, Guillaume Andrey, Thi Hanh Nguyen Huynh, Virginie Marcet, Jozsef Zákány, Denis Duboule, Leonardo Beccari
Published in: Proceedings of the National Academy of Sciences, Issue 113/48, 2016, Page(s) E7720-E7729, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1617141113

Large scale genomic reorganization of topological domains at the HoxD locus

Author(s): Pierre J. Fabre, Marion Leleu, Benjamin H. Mormann, Lucille Lopez-Delisle, Daan Noordermeer, Leonardo Beccari, Denis Duboule
Published in: Genome Biology, Issue 18/1, 2017, ISSN 1474-760X
Publisher: Genome Biology
DOI: 10.1186/s13059-017-1278-z

Embryonic timing, axial stem cells, chromatin dynamics, and the Hox clock

Author(s): Jacqueline Deschamps, Denis Duboule
Published in: Genes & Development, Issue 31/14, 2017, Page(s) 1406-1416, ISSN 0890-9369
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.303123.117

Hotair Is Dispensible for Mouse Development

Author(s): Ana Rita Amândio, Anamaria Necsulea, Elisabeth Joye, Bénédicte Mascrez, Denis Duboule
Published in: PLOS Genetics, Issue 12/12, 2016, Page(s) e1006232, ISSN 1553-7404
Publisher: PLoS
DOI: 10.1371/journal.pgen.1006232

Integration of Shh and Fgf signaling in controlling Hox gene expression in cultured limb cells

Author(s): Alan R. Rodrigues, Nayuta Yakushiji-Kaminatsui, Yuji Atsuta, Guillaume Andrey, Patrick Schorderet, Denis Duboule, Clifford J. Tabin
Published in: Proceedings of the National Academy of Sciences, Issue 114/12, 2017, Page(s) 3139-3144, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1620767114

Nanoscale spatial organization of the HoxD gene cluster in distinct transcriptional states

Author(s): Pierre J. Fabre, Alexander Benke, Elisabeth Joye, Thi Hanh Nguyen Huynh, Suliana Manley, Denis Duboule
Published in: Proceedings of the National Academy of Sciences, Issue 112/45, 2015, Page(s) 13964-13969, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1517972112

The HoxD cluster is a dynamic and resilient TAD boundary controlling the segregation of antagonistic regulatory landscapes

Author(s): Eddie Rodríguez-Carballo, Lucille Lopez-Delisle, Ye Zhan, Pierre J. Fabre, Leonardo Beccari, Imane El-Idrissi, Thi Hanh Nguyen Huynh, Hakan Ozadam, Job Dekker, Denis Duboule
Published in: Genes & Development, Issue 31/22, 2017, Page(s) 2264-2281, ISSN 0890-9369
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.307769.117

Control of growth and gut maturation by HoxD genes and the associated lncRNA Haglr

Author(s): Jozsef Zakany, Fabrice Darbellay, Bénédicte Mascrez, Anamaria Necsulea, Denis Duboule
Published in: Proceedings of the National Academy of Sciences, Issue 114/44, 2017, Page(s) E9290-E9299, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1712511114

A role for HOX13 proteins in the regulatory switch between TADs at the HoxD locus

Author(s): Leonardo Beccari, Nayuta Yakushiji-Kaminatsui, Joost M. Woltering, Anamaria Necsulea, Nicolas Lonfat, Eddie Rodríguez-Carballo, Benedicte Mascrez, Shiori Yamamoto, Atsushi Kuroiwa, Denis Duboule
Published in: Genes & Development, 2016, ISSN 0890-9369
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.281055.116

Reorganisation of Hoxd regulatory landscapes during the evolution of a snake-like body plan

Author(s): Isabel Guerreiro, Sandra Gitto, Ana Novoa, Julien Codourey, Thi Hanh Nguyen Huynh, Federico Gonzalez, Michel C Milinkovitch, Moises Mallo, Denis Duboule
Published in: eLife, Issue 5, 2016, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.16087