Topological organization of vertebrate regulatory landscapes: The Hox genes paradigm

Informazioni relative al progetto

RegulHox

ID dell’accordo di sovvenzione: 667156

DOI 10.3030/667156

Progetto chiuso

Data della firma CE 26 Giugno 2015

Data di avvio 1 Settembre 2015

Data di completamento 28 Febbraio 2021

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 2 499 628,00

Contributo UE € 2 499 628,00

Coordinato da

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland

Pubblicazioni

Peer reviewed articles (10)

Control of Hoxd gene transcription in the mammary bud by hijacking a preexisting regulatory landscape

Autori: Ruben Schep, Anamaria Necsulea, Eddie Rodríguez-Carballo, Isabel Guerreiro, Guillaume Andrey, Thi Hanh Nguyen Huynh, Virginie Marcet, Jozsef Zákány, Denis Duboule, Leonardo Beccari
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 113/48, 2016, Pagina/e E7720-E7729, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1617141113

Large scale genomic reorganization of topological domains at the HoxD locus

Autori: Pierre J. Fabre, Marion Leleu, Benjamin H. Mormann, Lucille Lopez-Delisle, Daan Noordermeer, Leonardo Beccari, Denis Duboule
Pubblicato in: Genome Biology, Numero 18/1, 2017, ISSN 1474-760X
Editore: Genome Biology
DOI: 10.1186/s13059-017-1278-z

Embryonic timing, axial stem cells, chromatin dynamics, and the Hox clock

Autori: Jacqueline Deschamps, Denis Duboule
Pubblicato in: Genes & Development, Numero 31/14, 2017, Pagina/e 1406-1416, ISSN 0890-9369
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.303123.117

Hotair Is Dispensible for Mouse Development

Autori: Ana Rita Amândio, Anamaria Necsulea, Elisabeth Joye, Bénédicte Mascrez, Denis Duboule
Pubblicato in: PLOS Genetics, Numero 12/12, 2016, Pagina/e e1006232, ISSN 1553-7404
Editore: PLoS
DOI: 10.1371/journal.pgen.1006232

Integration of Shh and Fgf signaling in controlling Hox gene expression in cultured limb cells

Autori: Alan R. Rodrigues, Nayuta Yakushiji-Kaminatsui, Yuji Atsuta, Guillaume Andrey, Patrick Schorderet, Denis Duboule, Clifford J. Tabin
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 114/12, 2017, Pagina/e 3139-3144, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1620767114

Nanoscale spatial organization of the HoxD gene cluster in distinct transcriptional states

Autori: Pierre J. Fabre, Alexander Benke, Elisabeth Joye, Thi Hanh Nguyen Huynh, Suliana Manley, Denis Duboule
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 112/45, 2015, Pagina/e 13964-13969, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1517972112

The HoxD cluster is a dynamic and resilient TAD boundary controlling the segregation of antagonistic regulatory landscapes

Autori: Eddie Rodríguez-Carballo, Lucille Lopez-Delisle, Ye Zhan, Pierre J. Fabre, Leonardo Beccari, Imane El-Idrissi, Thi Hanh Nguyen Huynh, Hakan Ozadam, Job Dekker, Denis Duboule
Pubblicato in: Genes & Development, Numero 31/22, 2017, Pagina/e 2264-2281, ISSN 0890-9369
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.307769.117

Control of growth and gut maturation by HoxD genes and the associated lncRNA Haglr

Autori: Jozsef Zakany, Fabrice Darbellay, Bénédicte Mascrez, Anamaria Necsulea, Denis Duboule
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 114/44, 2017, Pagina/e E9290-E9299, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1712511114

A role for HOX13 proteins in the regulatory switch between TADs at the HoxD locus

Autori: Leonardo Beccari, Nayuta Yakushiji-Kaminatsui, Joost M. Woltering, Anamaria Necsulea, Nicolas Lonfat, Eddie Rodríguez-Carballo, Benedicte Mascrez, Shiori Yamamoto, Atsushi Kuroiwa, Denis Duboule
Pubblicato in: Genes & Development, 2016, ISSN 0890-9369
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.281055.116

Reorganisation of Hoxd regulatory landscapes during the evolution of a snake-like body plan

Autori: Isabel Guerreiro, Sandra Gitto, Ana Novoa, Julien Codourey, Thi Hanh Nguyen Huynh, Federico Gonzalez, Michel C Milinkovitch, Moises Mallo, Denis Duboule
Pubblicato in: eLife, Numero 5, 2016, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/eLife.16087