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Digital Hybrid Breast PET/MRI for Enhanced Diagnosis of Breast Cancer

Objective

Breast cancer represents a leading cause of cancer death in women and a major socio-economic issue. With currently available methods, early diagnosis frequently fails. Moreover, beyond mere detection, there is an ever-increasing need for improved non-invasive characterisation of cancer. Targeted therapies require an in-depth analysis of cancer to select and guide appropriate treatment. Both, PET and MRI can provide molecular and functional information that may be of pivotal importance for tailoring therapy. However, current whole-body PET/MRI systems lack the necessary sensitivity and resolution for this task. HYPMED addresses this by engineering an innovative imaging tool. HYPMED will integrate an innovative fully-digital MRI-transparent PET-detector into a novel multi-channel PET-transparent MRI surface coil. The PET-RF insert will allow unprecedented imaging of breast cancer with high-resolution/ultra-high sensitivity PET, combined with high-level structural and functional MRI, and allow minimal-invasive MR- and PET-guided targeted biopsy. Moreover with such PET-RF inserts, every regular clinical MR-system can, upon demand, be turned into a hybrid system. We will evaluate the impact of this technology on breast cancer diagnosis, prediction, and monitoring/assessment of treatment response by a carefully designed clinical study that employs established and novel PET tracers in 250 patients. Imaging data will be correlated with established and novel molecular biomarkers; results will be compared to those obtained from whole-body PET/MRI and PET/CT. A multidisciplinary consortium of clinical scientists, 3 SMEs and an industry partner will pave the way for commercialization of HYPMED products for advanced clinical decision making in cancer patients. Once HYPMED is successful, we will expand this approach to other applications such as prostate cancer or cardiac hybrid imaging, and thus introduce a paradigm shift in the field of PET/MR hybrid imaging as a whole.

Field of science

  • /medical and health sciences/clinical medicine/oncology/cancer
  • /medical and health sciences/clinical medicine/oncology/cancer/breast cancer
  • /medical and health sciences/clinical medicine/oncology/cancer/prostate cancer

Call for proposal

H2020-PHC-2015-two-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

EIBIR GEMEINNUTZIGE GMBH ZUR FORDERUNG DER ERFORSCHUNG DER BIOMEDIZINISCHEN BILDGEBUNG
Address
Neutorgasse 9/2
1010 Wien
Austria
Activity type
Research Organisations
EU contribution
€ 394 637,50

Participants (9)

UNIVERSITAETSKLINIKUM AACHEN
Germany
EU contribution
€ 1 971 303,75
Address
Pauwelsstrasse 30
52074 Aachen
Activity type
Higher or Secondary Education Establishments
FORSCHUNGSZENTRUM JULICH GMBH
Germany
EU contribution
€ 2 500
Address
Wilhelm Johnen Strasse
52428 Julich
Activity type
Research Organisations
MEDIZINISCHE UNIVERSITAET WIEN
Austria
EU contribution
€ 297 875
Address
Spitalgasse 23
1090 Wien
Activity type
Higher or Secondary Education Establishments
TECHNISCHE UNIVERSITEIT DELFT
Netherlands
EU contribution
€ 967 770
Address
Stevinweg 1
2628 CN Delft
Activity type
Higher or Secondary Education Establishments
WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER
Germany
EU contribution
€ 106 625
Address
Schlossplatz 2
48149 Muenster
Activity type
Higher or Secondary Education Establishments
NORAS MRI PRODUCTS GMBH
Germany
EU contribution
€ 595 875
Address
Leibnizstrasse 4
97204 Hochberg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FUTURA COMPOSITES BV
Netherlands
EU contribution
€ 1 132 100
Address
Marconistraat 40
1704 RG Heerhugowaard
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INTRASENSE
France
EU contribution
€ 117 967,50
Address
1231 Avenue Du Mondial 98
34000 Montpellier
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
PHILIPS ELECTRONICS NEDERLAND BV
Netherlands
EU contribution
€ 275 303,75
Address
High Tech Campus 52
5656 AG Eindhoven
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)