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Mechanisms underlying hepatocellular carcinoma pathogenesis and impact of co-morbidities.

Deliverables

Final dissemination and exploitation plan

A final dissemination and exploitation plan for using of dissemination knowledge and optimized exploitation of the results will be prepared at the end of the action.

Website development and management

The HEP-CAR website will be accessible on the internet at month 6 and it will be revised and improved during the whole course of the action. Part of the website will password-protected and dedicated to internal communication.

Publications

Status of Direct-Acting Antiviral Therapy for Hepatitis C Virus Infection and Remaining Challenges

Author(s): Thomas F. Baumert, Thomas Berg, Joseph K. Lim, David R. Nelson
Published in: Gastroenterology, Issue 156, 2018, Page(s) 431-445, ISSN 0016-5085
DOI: 10.1053/j.gastro.2018.10.024

Claudins in viral infection: from entry to spread

Author(s): Che C. Colpitts, Thomas F. Baumert
Published in: Pflügers Archiv - European Journal of Physiology, Issue 469/1, 2017, Page(s) 27-34, ISSN 0031-6768
DOI: 10.1007/s00424-016-1908-4

Entry Inhibitors: A Perspective for Prevention of Hepatitis C Virus Infection in Organ Transplantation

Author(s): Che C. Colpitts, Raymond T. Chung, Thomas F. Baumert
Published in: ACS Infectious Diseases, Issue 3/9, 2017, Page(s) 620-623, ISSN 2373-8227
DOI: 10.1021/acsinfecdis.7b00091

Host-targeting therapies for hepatitis C virus infection: current developments and future applications

Author(s): Emilie Crouchet, Florian Wrensch, Catherine Schuster, Mirjam B. Zeisel, Thomas F. Baumert
Published in: Therapeutic Advances in Gastroenterology, Issue 11, 2018, Page(s) 175628481875948, ISSN 1756-2848
DOI: 10.1177/1756284818759483

The functional role of sodium taurocholate cotransporting polypeptide NTCP in the life cycle of hepatitis B, C and D viruses

Author(s): Carla Eller, Laura Heydmann, Che C. Colpitts, Eloi R. Verrier, Catherine Schuster, Thomas F. Baumert
Published in: Cellular and Molecular Life Sciences, Issue 75/21, 2018, Page(s) 3895-3905, ISSN 1420-682X
DOI: 10.1007/s00018-018-2892-y

A novel neutralizing human monoclonal antibody broadly abrogates hepatitis C virus infection in vitro and in vivo

Author(s): Isabelle Desombere, Ahmed Atef Mesalam, Richard A. Urbanowicz, Freya Van Houtte, Lieven Verhoye, Zhen-Yong Keck, Ali Farhoudi, Koen Vercauteren, Karin E. Weening, Thomas F. Baumert, Arvind H. Patel, Steven K.H. Foung, Jonathan Ball, Geert Leroux-Roels, Philip Meuleman
Published in: Antiviral Research, Issue 148, 2017, Page(s) 53-64, ISSN 0166-3542
DOI: 10.1016/j.antiviral.2017.10.015

Nuclear Translocation of RELB is Increased in Diseased Human Liver and Promotes Ductular Reaction and Biliary Fibrosis in Mice

Author(s): Christin Elßner, Benjamin Goeppert, Thomas Longerich, Anna-Lena Scherr, Jan Stindt, Lahiri Kanth Nanduri, Christian Rupp, Jakob Nikolas Kather, Nathalie Schmitt, Nicole Kautz, Kai Breuhahn, Lars Ismail, Danijela Heide, Jenny Hetzer, María García-Beccaria, Nadine Hövelmeyer, Ari Waisman, Toni Urbanik, Sebastian Mueller, Georg Gdynia, Jesus M. Banales, Stephanie Roessler, Peter Schirmacher, Dirk
Published in: Gastroenterology, Issue 156(4), 2018, Page(s) 1190-1205.e14, ISSN 0016-5085
DOI: 10.1053/j.gastro.2018.11.018

EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma

Author(s): Peter R. Galle, Alejandro Forner, Josep M. Llovet, Vincenzo Mazzaferro, Fabio Piscaglia, Jean-Luc Raoul, Peter Schirmacher, Valérie Vilgrain
Published in: Journal of Hepatology, Issue 69/1, 2018, Page(s) 182-236, ISSN 0168-8278
DOI: 10.1016/j.jhep.2018.03.019

Integrative analysis defines distinct prognostic subgroups of intrahepatic cholangiocarcinoma

Author(s): Benjamin Goeppert, Reka Toth, Stephan Singer, Thomas Albrecht, Daniel B. Lipka, Pavlo Lutsik, David Brocks, Marion Baehr, Oliver Muecke, Yassen Assenov, Lei Gu, Volker Endris, Albrecht Stenzinger, Arianeb Mehrabi, Peter Schirmacher, Christoph Plass, Dieter Weichenhan, Stephanie Roessler
Published in: Hepatology, 2019, ISSN 0270-9139
DOI: 10.1002/hep.30493

Signalome-wide assessment of host cell response to hepatitis C virus

Author(s): Gholamreza Haqshenas, Jianmin Wu, Kaylene J. Simpson, Roger J. Daly, Hans J. Netter, Thomas F. Baumert, Christian Doerig
Published in: Nature Communications, Issue 8, 2017, Page(s) 15158, ISSN 2041-1723
DOI: 10.1038/ncomms15158

Hepatitis B Virus Activates Signal Transducer and Activator of Transcription 3 Supporting Hepatocyte Survival and Virus Replication

Author(s): Marianna Hösel, Maria Quasdorff, Marc Ringelhan, Hamid Kashkar, Svenja Debey-Pascher, Martin F. Sprinzl, Jan-Hendrik Bockmann, Silke Arzberger, Dennis Webb, Gesa von Olshausen, Achim Weber, Joachim L. Schultze, Hildegard Büning, Mathias Heikenwalder, Ulrike Protzer
Published in: Cellular and Molecular Gastroenterology and Hepatology, Issue 4/3, 2017, Page(s) 339-363, ISSN 2352-345X
DOI: 10.1016/j.jcmgh.2017.07.003

Mapping Determinants of Virus Neutralization and Viral Escape for Rational Design of a Hepatitis C Virus Vaccine

Author(s): Mei-Le Keck, Florian Wrensch, Brian G. Pierce, Thomas F. Baumert, Steven K. H. Foung
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
DOI: 10.3389/fimmu.2018.01194

Hepatitis B virus genome recycling and de novo secondary infection events maintain stable cccDNA levels

Author(s): Chunkyu Ko, Anindita Chakraborty, Wen-Min Chou, Julia Hasreiter, Jochen M. Wettengel, Daniela Stadler, Romina Bester, Theresa Asen, Ke Zhang, Karin Wisskirchen, Jane A. McKeating, Wang-Shick Ryu, Ulrike Protzer
Published in: Journal of Hepatology, Issue 69/6, 2018, Page(s) 1231-1241, ISSN 0168-8278
DOI: 10.1016/j.jhep.2018.08.012

IFN-α-mediated Base Excision Repair Pathway Correlates with Antiviral Response Against Hepatitis B Virus Infection

Author(s): Yong Li, Yuchen Xia, Meifang Han, Guang Chen, Dake Zhang, Wolfgang E. Thasler, Ulrike Protzer, Qin Ning
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
DOI: 10.1038/s41598-017-13082-z

Hepatitis B Virus Core Variants, Liver Fibrosis, and Hepatocellular Carcinoma

Author(s): Gaetan Ligat, Catherine Schuster, Thomas F. Baumert
Published in: Hepatology, Issue 69/1, 2019, Page(s) 5-8, ISSN 0270-9139
DOI: 10.1002/hep.30231

A pilot study of ultra-deep targeted sequencing of plasma DNA identifies driver mutations in hepatocellular carcinoma

Author(s): Ismail Labgaa, Carlos Villacorta-Martin, Delia D’Avola, Amanda J. Craig, Johann von Felden, Sebastiao N. Martins-Filho, Daniela Sia, Ashley Stueck, Stephen C. Ward, M. Isabel Fiel, Milind Mahajan, Parissa Tabrizian, Swan N. Thung, Celina Ang, Scott L. Friedman, Josep M. Llovet, Myron Schwartz, Augusto Villanueva
Published in: Oncogene, Issue 37/27, 2018, Page(s) 3740-3752, ISSN 0950-9232
DOI: 10.1038/s41388-018-0206-3

Molecular therapies and precision medicine for hepatocellular carcinoma

Author(s): Josep M. Llovet, Robert Montal, Daniela Sia, Richard S. Finn
Published in: Nature Reviews Clinical Oncology, Issue 15/10, 2018, Page(s) 599-616, ISSN 1759-4774
DOI: 10.1038/s41571-018-0073-4

Pilot study of living donor liver transplantation for patients with hepatocellular carcinoma exceeding Milan Criteria (Barcelona Clinic Liver Cancer extended criteria)

Author(s): Josep M. Llovet, Mihai Pavel, Jordi Rimola, Maria Alba Diaz, Jordi Colmenero, David Saavedra-Perez, Constantino Fondevila, Carmen Ayuso, Josep Fuster, Pere Ginès, Jordi Bruix, Juan Carlos Garcia-Valdecasas
Published in: Liver Transplantation, Issue 24/3, 2018, Page(s) 369-379, ISSN 1527-6465
DOI: 10.1002/lt.24977

Viral hepatitis: The bumpy road to animal models for HBV infection

Author(s): Ulrike Protzer
Published in: Nature Reviews Gastroenterology & Hepatology, Issue 14/6, 2017, Page(s) 327-328, ISSN 1759-5045
DOI: 10.1038/nrgastro.2017.44

Beyond viral dependence: The pathological consequences of HCV-induced EGF signaling

Author(s): Armando Andres Roca Suarez, Thomas F. Baumert, Joachim Lupberger
Published in: Journal of Hepatology, Issue 69/3, 2018, Page(s) 564-566, ISSN 0168-8278
DOI: 10.1016/j.jhep.2018.05.033

Viral manipulation of STAT3: Evade, exploit, and injure

Author(s): Armando Andres Roca Suarez, Nicolaas Van Renne, Thomas F. Baumert, Joachim Lupberger
Published in: PLOS Pathogens, Issue 14/3, 2018, Page(s) e1006839, ISSN 1553-7374
DOI: 10.1371/journal.ppat.1006839

Liver cancer: Translating '–omics' results into precision medicine for hepatocellular carcinoma

Author(s): Daniela Sia, Josep M. Llovet
Published in: Nature Reviews Gastroenterology & Hepatology, 2017, ISSN 1759-5045
DOI: 10.1038/nrgastro.2017.103

Trunk mutational events present minimal intra- and inter-tumoral heterogeneity in hepatocellular carcinoma

Author(s): Sara Torrecilla, Daniela Sia, Andrew N. Harrington, Zhongyang Zhang, Laia Cabellos, Helena Cornella, Agrin Moeini, Genis Camprecios, Wei-Qiang Leow, Maria Isabel Fiel, Ke Hao, Laia Bassaganyas, Milind Mahajan, Swan N. Thung, Augusto Villanueva, Sander Florman, Myron E. Schwartz, Josep M. Llovet
Published in: Journal of Hepatology, Issue 67/6, 2017, Page(s) 1222-1231, ISSN 0168-8278
DOI: 10.1016/j.jhep.2017.08.013

Hepatitis B Virus Evasion From Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase Sensing in Human Hepatocytes

Author(s): Eloi R. Verrier, Seung-Ae Yim, Laura Heydmann, Houssein El Saghire, Charlotte Bach, Vincent Turon-Lagot, Laurent Mailly, Sarah C. Durand, Julie Lucifora, David Durantel, Patrick Pessaux, Nicolas Manel, Ivan Hirsch, Mirjam B. Zeisel, Nathalie Pochet, Catherine Schuster, Thomas F. Baumert
Published in: Hepatology, Issue 68/5, 2018, Page(s) 1695-1709, ISSN 0270-9139
DOI: 10.1002/hep.30054

Hepatocellular carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†

Author(s): A Vogel, A Cervantes, I Chau, B Daniele, J Llovet, T Meyer, J -C Nault, U Neumann, J Ricke, B Sangro, P Schirmacher, C Verslype, C J Zech, D Arnold, E Martinelli
Published in: Annals of Oncology, Issue 29/Supplement_4, 2018, Page(s) iv238-iv255, ISSN 0923-7534
DOI: 10.1093/annonc/mdy308

"Hepatitis B virus promotes β-catenin-signalling and disassembly of adherens junctions in a Src kinase dependent fashion"

Author(s): Gesa von Olshausen, Maria Quasdorff, Romina Bester, Silke Arzberger, Chunkyu Ko, Maarten van de Klundert, Ke Zhang, Margarete Odenthal, Marc Ringelhan, Carien M. Niessen, Ulrike Protzer
Published in: Oncotarget, Issue 9/74, 2018, ISSN 1949-2553
DOI: 10.18632/oncotarget.26103

Cytoplasmic localization of the cell polarity factor scribble supports liver tumor formation and tumor cell invasiveness

Author(s): Shan Wan, Anne-Sophie Meyer, Sofia Maria Elisabeth Weiler, Christian Rupp, Marcell Tóth, Carsten Sticht, Stephan Singer, Stefan Thomann, Stephanie Roessler, Marina Schorpp-Kistner, Jennifer Schmitt, Norbert Gretz, Peter Angel, Darjus Felix Tschaharganeh, Jens Marquardt, Peter Schirmacher, Federico Pinna, Kai Breuhahn
Published in: Hepatology, Issue 67/5, 2018, Page(s) 1842-1856, ISSN 0270-9139
DOI: 10.1002/hep.29669

Early Transcriptional Divergence Marks Virus-Specific Primary Human CD8+ T Cells in Chronic versus Acute Infection

Author(s): David Wolski, Peter K. Foote, Diana Y. Chen, Lia L. Lewis-Ximenez, Catherine Fauvelle, Jasneet Aneja, Andreas Walker, Pierre Tonnerre, Almudena Torres-Cornejo, Daniel Kvistad, Sabrina Imam, Michael T. Waring, Damien C. Tully, Todd M. Allen, Raymond T. Chung, Jörg Timm, W. Nicholas Haining, Arthur Y. Kim, Thomas F. Baumert, Georg M. Lauer
Published in: Immunity, Issue 47/4, 2017, Page(s) 648-663.e8, ISSN 1074-7613
DOI: 10.1016/j.immuni.2017.09.006

Hepatitis C Virus (HCV)–Apolipoprotein Interactions and Immune Evasion and Their Impact on HCV Vaccine Design

Author(s): Florian Wrensch, Emilie Crouchet, Gaetan Ligat, Mirjam B. Zeisel, Zhen-Yong Keck, Steven K. H. Foung, Catherine Schuster, Thomas F. Baumert
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
DOI: 10.3389/fimmu.2018.01436

Secreted Interferon-Inducible Factors Restrict Hepatitis B and C Virus Entry In Vitro

Author(s): Yuchen Xia, Xiaoming Cheng, Christoph K. Blossey, Karin Wisskirchen, Knud Esser, Ulrike Protzer
Published in: Journal of Immunology Research, Issue 2017, 2017, Page(s) 1-12, ISSN 2314-8861
DOI: 10.1155/2017/4828936

Control of Hepatitis B Virus by Cytokines

Author(s): Yuchen Xia, Ulrike Protzer
Published in: Viruses, Issue 9/1, 2017, Page(s) 18, ISSN 1999-4915
DOI: 10.3390/v9010018

Tight junction proteins in gastrointestinal and liver disease

Author(s): Mirjam B Zeisel, Punita Dhawan, Thomas F Baumert
Published in: Gut, 2018, Page(s) gutjnl-2018-316906, ISSN 0017-5749
DOI: 10.1136/gutjnl-2018-316906

Protein kinase D at the Golgi controls NLRP3 inflammasome activation

Author(s): Zhirong Zhang, Gergö Meszaros, Wan-ting He, Yanfang Xu, Helena de Fatima Magliarelli, Laurent Mailly, Michael Mihlan, Yansheng Liu, Marta Puig Gámez, Alexander Goginashvili, Adrien Pasquier, Olga Bielska, Bénédicte Neven, Pierre Quartier, Rudolf Aebersold, Thomas F. Baumert, Philippe Georgel, Jiahuai Han, Romeo Ricci
Published in: The Journal of Experimental Medicine, Issue 214/9, 2017, Page(s) 2671-2693, ISSN 0022-1007
DOI: 10.1084/jem.20162040

Interplay between circadian clock and viral infection

Author(s): Xiaodong Zhuang, Srinivasa Bhargav Rambhatla, Alvina G. Lai, Jane A. McKeating
Published in: Journal of Molecular Medicine, Issue 95/12, 2017, Page(s) 1283-1289, ISSN 0946-2716
DOI: 10.1007/s00109-017-1592-7

The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication

Author(s): Xiaodong Zhuang, Andrea Magri, Michelle Hill, Alvina G. Lai, Abhinav Kumar, Srinivasa Bhargav Rambhatla, Claire L. Donald, Andrea F. Lopez-Clavijo, Simon Rudge, Katherine Pinnick, Wai Hoong Chang, Peter A. C. Wing, Ryan Brown, Ximing Qin, Peter Simmonds, Thomas F. Baumert, David Ray, Andrew Loudon, Peter Balfe, Michael Wakelam, Sam Butterworth, Alain Kohl, Catherine L. Jopling, Nicole Zitzmann, Ja
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
DOI: 10.1038/s41467-019-08299-7

Daytime variation in hepatitis C virus replication kinetics following liver transplant

Author(s): Xiaodong Zhuang, Alvina G. Lai, Jane A. McKeating, Ian Rowe, Peter Balfe
Published in: Wellcome Open Research, Issue 3, 2018, Page(s) 96, ISSN 2398-502X
DOI: 10.12688/wellcomeopenres.14696.2

Glucose and glutamine availability regulate HepG2 transcriptional responses to low oxygen

Author(s): Alvina G. Lai, Donall Forde, Wai Hoong Chang, Fang Yuan, Xiaodong Zhuang, Claudia Orbegozo Rubio, Chun-Xiao Song, Jane A. McKeating
Published in: Wellcome Open Research, Issue 3, 2018, Page(s) 126, ISSN 2398-502X
DOI: 10.12688/wellcomeopenres.14839.1

Hepatitis C virus infection is associated with hepatic and adipose tissue insulin resistance that improves after viral cure

Author(s): Teegan R. Lim, Jonathan M. Hazlehurst, Andrei I. Oprescu, Matthew J. Armstrong, Sewa F. Abdullah, Nigel P. Davies, Robert Flintham, Peter Balfe, David J. Mutimer, Jane A. McKeating, Jeremy W. Tomlinson
Published in: Clinical Endocrinology, 2018, Page(s) [Epub ahead of print], ISSN 0300-0664
DOI: 10.1111/cen.13924

Metallo supramolecular cylinders inhibit HIV-1 TAR-TAT complex formation and viral replication in cellulo

Author(s): Lucia Cardo, Isabel Nawroth, Peter J. Cail, Jane A. McKeating, Michael J. Hannon
Published in: Scientific Reports, Issue 8/1, 2018, Page(s) 13342, ISSN 2045-2322
DOI: 10.1038/s41598-018-31513-3

A new panel of epitope mapped monoclonal antibodies recognising the prototypical tetraspanin CD81

Author(s): Joe Grove, Ke Hu, Michelle J. Farquhar, Margaret Goodall, Lucas Walker, Mohammed Jamshad, Heidi E. Drummer, Roslyn M. Bill, Peter Balfe, Jane A. McKeating
Published in: Wellcome Open Research, Issue 2, 2017, Page(s) 82, ISSN 2398-502X
DOI: 10.12688/wellcomeopenres.12058.1

Insights From Deep Sequencing of the HBV Genome—Unique, Tiny, and Misunderstood

Author(s): Anna L. McNaughton, Valentina D’Arienzo, M. Azim Ansari, Sheila F. Lumley, Margaret Littlejohn, Peter Revill, Jane A. McKeating, Philippa C. Matthews
Published in: Gastroenterology, Issue 156/2, 2019, Page(s) 384-399, ISSN 0016-5085
DOI: 10.1053/j.gastro.2018.07.058

The immunology of hepatocellular carcinoma

Author(s): Marc Ringelhan, Dominik Pfister, Tracy O’Connor, Eli Pikarsky, Mathias Heikenwalder
Published in: Nature Immunology, Issue 19/3, 2018, Page(s) 222-232, ISSN 1529-2908
DOI: 10.1038/s41590-018-0044-z

Single cell polarity in liquid phase facilitates tumour metastasis

Author(s): Anna Lorentzen, Paul F. Becker, Jan Kosla, Massimo Saini, Kathrin Weidele, Paolo Ronchi, Corinna Klein, Monika J. Wolf, Felix Geist, Bastian Seubert, Marc Ringelhan, Daniela Mihic-Probst, Knud Esser, Marko Roblek, Felix Kuehne, Gaia Bianco, Tracy O’Connor, Quentin Müller, Kathleen Schuck, Sebastian Lange, Daniel Hartmann, Saskia Spaich, Olaf Groß, Jochen Utikal, Sebastian Haferkamp, Martin R.
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
DOI: 10.1038/s41467-018-03139-6

PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells

Author(s): Athena Georgilis, Sabrina Klotz, Christopher J. Hanley, Nicolas Herranz, Benedikt Weirich, Beatriz Morancho, Ana Carolina Leote, Luana D'Artista, Suchira Gallage, Marco Seehawer, Thomas Carroll, Gopuraja Dharmalingam, Keng Boon Wee, Marco Mellone, Joaquim Pombo, Danijela Heide, Ernesto Guccione, Joaquín Arribas, Nuno L. Barbosa-Morais, Mathias Heikenwalder, Gareth J. Thomas, Lars Zender, Jesús G
Published in: Cancer Cell, Issue 34/1, 2018, Page(s) 85-102.e9, ISSN 1535-6108
DOI: 10.1016/j.ccell.2018.06.007

A human liver cell atlas reveals heterogeneity and epithelial progenitors

Author(s): Nadim Aizarani, Antonio Saviano, Sagar, Laurent Mailly, Sarah Durand, Josip S. Herman, Patrick Pessaux, Thomas F. Baumert, Dominic Grün
Published in: Nature, Issue 572/7768, 2019, Page(s) 199-204, ISSN 0028-0836
DOI: 10.1038/s41586-019-1373-2

Addressing the Challenges of Hepatitis C Cure and Persistent Risk of Hepatocellular Carcinoma

Author(s): Thomas F. Baumert, Yujin Hoshida
Published in: Viruses, Issue 11/5, 2019, Page(s) 441, ISSN 1999-4915
DOI: 10.3390/v11050441

Chronic hepatitis C virus infection and pathogenesis of hepatocellular carcinoma

Author(s): Simonetta Bandiera, C Billie Bian, Yujin Hoshida, Thomas F Baumert, Mirjam B Zeisel
Published in: Current Opinion in Virology, Issue 20, 2016, Page(s) 99-105, ISSN 1879-6257
DOI: 10.1016/j.coviro.2016.09.010

Ultrasound‐Guided Approaches to Improve Orthotopic Mouse Xenograft Models for Hepatocellular Carcinoma

Author(s): Ghina Bou About, Emilie Thiebault, Marie Wattenhofer‐Donzé, Hugues Jacobs, Alain Guimond, Tania Sorg, Eric Robinet, Thomas F. Baumert, Laurent Monassier, Yann Herault
Published in: Current Protocols in Mouse Biology, Issue 9/2, 2019, ISSN 2161-2617
DOI: 10.1002/cpmo.62

Hepatitis C virus cell entry: a target for novel antiviral strategies to address limitations of direct acting antivirals

Author(s): Che C. Colpitts, Thomas F. Baumert
Published in: Hepatology International, Issue 10/5, 2016, Page(s) 741-748, ISSN 1936-0533
DOI: 10.1007/s12072-016-9724-7

A PCR assay to quantify patterns of HBV transcription

Author(s): Valentina D’Arienzo, Andrea Magri, James M. Harris, Peter A. C. Wing, Chunkyu Ko, Claudia Orbegozo Rubio, Peter A. Revill, Ulrike Protzer, Peter Balfe, Jane A. McKeating
Published in: Journal of General Virology, 2019, ISSN 0022-1317
DOI: 10.1099/jgv.0.001373

Hepatitis C virus vaccine candidates inducing protective neutralizing antibodies

Author(s): Catherine Fauvelle, Che C. Colpitts, Zhen-yong Keck, Brian G. Pierce, Steven K. H. Foung, Thomas F. Baumert
Published in: Expert Review of Vaccines, Issue 15/12, 2016, Page(s) 1535-1544, ISSN 1476-0584
DOI: 10.1080/14760584.2016.1194759

Zooming in on liver zonation

Author(s): Daniel J. Felmlee, Dominic Grün, Thomas F. Baumert
Published in: Hepatology, Issue 67/2, 2017, Page(s) 784-787, ISSN 0270-9139
DOI: 10.1002/hep.29554

Editorial: Current Progress and Challenges in the Development of a B Cell Based Hepatitis C Virus Vaccine

Author(s): Steven K. H. Foung, Thomas F. Baumert
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
DOI: 10.3389/fimmu.2018.02577

Targeting Innate and Adaptive Immune Responses to Cure Chronic HBV Infection

Author(s): Adam J. Gehring, Ulrike Protzer
Published in: Gastroenterology, Issue 156/2, 2019, Page(s) 325-337, ISSN 0016-5085
DOI: 10.1053/j.gastro.2018.10.032

Genomic characterization of cholangiocarcinoma in primary sclerosing cholangitis reveals novel therapeutic opportunities

Author(s): Benjamin Goeppert, Trine Folseraas, Stephanie Roessler, Matthias Kloor, Anna‐Lena Volckmar, Volker Endris, Ivo Buchhalter, Albrecht Stenzinger, Krzysztof Grzyb, Marit M. Grimsrud, Barbara Gornicka, Erik von Seth, Gary M. Reynolds, Andre Franke, Daniel N. Gotthardt, Arianeb Mehrabi, Angela Cheung, Joanne Verheij, Johanna Arola, Heikki Mäkisalo, Tor J. Eide, Sören Weidemann, John C. Cheville, Gi
Published in: Hepatology, 2020, ISSN 0270-9139
DOI: 10.1002/hep.31110

HCV-Induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response

Author(s): Nourdine Hamdane, Frank Jühling, Emilie Crouchet, Houssein El Saghire, Christine Thumann, Marine A. Oudot, Simonetta Bandiera, Antonio Saviano, Clara Ponsolles, Armando Andres Roca Suarez, Shen Li, Naoto Fujiwara, Atsushi Ono, Irwin Davidson, Nabeel Bardeesy, Christian Schmidl, Christoph Bock, Catherine Schuster, Joachim Lupberger, François Habersetzer, Michel Doffoël, Tullio Piardi, Daniele So
Published in: Gastroenterology, Issue 156/8, 2019, Page(s) 2313-2329.e7, ISSN 0016-5085
DOI: 10.1053/j.gastro.2019.02.038

A New Role for Capsid Assembly Modulators To Target Mature Hepatitis B Virus Capsids and Prevent Virus Infection

Author(s): Chunkyu Ko, Romina Bester, Xue Zhou, Zhiheng Xu, Christoph Blossey, Julia Sacherl, Florian W. R. Vondran, Lu Gao, Ulrike Protzer
Published in: Antimicrobial Agents and Chemotherapy, Issue 64/1, 2019, ISSN 0066-4804
DOI: 10.1128/aac.01440-19

Functional microRNA screen uncovers O-linked N-acetylglucosamine transferase as a host factor modulating hepatitis C virus morphogenesis and infectivity

Author(s): Katharina Herzog, Simonetta Bandiera, Sophie Pernot, Catherine Fauvelle, Frank Jühling, Amélie Weiss, Anne Bull, Sarah C Durand, Béatrice Chane-Woon-Ming, Sébastien Pfeffer, Marion Mercey, Hervé Lerat, Jean-Christophe Meunier, Wolfgang Raffelsberger, Laurent Brino, Thomas F Baumert, Mirjam B Zeisel
Published in: Gut, Issue 69/2, 2020, Page(s) 380-392, ISSN 0017-5749
DOI: 10.1136/gutjnl-2018-317423

Revisiting Hepatitis B Virus: Challenges of Curative Therapies

Author(s): Jianming Hu, Ulrike Protzer, Aleem Siddiqui
Published in: Journal of Virology, Issue 93/20, 2019, ISSN 0022-538X
DOI: 10.1128/jvi.01032-19

An E. coli-produced single-chain variable fragment (scFv) targeting hepatitis B virus surface protein potently inhibited virion secretion

Author(s): Cheng Li, Yang Wang, Tiantian Liu, Matthias Niklasch, Ke Qiao, Sarah Durand, Li Chen, Mifang Liang, Thomas F. Baumert, Shuping Tong, Michael Nassal, Yu-Mei Wen, Yong-Xiang Wang
Published in: Antiviral Research, Issue 162, 2019, Page(s) 118-129, ISSN 0166-3542
DOI: 10.1016/j.antiviral.2018.12.019

Randomized trials and endpoints in advanced HCC: Role of PFS as a surrogate of survival

Author(s): Josep M. Llovet, Robert Montal, Augusto Villanueva
Published in: Journal of Hepatology, Issue 70/6, 2019, Page(s) 1262-1277, ISSN 0168-8278
DOI: 10.1016/j.jhep.2019.01.028

Combined Analysis of Metabolomes, Proteomes, and Transcriptomes of Hepatitis C Virus–Infected Cells and Liver to Identify Pathways Associated With Disease Development

Author(s): Joachim Lupberger, Tom Croonenborghs, Armando Andres Roca Suarez, Nicolaas Van Renne, Frank Jühling, Marine A. Oudot, Alessia Virzì, Simonetta Bandiera, Carole Jamey, Gergö Meszaros, Daniel Brumaru, Atish Mukherji, Sarah C. Durand, Laura Heydmann, Eloi R. Verrier, Hussein El Saghire, Nourdine Hamdane, Ralf Bartenschlager, Shaunt Fereshetian, Evelyn Ramberger, Rileen Sinha, Mohsen Nabian, Celine
Published in: Gastroenterology, Issue 157/2, 2019, Page(s) 537-551.e9, ISSN 0016-5085
DOI: 10.1053/j.gastro.2019.04.003

Toward novel immunocompetent animal models for hepatitis B virus infection

Author(s): Laurent Mailly, Mirjam B. Zeisel, Thomas F. Baumert
Published in: Hepatology, Issue 66/3, 2017, Page(s) 691-693, ISSN 0270-9139
DOI: 10.1002/hep.29249

In vivo combination of human anti-envelope glycoprotein E2 and -Claudin-1 monoclonal antibodies for prevention of hepatitis C virus infection

Author(s): Laurent Mailly, Florian Wrensch, Laura Heydmann, Catherine Fauvelle, Nicolas Brignon, Mirjam B. Zeisel, Patrick Pessaux, Zhen-yong Keck, Catherine Schuster, Thomas R. Fuerst, Steven K.H. Foung, Thomas F. Baumert
Published in: Antiviral Research, Issue 162, 2019, Page(s) 136-141, ISSN 0166-3542
DOI: 10.1016/j.antiviral.2018.12.018

The Innate Antiviral Response in Animals: An Evolutionary Perspective from Flagellates to Humans

Author(s): Karim Majzoub, Florian Wrensch, Thomas F. Baumert
Published in: Viruses, Issue 11/8, 2019, Page(s) 758, ISSN 1999-4915
DOI: 10.3390/v11080758

An Immune Gene Expression Signature Associated With Development of Human Hepatocellular Carcinoma Identifies Mice That Respond to Chemopreventive Agents

Author(s): Agrin Moeini, Sara Torrecilla, Victoria Tovar, Carla Montironi, Carmen Andreu-Oller, Judit Peix, Mónica Higuera, Dominik Pfister, Pierluigi Ramadori, Roser Pinyol, Manel Solé, Mathias Heikenwälder, Scott L. Friedman, Daniela Sia, Josep M. Llovet
Published in: Gastroenterology, Issue 157/5, 2019, Page(s) 1383-1397.e11, ISSN 0016-5085
DOI: 10.1053/j.gastro.2019.07.028

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer

Author(s): Mohsen Malehmir, Dominik Pfister, Suchira Gallage, Marta Szydlowska, Donato Inverso, Elena Kotsiliti, Valentina Leone, Moritz Peiseler, Bas G. J. Surewaard, Dominik Rath, Adnan Ali, Monika Julia Wolf, Hannah Drescher, Marc E. Healy, Daniel Dauch, Daniela Kroy, Oliver Krenkel, Marlene Kohlhepp, Thomas Engleitner, Alexander Olkus, Tjeerd Sijmonsma, Julia Volz, Carsten Deppermann, David Stegner, Patr
Published in: Nature Medicine, Issue 25/4, 2019, Page(s) 641-655, ISSN 1078-8956
DOI: 10.1038/s41591-019-0379-5

The circadian clock and liver function in health and disease

Author(s): Atish Mukherji, Shannon M. Bailey, Bart Staels, Thomas F. Baumert
Published in: Journal of Hepatology, Issue 71/1, 2019, Page(s) 200-211, ISSN 0168-8278
DOI: 10.1016/j.jhep.2019.03.020

Molecular predictors of prevention of recurrence in HCC with sorafenib as adjuvant treatment and prognostic factors in the phase 3 STORM trial

Author(s): Roser Pinyol, Robert Montal, Laia Bassaganyas, Daniela Sia, Tadatoshi Takayama, Gar-Yang Chau, Vincenzo Mazzaferro, Sasan Roayaie, Han Chu Lee, Norihiro Kokudo, Zhongyang Zhang, Sara Torrecilla, Agrin Moeini, Leonardo Rodriguez-Carunchio, Edward Gane, Chris Verslype, Adina Emilia Croitoru, Umberto Cillo, Manuel de la Mata, Luigi Lupo, Simone Strasser, Joong-Won Park, Jordi Camps, Manel Solé, Swan
Published in: Gut, Issue 68/6, 2019, Page(s) 1065-1075, ISSN 0017-5749
DOI: 10.1136/gutjnl-2018-316408

Immune Exclusion-Wnt/CTNNB1 Class Predicts Resistance to Immunotherapies in HCC

Author(s): Roser Pinyol, Daniela Sia, Josep M. Llovet
Published in: Clinical Cancer Research, Issue 25/7, 2019, Page(s) 2021-2023, ISSN 1078-0432
DOI: 10.1158/1078-0432.ccr-18-3778

Uncovering the mechanism of action of aspirin in HCC chemoprevention

Author(s): Natascha Roehlen, Thomas F. Baumert
Published in: EBioMedicine, Issue 46, 2019, Page(s) 21-22, ISSN 2352-3964
DOI: 10.1016/j.ebiom.2019.07.047

β-Catenin Activation Promotes Immune Escape and Resistance to Anti–PD-1 Therapy in Hepatocellular Carcinoma

Author(s): Marina Ruiz de Galarreta, Erin Bresnahan, Pedro Molina-Sánchez, Katherine E. Lindblad, Barbara Maier, Daniela Sia, Marc Puigvehi, Verónica Miguela, María Casanova-Acebes, Maxime Dhainaut, Carlos Villacorta-Martin, Aatur D. Singhi, Akshata Moghe, Johann von Felden, Lauren Tal Grinspan, Shuang Wang, Alice O. Kamphorst, Satdarshan P. Monga, Brian D. Brown, Augusto Villanueva, Josep M. Llovet, Miri
Published in: Cancer Discovery, Issue 9/8, 2019, Page(s) 1124-1141, ISSN 2159-8274
DOI: 10.1158/2159-8290.cd-19-0074

Oxidative Stress Triggers Selective tRNA Retrograde Transport in Human Cells during the Integrated Stress Response

Author(s): Schwenzer, H.; Jühling, F.; Chu, A.; Pallett, L. J.; Baumert, T. F.; Maini, M.; Fassati, A.
Published in: Cell Reports , 26 (12) 3416-3428.e5. (2019), Issue 10, 2019

Follicular T helper cells shape the HCV-specific CD4+ T cell repertoire after virus elimination

Author(s): Maike Smits, Katharina Zoldan, Naveed Ishaque, Zuguang Gu, Katharina Jechow, Dominik Wieland, Christian Conrad, Roland Eils, Catherine Fauvelle, Thomas F. Baumert, Florian Emmerich, Bertram Bengsch, Christoph Neumann-Haefelin, Maike Hofmann, Robert Thimme, Tobias Boettler
Published in: Journal of Clinical Investigation, Issue 130/2, 2019, Page(s) 998-1009, ISSN 0021-9738
DOI: 10.1172/jci129642

Inefficient induction of circulating TAA-specific CD8+ T-cell responses in hepatocellular carcinoma

Author(s): Catrin Tauber, Liangliang Hao, Kaelyn Brown, Jihoon Lim, Sangeeta N. Bhatia, Frank J. Slack
Published in: Oncotarget, Issue 10/50, 2019, ISSN 1949-2553
DOI: 10.18632/oncotarget.27146

Broad neutralization of hepatitis C virus-resistant variants by Civacir hepatitis C immunoglobulin

Author(s): Rajiv G. Tawar, Laura Heydmann, Charlotte Bach, Jörg Schüttrumpf, Shailesh Chavan, Barnabas J. King, C. Patrick McClure, Jonathan K. Ball, Patrick Pessaux, François Habersetzer, Ralf Bartenschlager, Mirjam B. Zeisel, Thomas F. Baumert
Published in: Hepatology, Issue 64/5, 2016, Page(s) 1495-1506, ISSN 0270-9139
DOI: 10.1002/hep.28767

Hepatitis B Virus–Hepatocyte Interactions and Innate Immune Responses: Experimental Models and Molecular Mechanisms

Author(s): Emmanuel Thomas, Thomas F. Baumert
Published in: Seminars in Liver Disease, Issue 39/03, 2019, Page(s) 301-314, ISSN 0272-8087
DOI: 10.1055/s-0039-1685518

Cell Culture Models for the Investigation of Hepatitis B and D Virus Infection

Author(s): Eloi Verrier, Che Colpitts, Catherine Schuster, Mirjam Zeisel, Thomas Baumert
Published in: Viruses, Issue 8/9, 2016, Page(s) 261, ISSN 1999-4915
DOI: 10.3390/v8090261

Hepatitis B virus receptors and molecular drug targets

Author(s): Eloi R. Verrier, Che C. Colpitts, Camille Sureau, Thomas F. Baumert
Published in: Hepatology International, Issue 10/4, 2016, Page(s) 567-573, ISSN 1936-0533
DOI: 10.1007/s12072-016-9718-5

Combined small molecule and loss-of-function screen uncovers estrogen receptor alpha and CAD as host factors for HDV infection and antiviral targets

Author(s): Eloi R Verrier, Amélie Weiss, Charlotte Bach, Laura Heydmann, Vincent Turon-Lagot, Arnaud Kopp, Houssein El Saghire, Emilie Crouchet, Patrick Pessaux, Thomas Garcia, Patrick Pale, Mirjam B Zeisel, Camille Sureau, Catherine Schuster, Laurent Brino, Thomas F Baumert
Published in: Gut, Issue 69/1, 2019, Page(s) 158-167, ISSN 0017-5749
DOI: 10.1136/gutjnl-2018-317065

Oncogenic Signaling Induced by HCV Infection

Author(s): Alessia Virzì, Armando Roca Suarez, Thomas Baumert, Joachim Lupberger
Published in: Viruses, Issue 10/10, 2018, Page(s) 538, ISSN 1999-4915
DOI: 10.3390/v10100538

Rewiring Host Signaling: Hepatitis C Virus in Liver Pathogenesis

Author(s): Alessia Virzì, Armando Andres Roca Suarez, Thomas F. Baumert, Joachim Lupberger
Published in: Cold Spring Harbor Perspectives in Medicine, Issue 10/1, 2020, Page(s) a037366, ISSN 2157-1422
DOI: 10.1101/cshperspect.a037366

A dual role for SAMHD1 in regulating HBV cccDNA and RT-dependent particle genesis

Author(s): Peter AC Wing, Tamara Davenne, Jochen Wettengel, Alvina G Lai, Xiaodong Zhuang, Anindita Chakraborty, Valentina D’Arienzo, Catharina Kramer, Chunkyu Ko, James M Harris, Sabrina Schreiner, Martin Higgs, Stephanie Roessler, Joanna L Parish, Ulrike Protzer, Peter Balfe, Jan Rehwinkel, Jane A McKeating
Published in: Life Science Alliance, Issue 2/2, 2019, Page(s) e201900355, ISSN 2575-1077
DOI: 10.26508/lsa.201900355

Radiomics in hepatocellular carcinoma: a quantitative review

Author(s): Taiga Wakabayashi, Farid Ouhmich, Cristians Gonzalez-Cabrera, Emanuele Felli, Antonio Saviano, Vincent Agnus, Peter Savadjiev, Thomas F. Baumert, Patrick Pessaux, Jacques Marescaux, Benoit Gallix
Published in: Hepatology International, Issue 13/5, 2019, Page(s) 546-559, ISSN 1936-0533
DOI: 10.1007/s12072-019-09973-0

Learning from a clinical cohort for HCV vaccine development

Author(s): Florian Wrensch, Zhen-yong Keck, Steven K.H. Foung, Thomas F. Baumert
Published in: Journal of Hepatology, Issue 71/1, 2019, Page(s) 9-11, ISSN 0168-8278
DOI: 10.1016/j.jhep.2019.03.030

Hepatitis B virus: is a cure possible?

Author(s): Mirjam B. Zeisel, Thomas F. Baumert
Published in: Expert Review of Clinical Pharmacology, Issue 9/9, 2016, Page(s) 1129-1130, ISSN 1751-2433
DOI: 10.1080/17512433.2016.1206466

Translation and protein expression of lncRNAs: Impact for liver disease and hepatocellular carcinoma

Author(s): Mirjam B. Zeisel, Thomas F. Baumert
Published in: Hepatology, Issue 64/2, 2016, Page(s) 671-674, ISSN 0270-9139
DOI: 10.1002/hep.28653

Platelets in chronic liver disease, from bench to bedside

Author(s): Pierluigi Ramadori, Thomas Klag, Nisar Peter Malek, Mathias Heikenwalder
Published in: JHEP Reports, Issue 1/6, 2019, Page(s) 448-459, ISSN 2589-5559
DOI: 10.1016/j.jhepr.2019.10.001

Molecular portrait of high alpha-fetoprotein in hepatocellular carcinoma: implications for biomarker-driven clinical trials

Author(s): Robert Montal, Carmen Andreu-Oller, Laia Bassaganyas, Roger Esteban-Fabró, Sebastián Moran, Carla Montironi, Agrin Moeini, Roser Pinyol, Judit Peix, Laia Cabellos, Augusto Villanueva, Daniela Sia, Vincenzo Mazzaferro, Manel Esteller, Josep M. Llovet
Published in: British Journal of Cancer, Issue 121/4, 2019, Page(s) 340-343, ISSN 0007-0920
DOI: 10.1038/s41416-019-0513-7

Mortality from liver cirrhosis and HCC in the DAA era: success in viral control is darkened by raise of metabolic disease

Author(s): Antonio Saviano, Thomas F. Baumert
Published in: HepatoBiliary Surgery and Nutrition, Issue 8/3, 2019, Page(s) 307-310, ISSN 2304-3881
DOI: 10.21037/hbsn.2019.01.21

Single-cell RNA-Seq of HBV-induced hepatocellular carcinoma reveals viral compartmentalization and cancer heterogeneity

Author(s): Jühling F, Verrier ER, Saviano A , El Saghire H, Heydmann H, Pessaux P, Pochet N, Schuster C, Baumert TF.
Published in: J Clin Invest, Issue in revision, 2020

Hepatitis C Virus-Induced Upregulation of MicroRNA miR-146a-5p in Hepatocytes Promotes Viral Infection and Deregulates Metabolic Pathways Associated with Liver Disease Pathogenesis

Author(s): Simonetta Bandiera, Sophie Pernot, Hussein El Saghire, Sarah C. Durand, Christine Thumann, Emilie Crouchet, Tao Ye, Isabel Fofana, Marine A. Oudot, Jochen Barths, Catherine Schuster, Patrick Pessaux, Markus H. Heim, Thomas F. Baumert, Mirjam B. Zeisel
Published in: Journal of Virology, Issue 90/14, 2016, Page(s) 6387-6400, ISSN 0022-538X
DOI: 10.1128/JVI.00619-16

N-Glycosylation of the Na+-Taurocholate Cotransporting Polypeptide (NTCP) Determines Its Trafficking and Stability and Is Required for Hepatitis B Virus Infection

Author(s): Monique D. Appelman, Anindita Chakraborty, Ulrike Protzer, Jane A. McKeating, Stan F. J. van de Graaf
Published in: PLOS ONE, Issue 12/1, 2017, Page(s) e0170419, ISSN 1932-6203
DOI: 10.1371/journal.pone.0170419

Hepatitis C-related hepatocellular carcinoma in the era of new generation antivirals

Author(s): Thomas F. Baumert, Frank Jühling, Atsushi Ono, Yujin Hoshida
Published in: BMC Medicine, Issue 15/1, 2017, ISSN 1741-7015
DOI: 10.1186/s12916-017-0815-7

Palbociclib (PD-0332991), a selective CDK4/6 inhibitor, restricts tumour growth in preclinical models of hepatocellular carcinoma

Author(s): Julien Bollard, Verónica Miguela, Marina Ruiz de Galarreta, Anu Venkatesh, C Billie Bian, Mark P Roberto, Victoria Tovar, Daniela Sia, Pedro Molina-Sánchez, Christie B Nguyen, Shigeki Nakagawa, Josep M Llovet, Yujin Hoshida, Amaia Lujambio
Published in: Gut, Issue 66/7, 2017, Page(s) 1286-1296, ISSN 0017-5749
DOI: 10.1136/gutjnl-2016-312268

Humanisation of a claudin-1-specific monoclonal antibody for clinical prevention and cure of HCV infection without escape

Author(s): Che C Colpitts, Rajiv G Tawar, Laurent Mailly, Christine Thumann, Laura Heydmann, Sarah C Durand, Fei Xiao, Eric Robinet, Patrick Pessaux, Mirjam B Zeisel, Thomas F Baumert
Published in: Gut, Issue pii: gutjnl-2016-312577, 2017, Page(s) gutjnl-2016-312577, ISSN 0017-5749
DOI: 10.1136/gutjnl-2016-312577

Multifaceted role of E-cadherin in hepatitis C virus infection and pathogenesis

Author(s): Che C. Colpitts, Joachim Lupberger, Thomas F. Baumert
Published in: Proceedings of the National Academy of Sciences, Issue 113/27, 2016, Page(s) 7298-7300, ISSN 0027-8424
DOI: 10.1073/pnas.1607732113

SMAD About Hepatitis C Virus Cell Entry and Liver Disease

Author(s): Che C. Colpitts, Thomas F. Baumert
Published in: Gastroenterology, Issue 152/1, 2017, Page(s) 21-23, ISSN 0016-5085
DOI: 10.1053/j.gastro.2016.11.029

SCARB1 variants and HCV infection: Host susceptibility is lost in translation

Author(s): Che C. Colpitts, Thomas F. Baumert
Published in: Journal of Hepatology, Issue 67(2), 2017, Page(s) 211-213, ISSN 0168-8278
DOI: 10.1016/j.jhep.2017.04.013

Extracellular lipid-free apolipoprotein E inhibits HCV replication and induces ABCG1-dependent cholesterol efflux

Author(s): Emilie Crouchet, Mathieu Lefèvre, Eloi R Verrier, Marine A Oudot, Thomas F Baumert, Catherine Schuster
Published in: Gut, Issue 66/5, 2017, Page(s) 896-907, ISSN 0017-5749
DOI: 10.1136/gutjnl-2015-311289

Autotaxin-lysophosphatidic acid receptor signalling regulates hepatitis C virus replication

Author(s): Michelle J. Farquhar, Isla S. Humphreys, Simon A. Rudge, Garrick K. Wilson, Bishnupriya Bhattacharya, Maria Ciaccia, Ke Hu, Qifeng Zhang, Laurent Mailly, Gary M. Reynolds, Margaret Ashcroft, Peter Balfe, Thomas F. Baumert, Stephanie Roessler, Michael J.O. Wakelam, Jane A. McKeating
Published in: Journal of Hepatology, Issue 66/5, 2017, Page(s) 919-929, ISSN 0168-8278
DOI: 10.1016/j.jhep.2017.01.009

The Measles Virus Receptor SLAMF1 Can Mediate Particle Endocytosis

Author(s): Daniel Gonçalves-Carneiro, Jane A. McKeating, Dalan Bailey
Published in: Journal of Virology, Issue 91/7, 2017, Page(s) e02255-16, ISSN 0022-538X
DOI: 10.1128/JVI.02255-16

Tracking HCV protease population diversity during transmission and susceptibility of founder populations to antiviral therapy

Author(s): Tanvi Khera, Daniel Todt, Koen Vercauteren, C. Patrick McClure, Lieven Verhoye, Ali Farhoudi, Sabin Bhuju, Robert Geffers, Thomas F. Baumert, Eike Steinmann, Philip Meuleman, Thomas Pietschmann, Richard J.P. Brown
Published in: Antiviral Research, Issue 139, 2017, Page(s) 129-137, ISSN 0166-3542
DOI: 10.1016/j.antiviral.2017.01.001

Objective response by mRECIST as a predictor and potential surrogate end-point of overall survival in advanced HCC

Author(s): Riccardo Lencioni, Robert Montal, Ferran Torres, Joong-Won Park, Thomas Decaens, Jean-Luc Raoul, Masatoshi Kudo, Charissa Chang, José Ríos, Valerie Boige, Eric Assenat, Yoon-Koo Kang, Ho-Yeong Lim, Ian Walters, Josep M. Llovet
Published in: Journal of Hepatology, Issue 66/6, 2017, Page(s) 1166-1172, ISSN 0168-8278
DOI: 10.1016/j.jhep.2017.01.012

Hepatocellular carcinoma

Author(s): Josep M. Llovet, Jessica Zucman-Rossi, Eli Pikarsky, Bruno Sangro, Myron Schwartz, Morris Sherman, Gregory Gores
Published in: Nature Reviews Disease Primers, Issue 2, 2016, Page(s) 16018, ISSN 2056-676X
DOI: 10.1038/nrdp.2016.18

Plasmodium P36 determines host cell receptor usage during sporozoite invasion

Author(s): Giulia Manzoni, Carine Marinach, Selma Topçu, Sylvie Briquet, Morgane Grand, Matthieu Tolle, Marion Gransagne, Julien Lescar, Chiara Andolina, Jean-François Franetich, Mirjam B Zeisel, Thierry Huby, Eric Rubinstein, Georges Snounou, Dominique Mazier, François Nosten, Thomas F Baumert, Olivier Silvie
Published in: eLife, Issue 6, 2017, ISSN 2050-084X
DOI: 10.7554/eLife.25903

IGF2 Is Up-regulated by Epigenetic Mechanisms in Hepatocellular Carcinomas and Is an Actionable Oncogene Product in Experimental Models

Author(s): Iris Martinez-Quetglas, Roser Pinyol, Daniel Dauch, Sara Torrecilla, Victoria Tovar, Agrin Moeini, Clara Alsinet, Anna Portela, Leonardo Rodriguez-Carunchio, Manel Solé, Amaia Lujambio, Augusto Villanueva, Swan Thung, Manel Esteller, Lars Zender, Josep M. Llovet
Published in: Gastroenterology, Issue 151/6, 2016, Page(s) 1192-1205, ISSN 0016-5085
DOI: 10.1053/j.gastro.2016.09.001

Mixed hepatocellular cholangiocarcinoma tumors: Cholangiolocellular carcinoma is a distinct molecular entity

Author(s): Agrin Moeini, Daniela Sia, Zhongyang Zhang, Genis Camprecios, Ashley Stueck, Hui Dong, Robert Montal, Laura Torrens, Iris Martinez-Quetglas, M. Isabel Fiel, Ke Hao, Augusto Villanueva, Swan N. Thung, Myron E. Schwartz, Josep M. Llovet
Published in: Journal of Hepatology, Issue 66/5, 2017, Page(s) 952-961, ISSN 0168-8278
DOI: 10.1016/j.jhep.2017.01.010

Viral hepatitis and liver cancer

Author(s): Marc Ringehan, Jane A. McKeating, Ulrike Protzer
Published in: Philosophical Transactions of the Royal Society B: Biological Sciences, Issue 372/1732, 2017, Page(s) 20160274, ISSN 0962-8436
DOI: 10.1098/rstb.2016.0274

Molecular Pathogenesis and Targeted Therapies for Intrahepatic Cholangiocarcinoma

Author(s): A. Moeini, D. Sia, N. Bardeesy, V. Mazzaferro, J. M. Llovet
Published in: Clinical Cancer Research, Issue 22/2, 2016, Page(s) 291-300, ISSN 1078-0432
DOI: 10.1158/1078-0432.CCR-14-3296

Identification of an Immune-specific Class of Hepatocellular Carcinoma, Based on Molecular Features

Author(s): Daniela Sia, Yang Jiao, Iris Martinez-Quetglas, Olga Kuchuk, Carlos Villacorta-Martin, Manuel Castro de Moura, Juan Putra, Genis Camprecios, Laia Bassaganyas, Nicholas Akers, Bojan Losic, Samuel Waxman, Swan N. Thung, Vincenzo Mazzaferro, Manel Esteller, Scott L. Friedman, Myron Schwartz, Augusto Villanueva, Josep M. Llovet
Published in: Gastroenterology, Issue pii: S0016-5085(17)35741-4, 2017, ISSN 0016-5085
DOI: 10.1053/j.gastro.2017.06.007

Imaging-based surrogate markers of transcriptome subclasses and signatures in hepatocellular carcinoma: preliminary results

Author(s): Bachir Taouli, Yujin Hoshida, Suguru Kakite, Xintong Chen, Poh Seng Tan, Xiaochen Sun, Shingo Kihira, Kensuke Kojima, Sara Toffanin, M. Isabel Fiel, Hadassa Hirschfield, Mathilde Wagner, Josep M. Llovet
Published in: European Radiology, 2017, ISSN 0938-7994
DOI: 10.1007/s00330-017-4844-6

Liver Cancer Cell of Origin, Molecular Class, and Effects on Patient Prognosis

Author(s): Daniela Sia, Augusto Villanueva, Scott L. Friedman, Josep M. Llovet
Published in: Gastroenterology, Issue 152/4, 2017, Page(s) 745-761, ISSN 0016-5085
DOI: 10.1053/j.gastro.2016.11.048

Tumour initiating cells and IGF/FGF signalling contribute to sorafenib resistance in hepatocellular carcinoma

Author(s): Victoria Tovar, Helena Cornella, Agrin Moeini, Samuel Vidal, Yujin Hoshida, Daniela Sia, Judit Peix, Laia Cabellos, Clara Alsinet, Sara Torrecilla, Iris Martinez-Quetglas, Juan José Lozano, Christèle Desbois-Mouthon, Manel Solé, Josep Domingo-Domenech, Augusto Villanueva, Josep M Llovet
Published in: Gut, Issue 66/3, 2017, Page(s) 530-540, ISSN 0017-5749
DOI: 10.1136/gutjnl-2015-309501

Advancing hepatitis B virus entry inhibitors

Author(s): Eloi R. Verrier, Catherine Schuster, Thomas F. Baumert
Published in: Journal of Hepatology, Issue 66/4, 2017, Page(s) 677-679, ISSN 0168-8278
DOI: 10.1016/j.jhep.2016.11.028

Solute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of Hepatocytes

Author(s): Eloi R. Verrier, Che C. Colpitts, Charlotte Bach, Laura Heydmann, Laetitia Zona, Fei Xiao, Christine Thumann, Emilie Crouchet, Raphaël Gaudin, Camille Sureau, François-Loïc Cosset, Jane A. McKeating, Patrick Pessaux, Yujin Hoshida, Catherine Schuster, Mirjam B. Zeisel, Thomas F. Baumert
Published in: Cell Reports, Issue 17/5, 2016, Page(s) 1357-1368, ISSN 2211-1247
DOI: 10.1016/j.celrep.2016.09.084

miR-135a-5p-mediated downregulation of protein tyrosine phosphatase receptor delta is a candidate driver of HCV-associated hepatocarcinogenesis

Author(s): Nicolaas Van Renne, Armando Andres Roca Suarez, Francois H T Duong, Claire Gondeau, Diego Calabrese, Nelly Fontaine, Amina Ababsa, Simonetta Bandiera, Tom Croonenborghs, Nathalie Pochet, Vito De Blasi, Patrick Pessaux, Tullio Piardi, Daniele Sommacale, Atsushi Ono, Kazuaki Chayama, Masashi Fujita, Hidewaki Nakagawa, Yujin Hoshida, Mirjam B Zeisel, Markus H Heim, Thomas F Baumert, Joachim Lupberger
Published in: Gut, Issue pii: gutjnl-2016-312270, 2017, Page(s) gutjnl-2016-312270, ISSN 0017-5749
DOI: 10.1136/gutjnl-2016-312270

Multimodal imaging of a humanized orthotopic model of hepatocellular carcinoma in immunodeficient mice

Author(s): Tao Wu, Emilie Heuillard, Véronique Lindner, Ghina Bou About, Mihaela Ignat, Jean-Philippe Dillenseger, Nicolas Anton, Eugénie Dalimier, Francine Gossé, Gael Fouré, Franck Blindauer, Céline Giraudeau, Hussein El-Saghire, Mourad Bouhadjar, Cynthia Calligaro, Tania Sorg, Philippe Choquet, Thierry Vandamme, Christophe Ferrand, Jacques Marescaux, Thomas F. Baumert, Michele Diana, Patrick Pessaux,
Published in: Scientific Reports, Issue 6/1, 2016, Page(s) 35230, ISSN 2045-2322
DOI: 10.1038/srep35230

Hepatitis Delta Virus histone mimicry drives the recruitment of chromatin remodelers for viral RNA replication

Author(s): Natali Abeywickrama-Samarakoon, Jean-Claude Cortay, Camille Sureau, Susanne Müller, Dulce Alfaiate, Francesca Guerrieri, Apirat Chaikuad, Martin Schröder, Philippe Merle, Massimo Levrero, Paul Dény
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
DOI: 10.1038/s41467-020-14299-9

Hepatitis B protein HBx binds the DLEU2 lncRNA to sustain cccDNA and host cancer-related gene transcription

Author(s): Debora Salerno, Letizia Chiodo, Vincenzo Alfano, Oceane Floriot, Grazia Cottone, Alexia Paturel, Matteo Pallocca, Marie-Laure Plissonnier, Safaa Jeddari, Laura Belloni, Mirjam Zeisel, Massimo Levrero, Francesca Guerrieri
Published in: Gut, 2020, Page(s) gutjnl-2019-319637, ISSN 0017-5749
DOI: 10.1136/gutjnl-2019-319637

Perspectives and limitations for nucleo(t)side analogs in future HBV therapies

Author(s): Massimo Levrero, Miroslava Subic, Francois Villeret, Fabien Zoulim
Published in: Current Opinion in Virology, Issue 30, 2018, Page(s) 80-89, ISSN 1879-6257
DOI: 10.1016/j.coviro.2018.04.006

Mechanisms of HBV-induced hepatocellular carcinoma

Author(s): Massimo Levrero, Jessica Zucman-Rossi
Published in: Journal of Hepatology, Issue 64/1, 2016, Page(s) S84-S101, ISSN 0168-8278
DOI: 10.1016/j.jhep.2016.02.021

The histone deacetylase inhibiting drug Entinostat induces lipid accumulation in differentiated HepaRG cells

Author(s): Abigail D. G. Nunn, Tullio Scopigno, Natalia Pediconi, Massimo Levrero, Henning Hagman, Juris Kiskis, Annika Enejder
Published in: Scientific Reports, Issue 6/1, 2016, ISSN 2045-2322
DOI: 10.1038/srep28025

Non-Coding RNAs and Hepatitis C Virus-Induced Hepatocellular Carcinoma

Author(s): Marie-Laure Plissonnier, Katharina Herzog, Massimo Levrero, Mirjam Zeisel
Published in: Viruses, Issue 10/11, 2018, Page(s) 591, ISSN 1999-4915
DOI: 10.3390/v10110591

Challenges to a Cure for HBV Infection

Author(s): Barbara Testoni, Massimo Levrero, Fabien Zoulim
Published in: Seminars in Liver Disease, Issue 37/03, 2017, Page(s) 231-242, ISSN 0272-8087
DOI: 10.1055/s-0037-1606212

miR-122-regulated metabolic circuits: micro-management of lipid metabolism in the human liver

Author(s): Mirjam B. Zeisel, Marie-Laure Plissonnier, Massimo Levrero
Published in: Non-coding RNA Investigation, Issue 2, 2018, Page(s) 45-45, ISSN 2522-6673
DOI: 10.21037/ncri.2018.07.02

NOTCH target gene HES5 mediates oncogenic and tumor suppressive functions in hepatocarcinogenesis.

Author(s): Luiken S, Fraas A, Bieg M, Sugiyanto R, Goeppert B, Singer S, Ploeger C, Warsow G, Marquardt JU, Sticht C, De La Torre C, Pusch S, Mehrabi A, Gretz N, Schlesner M, Eils R, Schirmacher P, Longerich T, Roessler S.
Published in: Oncogene, Issue conditionally accepted, 2020