Mechanisms underlying hepatocellular carcinoma pathogenesis and impact of co-morbidities.

Rezultaty

Final dissemination and exploitation plan

A final dissemination and exploitation plan for using of dissemination knowledge and optimized exploitation of the results will be prepared at the end of the action.

Website development and management

The HEP-CAR website will be accessible on the internet at month 6 and it will be revised and improved during the whole course of the action. Part of the website will password-protected and dedicated to internal communication.

Publikacje

Status of Direct-Acting Antiviral Therapy for Hepatitis C Virus Infection and Remaining Challenges

Autorzy: Thomas F. Baumert, Thomas Berg, Joseph K. Lim, David R. Nelson
Opublikowane w: Gastroenterology, Numer 156, 2018, Strona(/y) 431-445, ISSN 0016-5085
Wydawca: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2018.10.024

Claudins in viral infection: from entry to spread

Autorzy: Che C. Colpitts, Thomas F. Baumert
Opublikowane w: Pflügers Archiv - European Journal of Physiology, Numer 469/1, 2017, Strona(/y) 27-34, ISSN 0031-6768
Wydawca: Springer Verlag
DOI: 10.1007/s00424-016-1908-4

Entry Inhibitors: A Perspective for Prevention of Hepatitis C Virus Infection in Organ Transplantation

Autorzy: Che C. Colpitts, Raymond T. Chung, Thomas F. Baumert
Opublikowane w: ACS Infectious Diseases, Numer 3/9, 2017, Strona(/y) 620-623, ISSN 2373-8227
Wydawca: ACS Publications
DOI: 10.1021/acsinfecdis.7b00091

Host-targeting therapies for hepatitis C virus infection: current developments and future applications

Autorzy: Emilie Crouchet, Florian Wrensch, Catherine Schuster, Mirjam B. Zeisel, Thomas F. Baumert
Opublikowane w: Therapeutic Advances in Gastroenterology, Numer 11, 2018, Strona(/y) 175628481875948, ISSN 1756-2848
Wydawca: SAGE Publications
DOI: 10.1177/1756284818759483

The functional role of sodium taurocholate cotransporting polypeptide NTCP in the life cycle of hepatitis B, C and D viruses

Autorzy: Carla Eller, Laura Heydmann, Che C. Colpitts, Eloi R. Verrier, Catherine Schuster, Thomas F. Baumert
Opublikowane w: Cellular and Molecular Life Sciences, Numer 75/21, 2018, Strona(/y) 3895-3905, ISSN 1420-682X
Wydawca: Birkhauser Verlag
DOI: 10.1007/s00018-018-2892-y

A novel neutralizing human monoclonal antibody broadly abrogates hepatitis C virus infection in vitro and in vivo

Autorzy: Isabelle Desombere, Ahmed Atef Mesalam, Richard A. Urbanowicz, Freya Van Houtte, Lieven Verhoye, Zhen-Yong Keck, Ali Farhoudi, Koen Vercauteren, Karin E. Weening, Thomas F. Baumert, Arvind H. Patel, Steven K.H. Foung, Jonathan Ball, Geert Leroux-Roels, Philip Meuleman
Opublikowane w: Antiviral Research, Numer 148, 2017, Strona(/y) 53-64, ISSN 0166-3542
Wydawca: Elsevier BV
DOI: 10.1016/j.antiviral.2017.10.015

Nuclear Translocation of RELB is Increased in Diseased Human Liver and Promotes Ductular Reaction and Biliary Fibrosis in Mice

Autorzy: Christin Elßner, Benjamin Goeppert, Thomas Longerich, Anna-Lena Scherr, Jan Stindt, Lahiri Kanth Nanduri, Christian Rupp, Jakob Nikolas Kather, Nathalie Schmitt, Nicole Kautz, Kai Breuhahn, Lars Ismail, Danijela Heide, Jenny Hetzer, María García-Beccaria, Nadine Hövelmeyer, Ari Waisman, Toni Urbanik, Sebastian Mueller, Georg Gdynia, Jesus M. Banales, Stephanie Roessler, Peter Schirmacher, Dirk
Opublikowane w: Gastroenterology, Numer 156(4), 2018, Strona(/y) 1190-1205.e14, ISSN 0016-5085
Wydawca: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2018.11.018

EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma

Autorzy: Peter R. Galle, Alejandro Forner, Josep M. Llovet, Vincenzo Mazzaferro, Fabio Piscaglia, Jean-Luc Raoul, Peter Schirmacher, Valérie Vilgrain
Opublikowane w: Journal of Hepatology, Numer 69/1, 2018, Strona(/y) 182-236, ISSN 0168-8278
Wydawca: Elsevier BV
DOI: 10.1016/j.jhep.2018.03.019

Integrative analysis defines distinct prognostic subgroups of intrahepatic cholangiocarcinoma

Autorzy: Benjamin Goeppert, Reka Toth, Stephan Singer, Thomas Albrecht, Daniel B. Lipka, Pavlo Lutsik, David Brocks, Marion Baehr, Oliver Muecke, Yassen Assenov, Lei Gu, Volker Endris, Albrecht Stenzinger, Arianeb Mehrabi, Peter Schirmacher, Christoph Plass, Dieter Weichenhan, Stephanie Roessler
Opublikowane w: Hepatology, 2019, ISSN 0270-9139
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/hep.30493

Signalome-wide assessment of host cell response to hepatitis C virus

Autorzy: Gholamreza Haqshenas, Jianmin Wu, Kaylene J. Simpson, Roger J. Daly, Hans J. Netter, Thomas F. Baumert, Christian Doerig
Opublikowane w: Nature Communications, Numer 8, 2017, Strona(/y) 15158, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/ncomms15158

Hepatitis B Virus Activates Signal Transducer and Activator of Transcription 3 Supporting Hepatocyte Survival and Virus Replication

Autorzy: Marianna Hösel, Maria Quasdorff, Marc Ringelhan, Hamid Kashkar, Svenja Debey-Pascher, Martin F. Sprinzl, Jan-Hendrik Bockmann, Silke Arzberger, Dennis Webb, Gesa von Olshausen, Achim Weber, Joachim L. Schultze, Hildegard Büning, Mathias Heikenwalder, Ulrike Protzer
Opublikowane w: Cellular and Molecular Gastroenterology and Hepatology, Numer 4/3, 2017, Strona(/y) 339-363, ISSN 2352-345X
Wydawca: Elsevier Inc.
DOI: 10.1016/j.jcmgh.2017.07.003

Mapping Determinants of Virus Neutralization and Viral Escape for Rational Design of a Hepatitis C Virus Vaccine

Autorzy: Mei-Le Keck, Florian Wrensch, Brian G. Pierce, Thomas F. Baumert, Steven K. H. Foung
Opublikowane w: Frontiers in Immunology, Numer 9, 2018, ISSN 1664-3224
Wydawca: Frontiers Media SA
DOI: 10.3389/fimmu.2018.01194

Hepatitis B virus genome recycling and de novo secondary infection events maintain stable cccDNA levels

Autorzy: Chunkyu Ko, Anindita Chakraborty, Wen-Min Chou, Julia Hasreiter, Jochen M. Wettengel, Daniela Stadler, Romina Bester, Theresa Asen, Ke Zhang, Karin Wisskirchen, Jane A. McKeating, Wang-Shick Ryu, Ulrike Protzer
Opublikowane w: Journal of Hepatology, Numer 69/6, 2018, Strona(/y) 1231-1241, ISSN 0168-8278
Wydawca: Elsevier BV
DOI: 10.1016/j.jhep.2018.08.012

IFN-α-mediated Base Excision Repair Pathway Correlates with Antiviral Response Against Hepatitis B Virus Infection

Autorzy: Yong Li, Yuchen Xia, Meifang Han, Guang Chen, Dake Zhang, Wolfgang E. Thasler, Ulrike Protzer, Qin Ning
Opublikowane w: Scientific Reports, Numer 7/1, 2017, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-017-13082-z

Hepatitis B Virus Core Variants, Liver Fibrosis, and Hepatocellular Carcinoma

Autorzy: Gaetan Ligat, Catherine Schuster, Thomas F. Baumert
Opublikowane w: Hepatology, Numer 69/1, 2019, Strona(/y) 5-8, ISSN 0270-9139
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/hep.30231

A pilot study of ultra-deep targeted sequencing of plasma DNA identifies driver mutations in hepatocellular carcinoma

Autorzy: Ismail Labgaa, Carlos Villacorta-Martin, Delia D’Avola, Amanda J. Craig, Johann von Felden, Sebastiao N. Martins-Filho, Daniela Sia, Ashley Stueck, Stephen C. Ward, M. Isabel Fiel, Milind Mahajan, Parissa Tabrizian, Swan N. Thung, Celina Ang, Scott L. Friedman, Josep M. Llovet, Myron Schwartz, Augusto Villanueva
Opublikowane w: Oncogene, Numer 37/27, 2018, Strona(/y) 3740-3752, ISSN 0950-9232
Wydawca: Nature Publishing Group
DOI: 10.1038/s41388-018-0206-3

Molecular therapies and precision medicine for hepatocellular carcinoma

Autorzy: Josep M. Llovet, Robert Montal, Daniela Sia, Richard S. Finn
Opublikowane w: Nature Reviews Clinical Oncology, Numer 15/10, 2018, Strona(/y) 599-616, ISSN 1759-4774
Wydawca: Nature Publishing Group
DOI: 10.1038/s41571-018-0073-4

Pilot study of living donor liver transplantation for patients with hepatocellular carcinoma exceeding Milan Criteria (Barcelona Clinic Liver Cancer extended criteria)

Autorzy: Josep M. Llovet, Mihai Pavel, Jordi Rimola, Maria Alba Diaz, Jordi Colmenero, David Saavedra-Perez, Constantino Fondevila, Carmen Ayuso, Josep Fuster, Pere Ginès, Jordi Bruix, Juan Carlos Garcia-Valdecasas
Opublikowane w: Liver Transplantation, Numer 24/3, 2018, Strona(/y) 369-379, ISSN 1527-6465
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/lt.24977

Viral hepatitis: The bumpy road to animal models for HBV infection

Autorzy: Ulrike Protzer
Opublikowane w: Nature Reviews Gastroenterology & Hepatology, Numer 14/6, 2017, Strona(/y) 327-328, ISSN 1759-5045
Wydawca: Nature Publishing Group
DOI: 10.1038/nrgastro.2017.44

Beyond viral dependence: The pathological consequences of HCV-induced EGF signaling

Autorzy: Armando Andres Roca Suarez, Thomas F. Baumert, Joachim Lupberger
Opublikowane w: Journal of Hepatology, Numer 69/3, 2018, Strona(/y) 564-566, ISSN 0168-8278
Wydawca: Elsevier BV
DOI: 10.1016/j.jhep.2018.05.033

Viral manipulation of STAT3: Evade, exploit, and injure

Autorzy: Armando Andres Roca Suarez, Nicolaas Van Renne, Thomas F. Baumert, Joachim Lupberger
Opublikowane w: PLOS Pathogens, Numer 14/3, 2018, Strona(/y) e1006839, ISSN 1553-7374
Wydawca: -
DOI: 10.1371/journal.ppat.1006839

Liver cancer: Translating '–omics' results into precision medicine for hepatocellular carcinoma

Autorzy: Daniela Sia, Josep M. Llovet
Opublikowane w: Nature Reviews Gastroenterology & Hepatology, 2017, ISSN 1759-5045
Wydawca: Nature Publishing Group
DOI: 10.1038/nrgastro.2017.103

Trunk mutational events present minimal intra- and inter-tumoral heterogeneity in hepatocellular carcinoma

Autorzy: Sara Torrecilla, Daniela Sia, Andrew N. Harrington, Zhongyang Zhang, Laia Cabellos, Helena Cornella, Agrin Moeini, Genis Camprecios, Wei-Qiang Leow, Maria Isabel Fiel, Ke Hao, Laia Bassaganyas, Milind Mahajan, Swan N. Thung, Augusto Villanueva, Sander Florman, Myron E. Schwartz, Josep M. Llovet
Opublikowane w: Journal of Hepatology, Numer 67/6, 2017, Strona(/y) 1222-1231, ISSN 0168-8278
Wydawca: Elsevier BV
DOI: 10.1016/j.jhep.2017.08.013

Hepatitis B Virus Evasion From Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase Sensing in Human Hepatocytes

Autorzy: Eloi R. Verrier, Seung-Ae Yim, Laura Heydmann, Houssein El Saghire, Charlotte Bach, Vincent Turon-Lagot, Laurent Mailly, Sarah C. Durand, Julie Lucifora, David Durantel, Patrick Pessaux, Nicolas Manel, Ivan Hirsch, Mirjam B. Zeisel, Nathalie Pochet, Catherine Schuster, Thomas F. Baumert
Opublikowane w: Hepatology, Numer 68/5, 2018, Strona(/y) 1695-1709, ISSN 0270-9139
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/hep.30054

Hepatocellular carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†

Autorzy: A Vogel, A Cervantes, I Chau, B Daniele, J Llovet, T Meyer, J -C Nault, U Neumann, J Ricke, B Sangro, P Schirmacher, C Verslype, C J Zech, D Arnold, E Martinelli
Opublikowane w: Annals of Oncology, Numer 29/Supplement_4, 2018, Strona(/y) iv238-iv255, ISSN 0923-7534
Wydawca: Oxford University Press
DOI: 10.1093/annonc/mdy308

"Hepatitis B virus promotes β-catenin-signalling and disassembly of adherens junctions in a Src kinase dependent fashion"

Autorzy: Gesa von Olshausen, Maria Quasdorff, Romina Bester, Silke Arzberger, Chunkyu Ko, Maarten van de Klundert, Ke Zhang, Margarete Odenthal, Marc Ringelhan, Carien M. Niessen, Ulrike Protzer
Opublikowane w: Oncotarget, Numer 9/74, 2018, ISSN 1949-2553
Wydawca: Impact Journals
DOI: 10.18632/oncotarget.26103

Cytoplasmic localization of the cell polarity factor scribble supports liver tumor formation and tumor cell invasiveness

Autorzy: Shan Wan, Anne-Sophie Meyer, Sofia Maria Elisabeth Weiler, Christian Rupp, Marcell Tóth, Carsten Sticht, Stephan Singer, Stefan Thomann, Stephanie Roessler, Marina Schorpp-Kistner, Jennifer Schmitt, Norbert Gretz, Peter Angel, Darjus Felix Tschaharganeh, Jens Marquardt, Peter Schirmacher, Federico Pinna, Kai Breuhahn
Opublikowane w: Hepatology, Numer 67/5, 2018, Strona(/y) 1842-1856, ISSN 0270-9139
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/hep.29669

Early Transcriptional Divergence Marks Virus-Specific Primary Human CD8+ T Cells in Chronic versus Acute Infection

Autorzy: David Wolski, Peter K. Foote, Diana Y. Chen, Lia L. Lewis-Ximenez, Catherine Fauvelle, Jasneet Aneja, Andreas Walker, Pierre Tonnerre, Almudena Torres-Cornejo, Daniel Kvistad, Sabrina Imam, Michael T. Waring, Damien C. Tully, Todd M. Allen, Raymond T. Chung, Jörg Timm, W. Nicholas Haining, Arthur Y. Kim, Thomas F. Baumert, Georg M. Lauer
Opublikowane w: Immunity, Numer 47/4, 2017, Strona(/y) 648-663.e8, ISSN 1074-7613
Wydawca: Cell Press
DOI: 10.1016/j.immuni.2017.09.006

Hepatitis C Virus (HCV)–Apolipoprotein Interactions and Immune Evasion and Their Impact on HCV Vaccine Design

Autorzy: Florian Wrensch, Emilie Crouchet, Gaetan Ligat, Mirjam B. Zeisel, Zhen-Yong Keck, Steven K. H. Foung, Catherine Schuster, Thomas F. Baumert
Opublikowane w: Frontiers in Immunology, Numer 9, 2018, ISSN 1664-3224
Wydawca: Frontiers Media SA
DOI: 10.3389/fimmu.2018.01436

Secreted Interferon-Inducible Factors Restrict Hepatitis B and C Virus Entry In Vitro

Autorzy: Yuchen Xia, Xiaoming Cheng, Christoph K. Blossey, Karin Wisskirchen, Knud Esser, Ulrike Protzer
Opublikowane w: Journal of Immunology Research, Numer 2017, 2017, Strona(/y) 1-12, ISSN 2314-8861
Wydawca: Hindawi Publishing Corporation
DOI: 10.1155/2017/4828936

Control of Hepatitis B Virus by Cytokines

Autorzy: Yuchen Xia, Ulrike Protzer
Opublikowane w: Viruses, Numer 9/1, 2017, Strona(/y) 18, ISSN 1999-4915
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v9010018

Tight junction proteins in gastrointestinal and liver disease

Autorzy: Mirjam B Zeisel, Punita Dhawan, Thomas F Baumert
Opublikowane w: Gut, 2018, Strona(/y) gutjnl-2018-316906, ISSN 0017-5749
Wydawca: BMJ Publishing Group
DOI: 10.1136/gutjnl-2018-316906

Protein kinase D at the Golgi controls NLRP3 inflammasome activation

Autorzy: Zhirong Zhang, Gergö Meszaros, Wan-ting He, Yanfang Xu, Helena de Fatima Magliarelli, Laurent Mailly, Michael Mihlan, Yansheng Liu, Marta Puig Gámez, Alexander Goginashvili, Adrien Pasquier, Olga Bielska, Bénédicte Neven, Pierre Quartier, Rudolf Aebersold, Thomas F. Baumert, Philippe Georgel, Jiahuai Han, Romeo Ricci
Opublikowane w: The Journal of Experimental Medicine, Numer 214/9, 2017, Strona(/y) 2671-2693, ISSN 0022-1007
Wydawca: Rockefeller University Press
DOI: 10.1084/jem.20162040

Interplay between circadian clock and viral infection

Autorzy: Xiaodong Zhuang, Srinivasa Bhargav Rambhatla, Alvina G. Lai, Jane A. McKeating
Opublikowane w: Journal of Molecular Medicine, Numer 95/12, 2017, Strona(/y) 1283-1289, ISSN 0946-2716
Wydawca: Springer Verlag
DOI: 10.1007/s00109-017-1592-7

The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication

Autorzy: Xiaodong Zhuang, Andrea Magri, Michelle Hill, Alvina G. Lai, Abhinav Kumar, Srinivasa Bhargav Rambhatla, Claire L. Donald, Andrea F. Lopez-Clavijo, Simon Rudge, Katherine Pinnick, Wai Hoong Chang, Peter A. C. Wing, Ryan Brown, Ximing Qin, Peter Simmonds, Thomas F. Baumert, David Ray, Andrew Loudon, Peter Balfe, Michael Wakelam, Sam Butterworth, Alain Kohl, Catherine L. Jopling, Nicole Zitzmann, Ja
Opublikowane w: Nature Communications, Numer 10/1, 2019, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-019-08299-7

Daytime variation in hepatitis C virus replication kinetics following liver transplant

Autorzy: Xiaodong Zhuang, Alvina G. Lai, Jane A. McKeating, Ian Rowe, Peter Balfe
Opublikowane w: Wellcome Open Research, Numer 3, 2018, Strona(/y) 96, ISSN 2398-502X
Wydawca: -
DOI: 10.12688/wellcomeopenres.14696.2

Glucose and glutamine availability regulate HepG2 transcriptional responses to low oxygen

Autorzy: Alvina G. Lai, Donall Forde, Wai Hoong Chang, Fang Yuan, Xiaodong Zhuang, Claudia Orbegozo Rubio, Chun-Xiao Song, Jane A. McKeating
Opublikowane w: Wellcome Open Research, Numer 3, 2018, Strona(/y) 126, ISSN 2398-502X
Wydawca: -
DOI: 10.12688/wellcomeopenres.14839.1

Hepatitis C virus infection is associated with hepatic and adipose tissue insulin resistance that improves after viral cure

Autorzy: Teegan R. Lim, Jonathan M. Hazlehurst, Andrei I. Oprescu, Matthew J. Armstrong, Sewa F. Abdullah, Nigel P. Davies, Robert Flintham, Peter Balfe, David J. Mutimer, Jane A. McKeating, Jeremy W. Tomlinson
Opublikowane w: Clinical Endocrinology, 2018, Strona(/y) [Epub ahead of print], ISSN 0300-0664
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/cen.13924

Metallo supramolecular cylinders inhibit HIV-1 TAR-TAT complex formation and viral replication in cellulo

Autorzy: Lucia Cardo, Isabel Nawroth, Peter J. Cail, Jane A. McKeating, Michael J. Hannon
Opublikowane w: Scientific Reports, Numer 8/1, 2018, Strona(/y) 13342, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-018-31513-3

A new panel of epitope mapped monoclonal antibodies recognising the prototypical tetraspanin CD81

Autorzy: Joe Grove, Ke Hu, Michelle J. Farquhar, Margaret Goodall, Lucas Walker, Mohammed Jamshad, Heidi E. Drummer, Roslyn M. Bill, Peter Balfe, Jane A. McKeating
Opublikowane w: Wellcome Open Research, Numer 2, 2017, Strona(/y) 82, ISSN 2398-502X
Wydawca: -
DOI: 10.12688/wellcomeopenres.12058.1

Insights From Deep Sequencing of the HBV Genome—Unique, Tiny, and Misunderstood

Autorzy: Anna L. McNaughton, Valentina D’Arienzo, M. Azim Ansari, Sheila F. Lumley, Margaret Littlejohn, Peter Revill, Jane A. McKeating, Philippa C. Matthews
Opublikowane w: Gastroenterology, Numer 156/2, 2019, Strona(/y) 384-399, ISSN 0016-5085
Wydawca: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2018.07.058

The immunology of hepatocellular carcinoma

Autorzy: Marc Ringelhan, Dominik Pfister, Tracy O’Connor, Eli Pikarsky, Mathias Heikenwalder
Opublikowane w: Nature Immunology, Numer 19/3, 2018, Strona(/y) 222-232, ISSN 1529-2908
Wydawca: Nature Publishing Group
DOI: 10.1038/s41590-018-0044-z

Single cell polarity in liquid phase facilitates tumour metastasis

Autorzy: Anna Lorentzen, Paul F. Becker, Jan Kosla, Massimo Saini, Kathrin Weidele, Paolo Ronchi, Corinna Klein, Monika J. Wolf, Felix Geist, Bastian Seubert, Marc Ringelhan, Daniela Mihic-Probst, Knud Esser, Marko Roblek, Felix Kuehne, Gaia Bianco, Tracy O’Connor, Quentin Müller, Kathleen Schuck, Sebastian Lange, Daniel Hartmann, Saskia Spaich, Olaf Groß, Jochen Utikal, Sebastian Haferkamp, Martin R.
Opublikowane w: Nature Communications, Numer 9/1, 2018, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-018-03139-6

PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells

Autorzy: Athena Georgilis, Sabrina Klotz, Christopher J. Hanley, Nicolas Herranz, Benedikt Weirich, Beatriz Morancho, Ana Carolina Leote, Luana D'Artista, Suchira Gallage, Marco Seehawer, Thomas Carroll, Gopuraja Dharmalingam, Keng Boon Wee, Marco Mellone, Joaquim Pombo, Danijela Heide, Ernesto Guccione, Joaquín Arribas, Nuno L. Barbosa-Morais, Mathias Heikenwalder, Gareth J. Thomas, Lars Zender, Jesús G
Opublikowane w: Cancer Cell, Numer 34/1, 2018, Strona(/y) 85-102.e9, ISSN 1535-6108
Wydawca: Cell Press
DOI: 10.1016/j.ccell.2018.06.007

A human liver cell atlas reveals heterogeneity and epithelial progenitors

Autorzy: Nadim Aizarani, Antonio Saviano, Sagar, Laurent Mailly, Sarah Durand, Josip S. Herman, Patrick Pessaux, Thomas F. Baumert, Dominic Grün
Opublikowane w: Nature, Numer 572/7768, 2019, Strona(/y) 199-204, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/s41586-019-1373-2

Addressing the Challenges of Hepatitis C Cure and Persistent Risk of Hepatocellular Carcinoma

Autorzy: Thomas F. Baumert, Yujin Hoshida
Opublikowane w: Viruses, Numer 11/5, 2019, Strona(/y) 441, ISSN 1999-4915
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v11050441

Chronic hepatitis C virus infection and pathogenesis of hepatocellular carcinoma

Autorzy: Simonetta Bandiera, C Billie Bian, Yujin Hoshida, Thomas F Baumert, Mirjam B Zeisel
Opublikowane w: Current Opinion in Virology, Numer 20, 2016, Strona(/y) 99-105, ISSN 1879-6257
Wydawca: Elsevier BV
DOI: 10.1016/j.coviro.2016.09.010

Ultrasound‐Guided Approaches to Improve Orthotopic Mouse Xenograft Models for Hepatocellular Carcinoma

Autorzy: Ghina Bou About, Emilie Thiebault, Marie Wattenhofer‐Donzé, Hugues Jacobs, Alain Guimond, Tania Sorg, Eric Robinet, Thomas F. Baumert, Laurent Monassier, Yann Herault
Opublikowane w: Current Protocols in Mouse Biology, Numer 9/2, 2019, ISSN 2161-2617
Wydawca: -
DOI: 10.1002/cpmo.62

Hepatitis C virus cell entry: a target for novel antiviral strategies to address limitations of direct acting antivirals

Autorzy: Che C. Colpitts, Thomas F. Baumert
Opublikowane w: Hepatology International, Numer 10/5, 2016, Strona(/y) 741-748, ISSN 1936-0533
Wydawca: Springer Pub. Co.
DOI: 10.1007/s12072-016-9724-7

A PCR assay to quantify patterns of HBV transcription

Autorzy: Valentina D’Arienzo, Andrea Magri, James M. Harris, Peter A. C. Wing, Chunkyu Ko, Claudia Orbegozo Rubio, Peter A. Revill, Ulrike Protzer, Peter Balfe, Jane A. McKeating
Opublikowane w: Journal of General Virology, 2019, ISSN 0022-1317
Wydawca: Society for General Microbiology
DOI: 10.1099/jgv.0.001373

Hepatitis C virus vaccine candidates inducing protective neutralizing antibodies

Autorzy: Catherine Fauvelle, Che C. Colpitts, Zhen-yong Keck, Brian G. Pierce, Steven K. H. Foung, Thomas F. Baumert
Opublikowane w: Expert Review of Vaccines, Numer 15/12, 2016, Strona(/y) 1535-1544, ISSN 1476-0584
Wydawca: Future Drugs Ltd.
DOI: 10.1080/14760584.2016.1194759

Zooming in on liver zonation

Autorzy: Daniel J. Felmlee, Dominic Grün, Thomas F. Baumert
Opublikowane w: Hepatology, Numer 67/2, 2017, Strona(/y) 784-787, ISSN 0270-9139
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/hep.29554

Editorial: Current Progress and Challenges in the Development of a B Cell Based Hepatitis C Virus Vaccine

Autorzy: Steven K. H. Foung, Thomas F. Baumert
Opublikowane w: Frontiers in Immunology, Numer 9, 2018, ISSN 1664-3224
Wydawca: -
DOI: 10.3389/fimmu.2018.02577

Targeting Innate and Adaptive Immune Responses to Cure Chronic HBV Infection

Autorzy: Adam J. Gehring, Ulrike Protzer
Opublikowane w: Gastroenterology, Numer 156/2, 2019, Strona(/y) 325-337, ISSN 0016-5085
Wydawca: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2018.10.032

Genomic characterization of cholangiocarcinoma in primary sclerosing cholangitis reveals novel therapeutic opportunities

Autorzy: Benjamin Goeppert, Trine Folseraas, Stephanie Roessler, Matthias Kloor, Anna‐Lena Volckmar, Volker Endris, Ivo Buchhalter, Albrecht Stenzinger, Krzysztof Grzyb, Marit M. Grimsrud, Barbara Gornicka, Erik von Seth, Gary M. Reynolds, Andre Franke, Daniel N. Gotthardt, Arianeb Mehrabi, Angela Cheung, Joanne Verheij, Johanna Arola, Heikki Mäkisalo, Tor J. Eide, Sören Weidemann, John C. Cheville, Gi
Opublikowane w: Hepatology, 2020, ISSN 0270-9139
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/hep.31110

HCV-Induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response

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A New Role for Capsid Assembly Modulators To Target Mature Hepatitis B Virus Capsids and Prevent Virus Infection

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Toward novel immunocompetent animal models for hepatitis B virus infection

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The Innate Antiviral Response in Animals: An Evolutionary Perspective from Flagellates to Humans

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An Immune Gene Expression Signature Associated With Development of Human Hepatocellular Carcinoma Identifies Mice That Respond to Chemopreventive Agents

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The circadian clock and liver function in health and disease

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Immune Exclusion-Wnt/CTNNB1 Class Predicts Resistance to Immunotherapies in HCC

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Uncovering the mechanism of action of aspirin in HCC chemoprevention

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Hepatitis B Virus–Hepatocyte Interactions and Innate Immune Responses: Experimental Models and Molecular Mechanisms

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Oncogenic Signaling Induced by HCV Infection

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Rewiring Host Signaling: Hepatitis C Virus in Liver Pathogenesis

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Learning from a clinical cohort for HCV vaccine development

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Hepatitis B virus: is a cure possible?

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Translation and protein expression of lncRNAs: Impact for liver disease and hepatocellular carcinoma

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Mortality from liver cirrhosis and HCC in the DAA era: success in viral control is darkened by raise of metabolic disease

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Hepatitis C Virus-Induced Upregulation of MicroRNA miR-146a-5p in Hepatocytes Promotes Viral Infection and Deregulates Metabolic Pathways Associated with Liver Disease Pathogenesis

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N-Glycosylation of the Na+-Taurocholate Cotransporting Polypeptide (NTCP) Determines Its Trafficking and Stability and Is Required for Hepatitis B Virus Infection

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Humanisation of a claudin-1-specific monoclonal antibody for clinical prevention and cure of HCV infection without escape

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Multifaceted role of E-cadherin in hepatitis C virus infection and pathogenesis

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SMAD About Hepatitis C Virus Cell Entry and Liver Disease

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SCARB1 variants and HCV infection: Host susceptibility is lost in translation

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Extracellular lipid-free apolipoprotein E inhibits HCV replication and induces ABCG1-dependent cholesterol efflux

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Autotaxin-lysophosphatidic acid receptor signalling regulates hepatitis C virus replication

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The Measles Virus Receptor SLAMF1 Can Mediate Particle Endocytosis

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Tracking HCV protease population diversity during transmission and susceptibility of founder populations to antiviral therapy

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IGF2 Is Up-regulated by Epigenetic Mechanisms in Hepatocellular Carcinomas and Is an Actionable Oncogene Product in Experimental Models

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Molecular Pathogenesis and Targeted Therapies for Intrahepatic Cholangiocarcinoma

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Identification of an Immune-specific Class of Hepatocellular Carcinoma, Based on Molecular Features

Autorzy: Daniela Sia, Yang Jiao, Iris Martinez-Quetglas, Olga Kuchuk, Carlos Villacorta-Martin, Manuel Castro de Moura, Juan Putra, Genis Camprecios, Laia Bassaganyas, Nicholas Akers, Bojan Losic, Samuel Waxman, Swan N. Thung, Vincenzo Mazzaferro, Manel Esteller, Scott L. Friedman, Myron Schwartz, Augusto Villanueva, Josep M. Llovet
Opublikowane w: Gastroenterology, Numer pii: S0016-5085(17)35741-4, 2017, ISSN 0016-5085
Wydawca: W. B. Saunders Co., Ltd.
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Imaging-based surrogate markers of transcriptome subclasses and signatures in hepatocellular carcinoma: preliminary results

Autorzy: Bachir Taouli, Yujin Hoshida, Suguru Kakite, Xintong Chen, Poh Seng Tan, Xiaochen Sun, Shingo Kihira, Kensuke Kojima, Sara Toffanin, M. Isabel Fiel, Hadassa Hirschfield, Mathilde Wagner, Josep M. Llovet
Opublikowane w: European Radiology, 2017, ISSN 0938-7994
Wydawca: Springer Verlag
DOI: 10.1007/s00330-017-4844-6

Liver Cancer Cell of Origin, Molecular Class, and Effects on Patient Prognosis

Autorzy: Daniela Sia, Augusto Villanueva, Scott L. Friedman, Josep M. Llovet
Opublikowane w: Gastroenterology, Numer 152/4, 2017, Strona(/y) 745-761, ISSN 0016-5085
Wydawca: W. B. Saunders Co., Ltd.
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Tumour initiating cells and IGF/FGF signalling contribute to sorafenib resistance in hepatocellular carcinoma

Autorzy: Victoria Tovar, Helena Cornella, Agrin Moeini, Samuel Vidal, Yujin Hoshida, Daniela Sia, Judit Peix, Laia Cabellos, Clara Alsinet, Sara Torrecilla, Iris Martinez-Quetglas, Juan José Lozano, Christèle Desbois-Mouthon, Manel Solé, Josep Domingo-Domenech, Augusto Villanueva, Josep M Llovet
Opublikowane w: Gut, Numer 66/3, 2017, Strona(/y) 530-540, ISSN 0017-5749
Wydawca: BMJ Publishing Group
DOI: 10.1136/gutjnl-2015-309501

Advancing hepatitis B virus entry inhibitors

Autorzy: Eloi R. Verrier, Catherine Schuster, Thomas F. Baumert
Opublikowane w: Journal of Hepatology, Numer 66/4, 2017, Strona(/y) 677-679, ISSN 0168-8278
Wydawca: Elsevier BV
DOI: 10.1016/j.jhep.2016.11.028

Solute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of Hepatocytes

Autorzy: Eloi R. Verrier, Che C. Colpitts, Charlotte Bach, Laura Heydmann, Laetitia Zona, Fei Xiao, Christine Thumann, Emilie Crouchet, Raphaël Gaudin, Camille Sureau, François-Loïc Cosset, Jane A. McKeating, Patrick Pessaux, Yujin Hoshida, Catherine Schuster, Mirjam B. Zeisel, Thomas F. Baumert
Opublikowane w: Cell Reports, Numer 17/5, 2016, Strona(/y) 1357-1368, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2016.09.084

miR-135a-5p-mediated downregulation of protein tyrosine phosphatase receptor delta is a candidate driver of HCV-associated hepatocarcinogenesis

Autorzy: Nicolaas Van Renne, Armando Andres Roca Suarez, Francois H T Duong, Claire Gondeau, Diego Calabrese, Nelly Fontaine, Amina Ababsa, Simonetta Bandiera, Tom Croonenborghs, Nathalie Pochet, Vito De Blasi, Patrick Pessaux, Tullio Piardi, Daniele Sommacale, Atsushi Ono, Kazuaki Chayama, Masashi Fujita, Hidewaki Nakagawa, Yujin Hoshida, Mirjam B Zeisel, Markus H Heim, Thomas F Baumert, Joachim Lupberger
Opublikowane w: Gut, Numer pii: gutjnl-2016-312270, 2017, Strona(/y) gutjnl-2016-312270, ISSN 0017-5749
Wydawca: BMJ Publishing Group
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Multimodal imaging of a humanized orthotopic model of hepatocellular carcinoma in immunodeficient mice

Autorzy: Tao Wu, Emilie Heuillard, Véronique Lindner, Ghina Bou About, Mihaela Ignat, Jean-Philippe Dillenseger, Nicolas Anton, Eugénie Dalimier, Francine Gossé, Gael Fouré, Franck Blindauer, Céline Giraudeau, Hussein El-Saghire, Mourad Bouhadjar, Cynthia Calligaro, Tania Sorg, Philippe Choquet, Thierry Vandamme, Christophe Ferrand, Jacques Marescaux, Thomas F. Baumert, Michele Diana, Patrick Pessaux,
Opublikowane w: Scientific Reports, Numer 6/1, 2016, Strona(/y) 35230, ISSN 2045-2322
Wydawca: Nature Publishing Group
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Hepatitis Delta Virus histone mimicry drives the recruitment of chromatin remodelers for viral RNA replication

Autorzy: Natali Abeywickrama-Samarakoon, Jean-Claude Cortay, Camille Sureau, Susanne Müller, Dulce Alfaiate, Francesca Guerrieri, Apirat Chaikuad, Martin Schröder, Philippe Merle, Massimo Levrero, Paul Dény
Opublikowane w: Nature Communications, Numer 11/1, 2020, ISSN 2041-1723
Wydawca: Nature Publishing Group
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Hepatitis B protein HBx binds the DLEU2 lncRNA to sustain cccDNA and host cancer-related gene transcription

Autorzy: Debora Salerno, Letizia Chiodo, Vincenzo Alfano, Oceane Floriot, Grazia Cottone, Alexia Paturel, Matteo Pallocca, Marie-Laure Plissonnier, Safaa Jeddari, Laura Belloni, Mirjam Zeisel, Massimo Levrero, Francesca Guerrieri
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Wydawca: BMJ Publishing Group
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Perspectives and limitations for nucleo(t)side analogs in future HBV therapies

Autorzy: Massimo Levrero, Miroslava Subic, Francois Villeret, Fabien Zoulim
Opublikowane w: Current Opinion in Virology, Numer 30, 2018, Strona(/y) 80-89, ISSN 1879-6257
Wydawca: Elsevier BV
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Mechanisms of HBV-induced hepatocellular carcinoma

Autorzy: Massimo Levrero, Jessica Zucman-Rossi
Opublikowane w: Journal of Hepatology, Numer 64/1, 2016, Strona(/y) S84-S101, ISSN 0168-8278
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The histone deacetylase inhibiting drug Entinostat induces lipid accumulation in differentiated HepaRG cells

Autorzy: Abigail D. G. Nunn, Tullio Scopigno, Natalia Pediconi, Massimo Levrero, Henning Hagman, Juris Kiskis, Annika Enejder
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Non-Coding RNAs and Hepatitis C Virus-Induced Hepatocellular Carcinoma

Autorzy: Marie-Laure Plissonnier, Katharina Herzog, Massimo Levrero, Mirjam Zeisel
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Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
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Challenges to a Cure for HBV Infection

Autorzy: Barbara Testoni, Massimo Levrero, Fabien Zoulim
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miR-122-regulated metabolic circuits: micro-management of lipid metabolism in the human liver

Autorzy: Mirjam B. Zeisel, Marie-Laure Plissonnier, Massimo Levrero
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NOTCH target gene HES5 mediates oncogenic and tumor suppressive functions in hepatocarcinogenesis.

Autorzy: Luiken S, Fraas A, Bieg M, Sugiyanto R, Goeppert B, Singer S, Ploeger C, Warsow G, Marquardt JU, Sticht C, De La Torre C, Pusch S, Mehrabi A, Gretz N, Schlesner M, Eils R, Schirmacher P, Longerich T, Roessler S.
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