Mechanisms underlying hepatocellular carcinoma pathogenesis and impact of co-morbidities.

Resultado final

Final dissemination and exploitation plan

A final dissemination and exploitation plan for using of dissemination knowledge and optimized exploitation of the results will be prepared at the end of the action.

Website development and management

The HEP-CAR website will be accessible on the internet at month 6 and it will be revised and improved during the whole course of the action. Part of the website will password-protected and dedicated to internal communication.

Publicaciones

Status of Direct-Acting Antiviral Therapy for Hepatitis C Virus Infection and Remaining Challenges

Autores: Thomas F. Baumert, Thomas Berg, Joseph K. Lim, David R. Nelson
Publicado en: Gastroenterology, Edición 156, 2018, Página(s) 431-445, ISSN 0016-5085
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2018.10.024

Claudins in viral infection: from entry to spread

Autores: Che C. Colpitts, Thomas F. Baumert
Publicado en: Pflügers Archiv - European Journal of Physiology, Edición 469/1, 2017, Página(s) 27-34, ISSN 0031-6768
Editor: Springer Verlag
DOI: 10.1007/s00424-016-1908-4

Entry Inhibitors: A Perspective for Prevention of Hepatitis C Virus Infection in Organ Transplantation

Autores: Che C. Colpitts, Raymond T. Chung, Thomas F. Baumert
Publicado en: ACS Infectious Diseases, Edición 3/9, 2017, Página(s) 620-623, ISSN 2373-8227
Editor: ACS Publications
DOI: 10.1021/acsinfecdis.7b00091

Host-targeting therapies for hepatitis C virus infection: current developments and future applications

Autores: Emilie Crouchet, Florian Wrensch, Catherine Schuster, Mirjam B. Zeisel, Thomas F. Baumert
Publicado en: Therapeutic Advances in Gastroenterology, Edición 11, 2018, Página(s) 175628481875948, ISSN 1756-2848
Editor: SAGE Publications
DOI: 10.1177/1756284818759483

The functional role of sodium taurocholate cotransporting polypeptide NTCP in the life cycle of hepatitis B, C and D viruses

Autores: Carla Eller, Laura Heydmann, Che C. Colpitts, Eloi R. Verrier, Catherine Schuster, Thomas F. Baumert
Publicado en: Cellular and Molecular Life Sciences, Edición 75/21, 2018, Página(s) 3895-3905, ISSN 1420-682X
Editor: Birkhauser Verlag
DOI: 10.1007/s00018-018-2892-y

A novel neutralizing human monoclonal antibody broadly abrogates hepatitis C virus infection in vitro and in vivo

Autores: Isabelle Desombere, Ahmed Atef Mesalam, Richard A. Urbanowicz, Freya Van Houtte, Lieven Verhoye, Zhen-Yong Keck, Ali Farhoudi, Koen Vercauteren, Karin E. Weening, Thomas F. Baumert, Arvind H. Patel, Steven K.H. Foung, Jonathan Ball, Geert Leroux-Roels, Philip Meuleman
Publicado en: Antiviral Research, Edición 148, 2017, Página(s) 53-64, ISSN 0166-3542
Editor: Elsevier BV
DOI: 10.1016/j.antiviral.2017.10.015

Nuclear Translocation of RELB is Increased in Diseased Human Liver and Promotes Ductular Reaction and Biliary Fibrosis in Mice

Autores: Christin Elßner, Benjamin Goeppert, Thomas Longerich, Anna-Lena Scherr, Jan Stindt, Lahiri Kanth Nanduri, Christian Rupp, Jakob Nikolas Kather, Nathalie Schmitt, Nicole Kautz, Kai Breuhahn, Lars Ismail, Danijela Heide, Jenny Hetzer, María García-Beccaria, Nadine Hövelmeyer, Ari Waisman, Toni Urbanik, Sebastian Mueller, Georg Gdynia, Jesus M. Banales, Stephanie Roessler, Peter Schirmacher, Dirk
Publicado en: Gastroenterology, Edición 156(4), 2018, Página(s) 1190-1205.e14, ISSN 0016-5085
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2018.11.018

EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma

Autores: Peter R. Galle, Alejandro Forner, Josep M. Llovet, Vincenzo Mazzaferro, Fabio Piscaglia, Jean-Luc Raoul, Peter Schirmacher, Valérie Vilgrain
Publicado en: Journal of Hepatology, Edición 69/1, 2018, Página(s) 182-236, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2018.03.019

Integrative analysis defines distinct prognostic subgroups of intrahepatic cholangiocarcinoma

Autores: Benjamin Goeppert, Reka Toth, Stephan Singer, Thomas Albrecht, Daniel B. Lipka, Pavlo Lutsik, David Brocks, Marion Baehr, Oliver Muecke, Yassen Assenov, Lei Gu, Volker Endris, Albrecht Stenzinger, Arianeb Mehrabi, Peter Schirmacher, Christoph Plass, Dieter Weichenhan, Stephanie Roessler
Publicado en: Hepatology, 2019, ISSN 0270-9139
Editor: John Wiley & Sons Inc.
DOI: 10.1002/hep.30493

Signalome-wide assessment of host cell response to hepatitis C virus

Autores: Gholamreza Haqshenas, Jianmin Wu, Kaylene J. Simpson, Roger J. Daly, Hans J. Netter, Thomas F. Baumert, Christian Doerig
Publicado en: Nature Communications, Edición 8, 2017, Página(s) 15158, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/ncomms15158

Hepatitis B Virus Activates Signal Transducer and Activator of Transcription 3 Supporting Hepatocyte Survival and Virus Replication

Autores: Marianna Hösel, Maria Quasdorff, Marc Ringelhan, Hamid Kashkar, Svenja Debey-Pascher, Martin F. Sprinzl, Jan-Hendrik Bockmann, Silke Arzberger, Dennis Webb, Gesa von Olshausen, Achim Weber, Joachim L. Schultze, Hildegard Büning, Mathias Heikenwalder, Ulrike Protzer
Publicado en: Cellular and Molecular Gastroenterology and Hepatology, Edición 4/3, 2017, Página(s) 339-363, ISSN 2352-345X
Editor: Elsevier Inc.
DOI: 10.1016/j.jcmgh.2017.07.003

Mapping Determinants of Virus Neutralization and Viral Escape for Rational Design of a Hepatitis C Virus Vaccine

Autores: Mei-Le Keck, Florian Wrensch, Brian G. Pierce, Thomas F. Baumert, Steven K. H. Foung
Publicado en: Frontiers in Immunology, Edición 9, 2018, ISSN 1664-3224
Editor: Frontiers Media SA
DOI: 10.3389/fimmu.2018.01194

Hepatitis B virus genome recycling and de novo secondary infection events maintain stable cccDNA levels

Autores: Chunkyu Ko, Anindita Chakraborty, Wen-Min Chou, Julia Hasreiter, Jochen M. Wettengel, Daniela Stadler, Romina Bester, Theresa Asen, Ke Zhang, Karin Wisskirchen, Jane A. McKeating, Wang-Shick Ryu, Ulrike Protzer
Publicado en: Journal of Hepatology, Edición 69/6, 2018, Página(s) 1231-1241, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2018.08.012

IFN-α-mediated Base Excision Repair Pathway Correlates with Antiviral Response Against Hepatitis B Virus Infection

Autores: Yong Li, Yuchen Xia, Meifang Han, Guang Chen, Dake Zhang, Wolfgang E. Thasler, Ulrike Protzer, Qin Ning
Publicado en: Scientific Reports, Edición 7/1, 2017, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-017-13082-z

Hepatitis B Virus Core Variants, Liver Fibrosis, and Hepatocellular Carcinoma

Autores: Gaetan Ligat, Catherine Schuster, Thomas F. Baumert
Publicado en: Hepatology, Edición 69/1, 2019, Página(s) 5-8, ISSN 0270-9139
Editor: John Wiley & Sons Inc.
DOI: 10.1002/hep.30231

A pilot study of ultra-deep targeted sequencing of plasma DNA identifies driver mutations in hepatocellular carcinoma

Autores: Ismail Labgaa, Carlos Villacorta-Martin, Delia D’Avola, Amanda J. Craig, Johann von Felden, Sebastiao N. Martins-Filho, Daniela Sia, Ashley Stueck, Stephen C. Ward, M. Isabel Fiel, Milind Mahajan, Parissa Tabrizian, Swan N. Thung, Celina Ang, Scott L. Friedman, Josep M. Llovet, Myron Schwartz, Augusto Villanueva
Publicado en: Oncogene, Edición 37/27, 2018, Página(s) 3740-3752, ISSN 0950-9232
Editor: Nature Publishing Group
DOI: 10.1038/s41388-018-0206-3

Molecular therapies and precision medicine for hepatocellular carcinoma

Autores: Josep M. Llovet, Robert Montal, Daniela Sia, Richard S. Finn
Publicado en: Nature Reviews Clinical Oncology, Edición 15/10, 2018, Página(s) 599-616, ISSN 1759-4774
Editor: Nature Publishing Group
DOI: 10.1038/s41571-018-0073-4

Pilot study of living donor liver transplantation for patients with hepatocellular carcinoma exceeding Milan Criteria (Barcelona Clinic Liver Cancer extended criteria)

Autores: Josep M. Llovet, Mihai Pavel, Jordi Rimola, Maria Alba Diaz, Jordi Colmenero, David Saavedra-Perez, Constantino Fondevila, Carmen Ayuso, Josep Fuster, Pere Ginès, Jordi Bruix, Juan Carlos Garcia-Valdecasas
Publicado en: Liver Transplantation, Edición 24/3, 2018, Página(s) 369-379, ISSN 1527-6465
Editor: John Wiley & Sons Inc.
DOI: 10.1002/lt.24977

Viral hepatitis: The bumpy road to animal models for HBV infection

Autores: Ulrike Protzer
Publicado en: Nature Reviews Gastroenterology & Hepatology, Edición 14/6, 2017, Página(s) 327-328, ISSN 1759-5045
Editor: Nature Publishing Group
DOI: 10.1038/nrgastro.2017.44

Beyond viral dependence: The pathological consequences of HCV-induced EGF signaling

Autores: Armando Andres Roca Suarez, Thomas F. Baumert, Joachim Lupberger
Publicado en: Journal of Hepatology, Edición 69/3, 2018, Página(s) 564-566, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2018.05.033

Viral manipulation of STAT3: Evade, exploit, and injure

Autores: Armando Andres Roca Suarez, Nicolaas Van Renne, Thomas F. Baumert, Joachim Lupberger
Publicado en: PLOS Pathogens, Edición 14/3, 2018, Página(s) e1006839, ISSN 1553-7374
Editor: -
DOI: 10.1371/journal.ppat.1006839

Liver cancer: Translating '–omics' results into precision medicine for hepatocellular carcinoma

Autores: Daniela Sia, Josep M. Llovet
Publicado en: Nature Reviews Gastroenterology & Hepatology, 2017, ISSN 1759-5045
Editor: Nature Publishing Group
DOI: 10.1038/nrgastro.2017.103

Trunk mutational events present minimal intra- and inter-tumoral heterogeneity in hepatocellular carcinoma

Autores: Sara Torrecilla, Daniela Sia, Andrew N. Harrington, Zhongyang Zhang, Laia Cabellos, Helena Cornella, Agrin Moeini, Genis Camprecios, Wei-Qiang Leow, Maria Isabel Fiel, Ke Hao, Laia Bassaganyas, Milind Mahajan, Swan N. Thung, Augusto Villanueva, Sander Florman, Myron E. Schwartz, Josep M. Llovet
Publicado en: Journal of Hepatology, Edición 67/6, 2017, Página(s) 1222-1231, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2017.08.013

Hepatitis B Virus Evasion From Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase Sensing in Human Hepatocytes

Autores: Eloi R. Verrier, Seung-Ae Yim, Laura Heydmann, Houssein El Saghire, Charlotte Bach, Vincent Turon-Lagot, Laurent Mailly, Sarah C. Durand, Julie Lucifora, David Durantel, Patrick Pessaux, Nicolas Manel, Ivan Hirsch, Mirjam B. Zeisel, Nathalie Pochet, Catherine Schuster, Thomas F. Baumert
Publicado en: Hepatology, Edición 68/5, 2018, Página(s) 1695-1709, ISSN 0270-9139
Editor: John Wiley & Sons Inc.
DOI: 10.1002/hep.30054

Hepatocellular carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†

Autores: A Vogel, A Cervantes, I Chau, B Daniele, J Llovet, T Meyer, J -C Nault, U Neumann, J Ricke, B Sangro, P Schirmacher, C Verslype, C J Zech, D Arnold, E Martinelli
Publicado en: Annals of Oncology, Edición 29/Supplement_4, 2018, Página(s) iv238-iv255, ISSN 0923-7534
Editor: Oxford University Press
DOI: 10.1093/annonc/mdy308

"Hepatitis B virus promotes β-catenin-signalling and disassembly of adherens junctions in a Src kinase dependent fashion"

Autores: Gesa von Olshausen, Maria Quasdorff, Romina Bester, Silke Arzberger, Chunkyu Ko, Maarten van de Klundert, Ke Zhang, Margarete Odenthal, Marc Ringelhan, Carien M. Niessen, Ulrike Protzer
Publicado en: Oncotarget, Edición 9/74, 2018, ISSN 1949-2553
Editor: Impact Journals
DOI: 10.18632/oncotarget.26103

Cytoplasmic localization of the cell polarity factor scribble supports liver tumor formation and tumor cell invasiveness

Autores: Shan Wan, Anne-Sophie Meyer, Sofia Maria Elisabeth Weiler, Christian Rupp, Marcell Tóth, Carsten Sticht, Stephan Singer, Stefan Thomann, Stephanie Roessler, Marina Schorpp-Kistner, Jennifer Schmitt, Norbert Gretz, Peter Angel, Darjus Felix Tschaharganeh, Jens Marquardt, Peter Schirmacher, Federico Pinna, Kai Breuhahn
Publicado en: Hepatology, Edición 67/5, 2018, Página(s) 1842-1856, ISSN 0270-9139
Editor: John Wiley & Sons Inc.
DOI: 10.1002/hep.29669

Early Transcriptional Divergence Marks Virus-Specific Primary Human CD8+ T Cells in Chronic versus Acute Infection

Autores: David Wolski, Peter K. Foote, Diana Y. Chen, Lia L. Lewis-Ximenez, Catherine Fauvelle, Jasneet Aneja, Andreas Walker, Pierre Tonnerre, Almudena Torres-Cornejo, Daniel Kvistad, Sabrina Imam, Michael T. Waring, Damien C. Tully, Todd M. Allen, Raymond T. Chung, Jörg Timm, W. Nicholas Haining, Arthur Y. Kim, Thomas F. Baumert, Georg M. Lauer
Publicado en: Immunity, Edición 47/4, 2017, Página(s) 648-663.e8, ISSN 1074-7613
Editor: Cell Press
DOI: 10.1016/j.immuni.2017.09.006

Hepatitis C Virus (HCV)–Apolipoprotein Interactions and Immune Evasion and Their Impact on HCV Vaccine Design

Autores: Florian Wrensch, Emilie Crouchet, Gaetan Ligat, Mirjam B. Zeisel, Zhen-Yong Keck, Steven K. H. Foung, Catherine Schuster, Thomas F. Baumert
Publicado en: Frontiers in Immunology, Edición 9, 2018, ISSN 1664-3224
Editor: Frontiers Media SA
DOI: 10.3389/fimmu.2018.01436

Secreted Interferon-Inducible Factors Restrict Hepatitis B and C Virus Entry In Vitro

Autores: Yuchen Xia, Xiaoming Cheng, Christoph K. Blossey, Karin Wisskirchen, Knud Esser, Ulrike Protzer
Publicado en: Journal of Immunology Research, Edición 2017, 2017, Página(s) 1-12, ISSN 2314-8861
Editor: Hindawi Publishing Corporation
DOI: 10.1155/2017/4828936

Control of Hepatitis B Virus by Cytokines

Autores: Yuchen Xia, Ulrike Protzer
Publicado en: Viruses, Edición 9/1, 2017, Página(s) 18, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v9010018

Tight junction proteins in gastrointestinal and liver disease

Autores: Mirjam B Zeisel, Punita Dhawan, Thomas F Baumert
Publicado en: Gut, 2018, Página(s) gutjnl-2018-316906, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2018-316906

Protein kinase D at the Golgi controls NLRP3 inflammasome activation

Autores: Zhirong Zhang, Gergö Meszaros, Wan-ting He, Yanfang Xu, Helena de Fatima Magliarelli, Laurent Mailly, Michael Mihlan, Yansheng Liu, Marta Puig Gámez, Alexander Goginashvili, Adrien Pasquier, Olga Bielska, Bénédicte Neven, Pierre Quartier, Rudolf Aebersold, Thomas F. Baumert, Philippe Georgel, Jiahuai Han, Romeo Ricci
Publicado en: The Journal of Experimental Medicine, Edición 214/9, 2017, Página(s) 2671-2693, ISSN 0022-1007
Editor: Rockefeller University Press
DOI: 10.1084/jem.20162040

Interplay between circadian clock and viral infection

Autores: Xiaodong Zhuang, Srinivasa Bhargav Rambhatla, Alvina G. Lai, Jane A. McKeating
Publicado en: Journal of Molecular Medicine, Edición 95/12, 2017, Página(s) 1283-1289, ISSN 0946-2716
Editor: Springer Verlag
DOI: 10.1007/s00109-017-1592-7

The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication

Autores: Xiaodong Zhuang, Andrea Magri, Michelle Hill, Alvina G. Lai, Abhinav Kumar, Srinivasa Bhargav Rambhatla, Claire L. Donald, Andrea F. Lopez-Clavijo, Simon Rudge, Katherine Pinnick, Wai Hoong Chang, Peter A. C. Wing, Ryan Brown, Ximing Qin, Peter Simmonds, Thomas F. Baumert, David Ray, Andrew Loudon, Peter Balfe, Michael Wakelam, Sam Butterworth, Alain Kohl, Catherine L. Jopling, Nicole Zitzmann, Ja
Publicado en: Nature Communications, Edición 10/1, 2019, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-019-08299-7

Daytime variation in hepatitis C virus replication kinetics following liver transplant

Autores: Xiaodong Zhuang, Alvina G. Lai, Jane A. McKeating, Ian Rowe, Peter Balfe
Publicado en: Wellcome Open Research, Edición 3, 2018, Página(s) 96, ISSN 2398-502X
Editor: -
DOI: 10.12688/wellcomeopenres.14696.2

Glucose and glutamine availability regulate HepG2 transcriptional responses to low oxygen

Autores: Alvina G. Lai, Donall Forde, Wai Hoong Chang, Fang Yuan, Xiaodong Zhuang, Claudia Orbegozo Rubio, Chun-Xiao Song, Jane A. McKeating
Publicado en: Wellcome Open Research, Edición 3, 2018, Página(s) 126, ISSN 2398-502X
Editor: -
DOI: 10.12688/wellcomeopenres.14839.1

Hepatitis C virus infection is associated with hepatic and adipose tissue insulin resistance that improves after viral cure

Autores: Teegan R. Lim, Jonathan M. Hazlehurst, Andrei I. Oprescu, Matthew J. Armstrong, Sewa F. Abdullah, Nigel P. Davies, Robert Flintham, Peter Balfe, David J. Mutimer, Jane A. McKeating, Jeremy W. Tomlinson
Publicado en: Clinical Endocrinology, 2018, Página(s) [Epub ahead of print], ISSN 0300-0664
Editor: Blackwell Publishing Inc.
DOI: 10.1111/cen.13924

Metallo supramolecular cylinders inhibit HIV-1 TAR-TAT complex formation and viral replication in cellulo

Autores: Lucia Cardo, Isabel Nawroth, Peter J. Cail, Jane A. McKeating, Michael J. Hannon
Publicado en: Scientific Reports, Edición 8/1, 2018, Página(s) 13342, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-018-31513-3

A new panel of epitope mapped monoclonal antibodies recognising the prototypical tetraspanin CD81

Autores: Joe Grove, Ke Hu, Michelle J. Farquhar, Margaret Goodall, Lucas Walker, Mohammed Jamshad, Heidi E. Drummer, Roslyn M. Bill, Peter Balfe, Jane A. McKeating
Publicado en: Wellcome Open Research, Edición 2, 2017, Página(s) 82, ISSN 2398-502X
Editor: -
DOI: 10.12688/wellcomeopenres.12058.1

Insights From Deep Sequencing of the HBV Genome—Unique, Tiny, and Misunderstood

Autores: Anna L. McNaughton, Valentina D’Arienzo, M. Azim Ansari, Sheila F. Lumley, Margaret Littlejohn, Peter Revill, Jane A. McKeating, Philippa C. Matthews
Publicado en: Gastroenterology, Edición 156/2, 2019, Página(s) 384-399, ISSN 0016-5085
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2018.07.058

The immunology of hepatocellular carcinoma

Autores: Marc Ringelhan, Dominik Pfister, Tracy O’Connor, Eli Pikarsky, Mathias Heikenwalder
Publicado en: Nature Immunology, Edición 19/3, 2018, Página(s) 222-232, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/s41590-018-0044-z

Single cell polarity in liquid phase facilitates tumour metastasis

Autores: Anna Lorentzen, Paul F. Becker, Jan Kosla, Massimo Saini, Kathrin Weidele, Paolo Ronchi, Corinna Klein, Monika J. Wolf, Felix Geist, Bastian Seubert, Marc Ringelhan, Daniela Mihic-Probst, Knud Esser, Marko Roblek, Felix Kuehne, Gaia Bianco, Tracy O’Connor, Quentin Müller, Kathleen Schuck, Sebastian Lange, Daniel Hartmann, Saskia Spaich, Olaf Groß, Jochen Utikal, Sebastian Haferkamp, Martin R.
Publicado en: Nature Communications, Edición 9/1, 2018, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-018-03139-6

PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells

Autores: Athena Georgilis, Sabrina Klotz, Christopher J. Hanley, Nicolas Herranz, Benedikt Weirich, Beatriz Morancho, Ana Carolina Leote, Luana D'Artista, Suchira Gallage, Marco Seehawer, Thomas Carroll, Gopuraja Dharmalingam, Keng Boon Wee, Marco Mellone, Joaquim Pombo, Danijela Heide, Ernesto Guccione, Joaquín Arribas, Nuno L. Barbosa-Morais, Mathias Heikenwalder, Gareth J. Thomas, Lars Zender, Jesús G
Publicado en: Cancer Cell, Edición 34/1, 2018, Página(s) 85-102.e9, ISSN 1535-6108
Editor: Cell Press
DOI: 10.1016/j.ccell.2018.06.007

A human liver cell atlas reveals heterogeneity and epithelial progenitors

Autores: Nadim Aizarani, Antonio Saviano, Sagar, Laurent Mailly, Sarah Durand, Josip S. Herman, Patrick Pessaux, Thomas F. Baumert, Dominic Grün
Publicado en: Nature, Edición 572/7768, 2019, Página(s) 199-204, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-019-1373-2

Addressing the Challenges of Hepatitis C Cure and Persistent Risk of Hepatocellular Carcinoma

Autores: Thomas F. Baumert, Yujin Hoshida
Publicado en: Viruses, Edición 11/5, 2019, Página(s) 441, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v11050441

Chronic hepatitis C virus infection and pathogenesis of hepatocellular carcinoma

Autores: Simonetta Bandiera, C Billie Bian, Yujin Hoshida, Thomas F Baumert, Mirjam B Zeisel
Publicado en: Current Opinion in Virology, Edición 20, 2016, Página(s) 99-105, ISSN 1879-6257
Editor: Elsevier BV
DOI: 10.1016/j.coviro.2016.09.010

Ultrasound‐Guided Approaches to Improve Orthotopic Mouse Xenograft Models for Hepatocellular Carcinoma

Autores: Ghina Bou About, Emilie Thiebault, Marie Wattenhofer‐Donzé, Hugues Jacobs, Alain Guimond, Tania Sorg, Eric Robinet, Thomas F. Baumert, Laurent Monassier, Yann Herault
Publicado en: Current Protocols in Mouse Biology, Edición 9/2, 2019, ISSN 2161-2617
Editor: -
DOI: 10.1002/cpmo.62

Hepatitis C virus cell entry: a target for novel antiviral strategies to address limitations of direct acting antivirals

Autores: Che C. Colpitts, Thomas F. Baumert
Publicado en: Hepatology International, Edición 10/5, 2016, Página(s) 741-748, ISSN 1936-0533
Editor: Springer Pub. Co.
DOI: 10.1007/s12072-016-9724-7

A PCR assay to quantify patterns of HBV transcription

Autores: Valentina D’Arienzo, Andrea Magri, James M. Harris, Peter A. C. Wing, Chunkyu Ko, Claudia Orbegozo Rubio, Peter A. Revill, Ulrike Protzer, Peter Balfe, Jane A. McKeating
Publicado en: Journal of General Virology, 2019, ISSN 0022-1317
Editor: Society for General Microbiology
DOI: 10.1099/jgv.0.001373

Hepatitis C virus vaccine candidates inducing protective neutralizing antibodies

Autores: Catherine Fauvelle, Che C. Colpitts, Zhen-yong Keck, Brian G. Pierce, Steven K. H. Foung, Thomas F. Baumert
Publicado en: Expert Review of Vaccines, Edición 15/12, 2016, Página(s) 1535-1544, ISSN 1476-0584
Editor: Future Drugs Ltd.
DOI: 10.1080/14760584.2016.1194759

Zooming in on liver zonation

Autores: Daniel J. Felmlee, Dominic Grün, Thomas F. Baumert
Publicado en: Hepatology, Edición 67/2, 2017, Página(s) 784-787, ISSN 0270-9139
Editor: John Wiley & Sons Inc.
DOI: 10.1002/hep.29554

Editorial: Current Progress and Challenges in the Development of a B Cell Based Hepatitis C Virus Vaccine

Autores: Steven K. H. Foung, Thomas F. Baumert
Publicado en: Frontiers in Immunology, Edición 9, 2018, ISSN 1664-3224
Editor: -
DOI: 10.3389/fimmu.2018.02577

Targeting Innate and Adaptive Immune Responses to Cure Chronic HBV Infection

Autores: Adam J. Gehring, Ulrike Protzer
Publicado en: Gastroenterology, Edición 156/2, 2019, Página(s) 325-337, ISSN 0016-5085
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2018.10.032

Genomic characterization of cholangiocarcinoma in primary sclerosing cholangitis reveals novel therapeutic opportunities

Autores: Benjamin Goeppert, Trine Folseraas, Stephanie Roessler, Matthias Kloor, Anna‐Lena Volckmar, Volker Endris, Ivo Buchhalter, Albrecht Stenzinger, Krzysztof Grzyb, Marit M. Grimsrud, Barbara Gornicka, Erik von Seth, Gary M. Reynolds, Andre Franke, Daniel N. Gotthardt, Arianeb Mehrabi, Angela Cheung, Joanne Verheij, Johanna Arola, Heikki Mäkisalo, Tor J. Eide, Sören Weidemann, John C. Cheville, Gi
Publicado en: Hepatology, 2020, ISSN 0270-9139
Editor: John Wiley & Sons Inc.
DOI: 10.1002/hep.31110

HCV-Induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response

Autores: Nourdine Hamdane, Frank Jühling, Emilie Crouchet, Houssein El Saghire, Christine Thumann, Marine A. Oudot, Simonetta Bandiera, Antonio Saviano, Clara Ponsolles, Armando Andres Roca Suarez, Shen Li, Naoto Fujiwara, Atsushi Ono, Irwin Davidson, Nabeel Bardeesy, Christian Schmidl, Christoph Bock, Catherine Schuster, Joachim Lupberger, François Habersetzer, Michel Doffoël, Tullio Piardi, Daniele So
Publicado en: Gastroenterology, Edición 156/8, 2019, Página(s) 2313-2329.e7, ISSN 0016-5085
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2019.02.038

A New Role for Capsid Assembly Modulators To Target Mature Hepatitis B Virus Capsids and Prevent Virus Infection

Autores: Chunkyu Ko, Romina Bester, Xue Zhou, Zhiheng Xu, Christoph Blossey, Julia Sacherl, Florian W. R. Vondran, Lu Gao, Ulrike Protzer
Publicado en: Antimicrobial Agents and Chemotherapy, Edición 64/1, 2019, ISSN 0066-4804
Editor: American Society for Microbiology
DOI: 10.1128/aac.01440-19

Functional microRNA screen uncovers O-linked N-acetylglucosamine transferase as a host factor modulating hepatitis C virus morphogenesis and infectivity

Autores: Katharina Herzog, Simonetta Bandiera, Sophie Pernot, Catherine Fauvelle, Frank Jühling, Amélie Weiss, Anne Bull, Sarah C Durand, Béatrice Chane-Woon-Ming, Sébastien Pfeffer, Marion Mercey, Hervé Lerat, Jean-Christophe Meunier, Wolfgang Raffelsberger, Laurent Brino, Thomas F Baumert, Mirjam B Zeisel
Publicado en: Gut, Edición 69/2, 2020, Página(s) 380-392, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2018-317423

Revisiting Hepatitis B Virus: Challenges of Curative Therapies

Autores: Jianming Hu, Ulrike Protzer, Aleem Siddiqui
Publicado en: Journal of Virology, Edición 93/20, 2019, ISSN 0022-538X
Editor: American Society for Microbiology
DOI: 10.1128/jvi.01032-19

An E. coli-produced single-chain variable fragment (scFv) targeting hepatitis B virus surface protein potently inhibited virion secretion

Autores: Cheng Li, Yang Wang, Tiantian Liu, Matthias Niklasch, Ke Qiao, Sarah Durand, Li Chen, Mifang Liang, Thomas F. Baumert, Shuping Tong, Michael Nassal, Yu-Mei Wen, Yong-Xiang Wang
Publicado en: Antiviral Research, Edición 162, 2019, Página(s) 118-129, ISSN 0166-3542
Editor: Elsevier BV
DOI: 10.1016/j.antiviral.2018.12.019

Randomized trials and endpoints in advanced HCC: Role of PFS as a surrogate of survival

Autores: Josep M. Llovet, Robert Montal, Augusto Villanueva
Publicado en: Journal of Hepatology, Edición 70/6, 2019, Página(s) 1262-1277, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2019.01.028

Combined Analysis of Metabolomes, Proteomes, and Transcriptomes of Hepatitis C Virus–Infected Cells and Liver to Identify Pathways Associated With Disease Development

Autores: Joachim Lupberger, Tom Croonenborghs, Armando Andres Roca Suarez, Nicolaas Van Renne, Frank Jühling, Marine A. Oudot, Alessia Virzì, Simonetta Bandiera, Carole Jamey, Gergö Meszaros, Daniel Brumaru, Atish Mukherji, Sarah C. Durand, Laura Heydmann, Eloi R. Verrier, Hussein El Saghire, Nourdine Hamdane, Ralf Bartenschlager, Shaunt Fereshetian, Evelyn Ramberger, Rileen Sinha, Mohsen Nabian, Celine
Publicado en: Gastroenterology, Edición 157/2, 2019, Página(s) 537-551.e9, ISSN 0016-5085
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2019.04.003

Toward novel immunocompetent animal models for hepatitis B virus infection

Autores: Laurent Mailly, Mirjam B. Zeisel, Thomas F. Baumert
Publicado en: Hepatology, Edición 66/3, 2017, Página(s) 691-693, ISSN 0270-9139
Editor: John Wiley & Sons Inc.
DOI: 10.1002/hep.29249

In vivo combination of human anti-envelope glycoprotein E2 and -Claudin-1 monoclonal antibodies for prevention of hepatitis C virus infection

Autores: Laurent Mailly, Florian Wrensch, Laura Heydmann, Catherine Fauvelle, Nicolas Brignon, Mirjam B. Zeisel, Patrick Pessaux, Zhen-yong Keck, Catherine Schuster, Thomas R. Fuerst, Steven K.H. Foung, Thomas F. Baumert
Publicado en: Antiviral Research, Edición 162, 2019, Página(s) 136-141, ISSN 0166-3542
Editor: Elsevier BV
DOI: 10.1016/j.antiviral.2018.12.018

The Innate Antiviral Response in Animals: An Evolutionary Perspective from Flagellates to Humans

Autores: Karim Majzoub, Florian Wrensch, Thomas F. Baumert
Publicado en: Viruses, Edición 11/8, 2019, Página(s) 758, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v11080758

An Immune Gene Expression Signature Associated With Development of Human Hepatocellular Carcinoma Identifies Mice That Respond to Chemopreventive Agents

Autores: Agrin Moeini, Sara Torrecilla, Victoria Tovar, Carla Montironi, Carmen Andreu-Oller, Judit Peix, Mónica Higuera, Dominik Pfister, Pierluigi Ramadori, Roser Pinyol, Manel Solé, Mathias Heikenwälder, Scott L. Friedman, Daniela Sia, Josep M. Llovet
Publicado en: Gastroenterology, Edición 157/5, 2019, Página(s) 1383-1397.e11, ISSN 0016-5085
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2019.07.028

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer

Autores: Mohsen Malehmir, Dominik Pfister, Suchira Gallage, Marta Szydlowska, Donato Inverso, Elena Kotsiliti, Valentina Leone, Moritz Peiseler, Bas G. J. Surewaard, Dominik Rath, Adnan Ali, Monika Julia Wolf, Hannah Drescher, Marc E. Healy, Daniel Dauch, Daniela Kroy, Oliver Krenkel, Marlene Kohlhepp, Thomas Engleitner, Alexander Olkus, Tjeerd Sijmonsma, Julia Volz, Carsten Deppermann, David Stegner, Patr
Publicado en: Nature Medicine, Edición 25/4, 2019, Página(s) 641-655, ISSN 1078-8956
Editor: Nature Publishing Group
DOI: 10.1038/s41591-019-0379-5

The circadian clock and liver function in health and disease

Autores: Atish Mukherji, Shannon M. Bailey, Bart Staels, Thomas F. Baumert
Publicado en: Journal of Hepatology, Edición 71/1, 2019, Página(s) 200-211, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2019.03.020

Molecular predictors of prevention of recurrence in HCC with sorafenib as adjuvant treatment and prognostic factors in the phase 3 STORM trial

Autores: Roser Pinyol, Robert Montal, Laia Bassaganyas, Daniela Sia, Tadatoshi Takayama, Gar-Yang Chau, Vincenzo Mazzaferro, Sasan Roayaie, Han Chu Lee, Norihiro Kokudo, Zhongyang Zhang, Sara Torrecilla, Agrin Moeini, Leonardo Rodriguez-Carunchio, Edward Gane, Chris Verslype, Adina Emilia Croitoru, Umberto Cillo, Manuel de la Mata, Luigi Lupo, Simone Strasser, Joong-Won Park, Jordi Camps, Manel Solé, Swan
Publicado en: Gut, Edición 68/6, 2019, Página(s) 1065-1075, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2018-316408

Immune Exclusion-Wnt/CTNNB1 Class Predicts Resistance to Immunotherapies in HCC

Autores: Roser Pinyol, Daniela Sia, Josep M. Llovet
Publicado en: Clinical Cancer Research, Edición 25/7, 2019, Página(s) 2021-2023, ISSN 1078-0432
Editor: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-18-3778

Uncovering the mechanism of action of aspirin in HCC chemoprevention

Autores: Natascha Roehlen, Thomas F. Baumert
Publicado en: EBioMedicine, Edición 46, 2019, Página(s) 21-22, ISSN 2352-3964
Editor: Elsevier BV
DOI: 10.1016/j.ebiom.2019.07.047

β-Catenin Activation Promotes Immune Escape and Resistance to Anti–PD-1 Therapy in Hepatocellular Carcinoma

Autores: Marina Ruiz de Galarreta, Erin Bresnahan, Pedro Molina-Sánchez, Katherine E. Lindblad, Barbara Maier, Daniela Sia, Marc Puigvehi, Verónica Miguela, María Casanova-Acebes, Maxime Dhainaut, Carlos Villacorta-Martin, Aatur D. Singhi, Akshata Moghe, Johann von Felden, Lauren Tal Grinspan, Shuang Wang, Alice O. Kamphorst, Satdarshan P. Monga, Brian D. Brown, Augusto Villanueva, Josep M. Llovet, Miri
Publicado en: Cancer Discovery, Edición 9/8, 2019, Página(s) 1124-1141, ISSN 2159-8274
Editor: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-19-0074

Oxidative Stress Triggers Selective tRNA Retrograde Transport in Human Cells during the Integrated Stress Response

Autores: Schwenzer, H.; Jühling, F.; Chu, A.; Pallett, L. J.; Baumert, T. F.; Maini, M.; Fassati, A.
Publicado en: Cell Reports , 26 (12) 3416-3428.e5. (2019), Edición 10, 2019
Editor: -

Follicular T helper cells shape the HCV-specific CD4+ T cell repertoire after virus elimination

Autores: Maike Smits, Katharina Zoldan, Naveed Ishaque, Zuguang Gu, Katharina Jechow, Dominik Wieland, Christian Conrad, Roland Eils, Catherine Fauvelle, Thomas F. Baumert, Florian Emmerich, Bertram Bengsch, Christoph Neumann-Haefelin, Maike Hofmann, Robert Thimme, Tobias Boettler
Publicado en: Journal of Clinical Investigation, Edición 130/2, 2019, Página(s) 998-1009, ISSN 0021-9738
Editor: American Society for Clinical Investigation
DOI: 10.1172/jci129642

Inefficient induction of circulating TAA-specific CD8+ T-cell responses in hepatocellular carcinoma

Autores: Catrin Tauber, Liangliang Hao, Kaelyn Brown, Jihoon Lim, Sangeeta N. Bhatia, Frank J. Slack
Publicado en: Oncotarget, Edición 10/50, 2019, ISSN 1949-2553
Editor: Impact Journals
DOI: 10.18632/oncotarget.27146

Broad neutralization of hepatitis C virus-resistant variants by Civacir hepatitis C immunoglobulin

Autores: Rajiv G. Tawar, Laura Heydmann, Charlotte Bach, Jörg Schüttrumpf, Shailesh Chavan, Barnabas J. King, C. Patrick McClure, Jonathan K. Ball, Patrick Pessaux, François Habersetzer, Ralf Bartenschlager, Mirjam B. Zeisel, Thomas F. Baumert
Publicado en: Hepatology, Edición 64/5, 2016, Página(s) 1495-1506, ISSN 0270-9139
Editor: John Wiley & Sons Inc.
DOI: 10.1002/hep.28767

Hepatitis B Virus–Hepatocyte Interactions and Innate Immune Responses: Experimental Models and Molecular Mechanisms

Autores: Emmanuel Thomas, Thomas F. Baumert
Publicado en: Seminars in Liver Disease, Edición 39/03, 2019, Página(s) 301-314, ISSN 0272-8087
Editor: Thieme Medical Publishers
DOI: 10.1055/s-0039-1685518

Cell Culture Models for the Investigation of Hepatitis B and D Virus Infection

Autores: Eloi Verrier, Che Colpitts, Catherine Schuster, Mirjam Zeisel, Thomas Baumert
Publicado en: Viruses, Edición 8/9, 2016, Página(s) 261, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v8090261

Hepatitis B virus receptors and molecular drug targets

Autores: Eloi R. Verrier, Che C. Colpitts, Camille Sureau, Thomas F. Baumert
Publicado en: Hepatology International, Edición 10/4, 2016, Página(s) 567-573, ISSN 1936-0533
Editor: Springer Pub. Co.
DOI: 10.1007/s12072-016-9718-5

Combined small molecule and loss-of-function screen uncovers estrogen receptor alpha and CAD as host factors for HDV infection and antiviral targets

Autores: Eloi R Verrier, Amélie Weiss, Charlotte Bach, Laura Heydmann, Vincent Turon-Lagot, Arnaud Kopp, Houssein El Saghire, Emilie Crouchet, Patrick Pessaux, Thomas Garcia, Patrick Pale, Mirjam B Zeisel, Camille Sureau, Catherine Schuster, Laurent Brino, Thomas F Baumert
Publicado en: Gut, Edición 69/1, 2019, Página(s) 158-167, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2018-317065

Oncogenic Signaling Induced by HCV Infection

Autores: Alessia Virzì, Armando Roca Suarez, Thomas Baumert, Joachim Lupberger
Publicado en: Viruses, Edición 10/10, 2018, Página(s) 538, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v10100538

Rewiring Host Signaling: Hepatitis C Virus in Liver Pathogenesis

Autores: Alessia Virzì, Armando Andres Roca Suarez, Thomas F. Baumert, Joachim Lupberger
Publicado en: Cold Spring Harbor Perspectives in Medicine, Edición 10/1, 2020, Página(s) a037366, ISSN 2157-1422
Editor: -
DOI: 10.1101/cshperspect.a037366

A dual role for SAMHD1 in regulating HBV cccDNA and RT-dependent particle genesis

Autores: Peter AC Wing, Tamara Davenne, Jochen Wettengel, Alvina G Lai, Xiaodong Zhuang, Anindita Chakraborty, Valentina D’Arienzo, Catharina Kramer, Chunkyu Ko, James M Harris, Sabrina Schreiner, Martin Higgs, Stephanie Roessler, Joanna L Parish, Ulrike Protzer, Peter Balfe, Jan Rehwinkel, Jane A McKeating
Publicado en: Life Science Alliance, Edición 2/2, 2019, Página(s) e201900355, ISSN 2575-1077
Editor: -
DOI: 10.26508/lsa.201900355

Radiomics in hepatocellular carcinoma: a quantitative review

Autores: Taiga Wakabayashi, Farid Ouhmich, Cristians Gonzalez-Cabrera, Emanuele Felli, Antonio Saviano, Vincent Agnus, Peter Savadjiev, Thomas F. Baumert, Patrick Pessaux, Jacques Marescaux, Benoit Gallix
Publicado en: Hepatology International, Edición 13/5, 2019, Página(s) 546-559, ISSN 1936-0533
Editor: Springer Pub. Co.
DOI: 10.1007/s12072-019-09973-0

Learning from a clinical cohort for HCV vaccine development

Autores: Florian Wrensch, Zhen-yong Keck, Steven K.H. Foung, Thomas F. Baumert
Publicado en: Journal of Hepatology, Edición 71/1, 2019, Página(s) 9-11, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2019.03.030

Hepatitis B virus: is a cure possible?

Autores: Mirjam B. Zeisel, Thomas F. Baumert
Publicado en: Expert Review of Clinical Pharmacology, Edición 9/9, 2016, Página(s) 1129-1130, ISSN 1751-2433
Editor: Future Drugs Ltd.
DOI: 10.1080/17512433.2016.1206466

Translation and protein expression of lncRNAs: Impact for liver disease and hepatocellular carcinoma

Autores: Mirjam B. Zeisel, Thomas F. Baumert
Publicado en: Hepatology, Edición 64/2, 2016, Página(s) 671-674, ISSN 0270-9139
Editor: John Wiley & Sons Inc.
DOI: 10.1002/hep.28653

Platelets in chronic liver disease, from bench to bedside

Autores: Pierluigi Ramadori, Thomas Klag, Nisar Peter Malek, Mathias Heikenwalder
Publicado en: JHEP Reports, Edición 1/6, 2019, Página(s) 448-459, ISSN 2589-5559
Editor: -
DOI: 10.1016/j.jhepr.2019.10.001

Molecular portrait of high alpha-fetoprotein in hepatocellular carcinoma: implications for biomarker-driven clinical trials

Autores: Robert Montal, Carmen Andreu-Oller, Laia Bassaganyas, Roger Esteban-Fabró, Sebastián Moran, Carla Montironi, Agrin Moeini, Roser Pinyol, Judit Peix, Laia Cabellos, Augusto Villanueva, Daniela Sia, Vincenzo Mazzaferro, Manel Esteller, Josep M. Llovet
Publicado en: British Journal of Cancer, Edición 121/4, 2019, Página(s) 340-343, ISSN 0007-0920
Editor: Nature Publishing Group
DOI: 10.1038/s41416-019-0513-7

Mortality from liver cirrhosis and HCC in the DAA era: success in viral control is darkened by raise of metabolic disease

Autores: Antonio Saviano, Thomas F. Baumert
Publicado en: HepatoBiliary Surgery and Nutrition, Edición 8/3, 2019, Página(s) 307-310, ISSN 2304-3881
Editor: -
DOI: 10.21037/hbsn.2019.01.21

Single-cell RNA-Seq of HBV-induced hepatocellular carcinoma reveals viral compartmentalization and cancer heterogeneity

Autores: Jühling F, Verrier ER, Saviano A , El Saghire H, Heydmann H, Pessaux P, Pochet N, Schuster C, Baumert TF.
Publicado en: J Clin Invest, Edición in revision, 2020
Editor: -

Hepatitis C Virus-Induced Upregulation of MicroRNA miR-146a-5p in Hepatocytes Promotes Viral Infection and Deregulates Metabolic Pathways Associated with Liver Disease Pathogenesis

Autores: Simonetta Bandiera, Sophie Pernot, Hussein El Saghire, Sarah C. Durand, Christine Thumann, Emilie Crouchet, Tao Ye, Isabel Fofana, Marine A. Oudot, Jochen Barths, Catherine Schuster, Patrick Pessaux, Markus H. Heim, Thomas F. Baumert, Mirjam B. Zeisel
Publicado en: Journal of Virology, Edición 90/14, 2016, Página(s) 6387-6400, ISSN 0022-538X
Editor: American Society for Microbiology
DOI: 10.1128/JVI.00619-16

N-Glycosylation of the Na+-Taurocholate Cotransporting Polypeptide (NTCP) Determines Its Trafficking and Stability and Is Required for Hepatitis B Virus Infection

Autores: Monique D. Appelman, Anindita Chakraborty, Ulrike Protzer, Jane A. McKeating, Stan F. J. van de Graaf
Publicado en: PLOS ONE, Edición 12/1, 2017, Página(s) e0170419, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0170419

Autores: Thomas F. Baumert, Frank Jühling, Atsushi Ono, Yujin Hoshida
Publicado en: BMC Medicine, Edición 15/1, 2017, ISSN 1741-7015
Editor: BioMed Central
DOI: 10.1186/s12916-017-0815-7

Palbociclib (PD-0332991), a selective CDK4/6 inhibitor, restricts tumour growth in preclinical models of hepatocellular carcinoma

Autores: Julien Bollard, Verónica Miguela, Marina Ruiz de Galarreta, Anu Venkatesh, C Billie Bian, Mark P Roberto, Victoria Tovar, Daniela Sia, Pedro Molina-Sánchez, Christie B Nguyen, Shigeki Nakagawa, Josep M Llovet, Yujin Hoshida, Amaia Lujambio
Publicado en: Gut, Edición 66/7, 2017, Página(s) 1286-1296, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2016-312268

Humanisation of a claudin-1-specific monoclonal antibody for clinical prevention and cure of HCV infection without escape

Autores: Che C Colpitts, Rajiv G Tawar, Laurent Mailly, Christine Thumann, Laura Heydmann, Sarah C Durand, Fei Xiao, Eric Robinet, Patrick Pessaux, Mirjam B Zeisel, Thomas F Baumert
Publicado en: Gut, Edición pii: gutjnl-2016-312577, 2017, Página(s) gutjnl-2016-312577, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2016-312577

Multifaceted role of E-cadherin in hepatitis C virus infection and pathogenesis

Autores: Che C. Colpitts, Joachim Lupberger, Thomas F. Baumert
Publicado en: Proceedings of the National Academy of Sciences, Edición 113/27, 2016, Página(s) 7298-7300, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1607732113

SMAD About Hepatitis C Virus Cell Entry and Liver Disease

Autores: Che C. Colpitts, Thomas F. Baumert
Publicado en: Gastroenterology, Edición 152/1, 2017, Página(s) 21-23, ISSN 0016-5085
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2016.11.029

SCARB1 variants and HCV infection: Host susceptibility is lost in translation

Autores: Che C. Colpitts, Thomas F. Baumert
Publicado en: Journal of Hepatology, Edición 67(2), 2017, Página(s) 211-213, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2017.04.013

Extracellular lipid-free apolipoprotein E inhibits HCV replication and induces ABCG1-dependent cholesterol efflux

Autores: Emilie Crouchet, Mathieu Lefèvre, Eloi R Verrier, Marine A Oudot, Thomas F Baumert, Catherine Schuster
Publicado en: Gut, Edición 66/5, 2017, Página(s) 896-907, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2015-311289

Autotaxin-lysophosphatidic acid receptor signalling regulates hepatitis C virus replication

Autores: Michelle J. Farquhar, Isla S. Humphreys, Simon A. Rudge, Garrick K. Wilson, Bishnupriya Bhattacharya, Maria Ciaccia, Ke Hu, Qifeng Zhang, Laurent Mailly, Gary M. Reynolds, Margaret Ashcroft, Peter Balfe, Thomas F. Baumert, Stephanie Roessler, Michael J.O. Wakelam, Jane A. McKeating
Publicado en: Journal of Hepatology, Edición 66/5, 2017, Página(s) 919-929, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2017.01.009

The Measles Virus Receptor SLAMF1 Can Mediate Particle Endocytosis

Autores: Daniel Gonçalves-Carneiro, Jane A. McKeating, Dalan Bailey
Publicado en: Journal of Virology, Edición 91/7, 2017, Página(s) e02255-16, ISSN 0022-538X
Editor: American Society for Microbiology
DOI: 10.1128/JVI.02255-16

Tracking HCV protease population diversity during transmission and susceptibility of founder populations to antiviral therapy

Autores: Tanvi Khera, Daniel Todt, Koen Vercauteren, C. Patrick McClure, Lieven Verhoye, Ali Farhoudi, Sabin Bhuju, Robert Geffers, Thomas F. Baumert, Eike Steinmann, Philip Meuleman, Thomas Pietschmann, Richard J.P. Brown
Publicado en: Antiviral Research, Edición 139, 2017, Página(s) 129-137, ISSN 0166-3542
Editor: Elsevier BV
DOI: 10.1016/j.antiviral.2017.01.001

Objective response by mRECIST as a predictor and potential surrogate end-point of overall survival in advanced HCC

Autores: Riccardo Lencioni, Robert Montal, Ferran Torres, Joong-Won Park, Thomas Decaens, Jean-Luc Raoul, Masatoshi Kudo, Charissa Chang, José Ríos, Valerie Boige, Eric Assenat, Yoon-Koo Kang, Ho-Yeong Lim, Ian Walters, Josep M. Llovet
Publicado en: Journal of Hepatology, Edición 66/6, 2017, Página(s) 1166-1172, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2017.01.012

Hepatocellular carcinoma

Autores: Josep M. Llovet, Jessica Zucman-Rossi, Eli Pikarsky, Bruno Sangro, Myron Schwartz, Morris Sherman, Gregory Gores
Publicado en: Nature Reviews Disease Primers, Edición 2, 2016, Página(s) 16018, ISSN 2056-676X
Editor: -
DOI: 10.1038/nrdp.2016.18

Plasmodium P36 determines host cell receptor usage during sporozoite invasion

Autores: Giulia Manzoni, Carine Marinach, Selma Topçu, Sylvie Briquet, Morgane Grand, Matthieu Tolle, Marion Gransagne, Julien Lescar, Chiara Andolina, Jean-François Franetich, Mirjam B Zeisel, Thierry Huby, Eric Rubinstein, Georges Snounou, Dominique Mazier, François Nosten, Thomas F Baumert, Olivier Silvie
Publicado en: eLife, Edición 6, 2017, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/eLife.25903

IGF2 Is Up-regulated by Epigenetic Mechanisms in Hepatocellular Carcinomas and Is an Actionable Oncogene Product in Experimental Models

Autores: Iris Martinez-Quetglas, Roser Pinyol, Daniel Dauch, Sara Torrecilla, Victoria Tovar, Agrin Moeini, Clara Alsinet, Anna Portela, Leonardo Rodriguez-Carunchio, Manel Solé, Amaia Lujambio, Augusto Villanueva, Swan Thung, Manel Esteller, Lars Zender, Josep M. Llovet
Publicado en: Gastroenterology, Edición 151/6, 2016, Página(s) 1192-1205, ISSN 0016-5085
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2016.09.001

Mixed hepatocellular cholangiocarcinoma tumors: Cholangiolocellular carcinoma is a distinct molecular entity

Autores: Agrin Moeini, Daniela Sia, Zhongyang Zhang, Genis Camprecios, Ashley Stueck, Hui Dong, Robert Montal, Laura Torrens, Iris Martinez-Quetglas, M. Isabel Fiel, Ke Hao, Augusto Villanueva, Swan N. Thung, Myron E. Schwartz, Josep M. Llovet
Publicado en: Journal of Hepatology, Edición 66/5, 2017, Página(s) 952-961, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2017.01.010

Viral hepatitis and liver cancer

Autores: Marc Ringehan, Jane A. McKeating, Ulrike Protzer
Publicado en: Philosophical Transactions of the Royal Society B: Biological Sciences, Edición 372/1732, 2017, Página(s) 20160274, ISSN 0962-8436
Editor: Royal Society of London
DOI: 10.1098/rstb.2016.0274

Molecular Pathogenesis and Targeted Therapies for Intrahepatic Cholangiocarcinoma

Autores: A. Moeini, D. Sia, N. Bardeesy, V. Mazzaferro, J. M. Llovet
Publicado en: Clinical Cancer Research, Edición 22/2, 2016, Página(s) 291-300, ISSN 1078-0432
Editor: American Association for Cancer Research
DOI: 10.1158/1078-0432.CCR-14-3296

Identification of an Immune-specific Class of Hepatocellular Carcinoma, Based on Molecular Features

Autores: Daniela Sia, Yang Jiao, Iris Martinez-Quetglas, Olga Kuchuk, Carlos Villacorta-Martin, Manuel Castro de Moura, Juan Putra, Genis Camprecios, Laia Bassaganyas, Nicholas Akers, Bojan Losic, Samuel Waxman, Swan N. Thung, Vincenzo Mazzaferro, Manel Esteller, Scott L. Friedman, Myron Schwartz, Augusto Villanueva, Josep M. Llovet
Publicado en: Gastroenterology, Edición pii: S0016-5085(17)35741-4, 2017, ISSN 0016-5085
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2017.06.007

Imaging-based surrogate markers of transcriptome subclasses and signatures in hepatocellular carcinoma: preliminary results

Autores: Bachir Taouli, Yujin Hoshida, Suguru Kakite, Xintong Chen, Poh Seng Tan, Xiaochen Sun, Shingo Kihira, Kensuke Kojima, Sara Toffanin, M. Isabel Fiel, Hadassa Hirschfield, Mathilde Wagner, Josep M. Llovet
Publicado en: European Radiology, 2017, ISSN 0938-7994
Editor: Springer Verlag
DOI: 10.1007/s00330-017-4844-6

Liver Cancer Cell of Origin, Molecular Class, and Effects on Patient Prognosis

Autores: Daniela Sia, Augusto Villanueva, Scott L. Friedman, Josep M. Llovet
Publicado en: Gastroenterology, Edición 152/4, 2017, Página(s) 745-761, ISSN 0016-5085
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2016.11.048

Tumour initiating cells and IGF/FGF signalling contribute to sorafenib resistance in hepatocellular carcinoma

Autores: Victoria Tovar, Helena Cornella, Agrin Moeini, Samuel Vidal, Yujin Hoshida, Daniela Sia, Judit Peix, Laia Cabellos, Clara Alsinet, Sara Torrecilla, Iris Martinez-Quetglas, Juan José Lozano, Christèle Desbois-Mouthon, Manel Solé, Josep Domingo-Domenech, Augusto Villanueva, Josep M Llovet
Publicado en: Gut, Edición 66/3, 2017, Página(s) 530-540, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2015-309501

Advancing hepatitis B virus entry inhibitors

Autores: Eloi R. Verrier, Catherine Schuster, Thomas F. Baumert
Publicado en: Journal of Hepatology, Edición 66/4, 2017, Página(s) 677-679, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2016.11.028

Solute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of Hepatocytes

Autores: Eloi R. Verrier, Che C. Colpitts, Charlotte Bach, Laura Heydmann, Laetitia Zona, Fei Xiao, Christine Thumann, Emilie Crouchet, Raphaël Gaudin, Camille Sureau, François-Loïc Cosset, Jane A. McKeating, Patrick Pessaux, Yujin Hoshida, Catherine Schuster, Mirjam B. Zeisel, Thomas F. Baumert
Publicado en: Cell Reports, Edición 17/5, 2016, Página(s) 1357-1368, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2016.09.084

miR-135a-5p-mediated downregulation of protein tyrosine phosphatase receptor delta is a candidate driver of HCV-associated hepatocarcinogenesis

Autores: Nicolaas Van Renne, Armando Andres Roca Suarez, Francois H T Duong, Claire Gondeau, Diego Calabrese, Nelly Fontaine, Amina Ababsa, Simonetta Bandiera, Tom Croonenborghs, Nathalie Pochet, Vito De Blasi, Patrick Pessaux, Tullio Piardi, Daniele Sommacale, Atsushi Ono, Kazuaki Chayama, Masashi Fujita, Hidewaki Nakagawa, Yujin Hoshida, Mirjam B Zeisel, Markus H Heim, Thomas F Baumert, Joachim Lupberger
Publicado en: Gut, Edición pii: gutjnl-2016-312270, 2017, Página(s) gutjnl-2016-312270, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2016-312270

Multimodal imaging of a humanized orthotopic model of hepatocellular carcinoma in immunodeficient mice

Autores: Tao Wu, Emilie Heuillard, Véronique Lindner, Ghina Bou About, Mihaela Ignat, Jean-Philippe Dillenseger, Nicolas Anton, Eugénie Dalimier, Francine Gossé, Gael Fouré, Franck Blindauer, Céline Giraudeau, Hussein El-Saghire, Mourad Bouhadjar, Cynthia Calligaro, Tania Sorg, Philippe Choquet, Thierry Vandamme, Christophe Ferrand, Jacques Marescaux, Thomas F. Baumert, Michele Diana, Patrick Pessaux,
Publicado en: Scientific Reports, Edición 6/1, 2016, Página(s) 35230, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/srep35230

Hepatitis Delta Virus histone mimicry drives the recruitment of chromatin remodelers for viral RNA replication

Autores: Natali Abeywickrama-Samarakoon, Jean-Claude Cortay, Camille Sureau, Susanne Müller, Dulce Alfaiate, Francesca Guerrieri, Apirat Chaikuad, Martin Schröder, Philippe Merle, Massimo Levrero, Paul Dény
Publicado en: Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-14299-9

Hepatitis B protein HBx binds the DLEU2 lncRNA to sustain cccDNA and host cancer-related gene transcription

Autores: Debora Salerno, Letizia Chiodo, Vincenzo Alfano, Oceane Floriot, Grazia Cottone, Alexia Paturel, Matteo Pallocca, Marie-Laure Plissonnier, Safaa Jeddari, Laura Belloni, Mirjam Zeisel, Massimo Levrero, Francesca Guerrieri
Publicado en: Gut, 2020, Página(s) gutjnl-2019-319637, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2019-319637

Perspectives and limitations for nucleo(t)side analogs in future HBV therapies

Autores: Massimo Levrero, Miroslava Subic, Francois Villeret, Fabien Zoulim
Publicado en: Current Opinion in Virology, Edición 30, 2018, Página(s) 80-89, ISSN 1879-6257
Editor: Elsevier BV
DOI: 10.1016/j.coviro.2018.04.006

Mechanisms of HBV-induced hepatocellular carcinoma

Autores: Massimo Levrero, Jessica Zucman-Rossi
Publicado en: Journal of Hepatology, Edición 64/1, 2016, Página(s) S84-S101, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2016.02.021

The histone deacetylase inhibiting drug Entinostat induces lipid accumulation in differentiated HepaRG cells

Autores: Abigail D. G. Nunn, Tullio Scopigno, Natalia Pediconi, Massimo Levrero, Henning Hagman, Juris Kiskis, Annika Enejder
Publicado en: Scientific Reports, Edición 6/1, 2016, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/srep28025

Non-Coding RNAs and Hepatitis C Virus-Induced Hepatocellular Carcinoma

Autores: Marie-Laure Plissonnier, Katharina Herzog, Massimo Levrero, Mirjam Zeisel
Publicado en: Viruses, Edición 10/11, 2018, Página(s) 591, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v10110591

Challenges to a Cure for HBV Infection

Autores: Barbara Testoni, Massimo Levrero, Fabien Zoulim
Publicado en: Seminars in Liver Disease, Edición 37/03, 2017, Página(s) 231-242, ISSN 0272-8087
Editor: Thieme Medical Publishers
DOI: 10.1055/s-0037-1606212

miR-122-regulated metabolic circuits: micro-management of lipid metabolism in the human liver

Autores: Mirjam B. Zeisel, Marie-Laure Plissonnier, Massimo Levrero
Publicado en: Non-coding RNA Investigation, Edición 2, 2018, Página(s) 45-45, ISSN 2522-6673
Editor: -
DOI: 10.21037/ncri.2018.07.02

NOTCH target gene HES5 mediates oncogenic and tumor suppressive functions in hepatocarcinogenesis.

Autores: Luiken S, Fraas A, Bieg M, Sugiyanto R, Goeppert B, Singer S, Ploeger C, Warsow G, Marquardt JU, Sticht C, De La Torre C, Pusch S, Mehrabi A, Gretz N, Schlesner M, Eils R, Schirmacher P, Longerich T, Roessler S.
Publicado en: Oncogene, Edición conditionally accepted, 2020
Editor: -

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CLINICAL GENE SIGNATURE-BASED HUMAN CELL CULTURE MODEL AND USES THEREOF

Número de solicitud/publicación: 20 16059477
Fecha: 2016-04-28
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Número de solicitud/publicación: 20 17056703
Fecha: 2017-03-21
Solicitante(s): INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

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Número de solicitud/publicación: 20 18055829
Fecha: 2018-03-08
Solicitante(s): INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

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Número de solicitud/publicación: 20 14065676
Fecha: 2014-07-22
Solicitante(s): INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

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