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CORDIS - Risultati della ricerca dell’UE
CORDIS

Mechanisms underlying hepatocellular carcinoma pathogenesis and impact of co-morbidities.

Risultati finali

Final dissemination and exploitation plan

A final dissemination and exploitation plan for using of dissemination knowledge and optimized exploitation of the results will be prepared at the end of the action.

Website development and management

The HEP-CAR website will be accessible on the internet at month 6 and it will be revised and improved during the whole course of the action. Part of the website will password-protected and dedicated to internal communication.

Pubblicazioni

Status of Direct-Acting Antiviral Therapy for Hepatitis C Virus Infection and Remaining Challenges

Autori: Thomas F. Baumert, Thomas Berg, Joseph K. Lim, David R. Nelson
Pubblicato in: Gastroenterology, Numero 156, 2018, Pagina/e 431-445, ISSN 0016-5085
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2018.10.024

Claudins in viral infection: from entry to spread

Autori: Che C. Colpitts, Thomas F. Baumert
Pubblicato in: Pflügers Archiv - European Journal of Physiology, Numero 469/1, 2017, Pagina/e 27-34, ISSN 0031-6768
Editore: Springer Verlag
DOI: 10.1007/s00424-016-1908-4

Entry Inhibitors: A Perspective for Prevention of Hepatitis C Virus Infection in Organ Transplantation

Autori: Che C. Colpitts, Raymond T. Chung, Thomas F. Baumert
Pubblicato in: ACS Infectious Diseases, Numero 3/9, 2017, Pagina/e 620-623, ISSN 2373-8227
Editore: ACS Publications
DOI: 10.1021/acsinfecdis.7b00091

Host-targeting therapies for hepatitis C virus infection: current developments and future applications

Autori: Emilie Crouchet, Florian Wrensch, Catherine Schuster, Mirjam B. Zeisel, Thomas F. Baumert
Pubblicato in: Therapeutic Advances in Gastroenterology, Numero 11, 2018, Pagina/e 175628481875948, ISSN 1756-2848
Editore: SAGE Publications
DOI: 10.1177/1756284818759483

The functional role of sodium taurocholate cotransporting polypeptide NTCP in the life cycle of hepatitis B, C and D viruses

Autori: Carla Eller, Laura Heydmann, Che C. Colpitts, Eloi R. Verrier, Catherine Schuster, Thomas F. Baumert
Pubblicato in: Cellular and Molecular Life Sciences, Numero 75/21, 2018, Pagina/e 3895-3905, ISSN 1420-682X
Editore: Birkhauser Verlag
DOI: 10.1007/s00018-018-2892-y

A novel neutralizing human monoclonal antibody broadly abrogates hepatitis C virus infection in vitro and in vivo

Autori: Isabelle Desombere, Ahmed Atef Mesalam, Richard A. Urbanowicz, Freya Van Houtte, Lieven Verhoye, Zhen-Yong Keck, Ali Farhoudi, Koen Vercauteren, Karin E. Weening, Thomas F. Baumert, Arvind H. Patel, Steven K.H. Foung, Jonathan Ball, Geert Leroux-Roels, Philip Meuleman
Pubblicato in: Antiviral Research, Numero 148, 2017, Pagina/e 53-64, ISSN 0166-3542
Editore: Elsevier BV
DOI: 10.1016/j.antiviral.2017.10.015

Nuclear Translocation of RELB is Increased in Diseased Human Liver and Promotes Ductular Reaction and Biliary Fibrosis in Mice

Autori: Christin Elßner, Benjamin Goeppert, Thomas Longerich, Anna-Lena Scherr, Jan Stindt, Lahiri Kanth Nanduri, Christian Rupp, Jakob Nikolas Kather, Nathalie Schmitt, Nicole Kautz, Kai Breuhahn, Lars Ismail, Danijela Heide, Jenny Hetzer, María García-Beccaria, Nadine Hövelmeyer, Ari Waisman, Toni Urbanik, Sebastian Mueller, Georg Gdynia, Jesus M. Banales, Stephanie Roessler, Peter Schirmacher, Dirk
Pubblicato in: Gastroenterology, Numero 156(4), 2018, Pagina/e 1190-1205.e14, ISSN 0016-5085
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2018.11.018

EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma

Autori: Peter R. Galle, Alejandro Forner, Josep M. Llovet, Vincenzo Mazzaferro, Fabio Piscaglia, Jean-Luc Raoul, Peter Schirmacher, Valérie Vilgrain
Pubblicato in: Journal of Hepatology, Numero 69/1, 2018, Pagina/e 182-236, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2018.03.019

Integrative analysis defines distinct prognostic subgroups of intrahepatic cholangiocarcinoma

Autori: Benjamin Goeppert, Reka Toth, Stephan Singer, Thomas Albrecht, Daniel B. Lipka, Pavlo Lutsik, David Brocks, Marion Baehr, Oliver Muecke, Yassen Assenov, Lei Gu, Volker Endris, Albrecht Stenzinger, Arianeb Mehrabi, Peter Schirmacher, Christoph Plass, Dieter Weichenhan, Stephanie Roessler
Pubblicato in: Hepatology, 2019, ISSN 0270-9139
Editore: John Wiley & Sons Inc.
DOI: 10.1002/hep.30493

Signalome-wide assessment of host cell response to hepatitis C virus

Autori: Gholamreza Haqshenas, Jianmin Wu, Kaylene J. Simpson, Roger J. Daly, Hans J. Netter, Thomas F. Baumert, Christian Doerig
Pubblicato in: Nature Communications, Numero 8, 2017, Pagina/e 15158, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/ncomms15158

Hepatitis B Virus Activates Signal Transducer and Activator of Transcription 3 Supporting Hepatocyte Survival and Virus Replication

Autori: Marianna Hösel, Maria Quasdorff, Marc Ringelhan, Hamid Kashkar, Svenja Debey-Pascher, Martin F. Sprinzl, Jan-Hendrik Bockmann, Silke Arzberger, Dennis Webb, Gesa von Olshausen, Achim Weber, Joachim L. Schultze, Hildegard Büning, Mathias Heikenwalder, Ulrike Protzer
Pubblicato in: Cellular and Molecular Gastroenterology and Hepatology, Numero 4/3, 2017, Pagina/e 339-363, ISSN 2352-345X
Editore: Elsevier Inc.
DOI: 10.1016/j.jcmgh.2017.07.003

Mapping Determinants of Virus Neutralization and Viral Escape for Rational Design of a Hepatitis C Virus Vaccine

Autori: Mei-Le Keck, Florian Wrensch, Brian G. Pierce, Thomas F. Baumert, Steven K. H. Foung
Pubblicato in: Frontiers in Immunology, Numero 9, 2018, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/fimmu.2018.01194

Hepatitis B virus genome recycling and de novo secondary infection events maintain stable cccDNA levels

Autori: Chunkyu Ko, Anindita Chakraborty, Wen-Min Chou, Julia Hasreiter, Jochen M. Wettengel, Daniela Stadler, Romina Bester, Theresa Asen, Ke Zhang, Karin Wisskirchen, Jane A. McKeating, Wang-Shick Ryu, Ulrike Protzer
Pubblicato in: Journal of Hepatology, Numero 69/6, 2018, Pagina/e 1231-1241, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2018.08.012

IFN-α-mediated Base Excision Repair Pathway Correlates with Antiviral Response Against Hepatitis B Virus Infection

Autori: Yong Li, Yuchen Xia, Meifang Han, Guang Chen, Dake Zhang, Wolfgang E. Thasler, Ulrike Protzer, Qin Ning
Pubblicato in: Scientific Reports, Numero 7/1, 2017, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-017-13082-z

Hepatitis B Virus Core Variants, Liver Fibrosis, and Hepatocellular Carcinoma

Autori: Gaetan Ligat, Catherine Schuster, Thomas F. Baumert
Pubblicato in: Hepatology, Numero 69/1, 2019, Pagina/e 5-8, ISSN 0270-9139
Editore: John Wiley & Sons Inc.
DOI: 10.1002/hep.30231

A pilot study of ultra-deep targeted sequencing of plasma DNA identifies driver mutations in hepatocellular carcinoma

Autori: Ismail Labgaa, Carlos Villacorta-Martin, Delia D’Avola, Amanda J. Craig, Johann von Felden, Sebastiao N. Martins-Filho, Daniela Sia, Ashley Stueck, Stephen C. Ward, M. Isabel Fiel, Milind Mahajan, Parissa Tabrizian, Swan N. Thung, Celina Ang, Scott L. Friedman, Josep M. Llovet, Myron Schwartz, Augusto Villanueva
Pubblicato in: Oncogene, Numero 37/27, 2018, Pagina/e 3740-3752, ISSN 0950-9232
Editore: Nature Publishing Group
DOI: 10.1038/s41388-018-0206-3

Molecular therapies and precision medicine for hepatocellular carcinoma

Autori: Josep M. Llovet, Robert Montal, Daniela Sia, Richard S. Finn
Pubblicato in: Nature Reviews Clinical Oncology, Numero 15/10, 2018, Pagina/e 599-616, ISSN 1759-4774
Editore: Nature Publishing Group
DOI: 10.1038/s41571-018-0073-4

Pilot study of living donor liver transplantation for patients with hepatocellular carcinoma exceeding Milan Criteria (Barcelona Clinic Liver Cancer extended criteria)

Autori: Josep M. Llovet, Mihai Pavel, Jordi Rimola, Maria Alba Diaz, Jordi Colmenero, David Saavedra-Perez, Constantino Fondevila, Carmen Ayuso, Josep Fuster, Pere Ginès, Jordi Bruix, Juan Carlos Garcia-Valdecasas
Pubblicato in: Liver Transplantation, Numero 24/3, 2018, Pagina/e 369-379, ISSN 1527-6465
Editore: John Wiley & Sons Inc.
DOI: 10.1002/lt.24977

Viral hepatitis: The bumpy road to animal models for HBV infection

Autori: Ulrike Protzer
Pubblicato in: Nature Reviews Gastroenterology & Hepatology, Numero 14/6, 2017, Pagina/e 327-328, ISSN 1759-5045
Editore: Nature Publishing Group
DOI: 10.1038/nrgastro.2017.44

Beyond viral dependence: The pathological consequences of HCV-induced EGF signaling

Autori: Armando Andres Roca Suarez, Thomas F. Baumert, Joachim Lupberger
Pubblicato in: Journal of Hepatology, Numero 69/3, 2018, Pagina/e 564-566, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2018.05.033

Viral manipulation of STAT3: Evade, exploit, and injure

Autori: Armando Andres Roca Suarez, Nicolaas Van Renne, Thomas F. Baumert, Joachim Lupberger
Pubblicato in: PLOS Pathogens, Numero 14/3, 2018, Pagina/e e1006839, ISSN 1553-7374
Editore: -
DOI: 10.1371/journal.ppat.1006839

Liver cancer: Translating '–omics' results into precision medicine for hepatocellular carcinoma

Autori: Daniela Sia, Josep M. Llovet
Pubblicato in: Nature Reviews Gastroenterology & Hepatology, 2017, ISSN 1759-5045
Editore: Nature Publishing Group
DOI: 10.1038/nrgastro.2017.103

Trunk mutational events present minimal intra- and inter-tumoral heterogeneity in hepatocellular carcinoma

Autori: Sara Torrecilla, Daniela Sia, Andrew N. Harrington, Zhongyang Zhang, Laia Cabellos, Helena Cornella, Agrin Moeini, Genis Camprecios, Wei-Qiang Leow, Maria Isabel Fiel, Ke Hao, Laia Bassaganyas, Milind Mahajan, Swan N. Thung, Augusto Villanueva, Sander Florman, Myron E. Schwartz, Josep M. Llovet
Pubblicato in: Journal of Hepatology, Numero 67/6, 2017, Pagina/e 1222-1231, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2017.08.013

Hepatitis B Virus Evasion From Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase Sensing in Human Hepatocytes

Autori: Eloi R. Verrier, Seung-Ae Yim, Laura Heydmann, Houssein El Saghire, Charlotte Bach, Vincent Turon-Lagot, Laurent Mailly, Sarah C. Durand, Julie Lucifora, David Durantel, Patrick Pessaux, Nicolas Manel, Ivan Hirsch, Mirjam B. Zeisel, Nathalie Pochet, Catherine Schuster, Thomas F. Baumert
Pubblicato in: Hepatology, Numero 68/5, 2018, Pagina/e 1695-1709, ISSN 0270-9139
Editore: John Wiley & Sons Inc.
DOI: 10.1002/hep.30054

Hepatocellular carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†

Autori: A Vogel, A Cervantes, I Chau, B Daniele, J Llovet, T Meyer, J -C Nault, U Neumann, J Ricke, B Sangro, P Schirmacher, C Verslype, C J Zech, D Arnold, E Martinelli
Pubblicato in: Annals of Oncology, Numero 29/Supplement_4, 2018, Pagina/e iv238-iv255, ISSN 0923-7534
Editore: Oxford University Press
DOI: 10.1093/annonc/mdy308

"Hepatitis B virus promotes β-catenin-signalling and disassembly of adherens junctions in a Src kinase dependent fashion"

Autori: Gesa von Olshausen, Maria Quasdorff, Romina Bester, Silke Arzberger, Chunkyu Ko, Maarten van de Klundert, Ke Zhang, Margarete Odenthal, Marc Ringelhan, Carien M. Niessen, Ulrike Protzer
Pubblicato in: Oncotarget, Numero 9/74, 2018, ISSN 1949-2553
Editore: Impact Journals
DOI: 10.18632/oncotarget.26103

Cytoplasmic localization of the cell polarity factor scribble supports liver tumor formation and tumor cell invasiveness

Autori: Shan Wan, Anne-Sophie Meyer, Sofia Maria Elisabeth Weiler, Christian Rupp, Marcell Tóth, Carsten Sticht, Stephan Singer, Stefan Thomann, Stephanie Roessler, Marina Schorpp-Kistner, Jennifer Schmitt, Norbert Gretz, Peter Angel, Darjus Felix Tschaharganeh, Jens Marquardt, Peter Schirmacher, Federico Pinna, Kai Breuhahn
Pubblicato in: Hepatology, Numero 67/5, 2018, Pagina/e 1842-1856, ISSN 0270-9139
Editore: John Wiley & Sons Inc.
DOI: 10.1002/hep.29669

Early Transcriptional Divergence Marks Virus-Specific Primary Human CD8+ T Cells in Chronic versus Acute Infection

Autori: David Wolski, Peter K. Foote, Diana Y. Chen, Lia L. Lewis-Ximenez, Catherine Fauvelle, Jasneet Aneja, Andreas Walker, Pierre Tonnerre, Almudena Torres-Cornejo, Daniel Kvistad, Sabrina Imam, Michael T. Waring, Damien C. Tully, Todd M. Allen, Raymond T. Chung, Jörg Timm, W. Nicholas Haining, Arthur Y. Kim, Thomas F. Baumert, Georg M. Lauer
Pubblicato in: Immunity, Numero 47/4, 2017, Pagina/e 648-663.e8, ISSN 1074-7613
Editore: Cell Press
DOI: 10.1016/j.immuni.2017.09.006

Hepatitis C Virus (HCV)–Apolipoprotein Interactions and Immune Evasion and Their Impact on HCV Vaccine Design

Autori: Florian Wrensch, Emilie Crouchet, Gaetan Ligat, Mirjam B. Zeisel, Zhen-Yong Keck, Steven K. H. Foung, Catherine Schuster, Thomas F. Baumert
Pubblicato in: Frontiers in Immunology, Numero 9, 2018, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/fimmu.2018.01436

Secreted Interferon-Inducible Factors Restrict Hepatitis B and C Virus Entry In Vitro

Autori: Yuchen Xia, Xiaoming Cheng, Christoph K. Blossey, Karin Wisskirchen, Knud Esser, Ulrike Protzer
Pubblicato in: Journal of Immunology Research, Numero 2017, 2017, Pagina/e 1-12, ISSN 2314-8861
Editore: Hindawi Publishing Corporation
DOI: 10.1155/2017/4828936

Control of Hepatitis B Virus by Cytokines

Autori: Yuchen Xia, Ulrike Protzer
Pubblicato in: Viruses, Numero 9/1, 2017, Pagina/e 18, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v9010018

Tight junction proteins in gastrointestinal and liver disease

Autori: Mirjam B Zeisel, Punita Dhawan, Thomas F Baumert
Pubblicato in: Gut, 2018, Pagina/e gutjnl-2018-316906, ISSN 0017-5749
Editore: BMJ Publishing Group
DOI: 10.1136/gutjnl-2018-316906

Protein kinase D at the Golgi controls NLRP3 inflammasome activation

Autori: Zhirong Zhang, Gergö Meszaros, Wan-ting He, Yanfang Xu, Helena de Fatima Magliarelli, Laurent Mailly, Michael Mihlan, Yansheng Liu, Marta Puig Gámez, Alexander Goginashvili, Adrien Pasquier, Olga Bielska, Bénédicte Neven, Pierre Quartier, Rudolf Aebersold, Thomas F. Baumert, Philippe Georgel, Jiahuai Han, Romeo Ricci
Pubblicato in: The Journal of Experimental Medicine, Numero 214/9, 2017, Pagina/e 2671-2693, ISSN 0022-1007
Editore: Rockefeller University Press
DOI: 10.1084/jem.20162040

Interplay between circadian clock and viral infection

Autori: Xiaodong Zhuang, Srinivasa Bhargav Rambhatla, Alvina G. Lai, Jane A. McKeating
Pubblicato in: Journal of Molecular Medicine, Numero 95/12, 2017, Pagina/e 1283-1289, ISSN 0946-2716
Editore: Springer Verlag
DOI: 10.1007/s00109-017-1592-7

The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication

Autori: Xiaodong Zhuang, Andrea Magri, Michelle Hill, Alvina G. Lai, Abhinav Kumar, Srinivasa Bhargav Rambhatla, Claire L. Donald, Andrea F. Lopez-Clavijo, Simon Rudge, Katherine Pinnick, Wai Hoong Chang, Peter A. C. Wing, Ryan Brown, Ximing Qin, Peter Simmonds, Thomas F. Baumert, David Ray, Andrew Loudon, Peter Balfe, Michael Wakelam, Sam Butterworth, Alain Kohl, Catherine L. Jopling, Nicole Zitzmann, Ja
Pubblicato in: Nature Communications, Numero 10/1, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-08299-7

Daytime variation in hepatitis C virus replication kinetics following liver transplant

Autori: Xiaodong Zhuang, Alvina G. Lai, Jane A. McKeating, Ian Rowe, Peter Balfe
Pubblicato in: Wellcome Open Research, Numero 3, 2018, Pagina/e 96, ISSN 2398-502X
Editore: -
DOI: 10.12688/wellcomeopenres.14696.2

Glucose and glutamine availability regulate HepG2 transcriptional responses to low oxygen

Autori: Alvina G. Lai, Donall Forde, Wai Hoong Chang, Fang Yuan, Xiaodong Zhuang, Claudia Orbegozo Rubio, Chun-Xiao Song, Jane A. McKeating
Pubblicato in: Wellcome Open Research, Numero 3, 2018, Pagina/e 126, ISSN 2398-502X
Editore: -
DOI: 10.12688/wellcomeopenres.14839.1

Hepatitis C virus infection is associated with hepatic and adipose tissue insulin resistance that improves after viral cure

Autori: Teegan R. Lim, Jonathan M. Hazlehurst, Andrei I. Oprescu, Matthew J. Armstrong, Sewa F. Abdullah, Nigel P. Davies, Robert Flintham, Peter Balfe, David J. Mutimer, Jane A. McKeating, Jeremy W. Tomlinson
Pubblicato in: Clinical Endocrinology, 2018, Pagina/e [Epub ahead of print], ISSN 0300-0664
Editore: Blackwell Publishing Inc.
DOI: 10.1111/cen.13924

Metallo supramolecular cylinders inhibit HIV-1 TAR-TAT complex formation and viral replication in cellulo

Autori: Lucia Cardo, Isabel Nawroth, Peter J. Cail, Jane A. McKeating, Michael J. Hannon
Pubblicato in: Scientific Reports, Numero 8/1, 2018, Pagina/e 13342, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-018-31513-3

A new panel of epitope mapped monoclonal antibodies recognising the prototypical tetraspanin CD81

Autori: Joe Grove, Ke Hu, Michelle J. Farquhar, Margaret Goodall, Lucas Walker, Mohammed Jamshad, Heidi E. Drummer, Roslyn M. Bill, Peter Balfe, Jane A. McKeating
Pubblicato in: Wellcome Open Research, Numero 2, 2017, Pagina/e 82, ISSN 2398-502X
Editore: -
DOI: 10.12688/wellcomeopenres.12058.1

Insights From Deep Sequencing of the HBV Genome—Unique, Tiny, and Misunderstood

Autori: Anna L. McNaughton, Valentina D’Arienzo, M. Azim Ansari, Sheila F. Lumley, Margaret Littlejohn, Peter Revill, Jane A. McKeating, Philippa C. Matthews
Pubblicato in: Gastroenterology, Numero 156/2, 2019, Pagina/e 384-399, ISSN 0016-5085
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2018.07.058

The immunology of hepatocellular carcinoma

Autori: Marc Ringelhan, Dominik Pfister, Tracy O’Connor, Eli Pikarsky, Mathias Heikenwalder
Pubblicato in: Nature Immunology, Numero 19/3, 2018, Pagina/e 222-232, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/s41590-018-0044-z

Single cell polarity in liquid phase facilitates tumour metastasis

Autori: Anna Lorentzen, Paul F. Becker, Jan Kosla, Massimo Saini, Kathrin Weidele, Paolo Ronchi, Corinna Klein, Monika J. Wolf, Felix Geist, Bastian Seubert, Marc Ringelhan, Daniela Mihic-Probst, Knud Esser, Marko Roblek, Felix Kuehne, Gaia Bianco, Tracy O’Connor, Quentin Müller, Kathleen Schuck, Sebastian Lange, Daniel Hartmann, Saskia Spaich, Olaf Groß, Jochen Utikal, Sebastian Haferkamp, Martin R.
Pubblicato in: Nature Communications, Numero 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-018-03139-6

PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells

Autori: Athena Georgilis, Sabrina Klotz, Christopher J. Hanley, Nicolas Herranz, Benedikt Weirich, Beatriz Morancho, Ana Carolina Leote, Luana D'Artista, Suchira Gallage, Marco Seehawer, Thomas Carroll, Gopuraja Dharmalingam, Keng Boon Wee, Marco Mellone, Joaquim Pombo, Danijela Heide, Ernesto Guccione, Joaquín Arribas, Nuno L. Barbosa-Morais, Mathias Heikenwalder, Gareth J. Thomas, Lars Zender, Jesús G
Pubblicato in: Cancer Cell, Numero 34/1, 2018, Pagina/e 85-102.e9, ISSN 1535-6108
Editore: Cell Press
DOI: 10.1016/j.ccell.2018.06.007

A human liver cell atlas reveals heterogeneity and epithelial progenitors

Autori: Nadim Aizarani, Antonio Saviano, Sagar, Laurent Mailly, Sarah Durand, Josip S. Herman, Patrick Pessaux, Thomas F. Baumert, Dominic Grün
Pubblicato in: Nature, Numero 572/7768, 2019, Pagina/e 199-204, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-019-1373-2

Addressing the Challenges of Hepatitis C Cure and Persistent Risk of Hepatocellular Carcinoma

Autori: Thomas F. Baumert, Yujin Hoshida
Pubblicato in: Viruses, Numero 11/5, 2019, Pagina/e 441, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v11050441

Chronic hepatitis C virus infection and pathogenesis of hepatocellular carcinoma

Autori: Simonetta Bandiera, C Billie Bian, Yujin Hoshida, Thomas F Baumert, Mirjam B Zeisel
Pubblicato in: Current Opinion in Virology, Numero 20, 2016, Pagina/e 99-105, ISSN 1879-6257
Editore: Elsevier BV
DOI: 10.1016/j.coviro.2016.09.010

Ultrasound‐Guided Approaches to Improve Orthotopic Mouse Xenograft Models for Hepatocellular Carcinoma

Autori: Ghina Bou About, Emilie Thiebault, Marie Wattenhofer‐Donzé, Hugues Jacobs, Alain Guimond, Tania Sorg, Eric Robinet, Thomas F. Baumert, Laurent Monassier, Yann Herault
Pubblicato in: Current Protocols in Mouse Biology, Numero 9/2, 2019, ISSN 2161-2617
Editore: -
DOI: 10.1002/cpmo.62

Hepatitis C virus cell entry: a target for novel antiviral strategies to address limitations of direct acting antivirals

Autori: Che C. Colpitts, Thomas F. Baumert
Pubblicato in: Hepatology International, Numero 10/5, 2016, Pagina/e 741-748, ISSN 1936-0533
Editore: Springer Pub. Co.
DOI: 10.1007/s12072-016-9724-7

A PCR assay to quantify patterns of HBV transcription

Autori: Valentina D’Arienzo, Andrea Magri, James M. Harris, Peter A. C. Wing, Chunkyu Ko, Claudia Orbegozo Rubio, Peter A. Revill, Ulrike Protzer, Peter Balfe, Jane A. McKeating
Pubblicato in: Journal of General Virology, 2019, ISSN 0022-1317
Editore: Society for General Microbiology
DOI: 10.1099/jgv.0.001373

Hepatitis C virus vaccine candidates inducing protective neutralizing antibodies

Autori: Catherine Fauvelle, Che C. Colpitts, Zhen-yong Keck, Brian G. Pierce, Steven K. H. Foung, Thomas F. Baumert
Pubblicato in: Expert Review of Vaccines, Numero 15/12, 2016, Pagina/e 1535-1544, ISSN 1476-0584
Editore: Future Drugs Ltd.
DOI: 10.1080/14760584.2016.1194759

Zooming in on liver zonation

Autori: Daniel J. Felmlee, Dominic Grün, Thomas F. Baumert
Pubblicato in: Hepatology, Numero 67/2, 2017, Pagina/e 784-787, ISSN 0270-9139
Editore: John Wiley & Sons Inc.
DOI: 10.1002/hep.29554

Editorial: Current Progress and Challenges in the Development of a B Cell Based Hepatitis C Virus Vaccine

Autori: Steven K. H. Foung, Thomas F. Baumert
Pubblicato in: Frontiers in Immunology, Numero 9, 2018, ISSN 1664-3224
Editore: -
DOI: 10.3389/fimmu.2018.02577

Targeting Innate and Adaptive Immune Responses to Cure Chronic HBV Infection

Autori: Adam J. Gehring, Ulrike Protzer
Pubblicato in: Gastroenterology, Numero 156/2, 2019, Pagina/e 325-337, ISSN 0016-5085
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2018.10.032

Genomic characterization of cholangiocarcinoma in primary sclerosing cholangitis reveals novel therapeutic opportunities

Autori: Benjamin Goeppert, Trine Folseraas, Stephanie Roessler, Matthias Kloor, Anna‐Lena Volckmar, Volker Endris, Ivo Buchhalter, Albrecht Stenzinger, Krzysztof Grzyb, Marit M. Grimsrud, Barbara Gornicka, Erik von Seth, Gary M. Reynolds, Andre Franke, Daniel N. Gotthardt, Arianeb Mehrabi, Angela Cheung, Joanne Verheij, Johanna Arola, Heikki Mäkisalo, Tor J. Eide, Sören Weidemann, John C. Cheville, Gi
Pubblicato in: Hepatology, 2020, ISSN 0270-9139
Editore: John Wiley & Sons Inc.
DOI: 10.1002/hep.31110

HCV-Induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response

Autori: Nourdine Hamdane, Frank Jühling, Emilie Crouchet, Houssein El Saghire, Christine Thumann, Marine A. Oudot, Simonetta Bandiera, Antonio Saviano, Clara Ponsolles, Armando Andres Roca Suarez, Shen Li, Naoto Fujiwara, Atsushi Ono, Irwin Davidson, Nabeel Bardeesy, Christian Schmidl, Christoph Bock, Catherine Schuster, Joachim Lupberger, François Habersetzer, Michel Doffoël, Tullio Piardi, Daniele So
Pubblicato in: Gastroenterology, Numero 156/8, 2019, Pagina/e 2313-2329.e7, ISSN 0016-5085
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2019.02.038

A New Role for Capsid Assembly Modulators To Target Mature Hepatitis B Virus Capsids and Prevent Virus Infection

Autori: Chunkyu Ko, Romina Bester, Xue Zhou, Zhiheng Xu, Christoph Blossey, Julia Sacherl, Florian W. R. Vondran, Lu Gao, Ulrike Protzer
Pubblicato in: Antimicrobial Agents and Chemotherapy, Numero 64/1, 2019, ISSN 0066-4804
Editore: American Society for Microbiology
DOI: 10.1128/aac.01440-19

Functional microRNA screen uncovers O-linked N-acetylglucosamine transferase as a host factor modulating hepatitis C virus morphogenesis and infectivity

Autori: Katharina Herzog, Simonetta Bandiera, Sophie Pernot, Catherine Fauvelle, Frank Jühling, Amélie Weiss, Anne Bull, Sarah C Durand, Béatrice Chane-Woon-Ming, Sébastien Pfeffer, Marion Mercey, Hervé Lerat, Jean-Christophe Meunier, Wolfgang Raffelsberger, Laurent Brino, Thomas F Baumert, Mirjam B Zeisel
Pubblicato in: Gut, Numero 69/2, 2020, Pagina/e 380-392, ISSN 0017-5749
Editore: BMJ Publishing Group
DOI: 10.1136/gutjnl-2018-317423

Revisiting Hepatitis B Virus: Challenges of Curative Therapies

Autori: Jianming Hu, Ulrike Protzer, Aleem Siddiqui
Pubblicato in: Journal of Virology, Numero 93/20, 2019, ISSN 0022-538X
Editore: American Society for Microbiology
DOI: 10.1128/jvi.01032-19

An E. coli-produced single-chain variable fragment (scFv) targeting hepatitis B virus surface protein potently inhibited virion secretion

Autori: Cheng Li, Yang Wang, Tiantian Liu, Matthias Niklasch, Ke Qiao, Sarah Durand, Li Chen, Mifang Liang, Thomas F. Baumert, Shuping Tong, Michael Nassal, Yu-Mei Wen, Yong-Xiang Wang
Pubblicato in: Antiviral Research, Numero 162, 2019, Pagina/e 118-129, ISSN 0166-3542
Editore: Elsevier BV
DOI: 10.1016/j.antiviral.2018.12.019

Randomized trials and endpoints in advanced HCC: Role of PFS as a surrogate of survival

Autori: Josep M. Llovet, Robert Montal, Augusto Villanueva
Pubblicato in: Journal of Hepatology, Numero 70/6, 2019, Pagina/e 1262-1277, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2019.01.028

Combined Analysis of Metabolomes, Proteomes, and Transcriptomes of Hepatitis C Virus–Infected Cells and Liver to Identify Pathways Associated With Disease Development

Autori: Joachim Lupberger, Tom Croonenborghs, Armando Andres Roca Suarez, Nicolaas Van Renne, Frank Jühling, Marine A. Oudot, Alessia Virzì, Simonetta Bandiera, Carole Jamey, Gergö Meszaros, Daniel Brumaru, Atish Mukherji, Sarah C. Durand, Laura Heydmann, Eloi R. Verrier, Hussein El Saghire, Nourdine Hamdane, Ralf Bartenschlager, Shaunt Fereshetian, Evelyn Ramberger, Rileen Sinha, Mohsen Nabian, Celine
Pubblicato in: Gastroenterology, Numero 157/2, 2019, Pagina/e 537-551.e9, ISSN 0016-5085
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2019.04.003

Toward novel immunocompetent animal models for hepatitis B virus infection

Autori: Laurent Mailly, Mirjam B. Zeisel, Thomas F. Baumert
Pubblicato in: Hepatology, Numero 66/3, 2017, Pagina/e 691-693, ISSN 0270-9139
Editore: John Wiley & Sons Inc.
DOI: 10.1002/hep.29249

In vivo combination of human anti-envelope glycoprotein E2 and -Claudin-1 monoclonal antibodies for prevention of hepatitis C virus infection

Autori: Laurent Mailly, Florian Wrensch, Laura Heydmann, Catherine Fauvelle, Nicolas Brignon, Mirjam B. Zeisel, Patrick Pessaux, Zhen-yong Keck, Catherine Schuster, Thomas R. Fuerst, Steven K.H. Foung, Thomas F. Baumert
Pubblicato in: Antiviral Research, Numero 162, 2019, Pagina/e 136-141, ISSN 0166-3542
Editore: Elsevier BV
DOI: 10.1016/j.antiviral.2018.12.018

The Innate Antiviral Response in Animals: An Evolutionary Perspective from Flagellates to Humans

Autori: Karim Majzoub, Florian Wrensch, Thomas F. Baumert
Pubblicato in: Viruses, Numero 11/8, 2019, Pagina/e 758, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v11080758

An Immune Gene Expression Signature Associated With Development of Human Hepatocellular Carcinoma Identifies Mice That Respond to Chemopreventive Agents

Autori: Agrin Moeini, Sara Torrecilla, Victoria Tovar, Carla Montironi, Carmen Andreu-Oller, Judit Peix, Mónica Higuera, Dominik Pfister, Pierluigi Ramadori, Roser Pinyol, Manel Solé, Mathias Heikenwälder, Scott L. Friedman, Daniela Sia, Josep M. Llovet
Pubblicato in: Gastroenterology, Numero 157/5, 2019, Pagina/e 1383-1397.e11, ISSN 0016-5085
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2019.07.028

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer

Autori: Mohsen Malehmir, Dominik Pfister, Suchira Gallage, Marta Szydlowska, Donato Inverso, Elena Kotsiliti, Valentina Leone, Moritz Peiseler, Bas G. J. Surewaard, Dominik Rath, Adnan Ali, Monika Julia Wolf, Hannah Drescher, Marc E. Healy, Daniel Dauch, Daniela Kroy, Oliver Krenkel, Marlene Kohlhepp, Thomas Engleitner, Alexander Olkus, Tjeerd Sijmonsma, Julia Volz, Carsten Deppermann, David Stegner, Patr
Pubblicato in: Nature Medicine, Numero 25/4, 2019, Pagina/e 641-655, ISSN 1078-8956
Editore: Nature Publishing Group
DOI: 10.1038/s41591-019-0379-5

The circadian clock and liver function in health and disease

Autori: Atish Mukherji, Shannon M. Bailey, Bart Staels, Thomas F. Baumert
Pubblicato in: Journal of Hepatology, Numero 71/1, 2019, Pagina/e 200-211, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2019.03.020

Molecular predictors of prevention of recurrence in HCC with sorafenib as adjuvant treatment and prognostic factors in the phase 3 STORM trial

Autori: Roser Pinyol, Robert Montal, Laia Bassaganyas, Daniela Sia, Tadatoshi Takayama, Gar-Yang Chau, Vincenzo Mazzaferro, Sasan Roayaie, Han Chu Lee, Norihiro Kokudo, Zhongyang Zhang, Sara Torrecilla, Agrin Moeini, Leonardo Rodriguez-Carunchio, Edward Gane, Chris Verslype, Adina Emilia Croitoru, Umberto Cillo, Manuel de la Mata, Luigi Lupo, Simone Strasser, Joong-Won Park, Jordi Camps, Manel Solé, Swan
Pubblicato in: Gut, Numero 68/6, 2019, Pagina/e 1065-1075, ISSN 0017-5749
Editore: BMJ Publishing Group
DOI: 10.1136/gutjnl-2018-316408

Immune Exclusion-Wnt/CTNNB1 Class Predicts Resistance to Immunotherapies in HCC

Autori: Roser Pinyol, Daniela Sia, Josep M. Llovet
Pubblicato in: Clinical Cancer Research, Numero 25/7, 2019, Pagina/e 2021-2023, ISSN 1078-0432
Editore: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-18-3778

Uncovering the mechanism of action of aspirin in HCC chemoprevention

Autori: Natascha Roehlen, Thomas F. Baumert
Pubblicato in: EBioMedicine, Numero 46, 2019, Pagina/e 21-22, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/j.ebiom.2019.07.047

β-Catenin Activation Promotes Immune Escape and Resistance to Anti–PD-1 Therapy in Hepatocellular Carcinoma

Autori: Marina Ruiz de Galarreta, Erin Bresnahan, Pedro Molina-Sánchez, Katherine E. Lindblad, Barbara Maier, Daniela Sia, Marc Puigvehi, Verónica Miguela, María Casanova-Acebes, Maxime Dhainaut, Carlos Villacorta-Martin, Aatur D. Singhi, Akshata Moghe, Johann von Felden, Lauren Tal Grinspan, Shuang Wang, Alice O. Kamphorst, Satdarshan P. Monga, Brian D. Brown, Augusto Villanueva, Josep M. Llovet, Miri
Pubblicato in: Cancer Discovery, Numero 9/8, 2019, Pagina/e 1124-1141, ISSN 2159-8274
Editore: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-19-0074

Oxidative Stress Triggers Selective tRNA Retrograde Transport in Human Cells during the Integrated Stress Response

Autori: Schwenzer, H.; Jühling, F.; Chu, A.; Pallett, L. J.; Baumert, T. F.; Maini, M.; Fassati, A.
Pubblicato in: Cell Reports , 26 (12) 3416-3428.e5. (2019), Numero 10, 2019
Editore: -

Follicular T helper cells shape the HCV-specific CD4+ T cell repertoire after virus elimination

Autori: Maike Smits, Katharina Zoldan, Naveed Ishaque, Zuguang Gu, Katharina Jechow, Dominik Wieland, Christian Conrad, Roland Eils, Catherine Fauvelle, Thomas F. Baumert, Florian Emmerich, Bertram Bengsch, Christoph Neumann-Haefelin, Maike Hofmann, Robert Thimme, Tobias Boettler
Pubblicato in: Journal of Clinical Investigation, Numero 130/2, 2019, Pagina/e 998-1009, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci129642

Inefficient induction of circulating TAA-specific CD8+ T-cell responses in hepatocellular carcinoma

Autori: Catrin Tauber, Liangliang Hao, Kaelyn Brown, Jihoon Lim, Sangeeta N. Bhatia, Frank J. Slack
Pubblicato in: Oncotarget, Numero 10/50, 2019, ISSN 1949-2553
Editore: Impact Journals
DOI: 10.18632/oncotarget.27146

Broad neutralization of hepatitis C virus-resistant variants by Civacir hepatitis C immunoglobulin

Autori: Rajiv G. Tawar, Laura Heydmann, Charlotte Bach, Jörg Schüttrumpf, Shailesh Chavan, Barnabas J. King, C. Patrick McClure, Jonathan K. Ball, Patrick Pessaux, François Habersetzer, Ralf Bartenschlager, Mirjam B. Zeisel, Thomas F. Baumert
Pubblicato in: Hepatology, Numero 64/5, 2016, Pagina/e 1495-1506, ISSN 0270-9139
Editore: John Wiley & Sons Inc.
DOI: 10.1002/hep.28767

Hepatitis B Virus–Hepatocyte Interactions and Innate Immune Responses: Experimental Models and Molecular Mechanisms

Autori: Emmanuel Thomas, Thomas F. Baumert
Pubblicato in: Seminars in Liver Disease, Numero 39/03, 2019, Pagina/e 301-314, ISSN 0272-8087
Editore: Thieme Medical Publishers
DOI: 10.1055/s-0039-1685518

Cell Culture Models for the Investigation of Hepatitis B and D Virus Infection

Autori: Eloi Verrier, Che Colpitts, Catherine Schuster, Mirjam Zeisel, Thomas Baumert
Pubblicato in: Viruses, Numero 8/9, 2016, Pagina/e 261, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v8090261

Hepatitis B virus receptors and molecular drug targets

Autori: Eloi R. Verrier, Che C. Colpitts, Camille Sureau, Thomas F. Baumert
Pubblicato in: Hepatology International, Numero 10/4, 2016, Pagina/e 567-573, ISSN 1936-0533
Editore: Springer Pub. Co.
DOI: 10.1007/s12072-016-9718-5

Combined small molecule and loss-of-function screen uncovers estrogen receptor alpha and CAD as host factors for HDV infection and antiviral targets

Autori: Eloi R Verrier, Amélie Weiss, Charlotte Bach, Laura Heydmann, Vincent Turon-Lagot, Arnaud Kopp, Houssein El Saghire, Emilie Crouchet, Patrick Pessaux, Thomas Garcia, Patrick Pale, Mirjam B Zeisel, Camille Sureau, Catherine Schuster, Laurent Brino, Thomas F Baumert
Pubblicato in: Gut, Numero 69/1, 2019, Pagina/e 158-167, ISSN 0017-5749
Editore: BMJ Publishing Group
DOI: 10.1136/gutjnl-2018-317065

Oncogenic Signaling Induced by HCV Infection

Autori: Alessia Virzì, Armando Roca Suarez, Thomas Baumert, Joachim Lupberger
Pubblicato in: Viruses, Numero 10/10, 2018, Pagina/e 538, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v10100538

Rewiring Host Signaling: Hepatitis C Virus in Liver Pathogenesis

Autori: Alessia Virzì, Armando Andres Roca Suarez, Thomas F. Baumert, Joachim Lupberger
Pubblicato in: Cold Spring Harbor Perspectives in Medicine, Numero 10/1, 2020, Pagina/e a037366, ISSN 2157-1422
Editore: -
DOI: 10.1101/cshperspect.a037366

A dual role for SAMHD1 in regulating HBV cccDNA and RT-dependent particle genesis

Autori: Peter AC Wing, Tamara Davenne, Jochen Wettengel, Alvina G Lai, Xiaodong Zhuang, Anindita Chakraborty, Valentina D’Arienzo, Catharina Kramer, Chunkyu Ko, James M Harris, Sabrina Schreiner, Martin Higgs, Stephanie Roessler, Joanna L Parish, Ulrike Protzer, Peter Balfe, Jan Rehwinkel, Jane A McKeating
Pubblicato in: Life Science Alliance, Numero 2/2, 2019, Pagina/e e201900355, ISSN 2575-1077
Editore: -
DOI: 10.26508/lsa.201900355

Radiomics in hepatocellular carcinoma: a quantitative review

Autori: Taiga Wakabayashi, Farid Ouhmich, Cristians Gonzalez-Cabrera, Emanuele Felli, Antonio Saviano, Vincent Agnus, Peter Savadjiev, Thomas F. Baumert, Patrick Pessaux, Jacques Marescaux, Benoit Gallix
Pubblicato in: Hepatology International, Numero 13/5, 2019, Pagina/e 546-559, ISSN 1936-0533
Editore: Springer Pub. Co.
DOI: 10.1007/s12072-019-09973-0

Learning from a clinical cohort for HCV vaccine development

Autori: Florian Wrensch, Zhen-yong Keck, Steven K.H. Foung, Thomas F. Baumert
Pubblicato in: Journal of Hepatology, Numero 71/1, 2019, Pagina/e 9-11, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2019.03.030

Hepatitis B virus: is a cure possible?

Autori: Mirjam B. Zeisel, Thomas F. Baumert
Pubblicato in: Expert Review of Clinical Pharmacology, Numero 9/9, 2016, Pagina/e 1129-1130, ISSN 1751-2433
Editore: Future Drugs Ltd.
DOI: 10.1080/17512433.2016.1206466

Translation and protein expression of lncRNAs: Impact for liver disease and hepatocellular carcinoma

Autori: Mirjam B. Zeisel, Thomas F. Baumert
Pubblicato in: Hepatology, Numero 64/2, 2016, Pagina/e 671-674, ISSN 0270-9139
Editore: John Wiley & Sons Inc.
DOI: 10.1002/hep.28653

Platelets in chronic liver disease, from bench to bedside

Autori: Pierluigi Ramadori, Thomas Klag, Nisar Peter Malek, Mathias Heikenwalder
Pubblicato in: JHEP Reports, Numero 1/6, 2019, Pagina/e 448-459, ISSN 2589-5559
Editore: -
DOI: 10.1016/j.jhepr.2019.10.001

Molecular portrait of high alpha-fetoprotein in hepatocellular carcinoma: implications for biomarker-driven clinical trials

Autori: Robert Montal, Carmen Andreu-Oller, Laia Bassaganyas, Roger Esteban-Fabró, Sebastián Moran, Carla Montironi, Agrin Moeini, Roser Pinyol, Judit Peix, Laia Cabellos, Augusto Villanueva, Daniela Sia, Vincenzo Mazzaferro, Manel Esteller, Josep M. Llovet
Pubblicato in: British Journal of Cancer, Numero 121/4, 2019, Pagina/e 340-343, ISSN 0007-0920
Editore: Nature Publishing Group
DOI: 10.1038/s41416-019-0513-7

Mortality from liver cirrhosis and HCC in the DAA era: success in viral control is darkened by raise of metabolic disease

Autori: Antonio Saviano, Thomas F. Baumert
Pubblicato in: HepatoBiliary Surgery and Nutrition, Numero 8/3, 2019, Pagina/e 307-310, ISSN 2304-3881
Editore: -
DOI: 10.21037/hbsn.2019.01.21

Single-cell RNA-Seq of HBV-induced hepatocellular carcinoma reveals viral compartmentalization and cancer heterogeneity

Autori: Jühling F, Verrier ER, Saviano A , El Saghire H, Heydmann H, Pessaux P, Pochet N, Schuster C, Baumert TF.
Pubblicato in: J Clin Invest, Numero in revision, 2020
Editore: -

Hepatitis C Virus-Induced Upregulation of MicroRNA miR-146a-5p in Hepatocytes Promotes Viral Infection and Deregulates Metabolic Pathways Associated with Liver Disease Pathogenesis

Autori: Simonetta Bandiera, Sophie Pernot, Hussein El Saghire, Sarah C. Durand, Christine Thumann, Emilie Crouchet, Tao Ye, Isabel Fofana, Marine A. Oudot, Jochen Barths, Catherine Schuster, Patrick Pessaux, Markus H. Heim, Thomas F. Baumert, Mirjam B. Zeisel
Pubblicato in: Journal of Virology, Numero 90/14, 2016, Pagina/e 6387-6400, ISSN 0022-538X
Editore: American Society for Microbiology
DOI: 10.1128/JVI.00619-16

N-Glycosylation of the Na+-Taurocholate Cotransporting Polypeptide (NTCP) Determines Its Trafficking and Stability and Is Required for Hepatitis B Virus Infection

Autori: Monique D. Appelman, Anindita Chakraborty, Ulrike Protzer, Jane A. McKeating, Stan F. J. van de Graaf
Pubblicato in: PLOS ONE, Numero 12/1, 2017, Pagina/e e0170419, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0170419

Hepatitis C-related hepatocellular carcinoma in the era of new generation antivirals

Autori: Thomas F. Baumert, Frank Jühling, Atsushi Ono, Yujin Hoshida
Pubblicato in: BMC Medicine, Numero 15/1, 2017, ISSN 1741-7015
Editore: BioMed Central
DOI: 10.1186/s12916-017-0815-7

Palbociclib (PD-0332991), a selective CDK4/6 inhibitor, restricts tumour growth in preclinical models of hepatocellular carcinoma

Autori: Julien Bollard, Verónica Miguela, Marina Ruiz de Galarreta, Anu Venkatesh, C Billie Bian, Mark P Roberto, Victoria Tovar, Daniela Sia, Pedro Molina-Sánchez, Christie B Nguyen, Shigeki Nakagawa, Josep M Llovet, Yujin Hoshida, Amaia Lujambio
Pubblicato in: Gut, Numero 66/7, 2017, Pagina/e 1286-1296, ISSN 0017-5749
Editore: BMJ Publishing Group
DOI: 10.1136/gutjnl-2016-312268

Humanisation of a claudin-1-specific monoclonal antibody for clinical prevention and cure of HCV infection without escape

Autori: Che C Colpitts, Rajiv G Tawar, Laurent Mailly, Christine Thumann, Laura Heydmann, Sarah C Durand, Fei Xiao, Eric Robinet, Patrick Pessaux, Mirjam B Zeisel, Thomas F Baumert
Pubblicato in: Gut, Numero pii: gutjnl-2016-312577, 2017, Pagina/e gutjnl-2016-312577, ISSN 0017-5749
Editore: BMJ Publishing Group
DOI: 10.1136/gutjnl-2016-312577

Multifaceted role of E-cadherin in hepatitis C virus infection and pathogenesis

Autori: Che C. Colpitts, Joachim Lupberger, Thomas F. Baumert
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 113/27, 2016, Pagina/e 7298-7300, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1607732113

SMAD About Hepatitis C Virus Cell Entry and Liver Disease

Autori: Che C. Colpitts, Thomas F. Baumert
Pubblicato in: Gastroenterology, Numero 152/1, 2017, Pagina/e 21-23, ISSN 0016-5085
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2016.11.029

SCARB1 variants and HCV infection: Host susceptibility is lost in translation

Autori: Che C. Colpitts, Thomas F. Baumert
Pubblicato in: Journal of Hepatology, Numero 67(2), 2017, Pagina/e 211-213, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2017.04.013

Extracellular lipid-free apolipoprotein E inhibits HCV replication and induces ABCG1-dependent cholesterol efflux

Autori: Emilie Crouchet, Mathieu Lefèvre, Eloi R Verrier, Marine A Oudot, Thomas F Baumert, Catherine Schuster
Pubblicato in: Gut, Numero 66/5, 2017, Pagina/e 896-907, ISSN 0017-5749
Editore: BMJ Publishing Group
DOI: 10.1136/gutjnl-2015-311289

Autotaxin-lysophosphatidic acid receptor signalling regulates hepatitis C virus replication

Autori: Michelle J. Farquhar, Isla S. Humphreys, Simon A. Rudge, Garrick K. Wilson, Bishnupriya Bhattacharya, Maria Ciaccia, Ke Hu, Qifeng Zhang, Laurent Mailly, Gary M. Reynolds, Margaret Ashcroft, Peter Balfe, Thomas F. Baumert, Stephanie Roessler, Michael J.O. Wakelam, Jane A. McKeating
Pubblicato in: Journal of Hepatology, Numero 66/5, 2017, Pagina/e 919-929, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2017.01.009

The Measles Virus Receptor SLAMF1 Can Mediate Particle Endocytosis

Autori: Daniel Gonçalves-Carneiro, Jane A. McKeating, Dalan Bailey
Pubblicato in: Journal of Virology, Numero 91/7, 2017, Pagina/e e02255-16, ISSN 0022-538X
Editore: American Society for Microbiology
DOI: 10.1128/JVI.02255-16

Tracking HCV protease population diversity during transmission and susceptibility of founder populations to antiviral therapy

Autori: Tanvi Khera, Daniel Todt, Koen Vercauteren, C. Patrick McClure, Lieven Verhoye, Ali Farhoudi, Sabin Bhuju, Robert Geffers, Thomas F. Baumert, Eike Steinmann, Philip Meuleman, Thomas Pietschmann, Richard J.P. Brown
Pubblicato in: Antiviral Research, Numero 139, 2017, Pagina/e 129-137, ISSN 0166-3542
Editore: Elsevier BV
DOI: 10.1016/j.antiviral.2017.01.001

Objective response by mRECIST as a predictor and potential surrogate end-point of overall survival in advanced HCC

Autori: Riccardo Lencioni, Robert Montal, Ferran Torres, Joong-Won Park, Thomas Decaens, Jean-Luc Raoul, Masatoshi Kudo, Charissa Chang, José Ríos, Valerie Boige, Eric Assenat, Yoon-Koo Kang, Ho-Yeong Lim, Ian Walters, Josep M. Llovet
Pubblicato in: Journal of Hepatology, Numero 66/6, 2017, Pagina/e 1166-1172, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2017.01.012

Hepatocellular carcinoma

Autori: Josep M. Llovet, Jessica Zucman-Rossi, Eli Pikarsky, Bruno Sangro, Myron Schwartz, Morris Sherman, Gregory Gores
Pubblicato in: Nature Reviews Disease Primers, Numero 2, 2016, Pagina/e 16018, ISSN 2056-676X
Editore: -
DOI: 10.1038/nrdp.2016.18

Plasmodium P36 determines host cell receptor usage during sporozoite invasion

Autori: Giulia Manzoni, Carine Marinach, Selma Topçu, Sylvie Briquet, Morgane Grand, Matthieu Tolle, Marion Gransagne, Julien Lescar, Chiara Andolina, Jean-François Franetich, Mirjam B Zeisel, Thierry Huby, Eric Rubinstein, Georges Snounou, Dominique Mazier, François Nosten, Thomas F Baumert, Olivier Silvie
Pubblicato in: eLife, Numero 6, 2017, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/eLife.25903

IGF2 Is Up-regulated by Epigenetic Mechanisms in Hepatocellular Carcinomas and Is an Actionable Oncogene Product in Experimental Models

Autori: Iris Martinez-Quetglas, Roser Pinyol, Daniel Dauch, Sara Torrecilla, Victoria Tovar, Agrin Moeini, Clara Alsinet, Anna Portela, Leonardo Rodriguez-Carunchio, Manel Solé, Amaia Lujambio, Augusto Villanueva, Swan Thung, Manel Esteller, Lars Zender, Josep M. Llovet
Pubblicato in: Gastroenterology, Numero 151/6, 2016, Pagina/e 1192-1205, ISSN 0016-5085
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2016.09.001

Mixed hepatocellular cholangiocarcinoma tumors: Cholangiolocellular carcinoma is a distinct molecular entity

Autori: Agrin Moeini, Daniela Sia, Zhongyang Zhang, Genis Camprecios, Ashley Stueck, Hui Dong, Robert Montal, Laura Torrens, Iris Martinez-Quetglas, M. Isabel Fiel, Ke Hao, Augusto Villanueva, Swan N. Thung, Myron E. Schwartz, Josep M. Llovet
Pubblicato in: Journal of Hepatology, Numero 66/5, 2017, Pagina/e 952-961, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2017.01.010

Viral hepatitis and liver cancer

Autori: Marc Ringehan, Jane A. McKeating, Ulrike Protzer
Pubblicato in: Philosophical Transactions of the Royal Society B: Biological Sciences, Numero 372/1732, 2017, Pagina/e 20160274, ISSN 0962-8436
Editore: Royal Society of London
DOI: 10.1098/rstb.2016.0274

Molecular Pathogenesis and Targeted Therapies for Intrahepatic Cholangiocarcinoma

Autori: A. Moeini, D. Sia, N. Bardeesy, V. Mazzaferro, J. M. Llovet
Pubblicato in: Clinical Cancer Research, Numero 22/2, 2016, Pagina/e 291-300, ISSN 1078-0432
Editore: American Association for Cancer Research
DOI: 10.1158/1078-0432.CCR-14-3296

Identification of an Immune-specific Class of Hepatocellular Carcinoma, Based on Molecular Features

Autori: Daniela Sia, Yang Jiao, Iris Martinez-Quetglas, Olga Kuchuk, Carlos Villacorta-Martin, Manuel Castro de Moura, Juan Putra, Genis Camprecios, Laia Bassaganyas, Nicholas Akers, Bojan Losic, Samuel Waxman, Swan N. Thung, Vincenzo Mazzaferro, Manel Esteller, Scott L. Friedman, Myron Schwartz, Augusto Villanueva, Josep M. Llovet
Pubblicato in: Gastroenterology, Numero pii: S0016-5085(17)35741-4, 2017, ISSN 0016-5085
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2017.06.007

Imaging-based surrogate markers of transcriptome subclasses and signatures in hepatocellular carcinoma: preliminary results

Autori: Bachir Taouli, Yujin Hoshida, Suguru Kakite, Xintong Chen, Poh Seng Tan, Xiaochen Sun, Shingo Kihira, Kensuke Kojima, Sara Toffanin, M. Isabel Fiel, Hadassa Hirschfield, Mathilde Wagner, Josep M. Llovet
Pubblicato in: European Radiology, 2017, ISSN 0938-7994
Editore: Springer Verlag
DOI: 10.1007/s00330-017-4844-6

Liver Cancer Cell of Origin, Molecular Class, and Effects on Patient Prognosis

Autori: Daniela Sia, Augusto Villanueva, Scott L. Friedman, Josep M. Llovet
Pubblicato in: Gastroenterology, Numero 152/4, 2017, Pagina/e 745-761, ISSN 0016-5085
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2016.11.048

Tumour initiating cells and IGF/FGF signalling contribute to sorafenib resistance in hepatocellular carcinoma

Autori: Victoria Tovar, Helena Cornella, Agrin Moeini, Samuel Vidal, Yujin Hoshida, Daniela Sia, Judit Peix, Laia Cabellos, Clara Alsinet, Sara Torrecilla, Iris Martinez-Quetglas, Juan José Lozano, Christèle Desbois-Mouthon, Manel Solé, Josep Domingo-Domenech, Augusto Villanueva, Josep M Llovet
Pubblicato in: Gut, Numero 66/3, 2017, Pagina/e 530-540, ISSN 0017-5749
Editore: BMJ Publishing Group
DOI: 10.1136/gutjnl-2015-309501

Advancing hepatitis B virus entry inhibitors

Autori: Eloi R. Verrier, Catherine Schuster, Thomas F. Baumert
Pubblicato in: Journal of Hepatology, Numero 66/4, 2017, Pagina/e 677-679, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2016.11.028

Solute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of Hepatocytes

Autori: Eloi R. Verrier, Che C. Colpitts, Charlotte Bach, Laura Heydmann, Laetitia Zona, Fei Xiao, Christine Thumann, Emilie Crouchet, Raphaël Gaudin, Camille Sureau, François-Loïc Cosset, Jane A. McKeating, Patrick Pessaux, Yujin Hoshida, Catherine Schuster, Mirjam B. Zeisel, Thomas F. Baumert
Pubblicato in: Cell Reports, Numero 17/5, 2016, Pagina/e 1357-1368, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2016.09.084

miR-135a-5p-mediated downregulation of protein tyrosine phosphatase receptor delta is a candidate driver of HCV-associated hepatocarcinogenesis

Autori: Nicolaas Van Renne, Armando Andres Roca Suarez, Francois H T Duong, Claire Gondeau, Diego Calabrese, Nelly Fontaine, Amina Ababsa, Simonetta Bandiera, Tom Croonenborghs, Nathalie Pochet, Vito De Blasi, Patrick Pessaux, Tullio Piardi, Daniele Sommacale, Atsushi Ono, Kazuaki Chayama, Masashi Fujita, Hidewaki Nakagawa, Yujin Hoshida, Mirjam B Zeisel, Markus H Heim, Thomas F Baumert, Joachim Lupberger
Pubblicato in: Gut, Numero pii: gutjnl-2016-312270, 2017, Pagina/e gutjnl-2016-312270, ISSN 0017-5749
Editore: BMJ Publishing Group
DOI: 10.1136/gutjnl-2016-312270

Multimodal imaging of a humanized orthotopic model of hepatocellular carcinoma in immunodeficient mice

Autori: Tao Wu, Emilie Heuillard, Véronique Lindner, Ghina Bou About, Mihaela Ignat, Jean-Philippe Dillenseger, Nicolas Anton, Eugénie Dalimier, Francine Gossé, Gael Fouré, Franck Blindauer, Céline Giraudeau, Hussein El-Saghire, Mourad Bouhadjar, Cynthia Calligaro, Tania Sorg, Philippe Choquet, Thierry Vandamme, Christophe Ferrand, Jacques Marescaux, Thomas F. Baumert, Michele Diana, Patrick Pessaux,
Pubblicato in: Scientific Reports, Numero 6/1, 2016, Pagina/e 35230, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/srep35230

Hepatitis Delta Virus histone mimicry drives the recruitment of chromatin remodelers for viral RNA replication

Autori: Natali Abeywickrama-Samarakoon, Jean-Claude Cortay, Camille Sureau, Susanne Müller, Dulce Alfaiate, Francesca Guerrieri, Apirat Chaikuad, Martin Schröder, Philippe Merle, Massimo Levrero, Paul Dény
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-14299-9

Hepatitis B protein HBx binds the DLEU2 lncRNA to sustain cccDNA and host cancer-related gene transcription

Autori: Debora Salerno, Letizia Chiodo, Vincenzo Alfano, Oceane Floriot, Grazia Cottone, Alexia Paturel, Matteo Pallocca, Marie-Laure Plissonnier, Safaa Jeddari, Laura Belloni, Mirjam Zeisel, Massimo Levrero, Francesca Guerrieri
Pubblicato in: Gut, 2020, Pagina/e gutjnl-2019-319637, ISSN 0017-5749
Editore: BMJ Publishing Group
DOI: 10.1136/gutjnl-2019-319637

Perspectives and limitations for nucleo(t)side analogs in future HBV therapies

Autori: Massimo Levrero, Miroslava Subic, Francois Villeret, Fabien Zoulim
Pubblicato in: Current Opinion in Virology, Numero 30, 2018, Pagina/e 80-89, ISSN 1879-6257
Editore: Elsevier BV
DOI: 10.1016/j.coviro.2018.04.006

Mechanisms of HBV-induced hepatocellular carcinoma

Autori: Massimo Levrero, Jessica Zucman-Rossi
Pubblicato in: Journal of Hepatology, Numero 64/1, 2016, Pagina/e S84-S101, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2016.02.021

The histone deacetylase inhibiting drug Entinostat induces lipid accumulation in differentiated HepaRG cells

Autori: Abigail D. G. Nunn, Tullio Scopigno, Natalia Pediconi, Massimo Levrero, Henning Hagman, Juris Kiskis, Annika Enejder
Pubblicato in: Scientific Reports, Numero 6/1, 2016, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/srep28025

Non-Coding RNAs and Hepatitis C Virus-Induced Hepatocellular Carcinoma

Autori: Marie-Laure Plissonnier, Katharina Herzog, Massimo Levrero, Mirjam Zeisel
Pubblicato in: Viruses, Numero 10/11, 2018, Pagina/e 591, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v10110591

Challenges to a Cure for HBV Infection

Autori: Barbara Testoni, Massimo Levrero, Fabien Zoulim
Pubblicato in: Seminars in Liver Disease, Numero 37/03, 2017, Pagina/e 231-242, ISSN 0272-8087
Editore: Thieme Medical Publishers
DOI: 10.1055/s-0037-1606212

miR-122-regulated metabolic circuits: micro-management of lipid metabolism in the human liver

Autori: Mirjam B. Zeisel, Marie-Laure Plissonnier, Massimo Levrero
Pubblicato in: Non-coding RNA Investigation, Numero 2, 2018, Pagina/e 45-45, ISSN 2522-6673
Editore: -
DOI: 10.21037/ncri.2018.07.02

NOTCH target gene HES5 mediates oncogenic and tumor suppressive functions in hepatocarcinogenesis.

Autori: Luiken S, Fraas A, Bieg M, Sugiyanto R, Goeppert B, Singer S, Ploeger C, Warsow G, Marquardt JU, Sticht C, De La Torre C, Pusch S, Mehrabi A, Gretz N, Schlesner M, Eils R, Schirmacher P, Longerich T, Roessler S.
Pubblicato in: Oncogene, Numero conditionally accepted, 2020
Editore: -

Diritti di proprietà intellettuale

CLINICAL GENE SIGNATURE-BASED HUMAN CELL CULTURE MODEL AND USES THEREOF

Numero candidatura/pubblicazione: 20 16059477
Data: 2016-04-28
Candidato/i: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

HUMANIZED ANTI-CLAUDIN-1 ANTIBODIES AND USES THEREOF

Numero candidatura/pubblicazione: 20 17056703
Data: 2017-03-21
Candidato/i: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

DISINTEGRATABLE POROUS ORGANOSILICA OR ORGANOMETALOXIDE NANOPARTICLES AND USES THEREOF AS VEHICLE FOR CONTROLLED DELIVERY OF siRNA

Numero candidatura/pubblicazione: 20 18055829
Data: 2018-03-08
Candidato/i: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

ANTI-CLAUDIN 1 ANTIBODIES FOR USE IN THE TREATMENT OF COLORECTAL CANCER

Numero candidatura/pubblicazione: 20 14065676
Data: 2014-07-22
Candidato/i: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

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