Comorbidity and Synapse Biology in Clinically Overlapping Psychiatric Disorders

Información del proyecto

COSYN

Identificador del acuerdo de subvención: 667301

DOI

10.3030/667301

Proyecto cerrado

Fecha de la firma de la CE 9 Diciembre 2015

Fecha de inicio 1 Enero 2016

Fecha de finalización 31 Diciembre 2020

Financiado con arreglo a

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coste total

€ 6 000 000,00

Aportación de la UE

€ 5 925 000,00

Coordinado por

KAROLINSKA INSTITUTET
Sweden

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Other (2)

Public lectures on synapses in human neuronal networks

Key note speaker on public conferences in European countries explaining the methods involved to the general public

Open access (public) conference on COSYN results & focus with patients and caregivers

Public conference: especially invited guests are patients and caregivers. Outcome of results discussions.

Documents, reports (2)

Report on outreach activities internal and external

Report on outreach activities: scientific and general public

Outreach activities (debate) on the philosophy of using patient-own cells for a new generation of cellular models

Science cafe setting debate in at least two European countries

Publicaciones

Peer reviewed articles (20)

Induced pluripotent stem cell-based modeling of neurodegenerative diseases: a focus on autophagy

Autores: Johannes Jungverdorben, Andreas Till, Oliver Brüstle
Publicado en: Journal of Molecular Medicine, Edición 95/7, 2017, Página(s) 705-718, ISSN 0946-2716
Editor: Springer Verlag
DOI: 10.1007/s00109-017-1533-5

Defining the Genetic, Genomic, Cellular, and Diagnostic Architectures of Psychiatric Disorders

Autores: Patrick F. Sullivan, Daniel H. Geschwind
Publicado en: Cell, Edición 177/1, 2019, Página(s) 162-183, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2019.01.015

Polygenic burden has broader impact on health, cognition, and socioeconomic outcomes than most rare and high-risk copy number variants

Autores: Elmo Christian Saarentaus, Aki Samuli Havulinna, Nina Mars, Ari Ahola-Olli, Tuomo Tapio Johannes Kiiskinen, Juulia Partanen, Sanni Ruotsalainen, Mitja Kurki, Lea Martta Urpa, Lei Chen, Markus Perola, Veikko Salomaa, Juha Veijola, Minna Männikkö, Ira M. Hall, Olli Pietiläinen, Jaakko Kaprio, Samuli Ripatti, Mark Daly, Aarno Palotie
Publicado en: Molecular Psychiatry, 2021, ISSN 1359-4184
Editor: Nature Publishing Group
DOI: 10.1038/s41380-021-01026-z

Notch/Hes signaling and miR-9 engage in complex feedback interactions controlling neural progenitor cell proliferation and differentiation

Autores: Beate Roese-Koerner, Laura Stappert, Oliver Brüstle
Publicado en: Neurogenesis, Edición 4/1, 2017, Página(s) e1313647, ISSN 2326-2133
Editor: Taylor & Francis
DOI: 10.1080/23262133.2017.1313647

A Single-Cell Model for Synaptic Transmission and Plasticity in Human iPSC-Derived Neurons

Autores: Marieke Meijer, Kristina Rehbach, Jessie W. Brunner, Jessica A. Classen, Hanna C.A. Lammertse, Lola A. van Linge, Desiree Schut, Tamara Krutenko, Matthias Hebisch, L. Niels Cornelisse, Patrick F. Sullivan, Michael Peitz, Ruud F. Toonen, Oliver Brüstle, Matthijs Verhage
Publicado en: Cell Reports, Edición 27/7, 2019, Página(s) 2199-2211.e6, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2019.04.058

Modeling psychiatric disorders: from genomic findings to cellular phenotypes

Autores: A Falk, V M Heine, A J Harwood, P F Sullivan, M Peitz, O Brüstle, S Shen, Y-M Sun, J C Glover, D Posthuma, S Djurovic
Publicado en: Molecular Psychiatry, Edición 21/9, 2016, Página(s) 1167-1179, ISSN 1359-4184
Editor: Nature Publishing Group
DOI: 10.1038/mp.2016.89

Assessment of established techniques to determine developmental and malignant potential of human pluripotent stem cells

Autores: The International Stem Cell Initiative: Allison, T.F., Andrews, P.W., Avior, Y., Barbaric, I., Benvenisty, N., Bock, C., Brehm, J., Brüstle, O., Damjanov, I., Elefanty, A., Felkner, D., Gokhale, P.J., Halbritter, F., Healy, L.E., Hu, T.X., Knowles, B.B., Loring, J.F., Ludwig, T.E., Mayberry, R., Micallef, S., Mohamed, J.S., Müller, F.-J., Mummery, C.L., Nakatsuji, N., Ng, E.S., Oh, S.K.W., O’S
Publicado en: Nature Communications, Edición 9/1, 2018, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-018-04011-3

Increasing the Clinical Psychiatric Knowledge Base About Pathogenic Copy Number Variation

Autores: Patrick F. Sullivan, Michael J. Owen
Publicado en: American Journal of Psychiatry, Edición 177/3, 2020, Página(s) 204-209, ISSN 0002-953X
Editor: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.2019.19040335

Evolving principles underlying neural lineage conversion and their relevance for biomedical translation

Autores: Lea Jessica Flitsch, Oliver Brüstle
Publicado en: F1000Research, Edición 8, 2019, Página(s) 1548, ISSN 2046-1402
Editor: F1000 Research Ltd.
DOI: 10.12688/f1000research.18926.1

Whole-brain 3D mapping of human neural transplant innervation

Autores: Jonas Doerr, Martin Karl Schwarz, Dirk Wiedermann, Anke Leinhaas, Alina Jakobs, Florian Schloen, Inna Schwarz, Michael Diedenhofen, Nils Christian Braun, Philipp Koch, Daniel A. Peterson, Ulrich Kubitscheck, Mathias Hoehn, Oliver Brüstle
Publicado en: Nature Communications, Edición 8/1, 2017, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/ncomms14162

An Autaptic Culture System for Standardized Analyses of iPSC-Derived Human Neurons

Autores: Hong Jun Rhee, Ali H. Shaib, Kristina Rehbach, ChoongKu Lee, Peter Seif, Carolina Thomas, Erinn Gideons, Anja Guenther, Tamara Krutenko, Matthias Hebisch, Michael Peitz, Nils Brose, Oliver Brüstle, Jeong Seop Rhee
Publicado en: Cell Reports, Edición 27/7, 2019, Página(s) 2212-2228.e7, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2019.04.059

Homozygous STXBP1 variant causes encephalopathy and gain-of-function in synaptic transmission

Autores: Hanna C A Lammertse, Annemiek A van Berkel, Michele Iacomino, Ruud F Toonen, Pasquale Striano, Antonio Gambardella, Matthijs Verhage, Federico Zara
Publicado en: Brain, Edición 143/2, 2019, Página(s) 441-451, ISSN 0006-8950
Editor: Oxford University Press
DOI: 10.1093/brain/awz391

Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers

Autores: Nina Mars, Jukka T. Koskela, Pietari Ripatti, Tuomo T. J. Kiiskinen, Aki S. Havulinna, Joni V. Lindbohm, Ari Ahola-Olli, Mitja Kurki, Juha Karjalainen, Priit Palta, Benjamin M. Neale, Mark Daly, Veikko Salomaa, Aarno Palotie, Elisabeth Widén, Samuli Ripatti
Publicado en: Nature Medicine, Edición 26/4, 2020, Página(s) 549-557, ISSN 1078-8956
Editor: Nature Publishing Group
DOI: 10.1038/s41591-020-0800-0

Contribution of rare and common variants to intellectual disability in a sub-isolate of Northern Finland

Autores: Mitja I. Kurki, Elmo Saarentaus, Olli Pietiläinen, Padhraig Gormley, Dennis Lal, Sini Kerminen, Minna Torniainen-Holm, Eija Hämäläinen, Elisa Rahikkala, Riikka Keski-Filppula, Merja Rauhala, Satu Korpi-Heikkilä, Jonna Komulainen–Ebrahim, Heli Helander, Päivi Vieira, Minna Männikkö, Markku Peltonen, Aki S. Havulinna, Veikko Salomaa, Matti Pirinen, Jaana Suvisaari, Jukka S. Moilanen, Jarmo
Publicado en: Nature Communications, Edición 10/1, 2019, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-018-08262-y

Transcription Factor-Based Fate Specification and Forward Programming for Neural Regeneration

Autores: Lea J. Flitsch, Karen E. Laupman, Oliver Brüstle
Publicado en: Frontiers in Cellular Neuroscience, Edición 14, 2020, ISSN 1662-5102
Editor: Frontiers Research Foundation
DOI: 10.3389/fncel.2020.00121

The role of polygenic risk and susceptibility genes in breast cancer over the course of life

Autores: Nina Mars, Elisabeth Widén, Sini Kerminen, Tuomo Meretoja, Matti Pirinen, Pietro della Briotta Parolo, Priit Palta, Aarno Palotie, Jaakko Kaprio, Heikki Joensuu, Mark Daly, Samuli Ripatti
Publicado en: Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-19966-5

ANGPTL8 protein-truncating variant associated with lower serum triglycerides and risk of coronary disease

Autores: Pyry Helkkula, Tuomo Kiiskinen, Aki S. Havulinna, Juha Karjalainen, Seppo Koskinen, Veikko Salomaa, Mark J. Daly, Aarno Palotie, Ida Surakka, Samuli Ripatti
Publicado en: PLOS Genetics, Edición 17/4, 2021, Página(s) e1009501, ISSN 1553-7404
Editor: plos.org
DOI: 10.1371/journal.pgen.1009501

Human stem cell-based models for studying autism spectrum disorder-related neuronal dysfunction

Autores: Arquimedes Cheffer, Lea Jessica Flitsch, Tamara Krutenko, Pascal Röderer, Liubov Sokhranyaeva, Vira Iefremova, Mohamad Hajo, Michael Peitz, Martin Karl Schwarz, Oliver Brüstle
Publicado en: Molecular Autism, Edición 11/1, 2020, ISSN 2040-2392
Editor: BioMed Central
DOI: 10.1186/s13229-020-00383-w

MicroRNAs Engage in Complex Circuits Regulating Adult Neurogenesis

Autores: Laura Stappert, Frederike Klaus, Oliver Brüstle
Publicado en: Frontiers in Neuroscience, Edición 12, 2018, ISSN 1662-453X
Editor: Frontiers
DOI: 10.3389/fnins.2018.00707

Protocol for the Standardized Generation of Forward Programmed Cryopreservable Excitatory and Inhibitory Forebrain Neurons

Autores: Michael Peitz, Tamara Krutenko, Oliver Brüstle
Publicado en: STAR Protocols, Edición 1/1, 2020, Página(s) 100038, ISSN 2666-1667
Editor: Elsevier
DOI: 10.1016/j.xpro.2020.100038