Comorbidity and Synapse Biology in Clinically Overlapping Psychiatric Disorders

Rezultaty

Public lectures on synapses in human neuronal networks

Key note speaker on public conferences in European countries explaining the methods involved to the general public

Open access (public) conference on COSYN results & focus with patients and caregivers

Public conference: especially invited guests are patients and caregivers. Outcome of results discussions.

Report on outreach activities internal and external

Report on outreach activities: scientific and general public

Outreach activities (debate) on the philosophy of using patient-own cells for a new generation of cellular models

Science cafe setting debate in at least two European countries

Publikacje

Induced pluripotent stem cell-based modeling of neurodegenerative diseases: a focus on autophagy

Autorzy: Johannes Jungverdorben, Andreas Till, Oliver Brüstle
Opublikowane w: Journal of Molecular Medicine, Numer 95/7, 2017, Strona(/y) 705-718, ISSN 0946-2716
Wydawca: Springer Verlag
DOI: 10.1007/s00109-017-1533-5

Defining the Genetic, Genomic, Cellular, and Diagnostic Architectures of Psychiatric Disorders

Autorzy: Patrick F. Sullivan, Daniel H. Geschwind
Opublikowane w: Cell, Numer 177/1, 2019, Strona(/y) 162-183, ISSN 0092-8674
Wydawca: Cell Press
DOI: 10.1016/j.cell.2019.01.015

Polygenic burden has broader impact on health, cognition, and socioeconomic outcomes than most rare and high-risk copy number variants

Autorzy: Elmo Christian Saarentaus, Aki Samuli Havulinna, Nina Mars, Ari Ahola-Olli, Tuomo Tapio Johannes Kiiskinen, Juulia Partanen, Sanni Ruotsalainen, Mitja Kurki, Lea Martta Urpa, Lei Chen, Markus Perola, Veikko Salomaa, Juha Veijola, Minna Männikkö, Ira M. Hall, Olli Pietiläinen, Jaakko Kaprio, Samuli Ripatti, Mark Daly, Aarno Palotie
Opublikowane w: Molecular Psychiatry, 2021, ISSN 1359-4184
Wydawca: Nature Publishing Group
DOI: 10.1038/s41380-021-01026-z

Notch/Hes signaling and miR-9 engage in complex feedback interactions controlling neural progenitor cell proliferation and differentiation

Autorzy: Beate Roese-Koerner, Laura Stappert, Oliver Brüstle
Opublikowane w: Neurogenesis, Numer 4/1, 2017, Strona(/y) e1313647, ISSN 2326-2133
Wydawca: Taylor & Francis
DOI: 10.1080/23262133.2017.1313647

A Single-Cell Model for Synaptic Transmission and Plasticity in Human iPSC-Derived Neurons

Autorzy: Marieke Meijer, Kristina Rehbach, Jessie W. Brunner, Jessica A. Classen, Hanna C.A. Lammertse, Lola A. van Linge, Desiree Schut, Tamara Krutenko, Matthias Hebisch, L. Niels Cornelisse, Patrick F. Sullivan, Michael Peitz, Ruud F. Toonen, Oliver Brüstle, Matthijs Verhage
Opublikowane w: Cell Reports, Numer 27/7, 2019, Strona(/y) 2199-2211.e6, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2019.04.058

Modeling psychiatric disorders: from genomic findings to cellular phenotypes

Autorzy: A Falk, V M Heine, A J Harwood, P F Sullivan, M Peitz, O Brüstle, S Shen, Y-M Sun, J C Glover, D Posthuma, S Djurovic
Opublikowane w: Molecular Psychiatry, Numer 21/9, 2016, Strona(/y) 1167-1179, ISSN 1359-4184
Wydawca: Nature Publishing Group
DOI: 10.1038/mp.2016.89

Assessment of established techniques to determine developmental and malignant potential of human pluripotent stem cells

Autorzy: The International Stem Cell Initiative: Allison, T.F., Andrews, P.W., Avior, Y., Barbaric, I., Benvenisty, N., Bock, C., Brehm, J., Brüstle, O., Damjanov, I., Elefanty, A., Felkner, D., Gokhale, P.J., Halbritter, F., Healy, L.E., Hu, T.X., Knowles, B.B., Loring, J.F., Ludwig, T.E., Mayberry, R., Micallef, S., Mohamed, J.S., Müller, F.-J., Mummery, C.L., Nakatsuji, N., Ng, E.S., Oh, S.K.W., O’S
Opublikowane w: Nature Communications, Numer 9/1, 2018, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-018-04011-3

Increasing the Clinical Psychiatric Knowledge Base About Pathogenic Copy Number Variation

Autorzy: Patrick F. Sullivan, Michael J. Owen
Opublikowane w: American Journal of Psychiatry, Numer 177/3, 2020, Strona(/y) 204-209, ISSN 0002-953X
Wydawca: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.2019.19040335

Evolving principles underlying neural lineage conversion and their relevance for biomedical translation

Autorzy: Lea Jessica Flitsch, Oliver Brüstle
Opublikowane w: F1000Research, Numer 8, 2019, Strona(/y) 1548, ISSN 2046-1402
Wydawca: F1000 Research Ltd.
DOI: 10.12688/f1000research.18926.1

Whole-brain 3D mapping of human neural transplant innervation

Autorzy: Jonas Doerr, Martin Karl Schwarz, Dirk Wiedermann, Anke Leinhaas, Alina Jakobs, Florian Schloen, Inna Schwarz, Michael Diedenhofen, Nils Christian Braun, Philipp Koch, Daniel A. Peterson, Ulrich Kubitscheck, Mathias Hoehn, Oliver Brüstle
Opublikowane w: Nature Communications, Numer 8/1, 2017, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/ncomms14162

An Autaptic Culture System for Standardized Analyses of iPSC-Derived Human Neurons

Autorzy: Hong Jun Rhee, Ali H. Shaib, Kristina Rehbach, ChoongKu Lee, Peter Seif, Carolina Thomas, Erinn Gideons, Anja Guenther, Tamara Krutenko, Matthias Hebisch, Michael Peitz, Nils Brose, Oliver Brüstle, Jeong Seop Rhee
Opublikowane w: Cell Reports, Numer 27/7, 2019, Strona(/y) 2212-2228.e7, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2019.04.059

Homozygous STXBP1 variant causes encephalopathy and gain-of-function in synaptic transmission

Autorzy: Hanna C A Lammertse, Annemiek A van Berkel, Michele Iacomino, Ruud F Toonen, Pasquale Striano, Antonio Gambardella, Matthijs Verhage, Federico Zara
Opublikowane w: Brain, Numer 143/2, 2019, Strona(/y) 441-451, ISSN 0006-8950
Wydawca: Oxford University Press
DOI: 10.1093/brain/awz391

Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers

Autorzy: Nina Mars, Jukka T. Koskela, Pietari Ripatti, Tuomo T. J. Kiiskinen, Aki S. Havulinna, Joni V. Lindbohm, Ari Ahola-Olli, Mitja Kurki, Juha Karjalainen, Priit Palta, Benjamin M. Neale, Mark Daly, Veikko Salomaa, Aarno Palotie, Elisabeth Widén, Samuli Ripatti
Opublikowane w: Nature Medicine, Numer 26/4, 2020, Strona(/y) 549-557, ISSN 1078-8956
Wydawca: Nature Publishing Group
DOI: 10.1038/s41591-020-0800-0

Contribution of rare and common variants to intellectual disability in a sub-isolate of Northern Finland

Autorzy: Mitja I. Kurki, Elmo Saarentaus, Olli Pietiläinen, Padhraig Gormley, Dennis Lal, Sini Kerminen, Minna Torniainen-Holm, Eija Hämäläinen, Elisa Rahikkala, Riikka Keski-Filppula, Merja Rauhala, Satu Korpi-Heikkilä, Jonna Komulainen–Ebrahim, Heli Helander, Päivi Vieira, Minna Männikkö, Markku Peltonen, Aki S. Havulinna, Veikko Salomaa, Matti Pirinen, Jaana Suvisaari, Jukka S. Moilanen, Jarmo
Opublikowane w: Nature Communications, Numer 10/1, 2019, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-018-08262-y

Transcription Factor-Based Fate Specification and Forward Programming for Neural Regeneration

Autorzy: Lea J. Flitsch, Karen E. Laupman, Oliver Brüstle
Opublikowane w: Frontiers in Cellular Neuroscience, Numer 14, 2020, ISSN 1662-5102
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fncel.2020.00121

The role of polygenic risk and susceptibility genes in breast cancer over the course of life

Autorzy: Nina Mars, Elisabeth Widén, Sini Kerminen, Tuomo Meretoja, Matti Pirinen, Pietro della Briotta Parolo, Priit Palta, Aarno Palotie, Jaakko Kaprio, Heikki Joensuu, Mark Daly, Samuli Ripatti
Opublikowane w: Nature Communications, Numer 11/1, 2020, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-020-19966-5

ANGPTL8 protein-truncating variant associated with lower serum triglycerides and risk of coronary disease

Autorzy: Pyry Helkkula, Tuomo Kiiskinen, Aki S. Havulinna, Juha Karjalainen, Seppo Koskinen, Veikko Salomaa, Mark J. Daly, Aarno Palotie, Ida Surakka, Samuli Ripatti
Opublikowane w: PLOS Genetics, Numer 17/4, 2021, Strona(/y) e1009501, ISSN 1553-7404
Wydawca: plos.org
DOI: 10.1371/journal.pgen.1009501

Human stem cell-based models for studying autism spectrum disorder-related neuronal dysfunction

Autorzy: Arquimedes Cheffer, Lea Jessica Flitsch, Tamara Krutenko, Pascal Röderer, Liubov Sokhranyaeva, Vira Iefremova, Mohamad Hajo, Michael Peitz, Martin Karl Schwarz, Oliver Brüstle
Opublikowane w: Molecular Autism, Numer 11/1, 2020, ISSN 2040-2392
Wydawca: BioMed Central
DOI: 10.1186/s13229-020-00383-w

MicroRNAs Engage in Complex Circuits Regulating Adult Neurogenesis

Autorzy: Laura Stappert, Frederike Klaus, Oliver Brüstle
Opublikowane w: Frontiers in Neuroscience, Numer 12, 2018, ISSN 1662-453X
Wydawca: Frontiers
DOI: 10.3389/fnins.2018.00707

Protocol for the Standardized Generation of Forward Programmed Cryopreservable Excitatory and Inhibitory Forebrain Neurons

Autorzy: Michael Peitz, Tamara Krutenko, Oliver Brüstle
Opublikowane w: STAR Protocols, Numer 1/1, 2020, Strona(/y) 100038, ISSN 2666-1667
Wydawca: Elsevier
DOI: 10.1016/j.xpro.2020.100038

Rezultaty

Publikacje

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