Comorbidity and Synapse Biology in Clinically Overlapping Psychiatric Disorders

Livrables

Public lectures on synapses in human neuronal networks

Key note speaker on public conferences in European countries explaining the methods involved to the general public

Open access (public) conference on COSYN results & focus with patients and caregivers

Public conference: especially invited guests are patients and caregivers. Outcome of results discussions.

Report on outreach activities internal and external

Report on outreach activities: scientific and general public

Outreach activities (debate) on the philosophy of using patient-own cells for a new generation of cellular models

Science cafe setting debate in at least two European countries

Publications

Induced pluripotent stem cell-based modeling of neurodegenerative diseases: a focus on autophagy

Auteurs: Johannes Jungverdorben, Andreas Till, Oliver Brüstle
Publié dans: Journal of Molecular Medicine, Numéro 95/7, 2017, Page(s) 705-718, ISSN 0946-2716
Éditeur: Springer Verlag
DOI: 10.1007/s00109-017-1533-5

Defining the Genetic, Genomic, Cellular, and Diagnostic Architectures of Psychiatric Disorders

Auteurs: Patrick F. Sullivan, Daniel H. Geschwind
Publié dans: Cell, Numéro 177/1, 2019, Page(s) 162-183, ISSN 0092-8674
Éditeur: Cell Press
DOI: 10.1016/j.cell.2019.01.015

Polygenic burden has broader impact on health, cognition, and socioeconomic outcomes than most rare and high-risk copy number variants

Auteurs: Elmo Christian Saarentaus, Aki Samuli Havulinna, Nina Mars, Ari Ahola-Olli, Tuomo Tapio Johannes Kiiskinen, Juulia Partanen, Sanni Ruotsalainen, Mitja Kurki, Lea Martta Urpa, Lei Chen, Markus Perola, Veikko Salomaa, Juha Veijola, Minna Männikkö, Ira M. Hall, Olli Pietiläinen, Jaakko Kaprio, Samuli Ripatti, Mark Daly, Aarno Palotie
Publié dans: Molecular Psychiatry, 2021, ISSN 1359-4184
Éditeur: Nature Publishing Group
DOI: 10.1038/s41380-021-01026-z

Notch/Hes signaling and miR-9 engage in complex feedback interactions controlling neural progenitor cell proliferation and differentiation

Auteurs: Beate Roese-Koerner, Laura Stappert, Oliver Brüstle
Publié dans: Neurogenesis, Numéro 4/1, 2017, Page(s) e1313647, ISSN 2326-2133
Éditeur: Taylor & Francis
DOI: 10.1080/23262133.2017.1313647

A Single-Cell Model for Synaptic Transmission and Plasticity in Human iPSC-Derived Neurons

Auteurs: Marieke Meijer, Kristina Rehbach, Jessie W. Brunner, Jessica A. Classen, Hanna C.A. Lammertse, Lola A. van Linge, Desiree Schut, Tamara Krutenko, Matthias Hebisch, L. Niels Cornelisse, Patrick F. Sullivan, Michael Peitz, Ruud F. Toonen, Oliver Brüstle, Matthijs Verhage
Publié dans: Cell Reports, Numéro 27/7, 2019, Page(s) 2199-2211.e6, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2019.04.058

Modeling psychiatric disorders: from genomic findings to cellular phenotypes

Auteurs: A Falk, V M Heine, A J Harwood, P F Sullivan, M Peitz, O Brüstle, S Shen, Y-M Sun, J C Glover, D Posthuma, S Djurovic
Publié dans: Molecular Psychiatry, Numéro 21/9, 2016, Page(s) 1167-1179, ISSN 1359-4184
Éditeur: Nature Publishing Group
DOI: 10.1038/mp.2016.89

Assessment of established techniques to determine developmental and malignant potential of human pluripotent stem cells

Auteurs: The International Stem Cell Initiative: Allison, T.F., Andrews, P.W., Avior, Y., Barbaric, I., Benvenisty, N., Bock, C., Brehm, J., Brüstle, O., Damjanov, I., Elefanty, A., Felkner, D., Gokhale, P.J., Halbritter, F., Healy, L.E., Hu, T.X., Knowles, B.B., Loring, J.F., Ludwig, T.E., Mayberry, R., Micallef, S., Mohamed, J.S., Müller, F.-J., Mummery, C.L., Nakatsuji, N., Ng, E.S., Oh, S.K.W., O’S
Publié dans: Nature Communications, Numéro 9/1, 2018, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-018-04011-3

Increasing the Clinical Psychiatric Knowledge Base About Pathogenic Copy Number Variation

Auteurs: Patrick F. Sullivan, Michael J. Owen
Publié dans: American Journal of Psychiatry, Numéro 177/3, 2020, Page(s) 204-209, ISSN 0002-953X
Éditeur: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.2019.19040335

Evolving principles underlying neural lineage conversion and their relevance for biomedical translation

Auteurs: Lea Jessica Flitsch, Oliver Brüstle
Publié dans: F1000Research, Numéro 8, 2019, Page(s) 1548, ISSN 2046-1402
Éditeur: F1000 Research Ltd.
DOI: 10.12688/f1000research.18926.1

Whole-brain 3D mapping of human neural transplant innervation

Auteurs: Jonas Doerr, Martin Karl Schwarz, Dirk Wiedermann, Anke Leinhaas, Alina Jakobs, Florian Schloen, Inna Schwarz, Michael Diedenhofen, Nils Christian Braun, Philipp Koch, Daniel A. Peterson, Ulrich Kubitscheck, Mathias Hoehn, Oliver Brüstle
Publié dans: Nature Communications, Numéro 8/1, 2017, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/ncomms14162

An Autaptic Culture System for Standardized Analyses of iPSC-Derived Human Neurons

Auteurs: Hong Jun Rhee, Ali H. Shaib, Kristina Rehbach, ChoongKu Lee, Peter Seif, Carolina Thomas, Erinn Gideons, Anja Guenther, Tamara Krutenko, Matthias Hebisch, Michael Peitz, Nils Brose, Oliver Brüstle, Jeong Seop Rhee
Publié dans: Cell Reports, Numéro 27/7, 2019, Page(s) 2212-2228.e7, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2019.04.059

Homozygous STXBP1 variant causes encephalopathy and gain-of-function in synaptic transmission

Auteurs: Hanna C A Lammertse, Annemiek A van Berkel, Michele Iacomino, Ruud F Toonen, Pasquale Striano, Antonio Gambardella, Matthijs Verhage, Federico Zara
Publié dans: Brain, Numéro 143/2, 2019, Page(s) 441-451, ISSN 0006-8950
Éditeur: Oxford University Press
DOI: 10.1093/brain/awz391

Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers

Auteurs: Nina Mars, Jukka T. Koskela, Pietari Ripatti, Tuomo T. J. Kiiskinen, Aki S. Havulinna, Joni V. Lindbohm, Ari Ahola-Olli, Mitja Kurki, Juha Karjalainen, Priit Palta, Benjamin M. Neale, Mark Daly, Veikko Salomaa, Aarno Palotie, Elisabeth Widén, Samuli Ripatti
Publié dans: Nature Medicine, Numéro 26/4, 2020, Page(s) 549-557, ISSN 1078-8956
Éditeur: Nature Publishing Group
DOI: 10.1038/s41591-020-0800-0

Contribution of rare and common variants to intellectual disability in a sub-isolate of Northern Finland

Auteurs: Mitja I. Kurki, Elmo Saarentaus, Olli Pietiläinen, Padhraig Gormley, Dennis Lal, Sini Kerminen, Minna Torniainen-Holm, Eija Hämäläinen, Elisa Rahikkala, Riikka Keski-Filppula, Merja Rauhala, Satu Korpi-Heikkilä, Jonna Komulainen–Ebrahim, Heli Helander, Päivi Vieira, Minna Männikkö, Markku Peltonen, Aki S. Havulinna, Veikko Salomaa, Matti Pirinen, Jaana Suvisaari, Jukka S. Moilanen, Jarmo
Publié dans: Nature Communications, Numéro 10/1, 2019, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-018-08262-y

Transcription Factor-Based Fate Specification and Forward Programming for Neural Regeneration

Auteurs: Lea J. Flitsch, Karen E. Laupman, Oliver Brüstle
Publié dans: Frontiers in Cellular Neuroscience, Numéro 14, 2020, ISSN 1662-5102
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fncel.2020.00121

The role of polygenic risk and susceptibility genes in breast cancer over the course of life

Auteurs: Nina Mars, Elisabeth Widén, Sini Kerminen, Tuomo Meretoja, Matti Pirinen, Pietro della Briotta Parolo, Priit Palta, Aarno Palotie, Jaakko Kaprio, Heikki Joensuu, Mark Daly, Samuli Ripatti
Publié dans: Nature Communications, Numéro 11/1, 2020, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-020-19966-5

ANGPTL8 protein-truncating variant associated with lower serum triglycerides and risk of coronary disease

Auteurs: Pyry Helkkula, Tuomo Kiiskinen, Aki S. Havulinna, Juha Karjalainen, Seppo Koskinen, Veikko Salomaa, Mark J. Daly, Aarno Palotie, Ida Surakka, Samuli Ripatti
Publié dans: PLOS Genetics, Numéro 17/4, 2021, Page(s) e1009501, ISSN 1553-7404
Éditeur: plos.org
DOI: 10.1371/journal.pgen.1009501

Human stem cell-based models for studying autism spectrum disorder-related neuronal dysfunction

Auteurs: Arquimedes Cheffer, Lea Jessica Flitsch, Tamara Krutenko, Pascal Röderer, Liubov Sokhranyaeva, Vira Iefremova, Mohamad Hajo, Michael Peitz, Martin Karl Schwarz, Oliver Brüstle
Publié dans: Molecular Autism, Numéro 11/1, 2020, ISSN 2040-2392
Éditeur: BioMed Central
DOI: 10.1186/s13229-020-00383-w

MicroRNAs Engage in Complex Circuits Regulating Adult Neurogenesis

Auteurs: Laura Stappert, Frederike Klaus, Oliver Brüstle
Publié dans: Frontiers in Neuroscience, Numéro 12, 2018, ISSN 1662-453X
Éditeur: Frontiers
DOI: 10.3389/fnins.2018.00707

Protocol for the Standardized Generation of Forward Programmed Cryopreservable Excitatory and Inhibitory Forebrain Neurons

Auteurs: Michael Peitz, Tamara Krutenko, Oliver Brüstle
Publié dans: STAR Protocols, Numéro 1/1, 2020, Page(s) 100038, ISSN 2666-1667
Éditeur: Elsevier
DOI: 10.1016/j.xpro.2020.100038

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