Comorbidity and Synapse Biology in Clinically Overlapping Psychiatric Disorders

Project Information

COSYN

Grant agreement ID: 667301

DOI 10.3030/667301

Project closed

EC signature date 9 December 2015

Start date 1 January 2016

End date 31 December 2020

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost € 6 000 000,00

EU contribution € 5 925 000,00

Coordinated by

KAROLINSKA INSTITUTET
Sweden

Deliverables

Other (2)

Public lectures on synapses in human neuronal networks

Key note speaker on public conferences in European countries explaining the methods involved to the general public

Open access (public) conference on COSYN results & focus with patients and caregivers

Public conference: especially invited guests are patients and caregivers. Outcome of results discussions.

Documents, reports (2)

Report on outreach activities internal and external

Report on outreach activities: scientific and general public

Outreach activities (debate) on the philosophy of using patient-own cells for a new generation of cellular models

Science cafe setting debate in at least two European countries

Publications

Peer reviewed articles (20)

Induced pluripotent stem cell-based modeling of neurodegenerative diseases: a focus on autophagy

Author(s): Johannes Jungverdorben, Andreas Till, Oliver Brüstle
Published in: Journal of Molecular Medicine, Issue 95/7, 2017, Page(s) 705-718, ISSN 0946-2716
Publisher: Springer Verlag
DOI: 10.1007/s00109-017-1533-5

Defining the Genetic, Genomic, Cellular, and Diagnostic Architectures of Psychiatric Disorders

Author(s): Patrick F. Sullivan, Daniel H. Geschwind
Published in: Cell, Issue 177/1, 2019, Page(s) 162-183, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2019.01.015

Polygenic burden has broader impact on health, cognition, and socioeconomic outcomes than most rare and high-risk copy number variants

Author(s): Elmo Christian Saarentaus, Aki Samuli Havulinna, Nina Mars, Ari Ahola-Olli, Tuomo Tapio Johannes Kiiskinen, Juulia Partanen, Sanni Ruotsalainen, Mitja Kurki, Lea Martta Urpa, Lei Chen, Markus Perola, Veikko Salomaa, Juha Veijola, Minna Männikkö, Ira M. Hall, Olli Pietiläinen, Jaakko Kaprio, Samuli Ripatti, Mark Daly, Aarno Palotie
Published in: Molecular Psychiatry, 2021, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-021-01026-z

Notch/Hes signaling and miR-9 engage in complex feedback interactions controlling neural progenitor cell proliferation and differentiation

Author(s): Beate Roese-Koerner, Laura Stappert, Oliver Brüstle
Published in: Neurogenesis, Issue 4/1, 2017, Page(s) e1313647, ISSN 2326-2133
Publisher: Taylor & Francis
DOI: 10.1080/23262133.2017.1313647

A Single-Cell Model for Synaptic Transmission and Plasticity in Human iPSC-Derived Neurons

Author(s): Marieke Meijer, Kristina Rehbach, Jessie W. Brunner, Jessica A. Classen, Hanna C.A. Lammertse, Lola A. van Linge, Desiree Schut, Tamara Krutenko, Matthias Hebisch, L. Niels Cornelisse, Patrick F. Sullivan, Michael Peitz, Ruud F. Toonen, Oliver Brüstle, Matthijs Verhage
Published in: Cell Reports, Issue 27/7, 2019, Page(s) 2199-2211.e6, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.04.058

Modeling psychiatric disorders: from genomic findings to cellular phenotypes

Author(s): A Falk, V M Heine, A J Harwood, P F Sullivan, M Peitz, O Brüstle, S Shen, Y-M Sun, J C Glover, D Posthuma, S Djurovic
Published in: Molecular Psychiatry, Issue 21/9, 2016, Page(s) 1167-1179, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/mp.2016.89

Assessment of established techniques to determine developmental and malignant potential of human pluripotent stem cells

Author(s): The International Stem Cell Initiative: Allison, T.F., Andrews, P.W., Avior, Y., Barbaric, I., Benvenisty, N., Bock, C., Brehm, J., Brüstle, O., Damjanov, I., Elefanty, A., Felkner, D., Gokhale, P.J., Halbritter, F., Healy, L.E., Hu, T.X., Knowles, B.B., Loring, J.F., Ludwig, T.E., Mayberry, R., Micallef, S., Mohamed, J.S., Müller, F.-J., Mummery, C.L., Nakatsuji, N., Ng, E.S., Oh, S.K.W., O’S
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-04011-3

Increasing the Clinical Psychiatric Knowledge Base About Pathogenic Copy Number Variation

Author(s): Patrick F. Sullivan, Michael J. Owen
Published in: American Journal of Psychiatry, Issue 177/3, 2020, Page(s) 204-209, ISSN 0002-953X
Publisher: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.2019.19040335

Evolving principles underlying neural lineage conversion and their relevance for biomedical translation

Author(s): Lea Jessica Flitsch, Oliver Brüstle
Published in: F1000Research, Issue 8, 2019, Page(s) 1548, ISSN 2046-1402
Publisher: F1000 Research Ltd.
DOI: 10.12688/f1000research.18926.1

Whole-brain 3D mapping of human neural transplant innervation

Author(s): Jonas Doerr, Martin Karl Schwarz, Dirk Wiedermann, Anke Leinhaas, Alina Jakobs, Florian Schloen, Inna Schwarz, Michael Diedenhofen, Nils Christian Braun, Philipp Koch, Daniel A. Peterson, Ulrich Kubitscheck, Mathias Hoehn, Oliver Brüstle
Published in: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms14162

An Autaptic Culture System for Standardized Analyses of iPSC-Derived Human Neurons

Author(s): Hong Jun Rhee, Ali H. Shaib, Kristina Rehbach, ChoongKu Lee, Peter Seif, Carolina Thomas, Erinn Gideons, Anja Guenther, Tamara Krutenko, Matthias Hebisch, Michael Peitz, Nils Brose, Oliver Brüstle, Jeong Seop Rhee
Published in: Cell Reports, Issue 27/7, 2019, Page(s) 2212-2228.e7, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.04.059

Homozygous STXBP1 variant causes encephalopathy and gain-of-function in synaptic transmission

Author(s): Hanna C A Lammertse, Annemiek A van Berkel, Michele Iacomino, Ruud F Toonen, Pasquale Striano, Antonio Gambardella, Matthijs Verhage, Federico Zara
Published in: Brain, Issue 143/2, 2019, Page(s) 441-451, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awz391

Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers

Author(s): Nina Mars, Jukka T. Koskela, Pietari Ripatti, Tuomo T. J. Kiiskinen, Aki S. Havulinna, Joni V. Lindbohm, Ari Ahola-Olli, Mitja Kurki, Juha Karjalainen, Priit Palta, Benjamin M. Neale, Mark Daly, Veikko Salomaa, Aarno Palotie, Elisabeth Widén, Samuli Ripatti
Published in: Nature Medicine, Issue 26/4, 2020, Page(s) 549-557, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-020-0800-0

Contribution of rare and common variants to intellectual disability in a sub-isolate of Northern Finland

Author(s): Mitja I. Kurki, Elmo Saarentaus, Olli Pietiläinen, Padhraig Gormley, Dennis Lal, Sini Kerminen, Minna Torniainen-Holm, Eija Hämäläinen, Elisa Rahikkala, Riikka Keski-Filppula, Merja Rauhala, Satu Korpi-Heikkilä, Jonna Komulainen–Ebrahim, Heli Helander, Päivi Vieira, Minna Männikkö, Markku Peltonen, Aki S. Havulinna, Veikko Salomaa, Matti Pirinen, Jaana Suvisaari, Jukka S. Moilanen, Jarmo
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-08262-y

Transcription Factor-Based Fate Specification and Forward Programming for Neural Regeneration

Author(s): Lea J. Flitsch, Karen E. Laupman, Oliver Brüstle
Published in: Frontiers in Cellular Neuroscience, Issue 14, 2020, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/fncel.2020.00121

The role of polygenic risk and susceptibility genes in breast cancer over the course of life

Author(s): Nina Mars, Elisabeth Widén, Sini Kerminen, Tuomo Meretoja, Matti Pirinen, Pietro della Briotta Parolo, Priit Palta, Aarno Palotie, Jaakko Kaprio, Heikki Joensuu, Mark Daly, Samuli Ripatti
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-19966-5

ANGPTL8 protein-truncating variant associated with lower serum triglycerides and risk of coronary disease

Author(s): Pyry Helkkula, Tuomo Kiiskinen, Aki S. Havulinna, Juha Karjalainen, Seppo Koskinen, Veikko Salomaa, Mark J. Daly, Aarno Palotie, Ida Surakka, Samuli Ripatti
Published in: PLOS Genetics, Issue 17/4, 2021, Page(s) e1009501, ISSN 1553-7404
Publisher: plos.org
DOI: 10.1371/journal.pgen.1009501

Human stem cell-based models for studying autism spectrum disorder-related neuronal dysfunction

Author(s): Arquimedes Cheffer, Lea Jessica Flitsch, Tamara Krutenko, Pascal Röderer, Liubov Sokhranyaeva, Vira Iefremova, Mohamad Hajo, Michael Peitz, Martin Karl Schwarz, Oliver Brüstle
Published in: Molecular Autism, Issue 11/1, 2020, ISSN 2040-2392
Publisher: BioMed Central
DOI: 10.1186/s13229-020-00383-w

MicroRNAs Engage in Complex Circuits Regulating Adult Neurogenesis

Author(s): Laura Stappert, Frederike Klaus, Oliver Brüstle
Published in: Frontiers in Neuroscience, Issue 12, 2018, ISSN 1662-453X
Publisher: Frontiers
DOI: 10.3389/fnins.2018.00707

Protocol for the Standardized Generation of Forward Programmed Cryopreservable Excitatory and Inhibitory Forebrain Neurons

Author(s): Michael Peitz, Tamara Krutenko, Oliver Brüstle
Published in: STAR Protocols, Issue 1/1, 2020, Page(s) 100038, ISSN 2666-1667
Publisher: Elsevier
DOI: 10.1016/j.xpro.2020.100038