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Targeting epigenetic REPROGRamming of innate immune cells in Atherosclerosis Management and other chronic inflammatory diseases

Obiettivo

Up to 70% of cardiovascular events are not prevented by current therapeutic regimens. In search for additional, innovative strategies, immune cells have been recognized as key players contributing to atherosclerotic plaque progression and destabilization. Particularly the role of innate immune cells is of major interest, following the recent paradigm shift that innate immunity, considered to be incapable of learning ability, does exhibit a memory feature transduced via epigenetic modulation. Compelling evidence shows that atherosclerotic factors promote immune cell migration by pre-activation of innate immune cells. In this project called REPROGRAM, we aim to prove that innate immune cell activation via epigenetic reprogramming perpetuates the upheld systemic inflammatory state in cardiovascular disease which is common in other chronic inflammatory diseases. This opens a new therapeutic area in which epigenetic modulation of innate immune cells effectively decreases systemic inflammation impacting on chronic inflammation as well as the development of co-morbidities. The integrated use of in vitro, ex vivo and in vivo studies, including cells, mice and patients, allows translation from in vitro mechanisms to diseases (molecule-to-man) and extrapolation to cohorts (man-to-mass), enabling us to demonstrate relevance and therapeutic potential of targeting trained immunity in cardiovascular and chronic inflammatory diseases. Enforced by the promising data in oncology, the future prospects for epigenetic interventions in cardiovascular and chronic inflammatory diseases are eminent, attested by the large residual cardiovascular disease burden and the huge societal impact of other chronic inflammatory diseases. The REPROGRAM consortium consisting of key opinion leaders in the field of cardiovascular (systems) biology, immunology, epigenetic therapies and rheumatoid arthritis, with a large intersectoral network, guarantees rapid translation of early mechanistic discoveries

Invito a presentare proposte

H2020-PHC-2014-2015

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Bando secondario

H2020-PHC-2015-two-stage

Meccanismo di finanziamento

RIA - Research and Innovation action

Coordinatore

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Contribution nette de l'UE
€ 1 112 625,00
Indirizzo
Meibergdreef 15
1105AZ Amsterdam
Paesi Bassi

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Regione
West-Nederland Noord-Holland Groot-Amsterdam
Tipo di attività
Higher or Secondary Education Establishments
Contributo di paesi terzi
€ 0,00

Partecipanti (10)

STICHTING RADBOUD UNIVERSITEIT
Paesi Bassi
Contribution nette de l'UE
€ 973 500,00
Indirizzo
Houtlaan 4
6525 XZ Nijmegen

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Regione
Oost-Nederland Gelderland Arnhem/Nijmegen
Tipo di attività
Higher or Secondary Education Establishments
Contributo di paesi terzi
€ 0,00
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germania
Contribution nette de l'UE
€ 925 000,00
Indirizzo
Geschwister Scholl Platz 1
80539 Muenchen

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Regione
Bayern Oberbayern München, Kreisfreie Stadt
Tipo di attività
Higher or Secondary Education Establishments
Contributo di paesi terzi
€ 0,00
REGION HOVEDSTADEN
Danimarca
Contribution nette de l'UE
€ 255 000,00
Indirizzo
Kongens Vaenge 2
3400 Hillerod

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Regione
Danmark Hovedstaden Nordsjælland
Tipo di attività
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Contributo di paesi terzi
€ 0,00
UNIVERSITATEA DE MEDICINA SI FARMACIE IULIU HATIEGANU CLUJ-NAPOCA
Romania
Contribution nette de l'UE
€ 232 500,00
Indirizzo
Victor Babes Street 8
400012 Cluj-napoca

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Regione
Macroregiunea Unu Nord-Vest Cluj
Tipo di attività
Higher or Secondary Education Establishments
Contributo di paesi terzi
€ 0,00
UNIVERSITA DEGLI STUDI DI MILANO
Italia
Contribution nette de l'UE
€ 587 375,00
Indirizzo
Via Festa Del Perdono 7
20122 Milano

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Regione
Nord-Ovest Lombardia Milano
Tipo di attività
Higher or Secondary Education Establishments
Contributo di paesi terzi
€ 0,00
UNIVERSITAT ZURICH
Svizzera
Contribution nette de l'UE
€ 0,00
Indirizzo
Ramistrasse 71
8006 Zurich

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Regione
Schweiz/Suisse/Svizzera Zürich Zürich
Tipo di attività
Higher or Secondary Education Establishments
Contributo di paesi terzi
€ 750 000,00
THE GENERAL HOSPITAL CORPORATION
Stati Uniti
Contribution nette de l'UE
€ 600 000,00
Contributo di paesi terzi
€ 0,00
SENSILAB POLSKA SP ZOO - SKA
Polonia
Contribution nette de l'UE
€ 117 500,00
Indirizzo
Ul Gen Mariana Langiewicza 58
95 050 Konstantynow Lodzki

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PMI

L’organizzazione si è definita una PMI (piccola e media impresa) al momento della firma dell’accordo di sovvenzione.

Regione
Makroregion centralny Łódzkie Łódzki
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contributo di paesi terzi
€ 0,00
INSTITUT DE RECHERCHES INTERNATIONALES SERVIER IRIS
Francia
Contribution nette de l'UE
€ 225 000,00
Indirizzo
Rue Carnot 50
92284 Courbevoie

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Regione
Ile-de-France Ile-de-France Hauts-de-Seine
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contributo di paesi terzi
€ 0,00
DESCIN BV
Paesi Bassi
Contribution nette de l'UE
€ 221 500,00
Indirizzo
Conicksmeer 2
3645WG Vinkeveen

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PMI

L’organizzazione si è definita una PMI (piccola e media impresa) al momento della firma dell’accordo di sovvenzione.

Regione
West-Nederland Utrecht Utrecht
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contributo di paesi terzi
€ 0,00