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Targeting epigenetic REPROGRamming of innate immune cells in Atherosclerosis Management and other chronic inflammatory diseases

Risultati finali

Knowledge exploitation final report

Final report on knowledge exploitation results, including filed patents, spin-off initiatives, etc. during REPROGRAM and thereafter

Quality Assurance File

Report defining the working conditions based on the intaconsortium agreement and procedures defined in Annex 1: standard operation procedures, details on document, knowledge and data management, publication procedures, conflict resolution procedures, meetings arrangements and decision making structure, among other issues

Gender-specific analysis addressing distinct patterns in inflammatory activity

Report on the gender-specific analysis addressing distinct patterns in inflammatory activity, epigenetic control in men vs. women

Ex vivo analysis of monocyte phenotype/function/epigenome in patients with active vs. remissive RA

Report on ex vivo analysis of monocyte phenotype / function / epigenome in patients with active vs. remissive RA

50 BMT experiments in various mouse models

Report on 50 BMT experiments in various mouse models

Data on phenotype, function and epigenome of myeloid cells

Report on study data on phenotype, function and epigenome of myeloid cells harvested from patients with atherogenic risk factors

Roadmap for exploitation

Report incorporating extensive market research, innovation strategies, technology transfer policy, business opportunities among others ensuring swift knowledge exploitation for the expected outcomes of the project: 1. New therapeutic targets; 2. New cellular biomarkers; 3. New therapeutic strategies based on newly discovered disease pathways common to several chronic inflammatory diseases; 4. New opportunities in nanotechnology for targeted drug delivery in chronic inflammatory diseases; 5. New multimodal imaging techniques for systemic activation of innate immune cells.

Relation between gene-score and cardiovascular risk

Evaluation report of the relation between gene-score and cardiovascular risk in the general population

Young researcher training program

Report on the proposed young talent program actions during the REPROGRAM project, including complementary trainings, invited lectures, short laboratory/clinic visits.

Nanoparticle vs. unpackaged epigenetic modulator in vitro and experimental model

Report on the comparison of nanoparticle vs. unpackaged epigenetic modulators in in vitro studies and experimental models

PET/CT studies in patients with active and remissive RA

Report on in vivo PET/CT studies in patients with active and remissive RA

Local delivery strategy development for a epigenetic modulator

Feasibility report of local delivery strategy development for a epigenetic modulator

24 ldlr-/- experiments using either placebo or epigenetic modulator

Report on the 24 ldlr-/- experiments using either placebo or epigenetic modulator for 4 weeks

Validated gene score for modified epigenetic modulation

Report on the delivery of a validated gene score for modified epigenetic modulation in humans

Data management plan

Report containing: (1) detailed information on the procedures that will be implemented for data collection, use, consent, storage, protection, retention, destruction, and how the participants will be consented (2) a document from the responsible data management structure/individual stating that all planned measures comply with national and EU legislation, (3) If applicable copies of the i. notifications ii. approvals iii. opinions iv. authorisations from the relevant national data protection authorities for the proposed data collection and processing as well as reuse must be provided to the EU prior to any use.

Dissemination final report

Final report on dissemination results, including all scientific publications, newsletters, etc. during REPROGRAM and thereafter

In vitro tests of atherogenic factors on phenotype/function/epigenetics of human myeloid cells

Report on in vitro tests of atherogenic factors on phenotype/function/epigenetics of human myeloid cells

CID-associated DAMPs on human monocyte phenotype/function/epigenome

Report on in vitro tests of CID-associated DAMPs on human monocyte phenotype / function / epigenome

Epigenetic modulators on in vitro cell systems

Report on in vitro testing of the library of epigenetic modulators on in vitro cell systems

Pubblicazioni

CCR2 expression on circulating monocytes is associated with arterial wall inflammation assessed by 18F-FDG PET/CT in patients at risk for cardiovascular disease

Autori: Simone L Verweij, Raphaël Duivenvoorden, Lotte C A Stiekema, Nick S Nurmohamed, Fleur M van der Valk, Miranda Versloot, Hein J Verberne, Erik S G Stroes, Matthias Nahrendorf, Siroon Bekkering, Sophie J Bernelot Moens
Pubblicato in: Cardiovascular Research, 114/3, 2017, Page(s) 468-475, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvx224

Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis

Autori: Tom T.P. Seijkens, Claudia M. van Tiel, Pascal J.H. Kusters, Dorothee Atzler, Oliver Soehnlein, Barbara Zarzycka, Suzanne A.B.M. Aarts, Marnix Lameijer, Marion J. Gijbels, Linda Beckers, Myrthe den Toom, Bram Slütter, Johan Kuiper, Johan Duchene, Maria Aslani, Remco T.A. Megens, Cornelis van ‘t Veer, Gijs Kooij, Roy Schrijver, Marten A. Hoeksema, Louis Boon, Francois Fay, Jun Tang, Samantha Bax
Pubblicato in: Journal of the American College of Cardiology, 71/5, 2018, Page(s) 527-542, ISSN 0735-1097
Editore: Elsevier BV
DOI: 10.1016/j.jacc.2017.11.055

Exploring immune checkpoints as potential therapeutic targets in atherosclerosis

Autori: Pascal J H Kusters, Esther Lutgens, Tom T P Seijkens
Pubblicato in: Cardiovascular Research, 114/3, 2017, Page(s) 368-377, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvx248

Trained Innate Immunity as a Novel Mechanism Linking Infection and the Development of Atherosclerosis

Autori: Jenneke Leentjens, Siroon Bekkering, Leo A Joosten, Mihai G Netea, David P Burgner, Niels P Riksen
Pubblicato in: Circulation Research, 2018 Jan 24, 2018, Page(s) CIRCRESAHA.117.312465, ISSN 0009-7330
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCRESAHA.117.312465

The maturation of a ‘neural–hematopoietic’ inflammatory axis in cardiovascular disease

Autori: Lotte C.A. Stiekema, Johan G. Schnitzler, Matthias Nahrendorf, Erik S.G. Stroes
Pubblicato in: Current Opinion in Lipidology, 28/6, 2017, Page(s) 507-512, ISSN 0957-9672
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/MOL.0000000000000457

Monocyte and haematopoietic progenitor reprogramming as common mechanism underlying chronic inflammatory and cardiovascular diseases

Autori: Renate M Hoogeveen, Matthias Nahrendorf, Niels P Riksen, Mihai G Netea, Menno P J de Winther, Esther Lutgens, Børge G Nordestgaard, Michel Neidhart, Erik S G Stroes, Alberico L Catapano, Siroon Bekkering
Pubblicato in: European Heart Journal, 2017, ISSN 0195-668X
Editore: Oxford University Press
DOI: 10.1093/eurheartj/ehx581

Metabolic Induction of Trained Immunity through the Mevalonate Pathway

Autori: Siroon Bekkering, Rob J.W. Arts, Boris Novakovic, Ioannis Kourtzelis, Charlotte D.C.C. van der Heijden, Yang Li, Calin D. Popa, Rob ter Horst, Julia van Tuijl, Romana T. Netea-Maier, Frank L. van de Veerdonk, Triantafyllos Chavakis, Leo A.B. Joosten, Jos W.M. van der Meer, Henk Stunnenberg, Niels P. Riksen, Mihai G. Netea
Pubblicato in: Cell, 172/1-2, 2018, Page(s) 135-146.e9, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2017.11.025

Epigenetics and Trained Immunity

Autori: Charlotte D.C.C. van der Heijden, Marlies P. Noz, Leo A.B. Joosten, Mihai G. Netea, Niels P. Riksen, Samuel T. Keating
Pubblicato in: Antioxidants & Redox Signaling, 2017, ISSN 1523-0864
Editore: Mary Ann Liebert Inc.
DOI: 10.1089/ars.2017.7310

PCSK9 monoclonal antibodies reverse the pro-inflammatory profile of monocytes in familial hypercholesterolaemia

Autori: Sophie J. Bernelot Moens, Annette E. Neele, Jeffrey Kroon, Fleur M. van der Valk, Jan Van den Bossche, Marten A. Hoeksema, Renate M. Hoogeveen, Johan G. Schnitzler, Marie T. Baccara-Dinet, Garen Manvelian, Menno P.J. de Winther, Erik S.G. Stroes
Pubblicato in: European Heart Journal, 38/20, 2017, Page(s) 1584-1593, ISSN 0195-668X
Editore: Oxford University Press
DOI: 10.1093/eurheartj/ehx002

Remnant Cholesterol Elicits Arterial Wall Inflammation and a Multilevel Cellular Immune Response in HumansHighlights

Autori: Sophie J. Bernelot Moens, Simone L. Verweij, Johan G. Schnitzler, Lotte C.A. Stiekema, Merijn Bos, Anne Langsted, Carlijn Kuijk, Siroon Bekkering, Carlijn Voermans, Hein J. Verberne, Børge G. Nordestgaard, Erik S.G. Stroes, Jeffrey Kroon
Pubblicato in: Arteriosclerosis, Thrombosis, and Vascular Biology, 37/5, 2017, Page(s) 969-975, ISSN 1079-5642
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/ATVBAHA.116.308834

Nile Red Quantifier: a novel and quantitative tool to study lipid accumulation in patient-derived circulating monocytes using confocal microscopy

Autori: Johan G. Schnitzler, Sophie J. Bernelot Moens, Feiko Tiessens, Guido J. Bakker, Geesje M. Dallinga-Thie, Albert K. Groen, Max Nieuwdorp, Erik S. G. Stroes, Jeffrey Kroon
Pubblicato in: Journal of Lipid Research, 58/11, 2017, Page(s) 2210-2219, ISSN 0022-2275
Editore: Lipid Research, Inc.
DOI: 10.1194/jlr.D073197

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming

Autori: Anette Christ, Patrick Günther, Mario A.R. Lauterbach, Peter Duewell, Debjani Biswas, Karin Pelka, Claus J. Scholz, Marije Oosting, Kristian Haendler, Kevin Baßler, Kathrin Klee, Jonas Schulte-Schrepping, Thomas Ulas, Simone J.C.F.M. Moorlag, Vinod Kumar, Min Hi Park, Leo A.B. Joosten, Laszlo A. Groh, Niels P. Riksen, Terje Espevik, Andreas Schlitzer, Yang Li, Michael L. Fitzgerald, Mihai G. Net
Pubblicato in: Cell, 172/1-2, 2018, Page(s) 162-175.e14, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2017.12.013

Monocyte and macrophage immunometabolism in atherosclerosis

Autori: Laszlo Groh, Samuel T. Keating, Leo A. B. Joosten, Mihai G. Netea, Niels P. Riksen
Pubblicato in: Seminars in Immunopathology, 40/2, 2018, Page(s) 203-214, ISSN 1863-2297
Editore: Springer Verlag
DOI: 10.1007/s00281-017-0656-7

Epigenetics in diabetic nephropathy, immunity and metabolism

Autori: Samuel T. Keating, Janna A. van Diepen, Niels P. Riksen, Assam El-Osta
Pubblicato in: Diabetologia, 61/1, 2018, Page(s) 6-20, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-017-4490-1

Diabetes propels the risk for cardiovascular disease: sweet monocytes becoming aggressive?

Autori: Janna A. van Diepen, Kathrin Thiem, Rinke Stienstra, Niels P. Riksen, Cees J. Tack, Mihai G. Netea
Pubblicato in: Cellular and Molecular Life Sciences, 2016, ISSN 1420-682X
Editore: Birkhauser Verlag
DOI: 10.1007/s00018-016-2316-9

Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in HumansClinical Perspective

Autori: Fleur M. van der Valk, Siroon Bekkering, Jeffrey Kroon, Calvin Yeang, Jan Van den Bossche, Jaap D. van Buul, Amir Ravandi, Aart J. Nederveen, Hein J. Verberne, Corey Scipione, Max Nieuwdorp, Leo A.B. Joosten, Mihai G. Netea, Marlys L. Koschinsky, Joseph L. Witztum, Sotirios Tsimikas, Niels P. Riksen, Erik S.G. Stroes
Pubblicato in: Circulation, 134/8, 2016, Page(s) 611-624, ISSN 0009-7322
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCULATIONAHA.116.020838

Unexpected arterial wall and cellular inflammation in patients with rheumatoid arthritis in remission using biological therapy: a cross-sectional study

Autori: Sophie J. Bernelot Moens, Fleur M. van der Valk, Aart C. Strang, Jeffrey Kroon, Loek P. Smits, Eva L. Kneepkens, Hein J. Verberne, Jaap D. van Buul, Michael T. Nurmohamed, Erik S. G. Stroes
Pubblicato in: Arthritis Research & Therapy, 18/1, 2016, ISSN 1478-6362
Editore: BioMed Central
DOI: 10.1186/s13075-016-1008-z

Erratum to: Unexpected arterial wall and cellular inflammation in patients with rheumatoid arthritis in remission using biological therapy: a cross-sectional study

Autori: Sophie J. Bernelot Moens, Fleur M. van der Valk, Aart C. Strang, Jeffrey Kroon, Loek P. Smits, Eva L. Kneepkens, Hein J. Verberne, Jaap D. van Buul, Michael T. Nurmohamed, Erik S. G. Stroes
Pubblicato in: Arthritis Research & Therapy, 18/1, 2016, ISSN 1478-6362
Editore: BioMed Central
DOI: 10.1186/s13075-016-1198-4

Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation

Autori: Fabrizia Bonacina, David Coe, Guosu Wang, Maria P. Longhi, Andrea Baragetti, Annalisa Moregola, Katia Garlaschelli, Patrizia Uboldi, Fabio Pellegatta, Liliana Grigore, Lorenzo Da Dalt, Andrea Annoni, Silvia Gregori, Qingzhong Xiao, Donatella Caruso, Nico Mitro, Alberico L. Catapano, Federica M. Marelli-Berg, Giuseppe D. Norata
Pubblicato in: Nature Communications, 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-018-05322-1

Anti-PCSK9 antibodies for the treatment of heterozygous familial hypercholesterolemia: patient selection and perspectives

Autori: Alberico Catapano, Angela Pirillo, Giuseppe Danilo Norata
Pubblicato in: Vascular Health and Risk Management, Volume 13, 2017, Page(s) 343-351, ISSN 1178-2048
Editore: Dovepress
DOI: 10.2147/VHRM.S130338

Macrophages and Cardiovascular Health

Autori: Vanessa Frodermann, Matthias Nahrendorf
Pubblicato in: Physiological Reviews, 98/4, 2018, Page(s) 2523-2569, ISSN 0031-9333
Editore: American Physiological Society
DOI: 10.1152/physrev.00068.2017

Myeloid cell contributions to cardiovascular health and disease

Autori: Matthias Nahrendorf
Pubblicato in: Nature Medicine, 24/6, 2018, Page(s) 711-720, ISSN 1078-8956
Editore: Nature Publishing Group
DOI: 10.1038/s41591-018-0064-0

Imaging the Vascular Bone Marrow Niche During Inflammatory Stress

Autori: Katrien Vandoorne, David Rohde, Hye-Yeong Kim, Gabriel Courties, Gregory Wojtkiewicz, Lisa Honold, Friedrich Felix Hoyer, Vanessa Frodermann, Ribhu Nayar, Fanny Herisson, Yookyung Jung, Pauline A. Désogère, Claudio Vinegoni, Peter Caravan, Ralph Weissleder, David E. Sosnovik, Charles P. Lin, Filip K. Swirski, Matthias Nahrendorf
Pubblicato in: Circulation Research, 123/4, 2018, Page(s) 415-427, ISSN 0009-7330
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.118.313302

Myeloid Kdm6b deficiency results in advanced atherosclerosis

Autori: Annette E. Neele, Marion J.J. Gijbels, Saskia van der Velden, Marten A. Hoeksema, Marieke C.S. Boshuizen, Koen H.M. Prange, Hung-Jen Chen, Jan Van den Bossche, Cindy P.P.A. van Roomen, Annelie Shami, Johannes H.M. Levels, Jeffrey Kroon, Tina Lucas, Stefanie Dimmeler, Esther Lutgens, Menno P.J. de Winther
Pubblicato in: Atherosclerosis, 275, 2018, Page(s) 156-165, ISSN 0021-9150
Editore: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2018.05.052

CD40L Deficiency Protects Against Aneurysm Formation

Autori: Pascal J.H. Kusters, Tom T.P. Seijkens, Linda Beckers, Dirk Lievens, Holger Winkels, Vivian de Waard, Adriaan Duijvestijn, Moritz Lindquist Liljeqvist, Joy Roy, Alan Daugherty, Andrew Newby, Norbert Gerdes, Esther Lutgens
Pubblicato in: Arteriosclerosis, Thrombosis, and Vascular Biology, 38/5, 2018, Page(s) 1076-1085, ISSN 1079-5642
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.117.310640

2016 Jeffrey M. Hoeg Award Lecture

Autori: Ellen Rouwet, Esther Lutgens
Pubblicato in: Arteriosclerosis, Thrombosis, and Vascular Biology, 38/8, 2018, Page(s) 1678-1688, ISSN 1079-5642
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.118.307742

Future directions for therapeutic strategies in post-ischaemic vascularization: a position paper from European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology

Autori: Andrea Caporali, Magnus Bäck, Mat J Daemen, Imo E Hoefer, Elizabeth A Jones, Esther Lutgens, Christian M Matter, Marie-Luce Bochaton-Piallat, Arndt F Siekmann, Judith C Sluimer, Sabine Steffens, José Tuñón, Cecile Vindis, Jolanda J Wentzel, Seppo Ylä-Herttuala, Paul C Evans
Pubblicato in: Cardiovascular Research, 114/11, 2018, Page(s) 1411-1421, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvy184

Macrophage CD40 plays a minor role in obesity-induced metabolic dysfunction

Autori: Suzanne A. B. M. Aarts, Myrthe E. Reiche, Myrthe den Toom, Linda Beckers, Marion J. J. Gijbels, Norbert Gerdes, Menno P. J. de Winther, Esther Lutgens
Pubblicato in: PLOS ONE, 13/8, 2018, Page(s) e0202150, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0202150

Innate immune cell activation and epigenetic remodeling in symptomatic and asymptomatic atherosclerosis in humans in vivo

Autori: Siroon Bekkering, Inge van den Munckhof, Tim Nielen, Evert Lamfers, Charles Dinarello, Joost Rutten, Jacqueline de Graaf, Leo A.B. Joosten, Mihai G. Netea, Marc E.R. Gomes, Niels P. Riksen
Pubblicato in: Atherosclerosis, 254, 2016, Page(s) 228-236, ISSN 0021-9150
Editore: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2016.10.019

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

Autori: Rob J.W. Arts, Boris Novakovic, Rob ter Horst, Agostinho Carvalho, Siroon Bekkering, Ekta Lachmandas, Fernando Rodrigues, Ricardo Silvestre, Shih-Chin Cheng, Shuang-Yin Wang, Ehsan Habibi, Luís G. Gonçalves, Inês Mesquita, Cristina Cunha, Arjan van Laarhoven, Frank L. van de Veerdonk, David L. Williams, Jos W.M. van der Meer, Colin Logie, Luke A. O'Neill, Charles A. Dinarello, Niels P. Riksen,
Pubblicato in: Cell Metabolism, 24/6, 2016, Page(s) 807-819, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2016.10.008

In Vitro Experimental Model of Trained Innate Immunity in Human Primary Monocytes

Autori: Siroon Bekkering, Bastiaan A. Blok, Leo A. B. Joosten, Niels P. Riksen, Reinout van Crevel, Mihai G. Netea
Pubblicato in: Clinical and Vaccine Immunology, 23/12, 2016, Page(s) 926-933, ISSN 1556-6811
Editore: American Society for Microbiology
DOI: 10.1128/CVI.00349-16

Long-term activation of the innate immune system in atherosclerosis

Autori: Anette Christ, Siroon Bekkering, Eicke Latz, Niels P. Riksen
Pubblicato in: Seminars in Immunology, 28/4, 2016, Page(s) 384-393, ISSN 1044-5323
Editore: Academic Press
DOI: 10.1016/j.smim.2016.04.004

Biology of proprotein convertase subtilisin kexin 9: beyond low-density lipoprotein cholesterol lowering

Autori: Giuseppe Danilo Norata, Hagai Tavori, Angela Pirillo, Sergio Fazio, Alberico L. Catapano
Pubblicato in: Cardiovascular Research, 112/1, 2016, Page(s) 429-442, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvw194

TET1 is an important transcriptional activator of TNFα expression in macrophages

Autori: Fangfang Sun, Irene Abreu-Rodriguez, Shuang Ye, Steffen Gay, Oliver Distler, Michel Neidhart, Emmanuel Karouzakis
Pubblicato in: PLOS ONE, 14/6, 2019, Page(s) e0218551, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0218551

Oligomeric S100A4 Is Associated With Monocyte Innate Immune Memory and Bypass of Tolerance to Subsequent Stimulation With Lipopolysaccharides

Autori: Michel Neidhart, Agnieszka Pajak, Katerina Laskari, Niels P. Riksen, Leo A. B. Joosten, Mihai G. Netea, Esther Lutgens, Eric S. G. Stroes, Adrian Ciurea, Oliver Distler, Mariam Grigorian, Emmanuel Karouzakis
Pubblicato in: Frontiers in Immunology, 10, 2019, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2019.00791

Role of gut microbiota in chronic low-grade inflammation as potential driver for atherosclerotic cardiovascular disease: a systematic review of human studies

Autori: I. C. L. van den Munckhof, A. Kurilshikov, R. ter Horst, N. P. Riksen, L. A. B. Joosten, A. Zhernakova, J. Fu, S. T. Keating, M. G. Netea, J. de Graaf, J. H. W. Rutten
Pubblicato in: Obesity Reviews, 19/12, 2018, Page(s) 1719-1734, ISSN 1467-7881
Editore: Blackwell Publishing Inc.
DOI: 10.1111/obr.12750

Immunometabolism orchestrates training of innate immunity in atherosclerosis

Autori: Julia van Tuijl, Leo A B Joosten, Mihai G Netea, Siroon Bekkering, Niels P Riksen
Pubblicato in: Cardiovascular Research, 115/9, 2019, Page(s) 1416-1424, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvz107

Plant-based sterols and stanols in health & disease: “Consequences of human development in a plant-based environment?”

Autori: J. Plat, S. Baumgartner, T. Vanmierlo, D. Lütjohann, K.L. Calkins, D.G. Burrin, G. Guthrie, C. Thijs, A.A. Te Velde, A.C.E. Vreugdenhil, R. Sverdlov, J. Garssen, K. Wouters, E.A. Trautwein, T.G. Wolfs, C. van Gorp, M.T. Mulder, N.P. Riksen, A.K. Groen, R.P. Mensink
Pubblicato in: Progress in Lipid Research, 74, 2019, Page(s) 87-102, ISSN 0163-7827
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.plipres.2019.02.003

Getting to the marrow of trained immunity

Autori: Laszlo Groh, Mihai G Netea, Niels P Riksen, Samuel T Keating
Pubblicato in: Epigenomics, 10/9, 2018, Page(s) 1151-1154, ISSN 1750-1911
Editore: Future Medicine Ltd.
DOI: 10.2217/epi-2018-0098

Be aware, innate immune cells remember

Autori: Niels P. Riksen, Mihai G. Netea
Pubblicato in: Aging, 10/9, 2018, Page(s) 2218-2219, ISSN 1945-4589
Editore: Aging
DOI: 10.18632/aging.101552

Metabolism of innate immune cells

Autori: Niels P. Riksen, Rinke Stienstra
Pubblicato in: Current Opinion in Lipidology, 29/5, 2018, Page(s) 359-367, ISSN 0957-9672
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/mol.0000000000000539

Aldosterone induces trained immunity: the role of fatty acid synthesis

Autori: Charlotte D C C van der Heijden, Samuel T Keating, Laszlo Groh, Leo A B Joosten, Mihai G Netea, Niels P Riksen
Pubblicato in: Cardiovascular Research, 2019, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvz137

The mineralocorticoid receptor as a modulator of innate immunity and atherosclerosis

Autori: Charlotte D C C van der Heijden, Jaap Deinum, Leo A B Joosten, Mihai G Netea, Niels P Riksen
Pubblicato in: Cardiovascular Research, 114/7, 2018, Page(s) 944-953, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvy092

Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia

Autori: Siroon Bekkering, Lotte C.A. Stiekema, Sophie Bernelot Moens, Simone L. Verweij, Boris Novakovic, Koen Prange, Miranda Versloot, Jeanine E. Roeters van Lennep, Henk Stunnenberg, Menno de Winther, Erik S.G. Stroes, Leo A.B. Joosten, Mihai G. Netea, Niels P. Riksen
Pubblicato in: Cell Metabolism, 30/1, 2019, Page(s) 1-2, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2019.05.014

Trained immunity and atherosclerotic cardiovascular disease

Autori: Niels P. Riksen
Pubblicato in: Current Opinion in Lipidology, 30/5, 2019, Page(s) 395-400, ISSN 0957-9672
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/mol.0000000000000628

Deficiency of the T cell regulator Casitas B-cell lymphoma-B aggravates atherosclerosis by inducing CD8+ T cell-mediated macrophage death

Autori: Tom T P Seijkens, Kikkie Poels, Svenja Meiler, Claudia M van Tiel, Pascal J H Kusters, Myrthe Reiche, Dorothee Atzler, Holger Winkels, Marc Tjwa, Hessel Poelman, Bram Slütter, Johan Kuiper, Marion Gijbels, Jan Albert Kuivenhoven, Ljubica Perisic Matic, Gabrielle Paulsson-Berne, Ulf Hedin, Göran K Hansson, Gerry A F Nicolaes, Mat J A P Daemen, Christian Weber, Norbert Gerdes, Menno P J de Winther
Pubblicato in: European Heart Journal, 40/4, 2018, Page(s) 372-382, ISSN 0195-668X
Editore: Oxford University Press
DOI: 10.1093/eurheartj/ehy714

Identifying the anti-inflammatory response to lipid lowering therapy: a position paper from the working group on atherosclerosis and vascular biology of the European Society of Cardiology

Autori: José Tuñón, Lina Badimón, Marie-Luce Bochaton-Piallat, Bertrand Cariou, Mat J Daemen, Jesus Egido, Paul C Evans, Imo E Hoefer, Daniel F J Ketelhuth, Esther Lutgens, Christian M Matter, Claudia Monaco, Sabine Steffens, Erik Stroes, Cécile Vindis, Christian Weber, Magnus Bäck
Pubblicato in: Cardiovascular Research, 115/1, 2018, Page(s) 10-19, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvy293

The Interplay of Lipids, Lipoproteins, and Immunity in Atherosclerosis

Autori: Angela Pirillo, Fabrizia Bonacina, Giuseppe Danilo Norata, Alberico Luigi Catapano
Pubblicato in: Current Atherosclerosis Reports, 20/3, 2018, ISSN 1523-3804
Editore: Current Science Inc.
DOI: 10.1007/s11883-018-0715-0

Familial hypercholesterolemia treatments: Guidelines and new therapies

Autori: Frederick J. Raal, G. Kees Hovingh, Alberico L. Catapano
Pubblicato in: Atherosclerosis, 277, 2018, Page(s) 483-492, ISSN 0021-9150
Editore: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2018.06.859

Evaluation of the performance of Dutch Lipid Clinic Network score in an Italian FH population: The LIPIGEN study

Autori: Manuela Casula, Elena Olmastroni, Angela Pirillo, Alberico Luigi Catapano, Marcello Arca, Maurizio Averna, Stefano Bertolini, Sebastiano Calandra, Alberico Luigi Catapano, Patrizia Tarugi, Fabio Pellegatta, Francesco Angelico, Marcello Arca, Maurizio Averna, Andrea Bartuli, Giacomo Biasucci, Gianni Biolo, Luca Bonanni, Katia Bonomo, Claudio Borghi, Antonio Carlo Bossi, Adriana Branchi, Francesca C
Pubblicato in: Atherosclerosis, 277, 2018, Page(s) 413-418, ISSN 0021-9150
Editore: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2018.08.013

Prolonged hematopoietic and myeloid cellular response in patients after an acute coronary syndrome measured with 18F-DPA-714 PET/CT

Autori: Simone L. Verweij, Lotte C. A. Stiekema, Ronak Delewi, Kang H. Zheng, Sophie J. Bernelot Moens, Jeffrey Kroon, Charlotte I. Stroes, Miranda Versloot, Jan J. Piek, Hein J. Verberne, Erik S. G. Stroes
Pubblicato in: European Journal of Nuclear Medicine and Molecular Imaging, 45/11, 2018, Page(s) 1956-1963, ISSN 1619-7070
Editore: Springer Verlag
DOI: 10.1007/s00259-018-4038-8

Small molecule-mediated inhibition of CD40-TRAF6 reduces adverse cardiac remodelling in pressure overload induced heart failure

Autori: Lena Bosch, Judith de Haan, Tom Seijkens, Claudia van Tiel, Maike Brans, Gerard Pasterkamp, Esther Lutgens, Saskia de Jager
Pubblicato in: International Journal of Cardiology, 279, 2019, Page(s) 141-144, ISSN 0167-5273
Editore: Elsevier BV
DOI: 10.1016/j.ijcard.2018.12.076

The Link between Hematopoiesis and Atherosclerosis

Autori: Menno P.J. de Winther, Esther Lutgens
Pubblicato in: New England Journal of Medicine, 380/19, 2019, Page(s) 1869-1871, ISSN 0028-4793
Editore: Massachusetts Medical Society
DOI: 10.1056/nejmcibr1901397

Immunotherapy for cardiovascular disease

Autori: Esther Lutgens, Dorothee Atzler, Yvonne Döring, Johan Duchene, Sabine Steffens, Christian Weber
Pubblicato in: European Heart Journal, 40/48, 2019, Page(s) 3937-3946, ISSN 0195-668X
Editore: Oxford University Press
DOI: 10.1093/eurheartj/ehz283

Depletion of CD40 on CD11c+ cells worsens the metabolic syndrome and ameliorates hepatic inflammation during NASH

Autori: Suzanne Aarts, Myrthe Reiche, Myrthe den Toom, Marion Gijbels, Linda Beckers, Norbert Gerdes, Esther Lutgens
Pubblicato in: Scientific Reports, 9/1, 2019, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-50976-6

Epigenetic Quenching of VSMC Inflammation in CVD

Autori: Esther Lutgens
Pubblicato in: Arteriosclerosis, Thrombosis, and Vascular Biology, 39/11, 2019, Page(s) 2199-2200, ISSN 1079-5642
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.119.313345

Peritoneal macrophages have an impaired immune response in obesity which can be reversed by subsequent weight loss

Autori: Lisa Willemsen, Annette E Neele, Saskia van der Velden, Koen H M Prange, Myrthe den Toom, Cindy P A A van Roomen, Myrthe E Reiche, Guillermo R Griffith, Marion J J Gijbels, Esther Lutgens, Menno P J de Winther
Pubblicato in: BMJ Open Diabetes Research & Care, 7/1, 2019, Page(s) e000751, ISSN 2052-4897
Editore: BMJ journals
DOI: 10.1136/bmjdrc-2019-000751

Tissue-Specific Macrophage Responses to Remote Injury Impact the Outcome of Subsequent Local Immune Challenge

Autori: Friedrich Felix Hoyer, Kamila Naxerova, Maximilian J. Schloss, Maarten Hulsmans, Anil V. Nair, Partha Dutta, David M. Calcagno, Fanny Herisson, Atsushi Anzai, Yuan Sun, Gregory Wojtkiewicz, David Rohde, Vanessa Frodermann, Katrien Vandoorne, Gabriel Courties, Yoshiko Iwamoto, Christopher S. Garris, David L. Williams, Sylvie Breton, Dennis Brown, Michael Whalen, Peter Libby, Mikael J. Pittet, Kevin
Pubblicato in: Immunity, 51/5, 2019, Page(s) 899-914.e7, ISSN 1074-7613
Editore: Cell Press
DOI: 10.1016/j.immuni.2019.10.010

Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells

Autori: Vanessa Frodermann, David Rohde, Gabriel Courties, Nicolas Severe, Maximilian J. Schloss, Hajera Amatullah, Cameron S. McAlpine, Sebastian Cremer, Friedrich F. Hoyer, Fei Ji, Ian D. van Koeverden, Fanny Herisson, Lisa Honold, Gustavo Santos Masson, Shuang Zhang, Jana Grune, Yoshiko Iwamoto, Stephen P. Schmidt, Gregory R. Wojtkiewicz, I-Hsiu Lee, Karin Gustafsson, Gerard Pasterkamp, Saskia C. A. de
Pubblicato in: Nature Medicine, 25/11, 2019, Page(s) 1761-1771, ISSN 1078-8956
Editore: Nature Publishing Group
DOI: 10.1038/s41591-019-0633-x

Persistent arterial wall inflammation in patients with elevated lipoprotein(a) despite strong low-density lipoprotein cholesterol reduction by proprotein convertase subtilisin/kexin type 9 antibody treatment

Autori: Lotte C A Stiekema, Erik S G Stroes, Simone L Verweij, Helina Kassahun, Lisa Chen, Scott M Wasserman, Marc S Sabatine, Venkatesh Mani, Zahi A Fayad
Pubblicato in: European Heart Journal, 40/33, 2018, Page(s) 2775-2781, ISSN 0195-668X
Editore: Oxford University Press
DOI: 10.1093/eurheartj/ehy862

Specific and Complex Reprogramming of Cellular Metabolism in Myeloid Cells during Innate Immune Responses

Autori: Rinke Stienstra, Romana T. Netea-Maier, Niels P. Riksen, Leo A.B. Joosten, Mihai G. Netea
Pubblicato in: Cell Metabolism, 26/1, 2017, Page(s) 142-156, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2017.06.001

Planarians SET New Paths for Innate Immune Memory

Autori: Samuel T. Keating, Niels P. Riksen, Mihai G. Netea
Pubblicato in: EBioMedicine, 20, 2017, Page(s) 7-8, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/j.ebiom.2017.05.007

Macrophage Kdm6b controls the pro-fibrotic transcriptome signature of foam cells

Autori: Annette E Neele, Koen HM Prange, Marten A Hoeksema, Saskia van der Velden, Tina Lucas, Stefanie Dimmeler, Esther Lutgens, Jan Van den Bossche, Menno PJ de Winther
Pubblicato in: Epigenomics, 9/4, 2017, Page(s) 383-391, ISSN 1750-1911
Editore: Future Medicine Ltd.
DOI: 10.2217/epi-2016-0152

PCSK9 Antibody Alirocumab Attenuates Arterial Wall Inflammation Without Changes in Circulating Inflammatory Markers

Autori: Renate M. Hoogeveen, Tjerk S.J. Opstal, Yannick Kaiser, Lotte C.A. Stiekema, Jeffrey Kroon, Remco J.J. Knol, Willem A. Bax, Hein J. Verberne, Jan H. Cornel, Erik S.G. Stroes
Pubblicato in: JACC: Cardiovascular Imaging, 12/12, 2019, Page(s) 2571-2573, ISSN 1936-878X
Editore: Elsevier BV
DOI: 10.1016/j.jcmg.2019.06.022