Multi-modal, Endoscopic Biophotonic Imaging of Bladder Cancer for Point-of-Care Diagnosis

Project Information

MIB

Grant agreement ID: 667933

DOI 10.3030/667933

Project closed

EC signature date 9 December 2015

Start date 1 January 2016

End date 31 December 2021

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost € 5 983 807,50

EU contribution € 5 983 807,50

Coordinated by

DANMARKS TEKNISKE UNIVERSITET
Denmark

Deliverables

Demonstrators, pilots, prototypes (1)

Project Website

Project Website.

Publications

Peer reviewed articles (31)

Endoscopic optical coherence tomography with a flexible fiber bundle

Author(s): Lara M. Wurster; Laurin Ginner; Abhishek Kumar; Matthias Salas; Andreas Wartak; Rainer A. Leitgeb
Published in: Journal of Biomedical Optic, Issue 23, 2018, Page(s) 06600, ISSN 1083-3668
Publisher: S P I E - International Society for Optical Engineering
DOI: 10.1117/1.jbo.23.6.066001

Accurate in vivo tumor detection using plasmonic-enhanced shifted-excitation Raman difference spectroscopy (SERDS)

Author(s): Pietro Strobbia, Vanessa Cupil-Garcia, Bridget M. Crawford, Andrew M. Fales, T. Joshua Pfefer, Yang Liu, Martin Maiwald, Bernd Sumpf, and Tuan Vo-Dinh
Published in: Theranostics, Issue 11, 2021, Page(s) 4090–4102, ISSN 1838-7640
Publisher: Ivyspring International Publisher
DOI: 10.7150/thno.53101

Ultrashort pulse Kagome hollow-core photonic crystal fiber delivery for nonlinear optical imaging.

Author(s): Andreana; Le; Drexler; Unterhuber
Published in: Optics Letters, Issue 44, 2019, Page(s) 1588-1591, ISSN 0146-9592
Publisher: Optical Society of America
DOI: 10.1364/ol.44.001588

A submicrometre silicon-on-insulator resonator for ultrasound detection

Author(s): Rami Shnaiderman, Georg Wissmeyer, Okan Ülgen, Qutaiba Mustafa, Andriy Chmyrov & Vasilis Ntziachristos
Published in: Nature, Issue 585, 2020, Page(s) 372–378, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2685-y

Morpho-Molecular Metabolic Analysis and Classification of Human Pituitary Gland and Adenoma Biopsies Based on Multimodal Optical Imaging.

Author(s): Gabriel Giardina; Alexander Micko; Daniela Bovenkamp; Arno Krause; Fabian Placzek; Laszlo Papp; Denis Krajnc; Clemens P. Spielvogel; Michael Winklehner; Romana Höftberger; Greisa Vila; Marco Andreana; Rainer A. Leitgeb; Wolfgang Drexler; Stefan Wolfsberger; Angelika Unterhuber
Published in: Cancers, Issue 1, 2021, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13133234

Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography

Author(s): Rainer Leitgeb, Fabian Placzek, Elisabet Rank, Lisa Krainz, Richard Haindl, Qian Li, Mengyang Liu, Marco Andreana, Angelika Unterhuber, Tilman Schmoll, Wolfgang Drexler
Published in: Journal of Biomedical Optics, Issue 26/10, 2021, ISSN 1083-3668
Publisher: S P I E - International Society for Optical Engineering
DOI: 10.1117/1.jbo.26.10.100601

Manufacturing and assembly of an all-glass OCT microendoscope

Author(s): Yanis Taege, Gerardo González-Cerdas, Felix Jund, Hans Zappe, Caglar Ataman
Published in: Journal of Micromechanics and Microengineering, 2021, ISSN 0960-1317
Publisher: Institute of Physics Publishing
DOI: 10.1088/1361-6439/ac2d9d

Monolithic Master Oscillator Tilted Tapered Power Amplifier Emitting 9.5 W at 1060 nm

Author(s): Zink, Christof; Maabdorf, Andre; Fricke, Jorg; Ressel, Peter; Sumpf, Bernd; Erbert, Gotz; Trankle, Gunther
Published in: IEEE Photonics Technology Letters, Issue 32, 2020, Page(s) 59-62, ISSN 1041-1135
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/lpt.2019.2957063

Multimodal Optical Medical Imaging Concepts based on Optical Coherence Tomography

Author(s): Rainer A. Leitgeb; Rainer A. Leitgeb; Bernhard Baumann
Published in: Frontiers in Physics, Vol 6 (2018), Issue 6, 2018, ISSN 2296-424X
Publisher: Frontiers Media S.A
DOI: 10.3389/fphy.2018.00114

Interferometric optical fiber sensor for optoacoustic endomicroscopy.

Author(s): Okan Ülgen; Rami Shnaiderman; Christian Zakian; Vasilis Ntziachristos
Published in: Journal of Biophotonics, Issue 14, 2021, Page(s) e202000501, ISSN 1864-063X
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.202000501

Morpho-molecular signal correlation between optical coherence tomography and Raman spectroscopy for superior image interpretation and clinical diagnosis.

Author(s): Iwan W. Schie; Fabian Placzek; Florian Knorr; Eliana Cordero; Lara M. Wurster; Gregers G. Hermann; Karin Mogensen; Thomas Hasselager; Wolfgang Drexler; Jürgen Popp; Jürgen Popp; Rainer A. Leitgeb
Published in: Scientific Reports, Issue 11, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.21203/rs.3.rs-322204/v1

Comparison of optical coherence tomography angiography and narrow-band imaging using a bimodal endoscope.

Author(s): Lara M. Wurster; Simon Kretschmer; Jan Jäger; Fabian Placzek; Laurin Ginner; Wolfgang Drexler; Caglar Ataman; Rainer A. Leitgeb; Hans Zappe
Published in: Journal of Biomedical Optics, Issue 25, 2019, Page(s) 032003, ISSN 1083-3668
Publisher: S P I E - International Society for Optical Engineering
DOI: 10.1117/1.jbo.25.3.032003

Line Scan Raman Microspectroscopy for Label-Free Diagnosis of Human Pituitary Biopsies.

Author(s): Bovenkamp, Daniela; Micko, Alexander; Püls, Jeremias; Placzek, Fabian; Höftberger, Romana; Vila, Greisa; Leitgeb, Rainer; Drexler, Wolfgang; Andreana, Marco; Wolfsberger, Stefan; Unterhuber, Angelika
Published in: Molecules, 2019, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules24193577

Measuring the sensitivity to optical feedback of single-frequency high-power laser diodes

Author(s): Mathias Christensen, Christof Zink, Muhammad Tahir Jamal, Anders Kragh Hansen, Ole Bjarlin Jensen, and Bernd Sumpf
Published in: Journal of the Optical Society of America B, Issue 38, 2021, Page(s) 885-892, ISSN 0740-3224
Publisher: Optical Society of America
DOI: 10.1364/josab.417258

Raman ChemLighter: Fiber optic Raman probe imaging in combination with augmented chemical reality

Author(s): Yang, Wei; Mondol, Abdullah S.; Stiebing, Clara; Marcu, Laura; Popp, Jürgen; Schie, Iwan W.
Published in: Journal of Biophotonics, Issue 12, 2019, Page(s) 12:e201800447, ISSN 1864-063X
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.201800447

Rapid and adjustable shifted excitation Raman difference spectroscopy using a dual-wavelength diode laser at 785 nm

Author(s): Martin Maiwald, Bernd Sumpf, Günther Tränkle
Published in: Journal of Raman Spectroscopy, 2018, ISSN 0377-0486
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/jrs.5456

Combination of High-Resolution Optical Coherence Tomography and Raman Spectroscopy for Improved Staging and Grading in Bladder Cancer

Author(s): Daniela Bovenkamp, Ryan Sentosa, Elisabet Rank, Mikael Erkkilä, Fabian Placzek, Jeremias Püls, Wolfgang Drexler, Rainer Leitgeb, Nathalie Garstka, Shahrokh Shariat, Clara Stiebing, Iwan Schie, Jürgen Popp, Marco Andreana, Angelika Unterhuber
Published in: Applied Sciences, Issue 8/12, 2018, Page(s) 2371, ISSN 2076-3417
Publisher: MDPI AG
DOI: 10.3390/app8122371

Endoscopic optical coherence tomography angiography using a forward imaging piezo scanner probe

Author(s): Lara M. Wurster, Ronak N. Shah, Fabian Placzek, Simon Kretschmer, Michael Niederleithner, Laurin Ginner, Jason Ensher, Michael P. Minneman, Erich E. Hoover, Hans Zappe, Wolfgang Drexler, Rainer A. Leitgeb, Çağlar Ataman
Published in: Journal of Biophotonics, 2019, Page(s) e201800382, ISSN 1864-063X
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.201800382

MCmatlab: an open-source, user-friendly, MATLAB-integrated three-dimensional Monte Carlo light transport solver with heat diffusion and tissue damage

Author(s): Dominik Marti, Rikke N. Aasbjerg, Peter E. Andersen, Anders K. Hansen
Published in: Journal of Biomedical Optics, Issue 23/12, 2018, Page(s) 1, ISSN 1083-3668
Publisher: S P I E - International Society for Optical Engineering
DOI: 10.1117/1.jbo.23.12.121622

In-vivo Raman spectroscopy: from basics to applications

Author(s): Eliana Cordero
Published in: Journal of Biomedical Optics, Issue 23/07, 2018, Page(s) 1, ISSN 1083-3668
Publisher: S P I E - International Society for Optical Engineering
DOI: 10.1117/1.jbo.23.7.071210

Morpho-molecular ex vivo detection and grading of non-muscle-invasive bladder cancer using forward imaging probe based multimodal optical coherence tomography and Raman spectroscopy

Author(s): Fabian Placzek, Eliana Cordero Bautista, Simon Kretschmer, Lara M. Wurster, Florian Knorr, Gerardo González-Cerdas, Mikael T. Erkkilä, Patrick Stein, Çağlar Ataman, Gregers G. Hermann, Karin Mogensen, Thomas Hasselager, Peter E. Andersen, Hans Zappe, Jürgen Popp, Wolfgang Drexler, Rainer A. Leitgeb, Iwan W. Schie
Published in: The Analyst, 2020, ISSN 0003-2654
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9an01911a

Bladder tissue characterization using probe‐based Raman spectroscopy: Evaluation of tissue heterogeneity and influence on the model prediction

Author(s): Eliana Cordero, Jan Rüger, Dominik Marti, Abdullah S. Mondol, Thomas Hasselager, Karin Mogensen, Gregers G. Hermann, Jürgen Popp, Iwan W. Schie
Published in: Journal of Biophotonics, Issue 13/2, 2019, ISSN 1864-063X
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.201960025

Efficient generation of 3.5W laser light at 515nm by frequency doubling a single-frequency high power DBR tapered diode laser

Author(s): Ole Bjarlin Jensen, Anders Kragh Hansen, André Müller, Bernd Sumpf, Paul Michael Petersen, Peter E. Andersen
Published in: Optics Communications, Issue 392, 2017, Page(s) 167-170, ISSN 0030-4018
Publisher: Elsevier BV
DOI: 10.1016/j.optcom.2017.01.060

Evaluation of Shifted Excitation Raman Difference Spectroscopy and Comparison to Computational Background Correction Methods Applied to Biochemical Raman Spectra

Author(s): Eliana Cordero, Florian Korinth, Clara Stiebing, Christoph Krafft, Iwan Schie, Jürgen Popp
Published in: Sensors, Issue 17/8, 2017, Page(s) 1724, ISSN 1424-8220
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s17081724

Dual-wavelength diode laser with electrically adjustable wavelength distance at 785  nm

Author(s): Bernd Sumpf, Julia Kabitzke, Jörg Fricke, Peter Ressel, André Müller, Martin Maiwald, Günther Tränkle
Published in: Optics Letters, Issue 41/16, 2016, Page(s) 3694, ISSN 0146-9592
Publisher: Optical Society of America
DOI: 10.1364/OL.41.003694

Selecting optimal spectral bands for improved detection of autofluorescent biomarkers in multiphoton microscopy

Author(s): Björn-Ole Meyer, M. Pilar J. Stella, Bjørn Holst, Boye S. Nielsen, Kim Holmstrøm, Peter E. Andersen, Dominik Marti
Published in: Journal of Biomedical Optics, Issue 25/07, 2020, Page(s) 1, ISSN 1083-3668
Publisher: S P I E - International Society for Optical Engineering
DOI: 10.1117/1.jbo.25.7.071206

Silicon-Photonics Point Sensor for High-Resolution Optoacoustic Imaging

Author(s): Rami Shnaiderman, Qutaiba Mustafa, Okan Ülgen, Georg Wissmeyer, Héctor Estrada, Daniel Razansky, Andriy Chmyrov, Vasilis Ntziachristos
Published in: Advanced Optical Materials, Issue 9, 2021, Page(s) 2100256, ISSN 2195-1071
Publisher: Wiley
DOI: 10.1002/adom.202100256

Development and evaluation of a hand-held fiber-optic Raman probe with an integrated autofocus unit

Author(s): Yang Wei; Florian Knorr; Jürgen Popp; Iwan W. Schie
Published in: Optics Express, Issue 28, 2020, Page(s) 30760-30770, ISSN 1094-4087
Publisher: Optical Society of America
DOI: 10.1364/oe.401207

Morpho-Molecular Metabolic Analysis and Classification of Human Pituitary Gland and Adenoma Biopsies Based on Multimodal Optical Imaging

Author(s): Gabriel Giardina, Alexander Micko, Daniela Bovenkamp, Arno Krause, Fabian Placzek, Laszlo Papp, Denis Krajnc, Clemens P. Spielvogel, Michael Winklehner, Romana Höftberger, Greisa Vila, Marco Andreana, Rainer Leitgeb, Wolfgang Drexler, Stefan Wolfsberger, Angelika Unterhuber
Published in: Cancers, Issue 13/13, 2021, Page(s) 3234, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13133234

Depth resolved label-free multimodal optical imaging platform to study morpho-molecular composition of tissue

Author(s): Andreana; Sentosa; Erkkilä; Drexler; Unterhuber
Published in: Photochemical & Photobioogical Sciences, Issue 1, 2019, ISSN 1474-905X
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8pp00410b

En face optical coherence tomography: a technology review [Invited].

Author(s): Leitgeb, R. A.
Published in: Biomedical Optics Express, Issue 1, 2019, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/boe.10.002177

Conference proceedings (12)

CARS endomicroscopic imaging probe enabled by a double-core double-clad fiber and related focus-combining micro-optical concept

Author(s): Bernhard Messerschmidt, Ekaterina Pshenay-Severin, Gregor Matz, Karl Reichwald, Jörg Bierlich, Jens Kobelke, Hyeonsoo Bae, Tobias Meyer-Zedler, Michael Schmitt, Jürgen Popp
Published in: Proceedings Volume 11636, Optical Biopsy XIX: Toward Real-Time Spectroscopic Imaging and Diagnosis; 116360A (2021), 2021, ISSN 0277-786X
Publisher: SPIE Digital Library
DOI: 10.1117/12.2578538

Spectrally stabilized high-power high-brightness DBR-tapered lasers in the VIS and NIR range

Author(s): Bernd Sumpf, Katrin Paschke
Published in: Laser Resonators, Microresonators, and Beam Control XX, Issue 10518, 2018, Page(s) 44, ISBN 9781-510615229
Publisher: SPIE
DOI: 10.1117/12.2288425

High power diode lasers converted to the visible

Author(s): Ole B. Jensen, Anders K. Hansen, Peter E. Andersen, Mathias Christensen, Andre Muller, Mahmoud Tawfieq, Bernd Sumpf, Paul M. Petersen
Published in: 2017 IEEE High Power Diode Lasers and Systems Conference (HPD), Issue CFP1771I-ART, 2017, Page(s) 45-46, ISBN 978-1-5386-3263-5
Publisher: IEEE
DOI: 10.1109/HPD.2017.8261093

Simple fibre based dispersion management for two-photon excited fluorescence imaging through an endoscope

Author(s): Dominik Marti, Konstantinos Dimopoulos, Peter E. Andersen
Published in: Multiphoton Microscopy in the Biomedical Sciences XVIII, Issue 10498, 2018, Page(s) 70, ISBN 9781-510614826
Publisher: SPIE
DOI: 10.1117/12.2289533

Diffraction limited 1064nm monolithic DBR-master oscillator power amplifier with more than 7W output power

Author(s): André Maaβdorf, Peter Ressel, Martin Maiwald, Jörg Fricke, Bernd Sumpf, Günther Tränkle, Christof Zink, Gotz Erbert
Published in: Novel In-Plane Semiconductor Lasers XVII, Issue 10553, 2018, Page(s) 45, ISBN 9781-510615922
Publisher: SPIE
DOI: 10.1117/12.2288977

Shifted excitation Raman difference spectroscopy: from diode lasers to in situ applications

Author(s): Martin Maiwald, Bernd Sumpf
Published in: Plasmonics in Biology and Medicine XV, Issue 10509, 2018, Page(s) 2, ISBN 9781-510615045
Publisher: SPIE
DOI: 10.1117/12.2293058

Endoscopic Optical Coherence Tomography Angiography Using A Piezo Scanner

Author(s): Lara M. Wurster, Simon Kretschmer, Fabian Placzek, Sergio Vilches, Michael Niederleithner, Caglar Ataman, Hans Zappe, Rainer A. Leitgeb
Published in: 2018 International Conference on Optical MEMS and Nanophotonics (OMN), 2018, Page(s) 1-2, ISBN 978-1-5090-6374-1
Publisher: IEEE
DOI: 10.1109/OMN.2018.8454643

Improving Raman spectroscopy using diode lasers at 785 nm for shifted excitation Raman difference spectroscopy

Author(s): Martin Maiwald, Bernd Sumpf
Published in: Plasmonics in Biology and Medicine XVII, Issue 1125708, 2020, Page(s) 7, ISBN 9781-510632783
Publisher: SPIE
DOI: 10.1117/12.2554014

Micro-structured glass probe for endoscopic Optical Coherence Tomography

Author(s): Gerardo E. González-Cerdas, Patrick Stein, Simon Kretschmer, Christoph Bauer, Dragan Sandic, Caglar Ataman, Hans Zappe
Published in: Biomedical Spectroscopy, Microscopy, and Imaging, 2020, Page(s) 17, ISBN 9781-510634916
Publisher: SPIE
DOI: 10.1117/12.2555069

785nm dual-wavelength Y-branch DBR-RW diode laser with electrically adjustable wavelength distance between 0 nm and 2 nm

Author(s): Bernd Sumpf, Julia Kabitzke, Jörg Fricke, Peter Ressel, André Müller, Martin Maiwald, Günther Tränkle
Published in: Novel In-Plane Semiconductor Lasers XVI, Issue 10123, 2017, Page(s) 101230T
Publisher: SPIE
DOI: 10.1117/12.2248621

5,000 h reliable operation of 785nm dual-wavelength DBR-RW diode lasers suitable for Raman spectroscopy and SERDS

Author(s): Bernd Sumpf, André Müller, Martin Maiwald
Published in: Novel In-Plane Semiconductor Lasers XV, Issue 9767, 2016, Page(s) 97670T
Publisher: SPIE
DOI: 10.1117/12.2207659

MCmatlab: an open-source, user-friendly, MATLAB-integrated 3D Monte Carlo light transport solver with heat diffusion and tissue damage

Author(s): Dominik Marti, Rikke N. Aasbjerg, Peter E. Andersen, Anders K. Hansen
Published in: Optical Interactions with Tissue and Cells XXX, Issue 2019, 2019, Page(s) 27, ISBN 9781-510623958
Publisher: SPIE
DOI: 10.1117/12.2507754