Multi-modal, Endoscopic Biophotonic Imaging of Bladder Cancer for Point-of-Care Diagnosis

Informacje na temat projektu

MIB

Identyfikator umowy o grant: 667933

DOI

10.3030/667933

Projekt został zamknięty

Data podpisania przez KE 9 Grudnia 2015

Data rozpoczęcia 1 Stycznia 2016

Data zakończenia 31 Grudnia 2021

Finansowanie w ramach

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Koszt całkowity

€ 5 983 807,50

Wkład UE

€ 5 983 807,50

Koordynowany przez

DANMARKS TEKNISKE UNIVERSITET
Denmark

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Demonstrators, pilots, prototypes (1)

Project Website

Project Website.

Publikacje

Peer reviewed articles (31)

Endoscopic optical coherence tomography with a flexible fiber bundle

Autorzy: Lara M. Wurster; Laurin Ginner; Abhishek Kumar; Matthias Salas; Andreas Wartak; Rainer A. Leitgeb
Opublikowane w: Journal of Biomedical Optic, Numer 23, 2018, Strona(/y) 06600, ISSN 1083-3668
Wydawca: S P I E - International Society for Optical Engineering
DOI: 10.1117/1.jbo.23.6.066001

Accurate in vivo tumor detection using plasmonic-enhanced shifted-excitation Raman difference spectroscopy (SERDS)

Autorzy: Pietro Strobbia, Vanessa Cupil-Garcia, Bridget M. Crawford, Andrew M. Fales, T. Joshua Pfefer, Yang Liu, Martin Maiwald, Bernd Sumpf, and Tuan Vo-Dinh
Opublikowane w: Theranostics, Numer 11, 2021, Strona(/y) 4090–4102, ISSN 1838-7640
Wydawca: Ivyspring International Publisher
DOI: 10.7150/thno.53101

Ultrashort pulse Kagome hollow-core photonic crystal fiber delivery for nonlinear optical imaging.

Autorzy: Andreana; Le; Drexler; Unterhuber
Opublikowane w: Optics Letters, Numer 44, 2019, Strona(/y) 1588-1591, ISSN 0146-9592
Wydawca: Optical Society of America
DOI: 10.1364/ol.44.001588

A submicrometre silicon-on-insulator resonator for ultrasound detection

Autorzy: Rami Shnaiderman, Georg Wissmeyer, Okan Ülgen, Qutaiba Mustafa, Andriy Chmyrov & Vasilis Ntziachristos
Opublikowane w: Nature, Numer 585, 2020, Strona(/y) 372–378, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/s41586-020-2685-y

Morpho-Molecular Metabolic Analysis and Classification of Human Pituitary Gland and Adenoma Biopsies Based on Multimodal Optical Imaging.

Autorzy: Gabriel Giardina; Alexander Micko; Daniela Bovenkamp; Arno Krause; Fabian Placzek; Laszlo Papp; Denis Krajnc; Clemens P. Spielvogel; Michael Winklehner; Romana Höftberger; Greisa Vila; Marco Andreana; Rainer A. Leitgeb; Wolfgang Drexler; Stefan Wolfsberger; Angelika Unterhuber
Opublikowane w: Cancers, Numer 1, 2021, ISSN 2072-6694
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13133234

Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography

Autorzy: Rainer Leitgeb, Fabian Placzek, Elisabet Rank, Lisa Krainz, Richard Haindl, Qian Li, Mengyang Liu, Marco Andreana, Angelika Unterhuber, Tilman Schmoll, Wolfgang Drexler
Opublikowane w: Journal of Biomedical Optics, Numer 26/10, 2021, ISSN 1083-3668
Wydawca: S P I E - International Society for Optical Engineering
DOI: 10.1117/1.jbo.26.10.100601

Manufacturing and assembly of an all-glass OCT microendoscope

Autorzy: Yanis Taege, Gerardo González-Cerdas, Felix Jund, Hans Zappe, Caglar Ataman
Opublikowane w: Journal of Micromechanics and Microengineering, 2021, ISSN 0960-1317
Wydawca: Institute of Physics Publishing
DOI: 10.1088/1361-6439/ac2d9d

Monolithic Master Oscillator Tilted Tapered Power Amplifier Emitting 9.5 W at 1060 nm

Autorzy: Zink, Christof; Maabdorf, Andre; Fricke, Jorg; Ressel, Peter; Sumpf, Bernd; Erbert, Gotz; Trankle, Gunther
Opublikowane w: IEEE Photonics Technology Letters, Numer 32, 2020, Strona(/y) 59-62, ISSN 1041-1135
Wydawca: Institute of Electrical and Electronics Engineers
DOI: 10.1109/lpt.2019.2957063

Multimodal Optical Medical Imaging Concepts based on Optical Coherence Tomography

Autorzy: Rainer A. Leitgeb; Rainer A. Leitgeb; Bernhard Baumann
Opublikowane w: Frontiers in Physics, Vol 6 (2018), Numer 6, 2018, ISSN 2296-424X
Wydawca: Frontiers Media S.A
DOI: 10.3389/fphy.2018.00114

Interferometric optical fiber sensor for optoacoustic endomicroscopy.

Autorzy: Okan Ülgen; Rami Shnaiderman; Christian Zakian; Vasilis Ntziachristos
Opublikowane w: Journal of Biophotonics, Numer 14, 2021, Strona(/y) e202000501, ISSN 1864-063X
Wydawca: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.202000501

Morpho-molecular signal correlation between optical coherence tomography and Raman spectroscopy for superior image interpretation and clinical diagnosis.

Autorzy: Iwan W. Schie; Fabian Placzek; Florian Knorr; Eliana Cordero; Lara M. Wurster; Gregers G. Hermann; Karin Mogensen; Thomas Hasselager; Wolfgang Drexler; Jürgen Popp; Jürgen Popp; Rainer A. Leitgeb
Opublikowane w: Scientific Reports, Numer 11, 2021, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.21203/rs.3.rs-322204/v1

Comparison of optical coherence tomography angiography and narrow-band imaging using a bimodal endoscope.

Autorzy: Lara M. Wurster; Simon Kretschmer; Jan Jäger; Fabian Placzek; Laurin Ginner; Wolfgang Drexler; Caglar Ataman; Rainer A. Leitgeb; Hans Zappe
Opublikowane w: Journal of Biomedical Optics, Numer 25, 2019, Strona(/y) 032003, ISSN 1083-3668
Wydawca: S P I E - International Society for Optical Engineering
DOI: 10.1117/1.jbo.25.3.032003

Line Scan Raman Microspectroscopy for Label-Free Diagnosis of Human Pituitary Biopsies.

Autorzy: Bovenkamp, Daniela; Micko, Alexander; Püls, Jeremias; Placzek, Fabian; Höftberger, Romana; Vila, Greisa; Leitgeb, Rainer; Drexler, Wolfgang; Andreana, Marco; Wolfsberger, Stefan; Unterhuber, Angelika
Opublikowane w: Molecules, 2019, ISSN 1420-3049
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules24193577

Measuring the sensitivity to optical feedback of single-frequency high-power laser diodes

Autorzy: Mathias Christensen, Christof Zink, Muhammad Tahir Jamal, Anders Kragh Hansen, Ole Bjarlin Jensen, and Bernd Sumpf
Opublikowane w: Journal of the Optical Society of America B, Numer 38, 2021, Strona(/y) 885-892, ISSN 0740-3224
Wydawca: Optical Society of America
DOI: 10.1364/josab.417258

Raman ChemLighter: Fiber optic Raman probe imaging in combination with augmented chemical reality

Autorzy: Yang, Wei; Mondol, Abdullah S.; Stiebing, Clara; Marcu, Laura; Popp, Jürgen; Schie, Iwan W.
Opublikowane w: Journal of Biophotonics, Numer 12, 2019, Strona(/y) 12:e201800447, ISSN 1864-063X
Wydawca: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.201800447

Rapid and adjustable shifted excitation Raman difference spectroscopy using a dual-wavelength diode laser at 785 nm

Autorzy: Martin Maiwald, Bernd Sumpf, Günther Tränkle
Opublikowane w: Journal of Raman Spectroscopy, 2018, ISSN 0377-0486
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/jrs.5456

Combination of High-Resolution Optical Coherence Tomography and Raman Spectroscopy for Improved Staging and Grading in Bladder Cancer

Autorzy: Daniela Bovenkamp, Ryan Sentosa, Elisabet Rank, Mikael Erkkilä, Fabian Placzek, Jeremias Püls, Wolfgang Drexler, Rainer Leitgeb, Nathalie Garstka, Shahrokh Shariat, Clara Stiebing, Iwan Schie, Jürgen Popp, Marco Andreana, Angelika Unterhuber
Opublikowane w: Applied Sciences, Numer 8/12, 2018, Strona(/y) 2371, ISSN 2076-3417
Wydawca: MDPI AG
DOI: 10.3390/app8122371

Endoscopic optical coherence tomography angiography using a forward imaging piezo scanner probe

Autorzy: Lara M. Wurster, Ronak N. Shah, Fabian Placzek, Simon Kretschmer, Michael Niederleithner, Laurin Ginner, Jason Ensher, Michael P. Minneman, Erich E. Hoover, Hans Zappe, Wolfgang Drexler, Rainer A. Leitgeb, Çağlar Ataman
Opublikowane w: Journal of Biophotonics, 2019, Strona(/y) e201800382, ISSN 1864-063X
Wydawca: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.201800382

MCmatlab: an open-source, user-friendly, MATLAB-integrated three-dimensional Monte Carlo light transport solver with heat diffusion and tissue damage

Autorzy: Dominik Marti, Rikke N. Aasbjerg, Peter E. Andersen, Anders K. Hansen
Opublikowane w: Journal of Biomedical Optics, Numer 23/12, 2018, Strona(/y) 1, ISSN 1083-3668
Wydawca: S P I E - International Society for Optical Engineering
DOI: 10.1117/1.jbo.23.12.121622

In-vivo Raman spectroscopy: from basics to applications

Autorzy: Eliana Cordero
Opublikowane w: Journal of Biomedical Optics, Numer 23/07, 2018, Strona(/y) 1, ISSN 1083-3668
Wydawca: S P I E - International Society for Optical Engineering
DOI: 10.1117/1.jbo.23.7.071210

Morpho-molecular ex vivo detection and grading of non-muscle-invasive bladder cancer using forward imaging probe based multimodal optical coherence tomography and Raman spectroscopy

Autorzy: Fabian Placzek, Eliana Cordero Bautista, Simon Kretschmer, Lara M. Wurster, Florian Knorr, Gerardo González-Cerdas, Mikael T. Erkkilä, Patrick Stein, Çağlar Ataman, Gregers G. Hermann, Karin Mogensen, Thomas Hasselager, Peter E. Andersen, Hans Zappe, Jürgen Popp, Wolfgang Drexler, Rainer A. Leitgeb, Iwan W. Schie
Opublikowane w: The Analyst, 2020, ISSN 0003-2654
Wydawca: Royal Society of Chemistry
DOI: 10.1039/c9an01911a

Bladder tissue characterization using probe‐based Raman spectroscopy: Evaluation of tissue heterogeneity and influence on the model prediction

Autorzy: Eliana Cordero, Jan Rüger, Dominik Marti, Abdullah S. Mondol, Thomas Hasselager, Karin Mogensen, Gregers G. Hermann, Jürgen Popp, Iwan W. Schie
Opublikowane w: Journal of Biophotonics, Numer 13/2, 2019, ISSN 1864-063X
Wydawca: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.201960025

Efficient generation of 3.5W laser light at 515nm by frequency doubling a single-frequency high power DBR tapered diode laser

Autorzy: Ole Bjarlin Jensen, Anders Kragh Hansen, André Müller, Bernd Sumpf, Paul Michael Petersen, Peter E. Andersen
Opublikowane w: Optics Communications, Numer 392, 2017, Strona(/y) 167-170, ISSN 0030-4018
Wydawca: Elsevier BV
DOI: 10.1016/j.optcom.2017.01.060

Evaluation of Shifted Excitation Raman Difference Spectroscopy and Comparison to Computational Background Correction Methods Applied to Biochemical Raman Spectra

Autorzy: Eliana Cordero, Florian Korinth, Clara Stiebing, Christoph Krafft, Iwan Schie, Jürgen Popp
Opublikowane w: Sensors, Numer 17/8, 2017, Strona(/y) 1724, ISSN 1424-8220
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s17081724

Dual-wavelength diode laser with electrically adjustable wavelength distance at 785  nm

Autorzy: Bernd Sumpf, Julia Kabitzke, Jörg Fricke, Peter Ressel, André Müller, Martin Maiwald, Günther Tränkle
Opublikowane w: Optics Letters, Numer 41/16, 2016, Strona(/y) 3694, ISSN 0146-9592
Wydawca: Optical Society of America
DOI: 10.1364/OL.41.003694

Selecting optimal spectral bands for improved detection of autofluorescent biomarkers in multiphoton microscopy

Autorzy: Björn-Ole Meyer, M. Pilar J. Stella, Bjørn Holst, Boye S. Nielsen, Kim Holmstrøm, Peter E. Andersen, Dominik Marti
Opublikowane w: Journal of Biomedical Optics, Numer 25/07, 2020, Strona(/y) 1, ISSN 1083-3668
Wydawca: S P I E - International Society for Optical Engineering
DOI: 10.1117/1.jbo.25.7.071206

Silicon-Photonics Point Sensor for High-Resolution Optoacoustic Imaging

Autorzy: Rami Shnaiderman, Qutaiba Mustafa, Okan Ülgen, Georg Wissmeyer, Héctor Estrada, Daniel Razansky, Andriy Chmyrov, Vasilis Ntziachristos
Opublikowane w: Advanced Optical Materials, Numer 9, 2021, Strona(/y) 2100256, ISSN 2195-1071
Wydawca: Wiley
DOI: 10.1002/adom.202100256

Development and evaluation of a hand-held fiber-optic Raman probe with an integrated autofocus unit

Autorzy: Yang Wei; Florian Knorr; Jürgen Popp; Iwan W. Schie
Opublikowane w: Optics Express, Numer 28, 2020, Strona(/y) 30760-30770, ISSN 1094-4087
Wydawca: Optical Society of America
DOI: 10.1364/oe.401207

Morpho-Molecular Metabolic Analysis and Classification of Human Pituitary Gland and Adenoma Biopsies Based on Multimodal Optical Imaging

Autorzy: Gabriel Giardina, Alexander Micko, Daniela Bovenkamp, Arno Krause, Fabian Placzek, Laszlo Papp, Denis Krajnc, Clemens P. Spielvogel, Michael Winklehner, Romana Höftberger, Greisa Vila, Marco Andreana, Rainer Leitgeb, Wolfgang Drexler, Stefan Wolfsberger, Angelika Unterhuber
Opublikowane w: Cancers, Numer 13/13, 2021, Strona(/y) 3234, ISSN 2072-6694
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13133234

Depth resolved label-free multimodal optical imaging platform to study morpho-molecular composition of tissue

Autorzy: Andreana; Sentosa; Erkkilä; Drexler; Unterhuber
Opublikowane w: Photochemical & Photobioogical Sciences, Numer 1, 2019, ISSN 1474-905X
Wydawca: Royal Society of Chemistry
DOI: 10.1039/c8pp00410b

En face optical coherence tomography: a technology review [Invited].

Autorzy: Leitgeb, R. A.
Opublikowane w: Biomedical Optics Express, Numer 1, 2019, ISSN 2156-7085
Wydawca: The Optical Society
DOI: 10.1364/boe.10.002177

Conference proceedings (12)

CARS endomicroscopic imaging probe enabled by a double-core double-clad fiber and related focus-combining micro-optical concept

Autorzy: Bernhard Messerschmidt, Ekaterina Pshenay-Severin, Gregor Matz, Karl Reichwald, Jörg Bierlich, Jens Kobelke, Hyeonsoo Bae, Tobias Meyer-Zedler, Michael Schmitt, Jürgen Popp
Opublikowane w: Proceedings Volume 11636, Optical Biopsy XIX: Toward Real-Time Spectroscopic Imaging and Diagnosis; 116360A (2021), 2021, ISSN 0277-786X
Wydawca: SPIE Digital Library
DOI: 10.1117/12.2578538

Spectrally stabilized high-power high-brightness DBR-tapered lasers in the VIS and NIR range

Autorzy: Bernd Sumpf, Katrin Paschke
Opublikowane w: Laser Resonators, Microresonators, and Beam Control XX, Numer 10518, 2018, Strona(/y) 44, ISBN 9781-510615229
Wydawca: SPIE
DOI: 10.1117/12.2288425

High power diode lasers converted to the visible

Autorzy: Ole B. Jensen, Anders K. Hansen, Peter E. Andersen, Mathias Christensen, Andre Muller, Mahmoud Tawfieq, Bernd Sumpf, Paul M. Petersen
Opublikowane w: 2017 IEEE High Power Diode Lasers and Systems Conference (HPD), Numer CFP1771I-ART, 2017, Strona(/y) 45-46, ISBN 978-1-5386-3263-5
Wydawca: IEEE
DOI: 10.1109/HPD.2017.8261093

Simple fibre based dispersion management for two-photon excited fluorescence imaging through an endoscope

Autorzy: Dominik Marti, Konstantinos Dimopoulos, Peter E. Andersen
Opublikowane w: Multiphoton Microscopy in the Biomedical Sciences XVIII, Numer 10498, 2018, Strona(/y) 70, ISBN 9781-510614826
Wydawca: SPIE
DOI: 10.1117/12.2289533

Diffraction limited 1064nm monolithic DBR-master oscillator power amplifier with more than 7W output power

Autorzy: André Maaβdorf, Peter Ressel, Martin Maiwald, Jörg Fricke, Bernd Sumpf, Günther Tränkle, Christof Zink, Gotz Erbert
Opublikowane w: Novel In-Plane Semiconductor Lasers XVII, Numer 10553, 2018, Strona(/y) 45, ISBN 9781-510615922
Wydawca: SPIE
DOI: 10.1117/12.2288977

Shifted excitation Raman difference spectroscopy: from diode lasers to in situ applications

Autorzy: Martin Maiwald, Bernd Sumpf
Opublikowane w: Plasmonics in Biology and Medicine XV, Numer 10509, 2018, Strona(/y) 2, ISBN 9781-510615045
Wydawca: SPIE
DOI: 10.1117/12.2293058

Endoscopic Optical Coherence Tomography Angiography Using A Piezo Scanner

Autorzy: Lara M. Wurster, Simon Kretschmer, Fabian Placzek, Sergio Vilches, Michael Niederleithner, Caglar Ataman, Hans Zappe, Rainer A. Leitgeb
Opublikowane w: 2018 International Conference on Optical MEMS and Nanophotonics (OMN), 2018, Strona(/y) 1-2, ISBN 978-1-5090-6374-1
Wydawca: IEEE
DOI: 10.1109/OMN.2018.8454643

Improving Raman spectroscopy using diode lasers at 785 nm for shifted excitation Raman difference spectroscopy

Autorzy: Martin Maiwald, Bernd Sumpf
Opublikowane w: Plasmonics in Biology and Medicine XVII, Numer 1125708, 2020, Strona(/y) 7, ISBN 9781-510632783
Wydawca: SPIE
DOI: 10.1117/12.2554014

Micro-structured glass probe for endoscopic Optical Coherence Tomography

Autorzy: Gerardo E. González-Cerdas, Patrick Stein, Simon Kretschmer, Christoph Bauer, Dragan Sandic, Caglar Ataman, Hans Zappe
Opublikowane w: Biomedical Spectroscopy, Microscopy, and Imaging, 2020, Strona(/y) 17, ISBN 9781-510634916
Wydawca: SPIE
DOI: 10.1117/12.2555069

785nm dual-wavelength Y-branch DBR-RW diode laser with electrically adjustable wavelength distance between 0 nm and 2 nm

Autorzy: Bernd Sumpf, Julia Kabitzke, Jörg Fricke, Peter Ressel, André Müller, Martin Maiwald, Günther Tränkle
Opublikowane w: Novel In-Plane Semiconductor Lasers XVI, Numer 10123, 2017, Strona(/y) 101230T
Wydawca: SPIE
DOI: 10.1117/12.2248621

5,000 h reliable operation of 785nm dual-wavelength DBR-RW diode lasers suitable for Raman spectroscopy and SERDS

Autorzy: Bernd Sumpf, André Müller, Martin Maiwald
Opublikowane w: Novel In-Plane Semiconductor Lasers XV, Numer 9767, 2016, Strona(/y) 97670T
Wydawca: SPIE
DOI: 10.1117/12.2207659

MCmatlab: an open-source, user-friendly, MATLAB-integrated 3D Monte Carlo light transport solver with heat diffusion and tissue damage

Autorzy: Dominik Marti, Rikke N. Aasbjerg, Peter E. Andersen, Anders K. Hansen
Opublikowane w: Optical Interactions with Tissue and Cells XXX, Numer 2019, 2019, Strona(/y) 27, ISBN 9781-510623958
Wydawca: SPIE
DOI: 10.1117/12.2507754