Multi-modal, Endoscopic Biophotonic Imaging of Bladder Cancer for Point-of-Care Diagnosis

Información del proyecto

MIB

Identificador del acuerdo de subvención: 667933

DOI

10.3030/667933

Proyecto cerrado

Fecha de la firma de la CE 9 Diciembre 2015

Fecha de inicio 1 Enero 2016

Fecha de finalización 31 Diciembre 2021

Financiado con arreglo a

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coste total

€ 5 983 807,50

Aportación de la UE

€ 5 983 807,50

Coordinado por

DANMARKS TEKNISKE UNIVERSITET
Denmark

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Demonstrators, pilots, prototypes (1)

Project Website

Project Website.

Publicaciones

Peer reviewed articles (31)

Endoscopic optical coherence tomography with a flexible fiber bundle

Autores: Lara M. Wurster; Laurin Ginner; Abhishek Kumar; Matthias Salas; Andreas Wartak; Rainer A. Leitgeb
Publicado en: Journal of Biomedical Optic, Edición 23, 2018, Página(s) 06600, ISSN 1083-3668
Editor: S P I E - International Society for Optical Engineering
DOI: 10.1117/1.jbo.23.6.066001

Accurate in vivo tumor detection using plasmonic-enhanced shifted-excitation Raman difference spectroscopy (SERDS)

Autores: Pietro Strobbia, Vanessa Cupil-Garcia, Bridget M. Crawford, Andrew M. Fales, T. Joshua Pfefer, Yang Liu, Martin Maiwald, Bernd Sumpf, and Tuan Vo-Dinh
Publicado en: Theranostics, Edición 11, 2021, Página(s) 4090–4102, ISSN 1838-7640
Editor: Ivyspring International Publisher
DOI: 10.7150/thno.53101

Ultrashort pulse Kagome hollow-core photonic crystal fiber delivery for nonlinear optical imaging.

Autores: Andreana; Le; Drexler; Unterhuber
Publicado en: Optics Letters, Edición 44, 2019, Página(s) 1588-1591, ISSN 0146-9592
Editor: Optical Society of America
DOI: 10.1364/ol.44.001588

A submicrometre silicon-on-insulator resonator for ultrasound detection

Autores: Rami Shnaiderman, Georg Wissmeyer, Okan Ülgen, Qutaiba Mustafa, Andriy Chmyrov & Vasilis Ntziachristos
Publicado en: Nature, Edición 585, 2020, Página(s) 372–378, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-020-2685-y

Morpho-Molecular Metabolic Analysis and Classification of Human Pituitary Gland and Adenoma Biopsies Based on Multimodal Optical Imaging.

Autores: Gabriel Giardina; Alexander Micko; Daniela Bovenkamp; Arno Krause; Fabian Placzek; Laszlo Papp; Denis Krajnc; Clemens P. Spielvogel; Michael Winklehner; Romana Höftberger; Greisa Vila; Marco Andreana; Rainer A. Leitgeb; Wolfgang Drexler; Stefan Wolfsberger; Angelika Unterhuber
Publicado en: Cancers, Edición 1, 2021, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13133234

Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography

Autores: Rainer Leitgeb, Fabian Placzek, Elisabet Rank, Lisa Krainz, Richard Haindl, Qian Li, Mengyang Liu, Marco Andreana, Angelika Unterhuber, Tilman Schmoll, Wolfgang Drexler
Publicado en: Journal of Biomedical Optics, Edición 26/10, 2021, ISSN 1083-3668
Editor: S P I E - International Society for Optical Engineering
DOI: 10.1117/1.jbo.26.10.100601

Manufacturing and assembly of an all-glass OCT microendoscope

Autores: Yanis Taege, Gerardo González-Cerdas, Felix Jund, Hans Zappe, Caglar Ataman
Publicado en: Journal of Micromechanics and Microengineering, 2021, ISSN 0960-1317
Editor: Institute of Physics Publishing
DOI: 10.1088/1361-6439/ac2d9d

Monolithic Master Oscillator Tilted Tapered Power Amplifier Emitting 9.5 W at 1060 nm

Autores: Zink, Christof; Maabdorf, Andre; Fricke, Jorg; Ressel, Peter; Sumpf, Bernd; Erbert, Gotz; Trankle, Gunther
Publicado en: IEEE Photonics Technology Letters, Edición 32, 2020, Página(s) 59-62, ISSN 1041-1135
Editor: Institute of Electrical and Electronics Engineers
DOI: 10.1109/lpt.2019.2957063

Multimodal Optical Medical Imaging Concepts based on Optical Coherence Tomography

Autores: Rainer A. Leitgeb; Rainer A. Leitgeb; Bernhard Baumann
Publicado en: Frontiers in Physics, Vol 6 (2018), Edición 6, 2018, ISSN 2296-424X
Editor: Frontiers Media S.A
DOI: 10.3389/fphy.2018.00114

Interferometric optical fiber sensor for optoacoustic endomicroscopy.

Autores: Okan Ülgen; Rami Shnaiderman; Christian Zakian; Vasilis Ntziachristos
Publicado en: Journal of Biophotonics, Edición 14, 2021, Página(s) e202000501, ISSN 1864-063X
Editor: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.202000501

Morpho-molecular signal correlation between optical coherence tomography and Raman spectroscopy for superior image interpretation and clinical diagnosis.

Autores: Iwan W. Schie; Fabian Placzek; Florian Knorr; Eliana Cordero; Lara M. Wurster; Gregers G. Hermann; Karin Mogensen; Thomas Hasselager; Wolfgang Drexler; Jürgen Popp; Jürgen Popp; Rainer A. Leitgeb
Publicado en: Scientific Reports, Edición 11, 2021, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.21203/rs.3.rs-322204/v1

Comparison of optical coherence tomography angiography and narrow-band imaging using a bimodal endoscope.

Autores: Lara M. Wurster; Simon Kretschmer; Jan Jäger; Fabian Placzek; Laurin Ginner; Wolfgang Drexler; Caglar Ataman; Rainer A. Leitgeb; Hans Zappe
Publicado en: Journal of Biomedical Optics, Edición 25, 2019, Página(s) 032003, ISSN 1083-3668
Editor: S P I E - International Society for Optical Engineering
DOI: 10.1117/1.jbo.25.3.032003

Line Scan Raman Microspectroscopy for Label-Free Diagnosis of Human Pituitary Biopsies.

Autores: Bovenkamp, Daniela; Micko, Alexander; Püls, Jeremias; Placzek, Fabian; Höftberger, Romana; Vila, Greisa; Leitgeb, Rainer; Drexler, Wolfgang; Andreana, Marco; Wolfsberger, Stefan; Unterhuber, Angelika
Publicado en: Molecules, 2019, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules24193577

Measuring the sensitivity to optical feedback of single-frequency high-power laser diodes

Autores: Mathias Christensen, Christof Zink, Muhammad Tahir Jamal, Anders Kragh Hansen, Ole Bjarlin Jensen, and Bernd Sumpf
Publicado en: Journal of the Optical Society of America B, Edición 38, 2021, Página(s) 885-892, ISSN 0740-3224
Editor: Optical Society of America
DOI: 10.1364/josab.417258

Raman ChemLighter: Fiber optic Raman probe imaging in combination with augmented chemical reality

Autores: Yang, Wei; Mondol, Abdullah S.; Stiebing, Clara; Marcu, Laura; Popp, Jürgen; Schie, Iwan W.
Publicado en: Journal of Biophotonics, Edición 12, 2019, Página(s) 12:e201800447, ISSN 1864-063X
Editor: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.201800447

Rapid and adjustable shifted excitation Raman difference spectroscopy using a dual-wavelength diode laser at 785 nm

Autores: Martin Maiwald, Bernd Sumpf, Günther Tränkle
Publicado en: Journal of Raman Spectroscopy, 2018, ISSN 0377-0486
Editor: John Wiley & Sons Inc.
DOI: 10.1002/jrs.5456

Combination of High-Resolution Optical Coherence Tomography and Raman Spectroscopy for Improved Staging and Grading in Bladder Cancer

Autores: Daniela Bovenkamp, Ryan Sentosa, Elisabet Rank, Mikael Erkkilä, Fabian Placzek, Jeremias Püls, Wolfgang Drexler, Rainer Leitgeb, Nathalie Garstka, Shahrokh Shariat, Clara Stiebing, Iwan Schie, Jürgen Popp, Marco Andreana, Angelika Unterhuber
Publicado en: Applied Sciences, Edición 8/12, 2018, Página(s) 2371, ISSN 2076-3417
Editor: MDPI AG
DOI: 10.3390/app8122371

Endoscopic optical coherence tomography angiography using a forward imaging piezo scanner probe

Autores: Lara M. Wurster, Ronak N. Shah, Fabian Placzek, Simon Kretschmer, Michael Niederleithner, Laurin Ginner, Jason Ensher, Michael P. Minneman, Erich E. Hoover, Hans Zappe, Wolfgang Drexler, Rainer A. Leitgeb, Çağlar Ataman
Publicado en: Journal of Biophotonics, 2019, Página(s) e201800382, ISSN 1864-063X
Editor: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.201800382

MCmatlab: an open-source, user-friendly, MATLAB-integrated three-dimensional Monte Carlo light transport solver with heat diffusion and tissue damage

Autores: Dominik Marti, Rikke N. Aasbjerg, Peter E. Andersen, Anders K. Hansen
Publicado en: Journal of Biomedical Optics, Edición 23/12, 2018, Página(s) 1, ISSN 1083-3668
Editor: S P I E - International Society for Optical Engineering
DOI: 10.1117/1.jbo.23.12.121622

In-vivo Raman spectroscopy: from basics to applications

Autores: Eliana Cordero
Publicado en: Journal of Biomedical Optics, Edición 23/07, 2018, Página(s) 1, ISSN 1083-3668
Editor: S P I E - International Society for Optical Engineering
DOI: 10.1117/1.jbo.23.7.071210

Morpho-molecular ex vivo detection and grading of non-muscle-invasive bladder cancer using forward imaging probe based multimodal optical coherence tomography and Raman spectroscopy

Autores: Fabian Placzek, Eliana Cordero Bautista, Simon Kretschmer, Lara M. Wurster, Florian Knorr, Gerardo González-Cerdas, Mikael T. Erkkilä, Patrick Stein, Çağlar Ataman, Gregers G. Hermann, Karin Mogensen, Thomas Hasselager, Peter E. Andersen, Hans Zappe, Jürgen Popp, Wolfgang Drexler, Rainer A. Leitgeb, Iwan W. Schie
Publicado en: The Analyst, 2020, ISSN 0003-2654
Editor: Royal Society of Chemistry
DOI: 10.1039/c9an01911a

Bladder tissue characterization using probe‐based Raman spectroscopy: Evaluation of tissue heterogeneity and influence on the model prediction

Autores: Eliana Cordero, Jan Rüger, Dominik Marti, Abdullah S. Mondol, Thomas Hasselager, Karin Mogensen, Gregers G. Hermann, Jürgen Popp, Iwan W. Schie
Publicado en: Journal of Biophotonics, Edición 13/2, 2019, ISSN 1864-063X
Editor: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.201960025

Efficient generation of 3.5W laser light at 515nm by frequency doubling a single-frequency high power DBR tapered diode laser

Autores: Ole Bjarlin Jensen, Anders Kragh Hansen, André Müller, Bernd Sumpf, Paul Michael Petersen, Peter E. Andersen
Publicado en: Optics Communications, Edición 392, 2017, Página(s) 167-170, ISSN 0030-4018
Editor: Elsevier BV
DOI: 10.1016/j.optcom.2017.01.060

Evaluation of Shifted Excitation Raman Difference Spectroscopy and Comparison to Computational Background Correction Methods Applied to Biochemical Raman Spectra

Autores: Eliana Cordero, Florian Korinth, Clara Stiebing, Christoph Krafft, Iwan Schie, Jürgen Popp
Publicado en: Sensors, Edición 17/8, 2017, Página(s) 1724, ISSN 1424-8220
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s17081724

Dual-wavelength diode laser with electrically adjustable wavelength distance at 785  nm

Autores: Bernd Sumpf, Julia Kabitzke, Jörg Fricke, Peter Ressel, André Müller, Martin Maiwald, Günther Tränkle
Publicado en: Optics Letters, Edición 41/16, 2016, Página(s) 3694, ISSN 0146-9592
Editor: Optical Society of America
DOI: 10.1364/OL.41.003694

Selecting optimal spectral bands for improved detection of autofluorescent biomarkers in multiphoton microscopy

Autores: Björn-Ole Meyer, M. Pilar J. Stella, Bjørn Holst, Boye S. Nielsen, Kim Holmstrøm, Peter E. Andersen, Dominik Marti
Publicado en: Journal of Biomedical Optics, Edición 25/07, 2020, Página(s) 1, ISSN 1083-3668
Editor: S P I E - International Society for Optical Engineering
DOI: 10.1117/1.jbo.25.7.071206

Silicon-Photonics Point Sensor for High-Resolution Optoacoustic Imaging

Autores: Rami Shnaiderman, Qutaiba Mustafa, Okan Ülgen, Georg Wissmeyer, Héctor Estrada, Daniel Razansky, Andriy Chmyrov, Vasilis Ntziachristos
Publicado en: Advanced Optical Materials, Edición 9, 2021, Página(s) 2100256, ISSN 2195-1071
Editor: Wiley
DOI: 10.1002/adom.202100256

Development and evaluation of a hand-held fiber-optic Raman probe with an integrated autofocus unit

Autores: Yang Wei; Florian Knorr; Jürgen Popp; Iwan W. Schie
Publicado en: Optics Express, Edición 28, 2020, Página(s) 30760-30770, ISSN 1094-4087
Editor: Optical Society of America
DOI: 10.1364/oe.401207

Morpho-Molecular Metabolic Analysis and Classification of Human Pituitary Gland and Adenoma Biopsies Based on Multimodal Optical Imaging

Autores: Gabriel Giardina, Alexander Micko, Daniela Bovenkamp, Arno Krause, Fabian Placzek, Laszlo Papp, Denis Krajnc, Clemens P. Spielvogel, Michael Winklehner, Romana Höftberger, Greisa Vila, Marco Andreana, Rainer Leitgeb, Wolfgang Drexler, Stefan Wolfsberger, Angelika Unterhuber
Publicado en: Cancers, Edición 13/13, 2021, Página(s) 3234, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13133234

Depth resolved label-free multimodal optical imaging platform to study morpho-molecular composition of tissue

Autores: Andreana; Sentosa; Erkkilä; Drexler; Unterhuber
Publicado en: Photochemical & Photobioogical Sciences, Edición 1, 2019, ISSN 1474-905X
Editor: Royal Society of Chemistry
DOI: 10.1039/c8pp00410b

En face optical coherence tomography: a technology review [Invited].

Autores: Leitgeb, R. A.
Publicado en: Biomedical Optics Express, Edición 1, 2019, ISSN 2156-7085
Editor: The Optical Society
DOI: 10.1364/boe.10.002177

Conference proceedings (12)

CARS endomicroscopic imaging probe enabled by a double-core double-clad fiber and related focus-combining micro-optical concept

Autores: Bernhard Messerschmidt, Ekaterina Pshenay-Severin, Gregor Matz, Karl Reichwald, Jörg Bierlich, Jens Kobelke, Hyeonsoo Bae, Tobias Meyer-Zedler, Michael Schmitt, Jürgen Popp
Publicado en: Proceedings Volume 11636, Optical Biopsy XIX: Toward Real-Time Spectroscopic Imaging and Diagnosis; 116360A (2021), 2021, ISSN 0277-786X
Editor: SPIE Digital Library
DOI: 10.1117/12.2578538

Spectrally stabilized high-power high-brightness DBR-tapered lasers in the VIS and NIR range

Autores: Bernd Sumpf, Katrin Paschke
Publicado en: Laser Resonators, Microresonators, and Beam Control XX, Edición 10518, 2018, Página(s) 44, ISBN 9781-510615229
Editor: SPIE
DOI: 10.1117/12.2288425

High power diode lasers converted to the visible

Autores: Ole B. Jensen, Anders K. Hansen, Peter E. Andersen, Mathias Christensen, Andre Muller, Mahmoud Tawfieq, Bernd Sumpf, Paul M. Petersen
Publicado en: 2017 IEEE High Power Diode Lasers and Systems Conference (HPD), Edición CFP1771I-ART, 2017, Página(s) 45-46, ISBN 978-1-5386-3263-5
Editor: IEEE
DOI: 10.1109/HPD.2017.8261093

Simple fibre based dispersion management for two-photon excited fluorescence imaging through an endoscope

Autores: Dominik Marti, Konstantinos Dimopoulos, Peter E. Andersen
Publicado en: Multiphoton Microscopy in the Biomedical Sciences XVIII, Edición 10498, 2018, Página(s) 70, ISBN 9781-510614826
Editor: SPIE
DOI: 10.1117/12.2289533

Diffraction limited 1064nm monolithic DBR-master oscillator power amplifier with more than 7W output power

Autores: André Maaβdorf, Peter Ressel, Martin Maiwald, Jörg Fricke, Bernd Sumpf, Günther Tränkle, Christof Zink, Gotz Erbert
Publicado en: Novel In-Plane Semiconductor Lasers XVII, Edición 10553, 2018, Página(s) 45, ISBN 9781-510615922
Editor: SPIE
DOI: 10.1117/12.2288977

Shifted excitation Raman difference spectroscopy: from diode lasers to in situ applications

Autores: Martin Maiwald, Bernd Sumpf
Publicado en: Plasmonics in Biology and Medicine XV, Edición 10509, 2018, Página(s) 2, ISBN 9781-510615045
Editor: SPIE
DOI: 10.1117/12.2293058

Endoscopic Optical Coherence Tomography Angiography Using A Piezo Scanner

Autores: Lara M. Wurster, Simon Kretschmer, Fabian Placzek, Sergio Vilches, Michael Niederleithner, Caglar Ataman, Hans Zappe, Rainer A. Leitgeb
Publicado en: 2018 International Conference on Optical MEMS and Nanophotonics (OMN), 2018, Página(s) 1-2, ISBN 978-1-5090-6374-1
Editor: IEEE
DOI: 10.1109/OMN.2018.8454643

Improving Raman spectroscopy using diode lasers at 785 nm for shifted excitation Raman difference spectroscopy

Autores: Martin Maiwald, Bernd Sumpf
Publicado en: Plasmonics in Biology and Medicine XVII, Edición 1125708, 2020, Página(s) 7, ISBN 9781-510632783
Editor: SPIE
DOI: 10.1117/12.2554014

Micro-structured glass probe for endoscopic Optical Coherence Tomography

Autores: Gerardo E. González-Cerdas, Patrick Stein, Simon Kretschmer, Christoph Bauer, Dragan Sandic, Caglar Ataman, Hans Zappe
Publicado en: Biomedical Spectroscopy, Microscopy, and Imaging, 2020, Página(s) 17, ISBN 9781-510634916
Editor: SPIE
DOI: 10.1117/12.2555069

785nm dual-wavelength Y-branch DBR-RW diode laser with electrically adjustable wavelength distance between 0 nm and 2 nm

Autores: Bernd Sumpf, Julia Kabitzke, Jörg Fricke, Peter Ressel, André Müller, Martin Maiwald, Günther Tränkle
Publicado en: Novel In-Plane Semiconductor Lasers XVI, Edición 10123, 2017, Página(s) 101230T
Editor: SPIE
DOI: 10.1117/12.2248621

5,000 h reliable operation of 785nm dual-wavelength DBR-RW diode lasers suitable for Raman spectroscopy and SERDS

Autores: Bernd Sumpf, André Müller, Martin Maiwald
Publicado en: Novel In-Plane Semiconductor Lasers XV, Edición 9767, 2016, Página(s) 97670T
Editor: SPIE
DOI: 10.1117/12.2207659

MCmatlab: an open-source, user-friendly, MATLAB-integrated 3D Monte Carlo light transport solver with heat diffusion and tissue damage

Autores: Dominik Marti, Rikke N. Aasbjerg, Peter E. Andersen, Anders K. Hansen
Publicado en: Optical Interactions with Tissue and Cells XXX, Edición 2019, 2019, Página(s) 27, ISBN 9781-510623958
Editor: SPIE
DOI: 10.1117/12.2507754