Multi-modal, Endoscopic Biophotonic Imaging of Bladder Cancer for Point-of-Care Diagnosis

Informazioni relative al progetto

MIB

ID dell’accordo di sovvenzione: 667933

DOI

10.3030/667933

Progetto chiuso

Data della firma CE 9 Dicembre 2015

Data di avvio 1 Gennaio 2016

Data di completamento 31 Dicembre 2021

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale

€ 5 983 807,50

Contributo UE

€ 5 983 807,50

Coordinato da

DANMARKS TEKNISKE UNIVERSITET
Denmark

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Demonstrators, pilots, prototypes (1)

Project Website

Project Website.

Pubblicazioni

Peer reviewed articles (31)

Endoscopic optical coherence tomography with a flexible fiber bundle

Autori: Lara M. Wurster; Laurin Ginner; Abhishek Kumar; Matthias Salas; Andreas Wartak; Rainer A. Leitgeb
Pubblicato in: Journal of Biomedical Optic, Numero 23, 2018, Pagina/e 06600, ISSN 1083-3668
Editore: S P I E - International Society for Optical Engineering
DOI: 10.1117/1.jbo.23.6.066001

Accurate in vivo tumor detection using plasmonic-enhanced shifted-excitation Raman difference spectroscopy (SERDS)

Autori: Pietro Strobbia, Vanessa Cupil-Garcia, Bridget M. Crawford, Andrew M. Fales, T. Joshua Pfefer, Yang Liu, Martin Maiwald, Bernd Sumpf, and Tuan Vo-Dinh
Pubblicato in: Theranostics, Numero 11, 2021, Pagina/e 4090–4102, ISSN 1838-7640
Editore: Ivyspring International Publisher
DOI: 10.7150/thno.53101

Ultrashort pulse Kagome hollow-core photonic crystal fiber delivery for nonlinear optical imaging.

Autori: Andreana; Le; Drexler; Unterhuber
Pubblicato in: Optics Letters, Numero 44, 2019, Pagina/e 1588-1591, ISSN 0146-9592
Editore: Optical Society of America
DOI: 10.1364/ol.44.001588

A submicrometre silicon-on-insulator resonator for ultrasound detection

Autori: Rami Shnaiderman, Georg Wissmeyer, Okan Ülgen, Qutaiba Mustafa, Andriy Chmyrov & Vasilis Ntziachristos
Pubblicato in: Nature, Numero 585, 2020, Pagina/e 372–378, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-020-2685-y

Morpho-Molecular Metabolic Analysis and Classification of Human Pituitary Gland and Adenoma Biopsies Based on Multimodal Optical Imaging.

Autori: Gabriel Giardina; Alexander Micko; Daniela Bovenkamp; Arno Krause; Fabian Placzek; Laszlo Papp; Denis Krajnc; Clemens P. Spielvogel; Michael Winklehner; Romana Höftberger; Greisa Vila; Marco Andreana; Rainer A. Leitgeb; Wolfgang Drexler; Stefan Wolfsberger; Angelika Unterhuber
Pubblicato in: Cancers, Numero 1, 2021, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13133234

Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography

Autori: Rainer Leitgeb, Fabian Placzek, Elisabet Rank, Lisa Krainz, Richard Haindl, Qian Li, Mengyang Liu, Marco Andreana, Angelika Unterhuber, Tilman Schmoll, Wolfgang Drexler
Pubblicato in: Journal of Biomedical Optics, Numero 26/10, 2021, ISSN 1083-3668
Editore: S P I E - International Society for Optical Engineering
DOI: 10.1117/1.jbo.26.10.100601

Manufacturing and assembly of an all-glass OCT microendoscope

Autori: Yanis Taege, Gerardo González-Cerdas, Felix Jund, Hans Zappe, Caglar Ataman
Pubblicato in: Journal of Micromechanics and Microengineering, 2021, ISSN 0960-1317
Editore: Institute of Physics Publishing
DOI: 10.1088/1361-6439/ac2d9d

Monolithic Master Oscillator Tilted Tapered Power Amplifier Emitting 9.5 W at 1060 nm

Autori: Zink, Christof; Maabdorf, Andre; Fricke, Jorg; Ressel, Peter; Sumpf, Bernd; Erbert, Gotz; Trankle, Gunther
Pubblicato in: IEEE Photonics Technology Letters, Numero 32, 2020, Pagina/e 59-62, ISSN 1041-1135
Editore: Institute of Electrical and Electronics Engineers
DOI: 10.1109/lpt.2019.2957063

Multimodal Optical Medical Imaging Concepts based on Optical Coherence Tomography

Autori: Rainer A. Leitgeb; Rainer A. Leitgeb; Bernhard Baumann
Pubblicato in: Frontiers in Physics, Vol 6 (2018), Numero 6, 2018, ISSN 2296-424X
Editore: Frontiers Media S.A
DOI: 10.3389/fphy.2018.00114

Interferometric optical fiber sensor for optoacoustic endomicroscopy.

Autori: Okan Ülgen; Rami Shnaiderman; Christian Zakian; Vasilis Ntziachristos
Pubblicato in: Journal of Biophotonics, Numero 14, 2021, Pagina/e e202000501, ISSN 1864-063X
Editore: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.202000501

Morpho-molecular signal correlation between optical coherence tomography and Raman spectroscopy for superior image interpretation and clinical diagnosis.

Autori: Iwan W. Schie; Fabian Placzek; Florian Knorr; Eliana Cordero; Lara M. Wurster; Gregers G. Hermann; Karin Mogensen; Thomas Hasselager; Wolfgang Drexler; Jürgen Popp; Jürgen Popp; Rainer A. Leitgeb
Pubblicato in: Scientific Reports, Numero 11, 2021, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.21203/rs.3.rs-322204/v1

Comparison of optical coherence tomography angiography and narrow-band imaging using a bimodal endoscope.

Autori: Lara M. Wurster; Simon Kretschmer; Jan Jäger; Fabian Placzek; Laurin Ginner; Wolfgang Drexler; Caglar Ataman; Rainer A. Leitgeb; Hans Zappe
Pubblicato in: Journal of Biomedical Optics, Numero 25, 2019, Pagina/e 032003, ISSN 1083-3668
Editore: S P I E - International Society for Optical Engineering
DOI: 10.1117/1.jbo.25.3.032003

Line Scan Raman Microspectroscopy for Label-Free Diagnosis of Human Pituitary Biopsies.

Autori: Bovenkamp, Daniela; Micko, Alexander; Püls, Jeremias; Placzek, Fabian; Höftberger, Romana; Vila, Greisa; Leitgeb, Rainer; Drexler, Wolfgang; Andreana, Marco; Wolfsberger, Stefan; Unterhuber, Angelika
Pubblicato in: Molecules, 2019, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules24193577

Measuring the sensitivity to optical feedback of single-frequency high-power laser diodes

Autori: Mathias Christensen, Christof Zink, Muhammad Tahir Jamal, Anders Kragh Hansen, Ole Bjarlin Jensen, and Bernd Sumpf
Pubblicato in: Journal of the Optical Society of America B, Numero 38, 2021, Pagina/e 885-892, ISSN 0740-3224
Editore: Optical Society of America
DOI: 10.1364/josab.417258

Raman ChemLighter: Fiber optic Raman probe imaging in combination with augmented chemical reality

Autori: Yang, Wei; Mondol, Abdullah S.; Stiebing, Clara; Marcu, Laura; Popp, Jürgen; Schie, Iwan W.
Pubblicato in: Journal of Biophotonics, Numero 12, 2019, Pagina/e 12:e201800447, ISSN 1864-063X
Editore: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.201800447

Rapid and adjustable shifted excitation Raman difference spectroscopy using a dual-wavelength diode laser at 785 nm

Autori: Martin Maiwald, Bernd Sumpf, Günther Tränkle
Pubblicato in: Journal of Raman Spectroscopy, 2018, ISSN 0377-0486
Editore: John Wiley & Sons Inc.
DOI: 10.1002/jrs.5456

Combination of High-Resolution Optical Coherence Tomography and Raman Spectroscopy for Improved Staging and Grading in Bladder Cancer

Autori: Daniela Bovenkamp, Ryan Sentosa, Elisabet Rank, Mikael Erkkilä, Fabian Placzek, Jeremias Püls, Wolfgang Drexler, Rainer Leitgeb, Nathalie Garstka, Shahrokh Shariat, Clara Stiebing, Iwan Schie, Jürgen Popp, Marco Andreana, Angelika Unterhuber
Pubblicato in: Applied Sciences, Numero 8/12, 2018, Pagina/e 2371, ISSN 2076-3417
Editore: MDPI AG
DOI: 10.3390/app8122371

Endoscopic optical coherence tomography angiography using a forward imaging piezo scanner probe

Autori: Lara M. Wurster, Ronak N. Shah, Fabian Placzek, Simon Kretschmer, Michael Niederleithner, Laurin Ginner, Jason Ensher, Michael P. Minneman, Erich E. Hoover, Hans Zappe, Wolfgang Drexler, Rainer A. Leitgeb, Çağlar Ataman
Pubblicato in: Journal of Biophotonics, 2019, Pagina/e e201800382, ISSN 1864-063X
Editore: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.201800382

MCmatlab: an open-source, user-friendly, MATLAB-integrated three-dimensional Monte Carlo light transport solver with heat diffusion and tissue damage

Autori: Dominik Marti, Rikke N. Aasbjerg, Peter E. Andersen, Anders K. Hansen
Pubblicato in: Journal of Biomedical Optics, Numero 23/12, 2018, Pagina/e 1, ISSN 1083-3668
Editore: S P I E - International Society for Optical Engineering
DOI: 10.1117/1.jbo.23.12.121622

In-vivo Raman spectroscopy: from basics to applications

Autori: Eliana Cordero
Pubblicato in: Journal of Biomedical Optics, Numero 23/07, 2018, Pagina/e 1, ISSN 1083-3668
Editore: S P I E - International Society for Optical Engineering
DOI: 10.1117/1.jbo.23.7.071210

Morpho-molecular ex vivo detection and grading of non-muscle-invasive bladder cancer using forward imaging probe based multimodal optical coherence tomography and Raman spectroscopy

Autori: Fabian Placzek, Eliana Cordero Bautista, Simon Kretschmer, Lara M. Wurster, Florian Knorr, Gerardo González-Cerdas, Mikael T. Erkkilä, Patrick Stein, Çağlar Ataman, Gregers G. Hermann, Karin Mogensen, Thomas Hasselager, Peter E. Andersen, Hans Zappe, Jürgen Popp, Wolfgang Drexler, Rainer A. Leitgeb, Iwan W. Schie
Pubblicato in: The Analyst, 2020, ISSN 0003-2654
Editore: Royal Society of Chemistry
DOI: 10.1039/c9an01911a

Bladder tissue characterization using probe‐based Raman spectroscopy: Evaluation of tissue heterogeneity and influence on the model prediction

Autori: Eliana Cordero, Jan Rüger, Dominik Marti, Abdullah S. Mondol, Thomas Hasselager, Karin Mogensen, Gregers G. Hermann, Jürgen Popp, Iwan W. Schie
Pubblicato in: Journal of Biophotonics, Numero 13/2, 2019, ISSN 1864-063X
Editore: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.201960025

Efficient generation of 3.5W laser light at 515nm by frequency doubling a single-frequency high power DBR tapered diode laser

Autori: Ole Bjarlin Jensen, Anders Kragh Hansen, André Müller, Bernd Sumpf, Paul Michael Petersen, Peter E. Andersen
Pubblicato in: Optics Communications, Numero 392, 2017, Pagina/e 167-170, ISSN 0030-4018
Editore: Elsevier BV
DOI: 10.1016/j.optcom.2017.01.060

Evaluation of Shifted Excitation Raman Difference Spectroscopy and Comparison to Computational Background Correction Methods Applied to Biochemical Raman Spectra

Autori: Eliana Cordero, Florian Korinth, Clara Stiebing, Christoph Krafft, Iwan Schie, Jürgen Popp
Pubblicato in: Sensors, Numero 17/8, 2017, Pagina/e 1724, ISSN 1424-8220
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s17081724

Dual-wavelength diode laser with electrically adjustable wavelength distance at 785  nm

Autori: Bernd Sumpf, Julia Kabitzke, Jörg Fricke, Peter Ressel, André Müller, Martin Maiwald, Günther Tränkle
Pubblicato in: Optics Letters, Numero 41/16, 2016, Pagina/e 3694, ISSN 0146-9592
Editore: Optical Society of America
DOI: 10.1364/OL.41.003694

Selecting optimal spectral bands for improved detection of autofluorescent biomarkers in multiphoton microscopy

Autori: Björn-Ole Meyer, M. Pilar J. Stella, Bjørn Holst, Boye S. Nielsen, Kim Holmstrøm, Peter E. Andersen, Dominik Marti
Pubblicato in: Journal of Biomedical Optics, Numero 25/07, 2020, Pagina/e 1, ISSN 1083-3668
Editore: S P I E - International Society for Optical Engineering
DOI: 10.1117/1.jbo.25.7.071206

Silicon-Photonics Point Sensor for High-Resolution Optoacoustic Imaging

Autori: Rami Shnaiderman, Qutaiba Mustafa, Okan Ülgen, Georg Wissmeyer, Héctor Estrada, Daniel Razansky, Andriy Chmyrov, Vasilis Ntziachristos
Pubblicato in: Advanced Optical Materials, Numero 9, 2021, Pagina/e 2100256, ISSN 2195-1071
Editore: Wiley
DOI: 10.1002/adom.202100256

Development and evaluation of a hand-held fiber-optic Raman probe with an integrated autofocus unit

Autori: Yang Wei; Florian Knorr; Jürgen Popp; Iwan W. Schie
Pubblicato in: Optics Express, Numero 28, 2020, Pagina/e 30760-30770, ISSN 1094-4087
Editore: Optical Society of America
DOI: 10.1364/oe.401207

Morpho-Molecular Metabolic Analysis and Classification of Human Pituitary Gland and Adenoma Biopsies Based on Multimodal Optical Imaging

Autori: Gabriel Giardina, Alexander Micko, Daniela Bovenkamp, Arno Krause, Fabian Placzek, Laszlo Papp, Denis Krajnc, Clemens P. Spielvogel, Michael Winklehner, Romana Höftberger, Greisa Vila, Marco Andreana, Rainer Leitgeb, Wolfgang Drexler, Stefan Wolfsberger, Angelika Unterhuber
Pubblicato in: Cancers, Numero 13/13, 2021, Pagina/e 3234, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13133234

Depth resolved label-free multimodal optical imaging platform to study morpho-molecular composition of tissue

Autori: Andreana; Sentosa; Erkkilä; Drexler; Unterhuber
Pubblicato in: Photochemical & Photobioogical Sciences, Numero 1, 2019, ISSN 1474-905X
Editore: Royal Society of Chemistry
DOI: 10.1039/c8pp00410b

En face optical coherence tomography: a technology review [Invited].

Autori: Leitgeb, R. A.
Pubblicato in: Biomedical Optics Express, Numero 1, 2019, ISSN 2156-7085
Editore: The Optical Society
DOI: 10.1364/boe.10.002177

Conference proceedings (12)

CARS endomicroscopic imaging probe enabled by a double-core double-clad fiber and related focus-combining micro-optical concept

Autori: Bernhard Messerschmidt, Ekaterina Pshenay-Severin, Gregor Matz, Karl Reichwald, Jörg Bierlich, Jens Kobelke, Hyeonsoo Bae, Tobias Meyer-Zedler, Michael Schmitt, Jürgen Popp
Pubblicato in: Proceedings Volume 11636, Optical Biopsy XIX: Toward Real-Time Spectroscopic Imaging and Diagnosis; 116360A (2021), 2021, ISSN 0277-786X
Editore: SPIE Digital Library
DOI: 10.1117/12.2578538

Spectrally stabilized high-power high-brightness DBR-tapered lasers in the VIS and NIR range

Autori: Bernd Sumpf, Katrin Paschke
Pubblicato in: Laser Resonators, Microresonators, and Beam Control XX, Numero 10518, 2018, Pagina/e 44, ISBN 9781-510615229
Editore: SPIE
DOI: 10.1117/12.2288425

High power diode lasers converted to the visible

Autori: Ole B. Jensen, Anders K. Hansen, Peter E. Andersen, Mathias Christensen, Andre Muller, Mahmoud Tawfieq, Bernd Sumpf, Paul M. Petersen
Pubblicato in: 2017 IEEE High Power Diode Lasers and Systems Conference (HPD), Numero CFP1771I-ART, 2017, Pagina/e 45-46, ISBN 978-1-5386-3263-5
Editore: IEEE
DOI: 10.1109/HPD.2017.8261093

Simple fibre based dispersion management for two-photon excited fluorescence imaging through an endoscope

Autori: Dominik Marti, Konstantinos Dimopoulos, Peter E. Andersen
Pubblicato in: Multiphoton Microscopy in the Biomedical Sciences XVIII, Numero 10498, 2018, Pagina/e 70, ISBN 9781-510614826
Editore: SPIE
DOI: 10.1117/12.2289533

Diffraction limited 1064nm monolithic DBR-master oscillator power amplifier with more than 7W output power

Autori: André Maaβdorf, Peter Ressel, Martin Maiwald, Jörg Fricke, Bernd Sumpf, Günther Tränkle, Christof Zink, Gotz Erbert
Pubblicato in: Novel In-Plane Semiconductor Lasers XVII, Numero 10553, 2018, Pagina/e 45, ISBN 9781-510615922
Editore: SPIE
DOI: 10.1117/12.2288977

Shifted excitation Raman difference spectroscopy: from diode lasers to in situ applications

Autori: Martin Maiwald, Bernd Sumpf
Pubblicato in: Plasmonics in Biology and Medicine XV, Numero 10509, 2018, Pagina/e 2, ISBN 9781-510615045
Editore: SPIE
DOI: 10.1117/12.2293058

Endoscopic Optical Coherence Tomography Angiography Using A Piezo Scanner

Autori: Lara M. Wurster, Simon Kretschmer, Fabian Placzek, Sergio Vilches, Michael Niederleithner, Caglar Ataman, Hans Zappe, Rainer A. Leitgeb
Pubblicato in: 2018 International Conference on Optical MEMS and Nanophotonics (OMN), 2018, Pagina/e 1-2, ISBN 978-1-5090-6374-1
Editore: IEEE
DOI: 10.1109/OMN.2018.8454643

Improving Raman spectroscopy using diode lasers at 785 nm for shifted excitation Raman difference spectroscopy

Autori: Martin Maiwald, Bernd Sumpf
Pubblicato in: Plasmonics in Biology and Medicine XVII, Numero 1125708, 2020, Pagina/e 7, ISBN 9781-510632783
Editore: SPIE
DOI: 10.1117/12.2554014

Micro-structured glass probe for endoscopic Optical Coherence Tomography

Autori: Gerardo E. González-Cerdas, Patrick Stein, Simon Kretschmer, Christoph Bauer, Dragan Sandic, Caglar Ataman, Hans Zappe
Pubblicato in: Biomedical Spectroscopy, Microscopy, and Imaging, 2020, Pagina/e 17, ISBN 9781-510634916
Editore: SPIE
DOI: 10.1117/12.2555069

785nm dual-wavelength Y-branch DBR-RW diode laser with electrically adjustable wavelength distance between 0 nm and 2 nm

Autori: Bernd Sumpf, Julia Kabitzke, Jörg Fricke, Peter Ressel, André Müller, Martin Maiwald, Günther Tränkle
Pubblicato in: Novel In-Plane Semiconductor Lasers XVI, Numero 10123, 2017, Pagina/e 101230T
Editore: SPIE
DOI: 10.1117/12.2248621

5,000 h reliable operation of 785nm dual-wavelength DBR-RW diode lasers suitable for Raman spectroscopy and SERDS

Autori: Bernd Sumpf, André Müller, Martin Maiwald
Pubblicato in: Novel In-Plane Semiconductor Lasers XV, Numero 9767, 2016, Pagina/e 97670T
Editore: SPIE
DOI: 10.1117/12.2207659

MCmatlab: an open-source, user-friendly, MATLAB-integrated 3D Monte Carlo light transport solver with heat diffusion and tissue damage

Autori: Dominik Marti, Rikke N. Aasbjerg, Peter E. Andersen, Anders K. Hansen
Pubblicato in: Optical Interactions with Tissue and Cells XXX, Numero 2019, 2019, Pagina/e 27, ISBN 9781-510623958
Editore: SPIE
DOI: 10.1117/12.2507754