Objective Chimeric antigen receptors (CARs) are artificial surface receptors that can be introduced into somatic cells by genetic engineering and that act as recognition molecules like antibodies or T-cell receptors. In this respect, CARs are increasingly used for cellular therapy to redirect T-cells specifically towards killing of cancer cells. Recent success stories of cancer therapy with CAR modified T-cells have raised enormous scientific and public expectations to cure severely ill patients. However, there are still many obstacles to overcome for translation into clinics because the technology for GMP-compliant manufacture of genetically modified cellular products is extremely complex and expensive. Moreover, CAR therapy needs to be improved with respect to off-target activity, safety and potency. Consequently, the envisaged project is overall aiming at a particular technological breakthrough in cellular cancer therapy by delivering a comprehensive CARAT platform explicitly tailored for automated, easy-to-handle and cost-efficient manufacture of CAR-modified ATMP. Specifically, we aim:(a) to implement unique next-generation cell processing tools like the CliniMACS Prodigy(b) to develop advanced enabling technologies to obtain more effective and safer cellular products by improved gene delivery and innovative CARs design(c) to assemble tools and technologies towards an integrated CARAT process for automated GMP-compliant manufacture of gene-modified T-cells(d) to demonstrate proof-of-concept and regulatory compliance(e) to disseminate broadly applicable, simplified CAR T-cell technologiesIn summary, our vision is to overcome current hurdles for translation of cellular therapies and to elevate them to the next level of standard-of-care thus serving patients with so far incurable solid tumours and hematologic malignancies. Thereby, we will empower Europe to become a global leader in the development and commercialisation of CAR T-cell tools and technologies. Fields of science engineering and technologymechanical engineeringmanufacturing engineeringmedical and health sciencesmedical biotechnologygenetic engineeringgene therapymedical and health sciencesclinical medicineoncologymedical and health sciencesmedical biotechnologycells technologiesnatural sciencescomputer and information sciencessoftwaresoftware applications Keywords Chimeric antigen receptors CARs T cells cell therapy gene therapy cell manufacture ATMP cancer regulatory compliance GMP cell isolation automation monitoring logistic control safety Programme(s) H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being Main Programme H2020-EU.3.1.3. - Treating and managing disease Topic(s) PHC-16-2015 - Tools and technologies for advanced therapies Call for proposal H2020-PHC-2014-2015 See other projects for this call Sub call H2020-PHC-2015-two-stage Funding Scheme RIA - Research and Innovation action Coordinator MILTENYI BIOTEC BV & CO KG Net EU contribution € 171 913,75 Address FRIEDRICH EBERT STRASSE 68 51429 Bergisch Gladbach Germany See on map Region Nordrhein-Westfalen Köln Rheinisch-Bergischer Kreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 171 913,75 Participants (8) Sort alphabetically Sort by Net EU contribution Expand all Collapse all OSPEDALE SAN RAFFAELE SRL Italy Net EU contribution € 913 300,00 Address VIA OLGETTINA 60 20132 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 913 300,00 BUNDESINSTITUT FUR IMPFSTOFFE UND BIOMEDIZINISCHE ARZNEIMITTEL Germany Net EU contribution € 715 533,75 Address PAUL-EHRLICH-STRASSE 51-59 63225 Langen See on map Region Hessen Darmstadt Offenbach, Landkreis Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 715 533,75 INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France Net EU contribution € 646 770,00 Address RUE DE TOLBIAC 101 75654 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 646 770,00 UNIVERSITY COLLEGE LONDON United Kingdom Net EU contribution € 660 398,75 Address GOWER STREET WC1E 6BT London See on map Region London Inner London — West Camden and City of London Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 660 398,75 TRAKCEL LIMITED United Kingdom Net EU contribution € 422 750,00 Address 10/11 RALEIGH WALK BRIGANTINE PLACE CF10 4LN Cardiff See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Wales East Wales Cardiff and Vale of Glamorgan Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 422 750,00 UNIVERSITAETSKLINIKUM FREIBURG Germany Net EU contribution € 718 580,00 Address HUGSTETTER STRASSE 49 79106 Freiburg See on map Region Baden-Württemberg Freiburg Freiburg im Breisgau, Stadtkreis Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 718 580,00 EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH Germany Net EU contribution € 561 087,50 Address HEINRICH-HERTZ-ALLEE 1 66386 St Ingbert See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Saarland Saarland Saarpfalz-Kreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 561 087,50 MILTENYI BIOTEC GMBH Participation ended Germany Net EU contribution € 1 178 825,00 Address FRIEDRICH EBERT STRASSE 68 51429 Bergish Gladbach See on map Region Nordrhein-Westfalen Köln Rheinisch-Bergischer Kreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 178 825,00
