Description du projet
Le microbiote intestinal, une cible thérapeutique pour la fibrose hépatique liée à l’alcool?
Une forte consommation d’alcool peut entraîner une accumulation de graisse dans le foie, une inflammation et des lésions susceptibles de provoquer une maladie hépatique liée à l’alcool. Si elle est détectée et traitée à un stade précoce, la fibrose hépatique alcoolique peut être inversée. Le projet GALAXY, financé par l’UE, partira de l’hypothèse selon laquelle l’interaction entre le microbiome intestinal et le foie joue un rôle crucial dans le développement et la progression de la fibrose hépatique alcoolique. Les chercheurs étudieront l’interaction complexe entre le microbiote intestinal et le foie, identifieront des biomarqueurs et développeront des stratégies de soins de santé personnalisées pour les personnes à risque. L’objectif est de moduler le microbiote intestinal afin de prévenir et atténuer la fibrose hépatique alcoolique, ce qui s’accompagnera d’avantages socio-économiques évidents.
Objectif
Alcohol overuse is an important societal challenge with annual healthcare costs of over €22 billion in Europe. Alcohol is the main cause of liver cirrhosis, which is the 5th and 7th most common cause of life years lost in respectively Eastern and Western Europe. Cirrhosis is considered irreversible but its precursor, liver fibrosis, is reversible when detected before disease progression. GALAXY proposes that crosstalk between the gut microbiome and the liver influences the development and progression of alcoholic liver fibrosis. Here, a ‘dysbiotic’ microbiome in susceptible individuals leads to progressive liver fibrosis in combination with alcohol overuse. Therefore, interventions aiming to restore a healthy gut microbiome will reduce disease development. We will use state-of-the-art systems medicine tools to improve understanding of the complex interplay present during alcoholic liver fibrosis, to identify at-risk individuals in time and to develop personalised healthcare strategies for alcohol over-users (20% of the EU population >15 years old). GALAXY brings together partners with unique research competences in clinical hepatology, microbiome, multi-omics, biomarkers and bioinformatics. Our aim is to develop novel systems medicine tools which integrate clinical, multi-omics and lifestyle information from alcohol over-users at various stages of the disease and healthy individuals in order to: 1) identify signatures of host-microbial cross-talk during disease development and progression, 2) translate this into biomarkers for diagnosis, stratification and treatment monitoring in alcohol over users, and 3) evaluate new interventions to modulate gut microbiota towards prevention and mitigation of the disease in at-risk individuals. We will also study societal and economic impact of GALAXY biomarkers and treatments to accelerate future development. The GALAXY consortium includes strong SME partners who will enable the results to be exploited commercially.
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RIA - Research and Innovation actionCoordinateur
5230 Odense M
Danemark