Project description
Advancing personalised medicine through pharmacogenomics
Pharmacogenomics is a field of study that aims to understand how an individual's genetic makeup influences their response to drugs. By analysing an individual's genetic variations, pharmacogenomics seeks to develop personalised medicine approaches that can improve drug efficacy and minimise adverse reactions. It also plays a key role in drug development by helping identify patient subgroups that are more likely to benefit from a particular drug. The EU-funded U-PGx project aims to develop a pharmacogenomics approach using health IT solutions that will be tested in terms of feasibility and cost-effectiveness across several European countries. Results will be instrumental to the clinical implementation of pharmacogenomics.
Objective
Pharmacogenomics is the study of genetic variability affecting an individual’s response to a drug. Its use allows personalized medicine and reduction in ‘trial and error’ prescribing leading to more efficacious, safer and cost-effective drug therapy. The U-PGx consortium will investigate a pre-emptive genotyping approach (that is: multiple pharmacogenomic variants are collected prospectively and embedded into the patients’ electronic record) of a panel of important pharmacogenomic variants as a new model of personalised medicine. To meet this goal we combine existing pharmacogenomics guidelines and novel health IT solutions. Implementation will be conducted at a large scale in seven existing European health care environments and accounts for the diversity in health system organisations and settings. Feasibility, health outcome and cost-effectiveness will be investigated. We will formulate European strategies for improving clinical implementation of pharmacogenomics based on the findings of this project.
Fields of science
Programme(s)
Funding Scheme
RIA - Research and Innovation actionCoordinator
2333 ZA Leiden
Netherlands
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Participants (21)
L69 7ZX Liverpool
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
L7 8XP LIVERPOOL
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Participation ended
53175 Bonn
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17177 Stockholm
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WC2N 5AP London
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2500 GL DEN HAAG
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Participation ended
60438 FRANKFURT
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
Participation ended
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Participation ended
3435 CM Nieuwegein
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1090 Wien
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31062 Toulouse Cedex 9
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
75654 Paris
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751 05 Uppsala
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33081 AVIANO PN
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41071 Sevilla
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265 04 Rio Patras
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1000 Ljubljana
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70376 Stuttgart
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3584 CX Utrecht
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52074 Aachen
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60438 FRANKFURT
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