Ubiquitous Pharmacogenomics (U-PGx): Making actionable pharmacogenomic data and effective treatment optimization accessible to every European citizen

Deliverables

Therapeutic recommendations in Dutch, Greek, German, Italian, Slovene and Spanish

Therapeutic recommendations in Dutch Greek German Italian Slovene and Spanish

Report on ELSI education needs

Report on design of future study employing one promising model

Overall report on ELSI aspects of U-PGx

Overall report on ELSI aspects of UPGx

Survey to evaluate the state of PGx knowledge in the 7 participating countries

Report on ethical issues, guidelines, governance model and principals for patients included in U-PGx

Report on ethical issues guidelines governance model and principals for patients included in UPGx

Establishment of PK models for prediction of DDI and genetic polymorphisms on drug exposure for candidate genes included in the U-PGx trial

Establishment of PK models for prediction of DDI and genetic polymorphisms on drug exposure for candidate genes included in the UPGx trial

Detection, assessment and evaluation of clinically relevant DDI in the U-PGx trial

Detection assessment and evaluation of clinically relevant DDI in the UPGx trial

Report on detailed analysis of existing information infrastructures and requirements of implementation sites

Report on predictions from first model

Analysis of European regulatory requirements

Report on models identified to be developed

Policy recommendations on the pre-emptive use of U-PGx testing in routine clinical practice and uptake by health care systems

Policy recommendations on the preemptive use of UPGx testing in routine clinical practice and uptake by health care systems

Report on comparison of model predictions and observed data from WP4

Critical re-evaluation and first implementation of revised DPWG guidelines by consideration of relevant DDI

Critical reevaluation and first implementation of revised DPWG guidelines by consideration of relevant DDI

Report on predictions from further models

List of relevant genetic variants for pre-emptive PGx testing

List of relevant genetic variants for preemptive PGx testing

Report on the association of novel genomic variants and extreme phenotypes

Report on finalization endpoint data extraction from clinical database into NONMEM dataset

Report on public events and societal activities in relation with U-PGx

Report on public events and societal activities in relation with UPGx

PGx-guidelines therapeutic recommendations and risk-assessments in English

PGxguidelines therapeutic recommendations and riskassessments in English

Published review paper based upon the current scientific and grey literature on ethics of PGx

Midterm Review

Report on interoperability and development of a shared semantic model

Translated patient surveys for the web-based intensive monitoring system

Translated patient surveys for the webbased intensive monitoring system

Final report on decision support solutions at implementation sites

Organization of a U-PGx Personalized Medicine Day in France

Organization of a UPGx Personalized Medicine Day in France

Organization of the 1st patient/general public oriented PGx information events

Organization of the 1st patientgeneral public oriented PGx information events

Education programme for non-participants

Education programme for nonparticipants

Organization of a U-PGx Personalized Medicine Day in Greece

Organization of a UPGx Personalized Medicine Day in Greece

Organization of a U-PGx Personalized Medicine Day in the UK

Organization of a UPGx Personalized Medicine Day in the UK

Organization of the 3rd patient/general public-oriented PGx information event

Organization of a UPGx Personalized Medicine Day in Germany

Organization of a major 4-day U-PGx Personalized Medicine Symposium in Leiden, Netherlands

Organization of a major 4day UPGx Personalized Medicine Symposium in Leiden Netherlands

Summer school including ELSI topics (prepared by WP8) for medical and pharmacy students

Summer school including ELSI topics prepared by WP8 for medical and pharmacy students

Organization of the 2nd patient/general public oriented PGx information events

Organization of the 2nd patientgeneral public oriented PGx information events

Organization of a U-PGx Personalized Medicine Day in Slovenia

Organization of a UPGx Personalized Medicine Day in Slovenia

Organization of a U-PGx Personalized Medicine Day in Sweden

Organization of a UPGx Personalized Medicine Day in Sweden

Organization of a U-PGx Personalized Medicine Day in Spain

Organization of a UPGx Personalized Medicine Day in Spain

Promotional video will be produced that visualises and promotes the idea of the idea of personalised medicine and pre-emptive PGx testing

Promotional video will be produced that visualises and promotes the idea of the idea of personalised medicine and preemptive PGx testing

Workshop for participating healthcare professionals

Organization of a U-PGx Personalized Medicine Day in Austria

Organization of a UPGx Personalized Medicine Day in Austria

1st version of the public-domain web-based U-PGx information portal

1st version of the publicdomain webbased UPGx information portal

Delivery of decision support solutions including framework for digital infrastructure including secure cloud solutions

Dedicated webpage with secured login access for investigators and study staff

3rd version of the public-domain web-based PGx information portal

3rd version of the publicdomain webbased PGx information portal

Standardized Electronic Case Record Form (eCRF)

Standardized Electronic Case Record Form eCRF

A new model of cost-effectiveness analysis, taking into account the restriction of budget

A new model of costeffectiveness analysis taking into account the restriction of budget

Validated bioinformatics tool

2nd version of the public-domain web-based PGx information portal

2nd version of the publicdomain webbased PGx information portal

A standard cost-effectiveness model to assess cost-effectiveness of PGx testing in each implementation site

A standard costeffectiveness model to assess costeffectiveness of PGx testing in each implementation site

Release of open-source software artefacts for decision support solutions

Release of opensource software artefacts for decision support solutions

eLearning program for the train the trainers concept

updated version of DMP

first version of DMP

final version DMP

Release of open-source software artefacts describing semantic model

Release of opensource software artefacts describing semantic model

ELSI content for a summer school on PGx to be delivered by WP6

set of specifications for the selected PGx assays

Searching for OpenAIRE data...

Publications

Genetic Markers of the Host to Predict the Efficacy of Colorectal Cancer Targeted Therapy

Author(s): Elena De Mattia, Alessia Bignucolo, Giuseppe Toffoli, Erika Cecchin
Published in: Current Medicinal Chemistry, 27/25, 2020, Page(s) 4249-4273, ISSN 0929-8673
Publisher: Bentham Science Publishers
DOI: 10.2174/0929867326666190712151417

Germline Polymorphisms in the Nuclear Receptors PXR and VDR as Novel Prognostic Markers in Metastatic Colorectal Cancer Patients Treated With FOLFIRI

Author(s): Elena De Mattia, Jerry Polesel, Rossana Roncato, Adrien Labriet, Alessia Bignucolo, Eva Dreussi, Loredana Romanato, Michela Guardascione, Angela Buonadonna, Mario D'Andrea, Eric Lévesque, Derek Jonker, Félix Couture, Chantal Guillemette, Erika Cecchin, Giuseppe Toffoli
Published in: Frontiers in Oncology, 9, 2019, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2019.01312

Pharmacogenetics of the systemic treatment in advanced hepatocellular carcinoma.

Author(s): Elena De Mattia; Erika Cecchin; Michela Guardascione; Luisa Foltran; Tania Di Raimo; Francesco Angelini; Mario D’Andrea; Giuseppe Toffoli
Published in: World Journal of Gastroenterology, 4, 2019, ISSN 1007-9327
Publisher: W J G Press
DOI: 10.3748/wjg.v25.i29.3870

Population pharmacogenomics: an update on ethnogeographic differences and opportunities for precision public health.

Author(s): Zhou Y, Lauschke VM.
Published in: Human genetics, 2021, ISSN 0340-6717
Publisher: Springer Verlag
DOI: 10.1007/s00439-021-02385-x

Estimating the Effectiveness of DPYD Genotyping in Italian Individuals Suffering from Cancer Based on the Cost of Chemotherapy-Induced Toxicity

Author(s): Vasileios Fragoulakis, Rossana Roncato, Chiara Dalle Fratte, Fabrizio Ecca, Marina Bartsakoulia, Federico Innocenti, Giuseppe Toffoli, Erika Cecchin, George P. Patrinos, Christina Mitropoulou
Published in: The American Journal of Human Genetics, 104/6, 2019, Page(s) 1158-1168, ISSN 0002-9297
Publisher: University of Chicago Press
DOI: 10.1016/j.ajhg.2019.04.017

Evaluation of Current Regulation and Guidelines of Pharmacogenomic Drug Labels: Opportunities for Improvements.

Author(s): Shekhani R, Steinacher L, Swen JJ, Ingelman-Sundberg M.
Published in: Clinical pharmacology and therapeutics, 2020, ISSN 0009-9236
Publisher: Nature Publishing Group
DOI: 10.1002/cpt.1720

Tri-Allelic Haplotypes Determine and Differentiate Functionally Normal Allele CYP2D6*2 and Impaired Allele CYP2D6*41.

Author(s): Zanger UM, Momoi K, Hofmann U, Schwab M, Klein K.
Published in: Clinical pharmacology and therapeutics, 2021, ISSN 0009-9236
Publisher: Nature Publishing Group
DOI: 10.1002/cpt.2078

Pharmacogenetics Guidelines: Overview and Comparison of the DPWG, CPIC, CPNDS, and RNPGx Guidelines.

Author(s): Abdullah-Koolmees H, van Keulen AM, Nijenhuis M, Deneer VHM.
Published in: Frontiers in pharmacology, 2020, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2020.595219

Genomewide Association Study of Platelet Reactivity and Cardiovascular Response in Patients Treated With Clopidogrel: A Study by the International Clopidogrel Pharmacogenomics Consortium

Author(s): Shefali Setia Verma, Thomas O. Bergmeijer, Li Gong, Jean‐Luc Reny, Joshua P. Lewis, Braxton D. Mitchell, Dimitrios Alexopoulos, Daniel Aradi, Russ B. Altman, Kevin Bliden, Yuki Bradford, Gianluca Campo, Kiyuk Chang, John H. Cleator, Jean‐Pierre Déry, Nadia P. Dridi, Israel Fernandez‐Cadenas, Pierre Fontana, Meinrad Gawaz, Tobias Geisler, Gian Franco Gensini, Betti Giusti, Paul A. Gurbel, Wi
Published in: Clinical Pharmacology & Therapeutics, 108/5, 2020, Page(s) 1067-1077, ISSN 0009-9236
Publisher: Nature Publishing Group
DOI: 10.1002/cpt.1911

Substrate specificity of CYP2D6 genetic variants.

Author(s): van der Lee M, Guchelaar HJ, Swen JJ.
Published in: Pharmacogenomics, 2021, ISSN 1462-2416
Publisher: Ashley Publications Ltd.
DOI: 10.2217/pgs-2021-0093

Clinically Relevant Cytochrome P450 3A4 Induction Mechanisms and Drug Screening in Three‐Dimensional Spheroid Cultures of Primary Human Hepatocytes

Author(s): Delilah F.G. Hendriks, Sabine U. Vorrink, Tomas Smutny, Sarah C. Sim, Åsa Nordling, Shahid Ullah, Masaki Kumondai, Barry C. Jones, Inger Johansson, Tommy B. Andersson, Volker M. Lauschke, Magnus Ingelman‐Sundberg
Published in: Clinical Pharmacology & Therapeutics, 108/4, 2020, Page(s) 844-855, ISSN 0009-9236
Publisher: Nature Publishing Group
DOI: 10.1002/cpt.1860

Emerging strategies to bridge the gap between pharmacogenomic research and its clinical implementation

Author(s): Volker M. Lauschke, Magnus Ingelman-Sundberg
Published in: npj Genomic Medicine, 5/1, 2020, ISSN 2056-7944
Publisher: Springer Nature
DOI: 10.1038/s41525-020-0119-2

Toward predicting CYP2D6-mediated variable drug response from CYP2D6 gene sequencing data

Author(s): Maaike van der Lee; William G. Allard; Rolf H. A. M. Vossen; Renee Baak-Pablo; Roberta Menafra; Birgit A. L. M. Deiman; Maarten J. Deenen; Patrick Neven; Inger Johansson; Stefano Gastaldello; Magnus Ingelman-Sundberg; Henk-Jan Guchelaar; Jesse J. Swen; Seyed Yahya Anvar
Published in: VOLUME=13;ISSUE=603;TITLE=Science Translational Medicine, 6, 2021, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.abf3637

Can CYP Inhibition Overcome Chemotherapy Resistance?

Author(s): Magnus Ingelman-Sundberg, Volker M. Lauschke
Published in: Trends in Pharmacological Sciences, 41/8, 2020, Page(s) 503-506, ISSN 0165-6147
Publisher: Elsevier BV
DOI: 10.1016/j.tips.2020.05.007

Exome-Wide Analysis of the DiscovEHR Cohort Reveals Novel Candidate Pharmacogenomic Variants for Clinical Pharmacogenomics

Author(s): Maria-Theodora Pandi, Marc S. Williams, Peter van der Spek, Maria Koromina, George P. Patrinos
Published in: Genes, 11/5, 2020, Page(s) 561, ISSN 2073-4425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes11050561

Economic evaluation in psychiatric pharmacogenomics: a systematic review.

Author(s): Karamperis K, Koromina M, Papantoniou P, Skokou M, Kanellakis F, Mitropoulos K, Vozikis A, Müller DJ, Patrinos GP, Mitropoulou C.
Published in: The pharmacogenomics journal, 2021, ISSN 1470-269X
Publisher: Nature Publishing Group
DOI: 10.1038/s41397-021-00249-1

IL15RA and SMAD3 Genetic Variants Predict Overall Survival in Metastatic Colorectal Cancer Patients Treated with FOLFIRI Therapy: A New Paradigm.

Author(s): De Mattia E, Polesel J, Roncato R, Labriet A, Bignucolo A, Gagno S, Buonadonna A, D'Andrea M, Lévesque E, Jonker D, Couture F, Guillemette C, Cecchin E, Toffoli G.
Published in: Cancers, 2021, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13071705

Impact of CYP2C19 genotype on sertraline exposure in 1200 Scandinavian patients

Author(s): Line S. Bråten, Tore Haslemo, Marin M. Jukic, Magnus Ingelman-Sundberg, Espen Molden, Marianne K. Kringen
Published in: Neuropsychopharmacology, 45/3, 2020, Page(s) 570-576, ISSN 0893-133X
Publisher: Nature Publishing Group
DOI: 10.1038/s41386-019-0554-x

Impact of antipsychotic polypharmacy on nonadherence of oral antipsychotic drugs – A study based on blood sample analyses from 24,239 patients

Author(s): Robert L Smith, Marit Tveito, Lennart Kyllesø, Marin M Jukic, Magnus Ingelman-Sundberg, Ole A Andreassen, Espen Molden
Published in: European Neuropsychopharmacology, 37, 2020, Page(s) 64-69, ISSN 0924-977X
Publisher: Elsevier BV
DOI: 10.1016/j.euroneuro.2020.06.007

Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2D6 and opioids (codeine, tramadol and oxycodone).

Author(s): Matic M, Nijenhuis M, Soree B, de Boer-Veger NJ, Buunk AM, Houwink EJF, Mulder H, Rongen GAPJM, Weide JV, Wilffert B, Swen JJ, Guchelaar HJ, Deneer VHM, van Schaik RHN.
Published in: European journal of human genetics : EJHG, 2021, ISSN 1018-4813
Publisher: Natue Publishing Group
DOI: 10.1038/s41431-021-00920-y

Delineating significant genome-wide associations of variants with antipsychotic and antidepressant treatment response: implications for clinical pharmacogenomics.

Author(s): Koromina M, Koutsilieri S, Patrinos GP.
Published in: Human genomics, 2020, ISSN 1473-9542
Publisher: Henry Stewart Publications
DOI: 10.1186/s40246-019-0254-y

Application of Economic Evaluation to Assess Feasibility for Reimbursement of Genomic Testing as Part of Personalized Medicine Interventions

Author(s): Stavros Simeonidis, Stefania Koutsilieri, Athanassios Vozikis, David N. Cooper, Christina Mitropoulou, George P. Patrinos
Published in: Frontiers in Pharmacology, 10, 2019, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2019.00830

Rare genetic variability in human drug target genes modulates drug response and can guide precision medicine.

Author(s): Zhou Y, Arribas GH, Turku A, Jürgenson T, Mkrtchian S, Krebs K, Wang Y, Svobodova B, Milani L, Schulte G, Korabecny J, Gastaldello S, Lauschke VM.
Published in: Science advances, 2021, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abi6856

Global Frequencies of Clinically Important HLA Alleles and Their Implications For the Cost‐Effectiveness of Preemptive Pharmacogenetic Testing

Author(s): Yitian Zhou, Kristi Krebs, Lili Milani, Volker M. Lauschke
Published in: Clinical Pharmacology & Therapeutics, 2020, ISSN 0009-9236
Publisher: Nature Publishing Group
DOI: 10.1002/cpt.1944

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C19 and Proton Pump Inhibitor Dosing.

Author(s): Lima JJ, Thomas CD, Barbarino J, Desta Z, Van Driest SL, El Rouby N, Johnson JA, Cavallari LH, Shakhnovich V, Thacker DL, Scott SA, Schwab M, Uppugunduri CRS, Formea CM, Franciosi JP, Sangkuhl K, Gaedigk A, Klein TE, Gammal RS, Furuta T.
Published in: Clinical pharmacology and therapeutics, 2021, ISSN 0009-9236
Publisher: Nature Publishing Group
DOI: 10.1002/cpt.2015

CYP2B6 Functional Variability in Drug Metabolism and Exposure Across Populations-Implication for Drug Safety, Dosing, and Individualized Therapy.

Author(s): Langmia IM, Just KS, Yamoune S, Brockmöller J, Masimirembwa C, Stingl JC.
Published in: Frontiers in genetics, 2021, ISSN 1664-8021
Publisher: Frontiers Media
DOI: 10.3389/fgene.2021.692234

Novel genetic and epigenetic factors of importance for inter-individual differences in drug disposition, response and toxicity

Author(s): Lauschke, Volker M.; Zhou, Yitian; Ingelman-Sundberg, Magnus
Published in: Pharmacology & Therapeutics, 13, 2019, ISSN 0163-7258
Publisher: Pergamon Press
DOI: 10.1016/j.pharmthera.2019.01.002

Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2C19 and CYP2D6 and SSRIs.

Author(s): Brouwer JMJL, Nijenhuis M, Soree B, Guchelaar HJ, Swen JJ, van Schaik RHN, Weide JV, Rongen GAPJM, Buunk AM, de Boer-Veger NJ, Houwink EJF, van Westrhenen R, Wilffert B, Deneer VHM, Mulder H.
Published in: European journal of human genetics : EJHG, 2021, ISSN 1018-4813
Publisher: Natue Publishing Group
DOI: 10.1038/s41431-021-01004-7

A Clinical Drug-Drug Interaction Study Assessing a Novel Drug Transporter Phenotyping Cocktail With Adefovir, Sitagliptin, Metformin, Pitavastatin, and Digoxin

Author(s): Trueck, Christina; Hsin, Chih-Hsuan; Scherf-Clavel, Oliver; Schaeffeler, Elke; Lenssen, Rebekka; Gazzaz, Malaz; Gersie, Marleen; Taubert, Max; Quasdorff, Maria; Schwab, Matthias; Kinzig, Martina; Sörgel, Fritz; Stoffel, Marc S.; Fuhr, Uwe
Published in: Clinical pharmacology and therapeutics, 2019, ISSN 0009-9236
Publisher: Nature Publishing Group
DOI: 10.1002/cpt.1564

Global Pharmacogenomics Within Precision Medicine: Challenges and Opportunities

Author(s): Meghan J. Chenoweth, Kathleen M. Giacomini, Munir Pirmohamed, Susan L. Hill, Ron H.N. Schaik, Matthias Schwab, Alan R. Shuldiner, Mary V. Relling, Rachel F. Tyndale
Published in: Clinical Pharmacology & Therapeutics, 107/1, 2019, Page(s) 57-61, ISSN 0009-9236
Publisher: Nature Publishing Group
DOI: 10.1002/cpt.1664

The Impact of CYP3A4*22 on Tacrolimus Pharmacokinetics and Outcome in Clinical Practice at a Single Kidney Transplant Center

Author(s): Emaad Abdel-Kahaar, Stefan Winter, Roman Tremmel, Elke Schaeffeler, Christoph J. Olbricht, Eberhard Wieland, Matthias Schwab, Maria Shipkova, Simon U. Jaeger
Published in: Frontiers in Genetics, 10, 2019, ISSN 1664-8021
Publisher: Frontiers Media
DOI: 10.3389/fgene.2019.00871

Assessment of concomitant non-oncologic medication in patients with surgically treated renal cell carcinoma

Author(s): Neumann, Eva; Klaiber, Peter; Freitag, Kathleen; Schwab, Matthias; Schaeffeler, Elke; Hennenlotter, Jörg; Fend, Falko; Kruck, Stephan; Scharpf, Marcus; Stenzl, Arnulf; Bedke, Jens; Rausch, Steffen
Published in: Journal of cancer research and clinical oncology, 2019, ISSN 0171-5216
Publisher: Springer Verlag
DOI: 10.1007/s00432-019-02914-2

Testing association of rare genetic variants with resistance to three common antiseizure medications

Author(s): Stefan Wolking, Claudia Moreau, Anne T. Nies, Elke Schaeffeler, Mark McCormack, Pauls Auce, Andreja Avbersek, Felicitas Becker, Martin Krenn, Rikke S. Møller, Marina Nikanorova, Yvonne G. Weber, Sarah Weckhuysen, Gianpiero L. Cavalleri, Norman Delanty, Chantal Depondt, Michael R. Johnson, Bobby P.C. Koeleman, Wolfram S. Kunz, Anthony G. Marson, Josemir W. Sander, Graeme J. Sills, Pasquale Striano
Published in: Epilepsia, 61/4, 2020, Page(s) 657-666, ISSN 0013-9580
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/EPI.16467

Population-scale predictions of DPD and TPMT phenotypes using a quantitative pharmacogene-specific ensemble classifier

Author(s): Yitian Zhou, Carolina Dagli Hernandez, Volker M. Lauschke
Published in: British Journal of Cancer, 2020, ISSN 0007-0920
Publisher: Nature Publishing Group
DOI: 10.1038/s41416-020-01084-0

CYP2D6 in the Brain: Potential Impact on Adverse Drug Reactions in the Central Nervous System-Results From the ADRED Study.

Author(s): Katja S. Just; Harald Dormann; Mathias Freitag; Marlen Schurig; Miriam Böhme; Michael Steffens; Catharina Scholl; Thomas Seufferlein; Ingo Graeff; Matthias Schwab; Matthias Schwab; Matthias Schwab; Julia C. Stingl
Published in: Frontiers in Pharmacology, 9, 2021, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2021.624104

Development of the PG x‐Passport: A Panel of Actionable Germline Genetic Variants for Pre‐Emptive Pharmacogenetic Testing

Author(s): Cathelijne H. Wouden, Mandy H. van Rhenen, Wafa O.M. Jama, Magnus Ingelman‐Sundberg, Volker M. Lauschke, Lidija Konta, Matthias Schwab, Jesse J. Swen, Henk‐Jan Guchelaar
Published in: Clinical Pharmacology & Therapeutics, 106/4, 2019, Page(s) 866-873, ISSN 0009-9236
Publisher: Nature Publishing Group
DOI: 10.1002/cpt.1489

Application of long-read sequencing to elucidate complex pharmacogenomic regions: a proof of principle.

Author(s): van der Lee M, Rowell WJ, Menafra R, Guchelaar HJ, Swen JJ, Anvar SY.
Published in: The pharmacogenomics journal, 2022, ISSN 1470-269X
Publisher: Nature Publishing Group
DOI: 10.1038/s41397-021-00259-z

Effect of CYP2D6 genotype on exposure and efficacy of risperidone and aripiprazole: a retrospective, cohort study

Author(s): Marin M Jukic, Robert L Smith, Tore Haslemo, Espen Molden, Magnus Ingelman-Sundberg
Published in: The Lancet Psychiatry, 6/5, 2019, Page(s) 418-426, ISSN 2215-0366
Publisher: Elsevier Limited
DOI: 10.1016/s2215-0366(19)30088-4

Prediction of drug response and adverse drug reactions: From twin studies to Next Generation Sequencing

Author(s): Volker M. Lauschke, Magnus Ingelman-Sundberg
Published in: European Journal of Pharmaceutical Sciences, 130, 2019, Page(s) 65-77, ISSN 0928-0987
Publisher: Elsevier BV
DOI: 10.1016/j.ejps.2019.01.024

Generating evidence for precision medicine: considerations made by the Ubiquitous Pharmacogenomics Consortium when designing and operationalizing the PREPARE study

Author(s): Cathelijne H. van der Wouden, Stefan Böhringer, Erika Cecchin, Ka-Chun Cheung, Cristina Lucía Dávila-Fajardo, Vera H.M. Deneer, Vita Dolžan, Magnus Ingelman-Sundberg, Siv Jönsson, Mats O. Karlsson, Marjolein Kriek, Christina Mitropoulou, George P. Patrinos, Munir Pirmohamed, Emmanuelle Rial-Sebbag, Matthias Samwald, Matthias Schwab, Daniela Steinberger, Julia Stingl, Gere Sunder-Plassmann, Gi
Published in: Pharmacogenetics and Genomics, 30/6, 2020, Page(s) 131-144, ISSN 1744-6872
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/fpc.0000000000000405

Evaluation of the CYP2D6 Haplotype Activity Scores Based on Metabolic Ratios of 4,700 Patients Treated With Three Different CYP2D6 Substrates.

Author(s): Jukić MM, Smith RL, Molden E, Ingelman-Sundberg M.
Published in: Clinical pharmacology and therapeutics, 2021, ISSN 0009-9236
Publisher: Nature Publishing Group
DOI: 10.1002/cpt.2246

Germline variant burden in multidrug resistance transporters is a therapy‐specific predictor of survival in breast cancer patients

Author(s): Qingyang Xiao, Yitian Zhou, Stefan Winter, Florian Büttner, Elke Schaeffeler, Matthias Schwab, Volker M. Lauschke
Published in: International Journal of Cancer, 146/9, 2019, Page(s) 2475-2487, ISSN 0020-7136
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/ijc.32898

Pharmacogenomics in the UK National Health Service: opportunities and challenges.

Author(s): Turner RM, Newman WG, Bramon E, McNamee CJ, Wong WL, Misbah S, Hill S, Caulfield M, Pirmohamed M.
Published in: Pharmacogenomics, 2020, ISSN 1462-2416
Publisher: Ashley Publications Ltd.
DOI: 10.2217/pgs-2020-0091

The genetic landscape of the human solute carrier (SLC) transporter superfamily

Author(s): Lena Schaller, Volker M. Lauschke
Published in: Human Genetics, 138/11-12, 2019, Page(s) 1359-1377, ISSN 0340-6717
Publisher: Springer Verlag
DOI: 10.1007/s00439-019-02081-x

Pharmacogenomics of Antidepressant and Antipsychotic Treatment: How Far Have We Got and Where Are We Going?

Author(s): Roos van Westrhenen, Katherine J. Aitchison, Magnus Ingelman-Sundberg, Marin M. Jukić
Published in: Frontiers in Psychiatry, 11, 2020, ISSN 1664-0640
Publisher: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2020.00094

Frequencies of clinically important CYP2C19 and CYP2D6 alleles are graded across Europe

Author(s): Jelena Petrović, Vesna Pešić, Volker M. Lauschke
Published in: European Journal of Human Genetics, 28/1, 2020, Page(s) 88-94, ISSN 1018-4813
Publisher: Natue Publishing Group
DOI: 10.1038/s41431-019-0480-8

Pharmacogenomics for Primary Care: An Overview.

Author(s): Rollinson V, Turner R, Pirmohamed M.
Published in: Genes, 2020, ISSN 2073-4425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes11111337

Clinical Trial: CYP2D6 Related Dose Escalation of Tamoxifen in Breast Cancer Patients With Iranian Ethnic Background Resulted in Increased Concentrations of Tamoxifen and Its Metabolites

Author(s): Zahra Khalaj, Zohreh Baratieh, Parvaneh Nikpour, Matthias Schwab, Elke Schaeffeler, Fariborz Mokarian, Hossein Khanahmad, Rasoul Salehi, Thomas E. Mürdter, Mansoor Salehi
Published in: Frontiers in Pharmacology, 10, 2019, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2019.00530

[How to manage polypharmacia?].

Author(s): Jäger S, Schricker S, Tremmel R, Schaeffeler E, Schwab M.
Published in: Deutsche medizinische Wochenschrift (1946), 2021, ISSN 0012-0472
Publisher: Georg Thieme Verlag
DOI: 10.1055/a-1109-0814

Integrating Next-Generation Sequencing in the Clinical Pharmacogenomics Workflow

Author(s): Efstathia Giannopoulou, Theodora Katsila, Christina Mitropoulou, Evangelia-Eirini Tsermpini, George P. Patrinos
Published in: Frontiers in Pharmacology, 10, 2019, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2019.00384

The ethnogeographic variability of genetic factors underlying G6PD deficiency

Author(s): iamoglou S, Koromina M, Hishinuma E, Yamazaki S, Tsermpini EE, Kordou Z, Fukunaga K, Chantratita W, Zhou Y, Lauschke VM, Mushiroda T, Hiratsuka M, Patrinos GP.
Published in: Pharmacological research, 2021, ISSN 1043-6618
Publisher: Academic Press
DOI: 10.1016/j.phrs.2021.105904

Identification and functional validation of novel pharmacogenomic variants using a next-generation sequencing-based approach for clinical pharmacogenomics.

Author(s): Siamoglou S, Koromina M, Hishinuma E, Yamazaki S, Tsermpini EE, Kordou Z, Fukunaga K, Chantratita W, Zhou Y, Lauschke VM, Mushiroda T, Hiratsuka M, Patrinos GP.
Published in: Pharmacological research, 2022, ISSN 1043-6618
Publisher: Academic Press
DOI: 10.1016/j.phrs.2022.106087

Pharmacist-Initiated Pre-Emptive Pharmacogenetic Panel Testing with Clinical Decision Support in Primary Care: Record of PGx Results and Real-World Impact

Author(s): Cathelijne H. van der Wouden; Paul C. D. Bank; Kübra Özokcu; Jesse J. Swen; Henk-Jan Guchelaar
Published in: Issue 6, 11, 2019, ISSN 2073-4425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes10060416

Diagnostic Test Criteria for HLA Genotyping to Prevent Drug Hypersensitivity Reactions: A Systematic Review of Actionable HLA Recommendations in CPIC and DPWG Guidelines

Author(s): Lisanne E. N. Manson, Jesse J. Swen, Henk-Jan Guchelaar
Published in: Frontiers in Pharmacology, 11, 2020, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2020.567048

Characterization of Genetic Heterogeneity in Recurrent Metastases of Renal Cell Carcinoma.

Author(s): Sauter-Meyerhoff C, Bohnert R, Mazzola P, Stühler V, Kandabarau S, Büttner FA, Winter S, Herrmann L, Rausch S, Hennenlotter J, Fend F, Scharpf M, Stenzl A, Ossowski S, Bedke J, Schwab M, Schaeffeler E.
Published in: Cancers, 2021, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13246221

A Novel CYP2C-Haplotype Associated With Ultrarapid Metabolism of Escitalopram.

Author(s): Line Skute Bråten; Tore Haslemo; Marin M. Jukic; Marin M. Jukic; Maxim Ivanov; Magnus Ingelman-Sundberg; Espen Molden; Marianne Kristiansen Kringen
Published in: Clinical Pharmacology & Therapeutics, 13, 2021, ISSN 0009-9236
Publisher: Nature Publishing Group
DOI: 10.1002/cpt.2233

Exploring public genomics data for population pharmacogenomics

Author(s): Kleanthi Lakiotaki, Alexandros Kanterakis, Evgenia Kartsaki, Theodora Katsila, George P. Patrinos, George Potamias
Published in: PLOS ONE, 12/8, 2017, Page(s) e0182138, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0182138

Whole transcriptome analysis of human erythropoietic cells during ontogenesis suggests a role of VEGFA gene as modulator of fetal hemoglobin and pharmacogenomic biomarker of treatment response to hydroxyurea in β-type hemoglobinopathy patients

Author(s): Vasiliki Chondrou, Petros Kolovos, Argyro Sgourou, Alexandra Kourakli, Alexia Pavlidaki, Vlasia Kastrinou, Anne John, Argiris Symeonidis, Bassam R. Ali, Adamantia Papachatzopoulou, Theodora Katsila, George P. Patrinos
Published in: Human Genomics, 11/1, 2017, ISSN 1479-7364
Publisher: Springer Nature
DOI: 10.1186/s40246-017-0120-8

Genetic variation in human drug-related genes

Author(s): Charlotta Pauline Irmgard Schärfe, Roman Tremmel, Matthias Schwab, Oliver Kohlbacher, Debora Susan Marks
Published in: Genome Medicine, 9/1, 2017, ISSN 1756-994X
Publisher: BioMed Central
DOI: 10.1186/s13073-017-0502-5

Genomic variants in the FTO gene are associated with sporadic amyotrophic lateral sclerosis in Greek patients

Author(s): Konstantinos Mitropoulos, Eleni Merkouri Papadima, Georgia Xiromerisiou, Angeliki Balasopoulou, Kyriaki Charalampidou, Vasiliki Galani, Krystallia-Vassiliki Zafeiri, Efthymios Dardiotis, Styliani Ralli, Georgia Deretzi, Anne John, Kyriaki Kydonopoulou, Elpida Papadopoulou, Alba di Pardo, Fulya Akcimen, Annalisa Loizedda, Valerija Dobričić, Ivana Novaković, Vladimir S. Kostić, Clint Mizzi, Broc
Published in: Human Genomics, 11/1, 2017, ISSN 1479-7364
Publisher: Springer Nature
DOI: 10.1186/s40246-017-0126-2

Incidence of Exposure of Patients in the United States to Multiple Drugs for Which Pharmacogenomic Guidelines Are Available

Author(s): Matthias Samwald, Hong Xu, Kathrin Blagec, Philip E. Empey, Daniel C. Malone, Seid Mussa Ahmed, Patrick Ryan, Sebastian Hofer, Richard D. Boyce
Published in: PLOS ONE, 11/10, 2016, Page(s) e0164972, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0164972

Novel copy-number variations in pharmacogenes contribute to interindividual differences in drug pharmacokinetics

Author(s): María Santos, Mikko Niemi, Masahiro Hiratsuka, Masaki Kumondai, Magnus Ingelman-Sundberg, Volker M Lauschke, Cristina Rodríguez-Antona
Published in: Genetics in Medicine, 20/6, 2017, Page(s) 622-629, ISSN 1098-3600
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1038/gim.2017.156

Measuring the Value of Pharmacogenomics Evidence

Author(s): GP Patrinos, C Mitropoulou
Published in: Clinical Pharmacology & Therapeutics, 102/5, 2017, Page(s) 739-741, ISSN 0009-9236
Publisher: Nature Publishing Group
DOI: 10.1002/cpt.743

Pharmacogenomic Biomarkers for Improved Drug Therapy—Recent Progress and Future Developments

Author(s): Volker M. Lauschke, Lili Milani, Magnus Ingelman-Sundberg
Published in: The AAPS Journal, 20/1, 2018, ISSN 1550-7416
Publisher: Springer New York
DOI: 10.1208/s12248-017-0161-x

Pharmacogenomics: an overview

Author(s): Rollinson V, Turner R, Pirmohamed M
Published in: Clinical Pharmacist, 2017, ISSN 2053-6178
Publisher: Royal Pharmaceutical Society
DOI: 10.1211/CP.2017.20203640

Performance Ratio Based Resource Allocation Decision-Making in Genomic Medicine

Author(s): Vasilios Fragoulakis, Christina Mitropoulou, Daphne Katelidou, Ron H. van Schaik, Nikolaos Maniadakis, George P. Patrinos
Published in: OMICS: A Journal of Integrative Biology, 21/2, 2017, Page(s) 67-73, ISSN 1536-2310
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/omi.2016.0161

Pitfalls and Opportunities for Epigenomic Analyses Focused on Disease Diagnosis, Prognosis, and Therapy

Author(s): Volker M. Lauschke, Maxim Ivanov, Magnus Ingelman-Sundberg
Published in: Trends in Pharmacological Sciences, 38/9, 2017, Page(s) 765-770, ISSN 0165-6147
Publisher: Elsevier BV
DOI: 10.1016/j.tips.2017.05.007

Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles

Author(s): Oliver Burk, Maria Kuzikov, Thales Kronenberger, Judith Jeske, Oliver Keminer, Wolfgang E. Thasler, Matthias Schwab, Carsten Wrenger, Björn Windshügel
Published in: Archives of Toxicology, 92/4, 2018, Page(s) 1435-1451, ISSN 0340-5761
Publisher: Springer Verlag
DOI: 10.1007/s00204-018-2165-4

Population pharmacogenomics: impact on public health and drug development

Author(s): George P Patrinos
Published in: Pharmacogenomics, 19/1, 2018, Page(s) 3-6, ISSN 1462-2416
Publisher: Ashley Publications Ltd.
DOI: 10.2217/pgs-2017-0166

Pharmacoepigenetics and Toxicoepigenetics: Novel Mechanistic Insights and Therapeutic Opportunities

Author(s): Volker M. Lauschke, Isabel Barragan, Magnus Ingelman-Sundberg
Published in: Annual Review of Pharmacology and Toxicology, 58/1, 2018, Page(s) 161-185, ISSN 0362-1642
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-pharmtox-010617-053021

Impact of CYP2C19 Genotype on Escitalopram Exposure and Therapeutic Failure: A Retrospective Study Based on 2,087 Patients

Author(s): Marin M. Jukić, Tore Haslemo, Espen Molden, Magnus Ingelman-Sundberg
Published in: American Journal of Psychiatry, 175/5, 2018, Page(s) 463-470, ISSN 0002-953X
Publisher: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.2017.17050550

Implementing pharmacogenomics decision support across seven European countries: The Ubiquitous Pharmacogenomics (U-PGx) project

Author(s): Kathrin Blagec, Rudolf Koopmann, Mandy Crommentuijn – van Rhenen, Inge Holsappel, Cathelijne H van der Wouden, Lidija Konta, Hong Xu, Daniela Steinberger, Enrico Just, Jesse J Swen, Henk-Jan Guchelaar, Matthias Samwald
Published in: Journal of the American Medical Informatics Association, 25/7, 2018, Page(s) 893-898, ISSN 1067-5027
Publisher: Hanley and Belfus, Inc.
DOI: 10.1093/jamia/ocy005

Systemic regulation of bilirubin homeostasis: Potential benefits of hyperbilirubinemia

Author(s): Ryoichi Fujiwara, Mathias Haag, Elke Schaeffeler, Anne T. Nies, Ulrich M. Zanger, Matthias Schwab
Published in: Hepatology, 67/4, 2018, Page(s) 1609-1619, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hep.29599

Validation of a high-performance liquid chromatography method for thiopurine S-methyltransferase activity in whole blood using 6-mercaptopurine as substrate

Author(s): Hannah Rieger, Patrik Schmidt, Elke Schaeffeler, Manabu Abe, Mira Schiffhauer, Matthias Schwab, Nicolas von Ahsen, Gabriela Zurek, Hartmut Kirchherr, Maria Shipkova, Eberhard Wieland
Published in: Clinical Chemistry and Laboratory Medicine (CCLM), 56/5, 2018, Page(s) 803-809, ISSN 1434-6621
Publisher: Walter de Gruyter GmbH & Co. KG
DOI: 10.1515/cclm-2017-0670

Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points—Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC)

Author(s): Thomas O. Bergmeijer, Jean-Luc Reny, Ruth E. Pakyz, Li Gong, Joshua P. Lewis, Eun-Young Kim, Daniel Aradi, Israel Fernandez-Cadenas, Richard B. Horenstein, Ming Ta Michael Lee, Ryan M. Whaley, Joan Montaner, Gian Franco Gensini, John H. Cleator, Kiyuk Chang, Lene Holmvang, Willibald Hochholzer, Dan M. Roden, Stefan Winter, Russ B. Altman, Dimitrios Alexopoulos, Ho-Sook Kim, Jean-Pierre Déry, Mein
Published in: American Heart Journal, 198, 2018, Page(s) 152-159, ISSN 0002-8703
Publisher: Mosby Inc.
DOI: 10.1016/j.ahj.2017.12.010

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and Tamoxifen Therapy

Author(s): Matthew P. Goetz, Katrin Sangkuhl, Henk-Jan Guchelaar, Matthias Schwab, Michael Province, Michelle Whirl-Carrillo, W. Fraser Symmans, Howard L. McLeod, Mark J. Ratain, Hitoshi Zembutsu, Andrea Gaedigk, Ron H. van Schaik, James N. Ingle, Kelly E. Caudle, Teri E. Klein
Published in: Clinical Pharmacology & Therapeutics, 103/5, 2018, Page(s) 770-777, ISSN 0009-9236
Publisher: Nature Publishing Group
DOI: 10.1002/cpt.1007

How to Consider Rare Genetic Variants in Personalized Drug Therapy

Author(s): Volker M. Lauschke, Magnus Ingelman-Sundberg
Published in: Clinical Pharmacology & Therapeutics, 103/5, 2018, Page(s) 745-748, ISSN 0009-9236
Publisher: Nature Publishing Group
DOI: 10.1002/cpt.976

Improving decision making on DPYD and UGT1A1*28 patients’ profiling with an innovative reimbursement strategy

Author(s): Rossana Roncato, Erika Cecchin, Giuseppe Toffoli
Published in: Pharmacogenomics, 19/4, 2018, Page(s) 301-304, ISSN 1462-2416
Publisher: Ashley Publications Ltd.
DOI: 10.2217/pgs-2017-0303

Drinking Ethanol Has Few Acute Effects on CYP2C9, CYP2C19, NAT2, and P-Glycoprotein Activities but Somewhat Inhibits CYP1A2, CYP2D6, and Intestinal CYP3A: So What?

Author(s): Malaz Gazzaz, Martina Kinzig, Elke Schaeffeler, Martin Jübner, Chih-hsuan Hsin, Xia Li, Max Taubert, Christina Trueck, Juliane Iltgen-Breburda, Daria Kraus, Christian Queckenberg, Marc Stoffel, Matthias Schwab, Fritz Sörgel, Uwe Fuhr
Published in: Clinical Pharmacology & Therapeutics, 104/6, 2018, Page(s) 1249-1259, ISSN 0009-9236
Publisher: Nature Publishing Group
DOI: 10.1002/cpt.1083

Host genetic profiling to increase drug safety in colorectal cancer from discovery to implementation

Author(s): Erika Cecchin, Elena De Mattia, Fabrizio Ecca, Giuseppe Toffoli
Published in: Drug Resistance Updates, 39, 2018, Page(s) 18-40, ISSN 1368-7646
Publisher: Churchill Livingstone
DOI: 10.1016/j.drup.2018.07.001

From hype to reality: data science enabling personalized medicine

Author(s): Holger Fröhlich, Rudi Balling, Niko Beerenwinkel, Oliver Kohlbacher, Santosh Kumar, Thomas Lengauer, Marloes H. Maathuis, Yves Moreau, Susan A. Murphy, Teresa M. Przytycka, Michael Rebhan, Hannes Röst, Andreas Schuppert, Matthias Schwab, Rainer Spang, Daniel Stekhoven, Jimeng Sun, Andreas Weber, Daniel Ziemek, Blaz Zupan
Published in: BMC Medicine, 16/1, 2018, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-018-1122-7

Personalized laboratory medicine: a patient-centered future approach

Author(s): Irena Prodan Žitnik, Darko Černe, Irene Mancini, Lisa Simi, Mario Pazzagli, Chiara Di Resta, Helena Podgornik, Barbka Repič Lampret, Katarina Trebušak Podkrajšek, Csilla Sipeky, Ron van Schaik, Ivan Brandslund, Pieter Vermeersch, Matthias Schwab, Janja Marc
Published in: Clinical Chemistry and Laboratory Medicine (CCLM), 56/12, 2018, Page(s) 1981-1991, ISSN 1434-6621
Publisher: Walter de Gruyter GmbH & Co. KG
DOI: 10.1515/cclm-2018-0181

Genetic Variations Associated with Sleep Disorders in Patients with Schizophrenia: A Systematic Review

Author(s): Konstantinos Assimakopoulos, Katerina Karaivazoglou, Maria Skokou, Marina Kalogeropoulou, Panagiotis Kolios, Philippos Gourzis, George Patrinos, Evangelia Tsermpini
Published in: Medicines, 5/2, 2018, Page(s) 27, ISSN 2305-6320
Publisher: MDPI
DOI: 10.3390/medicines5020027

Global genetic diversity of human apolipoproteins and effects on cardiovascular disease risk

Author(s): Yitian Zhou, Reedik Mägi, Lili Milani, Volker M. Lauschke
Published in: Journal of Lipid Research, 59/10, 2018, Page(s) 1987-2000, ISSN 0022-2275
Publisher: Lipid Research, Inc.
DOI: 10.1194/jlr.p086710

The New Age of -omics in Urothelial Cancer – Re-wording Its Diagnosis and Treatment

Author(s): Theodora Katsila, Michalis Liontos, George P. Patrinos, Aristotelis Bamias, Dimitrios Kardamakis
Published in: EBioMedicine, 28, 2018, Page(s) 43-50, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2018.01.044

Comprehensive overview of the pharmacogenetic diversity in Ashkenazi Jews

Author(s): Yitian Zhou, Volker M Lauschke
Published in: Journal of Medical Genetics, 55/9, 2018, Page(s) 617-627, ISSN 0022-2593
Publisher: British Medical Association
DOI: 10.1136/jmedgenet-2018-105429

Pharmacogene Variation Consortium Gene Introduction: NUDT15

Author(s): Jun J. Yang, Michelle Whirl-Carrillo, Stuart A. Scott, Amy J. Turner, Matthias Schwab, Yoichi Tanaka, Guilherme Suarez-Kurtz, Elke Schaeffeler, Teri E. Klein, Neil A. Miller, Andrea Gaedigk
Published in: Clinical Pharmacology & Therapeutics, 2018, ISSN 0009-9236
Publisher: Nature Publishing Group
DOI: 10.1002/cpt.1268

Integrating rare genetic variants into pharmacogenetic drug response predictions

Author(s): Magnus Ingelman-Sundberg, Souren Mkrtchian, Yitian Zhou, Volker M. Lauschke
Published in: Human Genomics, 12/1, 2018, ISSN 1479-7364
Publisher: BMC
DOI: 10.1186/s40246-018-0157-3

Clinical and Functional Relevance of the Monocarboxylate Transporter Family in Disease Pathophysiology and Drug Therapy

Author(s): Pascale Fisel, Elke Schaeffeler, Matthias Schwab
Published in: Clinical and Translational Science, 11/4, 2018, Page(s) 352-364, ISSN 1752-8054
Publisher: Wiley-Blackwell
DOI: 10.1111/cts.12551

Searching for Clinically Relevant Biomarkers in Geriatric Oncology

Author(s): Theodora Katsila, George P. Patrinos, Dimitrios Kardamakis
Published in: BioMed Research International, 2018, 2018, Page(s) 1-7, ISSN 2314-6133
Publisher: Hindawi Publishing Corporation
DOI: 10.1155/2018/3793154

Functional characterization of CYP2D7 gene variants

Author(s): Marin M Jukic, Volker M Lauschke, Takahiro Saito, Masahiro Hiratsuka, Magnus Ingelman-Sundberg
Published in: Pharmacogenomics, 19/12, 2018, Page(s) 931-936, ISSN 1462-2416
Publisher: Ashley Publications Ltd.
DOI: 10.2217/pgs-2018-0065

Impact of NUDT15 genetics on severe thiopurine-related hematotoxicity in patients with European ancestry

Author(s): Elke Schaeffeler, Simon U. Jaeger, Verena Klumpp, Jun J. Yang, Svitlana Igel, Laura Hinze, Martin Stanulla, Matthias Schwab
Published in: Genetics in Medicine, 2019, ISSN 1098-3600
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1038/s41436-019-0448-7

A Clinical-Genetic Score to Identify Surgically Resected Colorectal Cancer Patients Benefiting From an Adjuvant Fluoropyrimidine-Based Therapy

Author(s): Elena De Mattia, Eva Dreussi, Marcella Montico, Sara Gagno, Chiara Zanusso, Luca Quartuccio, Salvatore De Vita, Michela Guardascione, Angela Buonadonna, Mario D’Andrea, Nicoletta Pella, Adolfo Favaretto, Enrico Mini, Stefania Nobili, Loredana Romanato, Erika Cecchin, Giuseppe Toffoli
Published in: Frontiers in Pharmacology, 9, 2018, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2018.01101

Population Pharmacokinetics of Mefloquine Intermittent Preventive Treatment for Malaria in Pregnancy in Gabon

Author(s): Michael Ramharter, Matthias Schwab, Ghyslain Mombo-Ngoma, Rella Zoleko Manego, Daisy Akerey-Diop, Arti Basra, Jean-Rodolphe Mackanga, Heike Würbel, Jan-Georg Wojtyniak, Raquel Gonzalez, Ute Hofmann, Mirjam Geditz, Pierre-Blaise Matsiegui, Peter G. Kremsner, Clara Menendez, Reinhold Kerb, Thorsten Lehr
Published in: Antimicrobial Agents and Chemotherapy, 63/2, 2019, Page(s) e01113-18, ISSN 0066-4804
Publisher: American Society for Microbiology
DOI: 10.1128/aac.01113-18

The Genotype for DPYD Risk Variants in Patients With Colorectal Cancer and the Related Toxicity Management Costs in Clinical Practice

Author(s): Giuseppe Toffoli, Federico Innocenti, Jerry Polesel, Elena De Mattia, Franca Sartor, Chiara Dalle Fratte, Fabrizio Ecca, Eva Dreussi, Elisa Palazzari, Michela Guardascione, Angela Buonadonna, Luisa Foltran, Marica Garziera, Alessia Bignucolo, Stefania Nobili, Enrico Mini, Adolfo Favaretto, Massimiliano Berretta, Mario D'Andrea, Antonino De Paoli, Rossana Roncato, Erika Cecchin
Published in: Clinical Pharmacology & Therapeutics, 2018, ISSN 0009-9236
Publisher: Nature Publishing Group
DOI: 10.1002/cpt.1257

Significantly lower CYP2D6 metabolism measured as the O/N -desmethylvenlafaxine metabolic ratio in carriers of CYP2D6*41 versus CYP2D6*9 or CYP2D6*10 : a study on therapeutic drug monitoring data from 1003 genotyped Scandinavian patients

Author(s): Tore Haslemo, Erik Eliasson, Marin M. Jukić, Magnus Ingelman-Sundberg, Espen Molden
Published in: British Journal of Clinical Pharmacology, 85/1, 2019, Page(s) 194-201, ISSN 0306-5251
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/bcp.13788

Computational Methods for the Pharmacogenetic Interpretation of Next Generation Sequencing Data

Author(s): Yitian Zhou, Kohei Fujikura, Souren Mkrtchian, Volker M. Lauschke
Published in: Frontiers in Pharmacology, 9, 2018, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2018.01437

Genetic variability and population diversity of the human SLCO (OATP) transporter family

Author(s): Boyao Zhang, Volker M. Lauschke
Published in: Pharmacological Research, 139, 2019, Page(s) 550-559, ISSN 1043-6618
Publisher: Academic Press
DOI: 10.1016/j.phrs.2018.10.017

Fast and scalable neural embedding models for biomedical sentence classification

Author(s): Asan Agibetov, Kathrin Blagec, Hong Xu, Matthias Samwald
Published in: BMC Bioinformatics, 19/1, 2018, ISSN 1471-2105
Publisher: BioMed Central
DOI: 10.1186/s12859-018-2496-4

An optimized prediction framework to assess the functional impact of pharmacogenetic variants

Author(s): Yitian Zhou, Souren Mkrtchian, Masaki Kumondai, Masahiro Hiratsuka, Volker M. Lauschke
Published in: The Pharmacogenomics Journal, 2018, ISSN 1470-269X
Publisher: Nature Publishing Group
DOI: 10.1038/s41397-018-0044-2

A brighter future for the implementation of pharmacogenomic testing

Author(s): Cathelijne H van der Wouden, Jesse J Swen, Matthias Samwald, Christina Mitropoulou, Matthias Schwab, Henk-Jan Guchelaar
Published in: European Journal of Human Genetics, 24/12, 2016, Page(s) 1658-1660, ISSN 1018-4813
Publisher: Natue Publishing Group
DOI: 10.1038/ejhg.2016.116

Pharmacometabolomics Informs Viromics toward Precision Medicine

Author(s): Angeliki Balasopoulou, George P. Patrinos, Theodora Katsila
Published in: Frontiers in Pharmacology, 7, 2016, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2016.00411

The Importance of Patient-Specific Factors for Hepatic Drug Response and Toxicity

Author(s): Volker Lauschke, Magnus Ingelman-Sundberg
Published in: International Journal of Molecular Sciences, 17/10, 2016, Page(s) 1714, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms17101714

Pharmacogenomics education and research at the Department of Pharmacy, University of Patras, Greece

Author(s): George P Patrinos, Theodora Katsila
Published in: Pharmacogenomics, 17/17, 2016, Page(s) 1865-1872, ISSN 1462-2416
Publisher: Ashley Publications Ltd.
DOI: 10.2217/pgs-2016-0142

Implementing Pharmacogenomics in Europe: Design and Implementation Strategy of the Ubiquitous Pharmacogenomics Consortium.

Author(s): van der Wouden CH, Cambon-Thomsen A, Cecchin E, Cheung KC, Dávila-Fajardo CL, Deneer VH, Dolžan V, Ingelman-Sundberg M, Jönsson S, Karlsson MO, Kriek M, Mitropoulou C, Patrinos GP, Pirmohamed M, Samwald M, Schaeffeler E, Schwab M, Steinberger D, Stingl J, Sunder-Plassmann G, Toffoli G, Turner RM, van Rhenen MH, Swen JJ, Guchelaar HJ; Ubiquitous Pharmacogenomics Consortium.
Published in: Clin Pharmacol Ther., 2017, ISSN 1532-6535
Publisher: Wiley
DOI: 10.1002/cpt.602

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 Genotype and Use of Ondansetron and Tropisetron.

Author(s): Bell GC, Caudle KE, Whirl-Carrillo M, Gordon RJ, Hikino K, Prows CA, Gaedigk A, Agundez JA, Sadhasivam S, Klein TE, Schwab M.
Published in: Clin Pharmacol Ther., 2016, ISSN 1532-6535
Publisher: Wiley
DOI: 10.1002/cpt.598

Impact of Membrane Drug Transporters on Resistance to Small-Molecule Tyrosine Kinase Inhibitors.

Author(s): Neul C, Schaeffeler E, Sparreboom A, Laufer S, Schwab M, Nies AT.
Published in: Trends Pharmacol Sci., 2016, ISSN 0165-6147
Publisher: Elsevier BV
DOI: 10.1016/j.tips.2016.08.003

Structure and function of multidrug and toxin extrusion proteins (MATEs) and their relevance to drug therapy and personalized medicine.

Author(s): Nies AT, Damme K, Kruck S, Schaeffeler E, Schwab M.
Published in: Arch Toxicol., 2016, ISSN 0340-5761
Publisher: Springer Verlag
DOI: 10.1007/s00204-016-1728-5

DNA Methylation of ADME Genes.

Author(s): Fisel P, Schaeffeler E, Schwab M.
Published in: Clin Pharmacol Ther., 2016, ISSN 1532-6535
Publisher: Wiley
DOI: 10.1002/cpt.343

The importance of drug transporter characterization to precision medicine.

Author(s): Fisel P, Nies AT, Schaeffeler E, Schwab M.
Published in: Expert Opin Drug Metab Toxicol., 2017, ISSN 1742-5255
Publisher: Ashley Publications Ltd.
DOI: 10.1080/17425255.2017.1290083

Polymorphic Variation in TPMT Is the Principal Determinant of TPMT Phenotype: A Meta-Analysis of Three Genome-Wide Association Studies

Author(s): R Tamm, R Mägi, R Tremmel, S Winter, E Mihailov, A Smid, A Möricke, K Klein, M Schrappe, M Stanulla, R Houlston, R Weinshilboum, Irena Mlinarič Raščan, A Metspalu, L Milani, M Schwab, E Schaeffeler
Published in: Clinical Pharmacology & Therapeutics, 101/5, 2017, Page(s) 684-695, ISSN 0009-9236
Publisher: Nature Publishing Group
DOI: 10.1002/cpt.540

Ubiquitous Pharmacogenomics (U-PGx): The time for implementation is now. An Horizon2020 program to drive pharmacogenomics into clinical practice.

Author(s): Cecchin E, Roncato R, Guchelaar HJ, Toffoli G, and for the Ubiquitous Pharmacogenomics Consortium.
Published in: Curr Pharm Biotechnol., 18 (3); 2017, 2017, Page(s) 204-209, ISSN 1389-2010
Publisher: Bentham Science Publishers
DOI: 10.2174/1389201018666170103103619

Translational learning from clinical studies predicts drug pharmacokinetics across patient populations

Author(s): Markus Krauss, Ute Hofmann, Clemens Schafmayer, Svitlana Igel, Jan Schlender, Christian Mueller, Mario Brosch, Witigo von Schoenfels, Wiebke Erhart, Andreas Schuppert, Michael Block, Elke Schaeffeler, Gabriele Boehmer, Linus Goerlitz, Jan Hoecker, Joerg Lippert, Reinhold Kerb, Jochen Hampe, Lars Kuepfer, Matthias Schwab
Published in: npj Systems Biology and Applications, 3/1, 2017, ISSN 2056-7189
Publisher: Nature Partner Journals
DOI: 10.1038/s41540-017-0012-5

Worldwide Distribution of Cytochrome P450 Alleles: A Meta-analysis of Population-scale Sequencing Projects

Author(s): Y Zhou, M Ingelman-Sundberg, VM Lauschke
Published in: Clinical Pharmacology & Therapeutics, 2017, ISSN 0009-9236
Publisher: Nature Publishing Group
DOI: 10.1002/cpt.690

Methyleugenol DNA adducts in human liver are associated with SULT1A1 copy number variations and expression levels

Author(s): Roman Tremmel, Kristin Herrmann, Wolfram Engst, Walter Meinl, Kathrin Klein, Hansruedi Glatt, Ulrich M. Zanger
Published in: Archives of Toxicology, 2017, ISSN 0340-5761
Publisher: Springer Verlag
DOI: 10.1007/s00204-017-1955-4

Medical education in pharmacogenomics—results from a survey on pharmacogenetic knowledge in healthcare professionals within the European pharmacogenomics clinical implementation project Ubiquitous Pharmacogenomics (U-PGx)

Author(s): Katja Susanne Just, Michael Steffens, Jesse Joachim Swen, George P. Patrinos, Henk-Jan Guchelaar, Julia Carolin Stingl
Published in: European Journal of Clinical Pharmacology, 2017, ISSN 0031-6970
Publisher: Springer Verlag
DOI: 10.1007/s00228-017-2292-5

The Ubiquitous Pharmacogenomics consortium: making effective treatment optimization accessible to every European citizen

Author(s): Lisanne EN Manson, Cathelijne H van der Wouden, Jesse J Swen, Henk-Jan Guchelaar
Published in: Pharmacogenomics, 18/11, 2017, Page(s) 1041-1045, ISSN 1462-2416
Publisher: Ashley Publications Ltd.
DOI: 10.2217/pgs-2017-0093

Expanded national database collection and data coverage in the FINDbase worldwide database for clinically relevant genomic variation allele frequencies

Author(s): Emmanouil Viennas, Angeliki Komianou, Clint Mizzi, Maja Stojiljkovic, Christina Mitropoulou, Juha Muilu, Mauno Vihinen, Panagiota Grypioti, Styliani Papadaki, Cristiana Pavlidis, Branka Zukic, Theodora Katsila, Peter J. van der Spek, Sonja Pavlovic, Giannis Tzimas, George P. Patrinos
Published in: Nucleic Acids Research, 45/D1, 2017, Page(s) D846-D853, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkw949

Exosomes: A Cancer Theranostics Road Map

Author(s): Angeliki Panagiotara, Athina Markou, Evi S. Lianidou, George P. Patrinos, Theodora Katsila
Published in: Public Health Genomics, 2017, ISSN 1662-4246
Publisher: S. Karger AG
DOI: 10.1159/000478253

Application of the DruGeVar Database in Cancer Genomics and Pharmacogenomics

Author(s): Konstantinos Sarris, Angeliki Komianou, George P. Patrinos, Theodora Katsila
Published in: Public Health Genomics, 2017, ISSN 1662-4246
Publisher: S. Karger AG
DOI: 10.1159/000478254

Pharmacometabolomics Informs Quantitative Radiomics for Glioblastoma Diagnostic Innovation

Author(s): Theodora Katsila, Minos-Timotheos Matsoukas, George P. Patrinos, Dimitrios Kardamakis
Published in: OMICS: A Journal of Integrative Biology, 21/8, 2017, Page(s) 429-439, ISSN 1536-2310
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/OMI.2017.0087

A Review of the Important Role of CYP2D6 in Pharmacogenomics.

Author(s): Taylor C, Crosby I, Yip V, Maguire P, Pirmohamed M, Turner RM.
Published in: Genes, 2020, ISSN 2073-4425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes11111295

Repurposing of Diagnostic Whole Exome Sequencing Data of 1,583 Individuals for Clinical Pharmacogenetics

Author(s): Maaike Lee, William G. Allard, Sander Bollen, Gijs W. E. Santen, Claudia A. L. Ruivenkamp, Mariëtte J. V. Hoffer, Marjolein Kriek, Henk‐Jan Guchelaar, Seyed Y. Anvar, Jesse J. Swen
Published in: Clinical Pharmacology & Therapeutics, 107/3, 2020, Page(s) 617-627, ISSN 0009-9236
Publisher: Nature Publishing Group
DOI: 10.1002/cpt.1665

Data-driven personalization of a physiologically based pharmacokinetic model for caffeine: A systematic assessment.

Author(s): Fendt R, Hofmann U, Schneider ARP, Schaeffeler E, Burghaus R, Yilmaz A, Blank LM, Kerb R, Lippert J, Schlender JF, Schwab M, Kuepfer L.
Published in: CPT: pharmacometrics & systems pharmacology, 2021, ISSN 2163-8306
Publisher: Nature Publishing Group
DOI: 10.1002/psp4.12646

Educating healthcare providers in the delivery of genomic medicine

Author(s): Jeanette McCarthy, George P Patrinos
Published in: Personalized Medicine, 16/3, 2019, Page(s) 187-188, ISSN 1741-0541
Publisher: Future Medicine Ltd.
DOI: 10.2217/pme-2019-0025

Association of CYP2C19 and CYP2D6 Poor and Intermediate Metabolizer Status With Antidepressant and Antipsychotic Exposure: A Systematic Review and Meta-analysis.

Author(s): Milosavljevic F, Bukvic N, Pavlovic Z, Miljevic C, Pešic V, Molden E, Ingelman-Sundberg M, Leucht S, Jukic MM.
Published in: JAMA psychiatry, 2021, ISSN 2168-622X
Publisher: American Medical Association
DOI: 10.1001/jamapsychiatry.2020.3643

Individualized versus Standardized Risk Assessment in Patients at High Risk for Adverse Drug Reactions (The IDrug Randomized Controlled Trial)-Never Change a Running System?

Author(s): Just KS, Scholl C, Boehme M, Kastenmüller K, Just JM, Bleckwenn M, Holdenrieder S, Meier F, Weckbecker K, Stingl JC.
Published in: Pharmaceuticals (Basel, Switzerland), 2021, ISSN 1424-8247
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph14101056

OpenBioLink: a benchmarking framework for large-scale biomedical link prediction

Author(s): Anna Breit, Simon Ott, Asan Agibetov, Matthias Samwald
Published in: Bioinformatics, 36/13, 2020, Page(s) 4097-4098, ISSN 1367-4803
Publisher: Oxford University Press
DOI: 10.1093/bioinformatics/btaa274

CYP3A5 is unlikely to mediate anticancer drug resistance in hepatocellular carcinoma

Author(s): Volker M Lauschke, Åsa Nordling, Yitian Zhou, Sara Fontalva, Isabel Barragan, Magnus Ingelman-Sundberg
Published in: Pharmacogenomics, 20/15, 2019, Page(s) 1085-1092, ISSN 1462-2416
Publisher: Ashley Publications Ltd.
DOI: 10.2217/pgs-2019-0094

Physiologically Based Pharmacokinetic Models for Prediction of Complex CYP2C8 and OATP1B1 (SLCO1B1) Drug–Drug–Gene Interactions: A Modeling Network of Gemfibrozil, Repaglinide, Pioglitazone, Rifampicin, Clarithromycin and Itraconazole

Author(s): Denise Türk, Nina Hanke, Sarah Wolf, Sebastian Frechen, Thomas Eissing, Thomas Wendl, Matthias Schwab, Thorsten Lehr
Published in: Clinical Pharmacokinetics, 58/12, 2019, Page(s) 1595-1607, ISSN 0312-5963
Publisher: Adis International Ltd.
DOI: 10.1007/s40262-019-00777-x

Germline and Somatic Pharmacogenomics to Refine Rectal Cancer Patients Selection for Neo-Adjuvant Chemoradiotherapy

Author(s): Elena De Mattia, Rossana Roncato, Elisa Palazzari, Giuseppe Toffoli, Erika Cecchin
Published in: Frontiers in Pharmacology, 11, 2020, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2020.00897

Physiologically‐Based Pharmacokinetic Models for CYP 1A2 Drug–Drug Interaction Prediction: A Modeling Network of Fluvoxamine, Theophylline, Caffeine, Rifampicin, and Midazolam

Author(s): Hannah Britz, Nina Hanke, Anke‐Katrin Volz, Olav Spigset, Matthias Schwab, Thomas Eissing, Thomas Wendl, Sebastian Frechen, Thorsten Lehr
Published in: CPT: Pharmacometrics & Systems Pharmacology, 8/5, 2019, Page(s) 296-307, ISSN 2163-8306
Publisher: Nature Publishing Group
DOI: 10.1002/psp4.12397

Copy number variation profiling in pharmacogenes using panel-based exome resequencing and correlation to human liver expression

Author(s): Roman Tremmel, Kathrin Klein, Florian Battke, Sarah Fehr, Stefan Winter, Tim Scheurenbrand, Elke Schaeffeler, Saskia Biskup, Matthias Schwab, Ulrich M. Zanger
Published in: Human Genetics, 139/2, 2020, Page(s) 137-149, ISSN 0340-6717
Publisher: Springer Verlag
DOI: 10.1007/s00439-019-02093-7

Neural sentence embedding models for semantic similarity estimation in the biomedical domain

Author(s): Kathrin Blagec, Hong Xu, Asan Agibetov, Matthias Samwald
Published in: BMC Bioinformatics, 20/1, 2019, ISSN 1471-2105
Publisher: BioMed Central
DOI: 10.1186/s12859-019-2789-2

Pharmacogenetics in Psychiatry: An Update on Clinical Usability

Author(s): Ron H. N. van Schaik, Daniel J. Müller, Alessandro Serretti, Magnus Ingelman-Sundberg
Published in: Frontiers in Pharmacology, 11, 2020, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2020.575540

Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene–drug interaction of DPYD and fluoropyrimidines

Author(s): Carin A. T. C. Lunenburg, Cathelijne H. van der Wouden, Marga Nijenhuis, Mandy H. Crommentuijn-van Rhenen, Nienke J. de Boer-Veger, Anne Marie Buunk, Elisa J. F. Houwink, Hans Mulder, Gerard A. Rongen, Ron H. N. van Schaik, Jan van der Weide, Bob Wilffert, Vera H. M. Deneer, Jesse J. Swen, Henk-Jan Guchelaar
Published in: European Journal of Human Genetics, 28/4, 2020, Page(s) 508-517, ISSN 1018-4813
Publisher: Natue Publishing Group
DOI: 10.1038/s41431-019-0540-0

Educating the Next Generation of Pharmacogenomics Experts: Global Educational Needs and Concepts

Author(s): Katja S. Just; Richard M. Turner; Vita Dolžan; Erika Cecchin; Jesse J. Swen; David Gurwitz; Julia C. Stingl
Published in: Clinical Pharmacology and Therapeutics, 4, 2019, ISSN 0009-9236
Publisher: Nature Publishing Group
DOI: 10.1002/cpt.1471

Assessing the Implementation of Pharmacogenomic Panel-Testing in Primary Care in the Netherlands Utilizing a Theoretical Framework.

Author(s): van der Wouden CH, Paasman E, Teichert M, Crone MR, Guchelaar HJ, Swen JJ.
Published in: Journal of clinical medicine, 2020, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm9030814

A New Panel-Based Next-Generation Sequencing Method for ADME Genes Reveals Novel Associations of Common and Rare Variants With Expression in a Human Liver Cohort

Author(s): Kathrin Klein, Roman Tremmel, Stefan Winter, Sarah Fehr, Florian Battke, Tim Scheurenbrand, Elke Schaeffeler, Saskia Biskup, Matthias Schwab, Ulrich M. Zanger
Published in: Frontiers in Genetics, 10, 2019, ISSN 1664-8021
Publisher: Frontiers Media
DOI: 10.3389/fgene.2019.00007

Pharmacometrics-Based Considerations for the Design of a Pharmacogenomic Clinical Trial Assessing Irinotecan Safety.

Author(s): Minichmayr IK, Karlsson MO, Jönsson S.
Published in: Pharmaceutical research, 2021, ISSN 0724-8741
Publisher: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11095-021-03024-w

Pharmacogenomics education in medical and pharmacy schools: conclusions of a global survey

Author(s): Nataša Karas Kuželički, Irena Prodan Žitnik, David Gurwitz, Adrian Llerena, Ingolf Cascorbi, Sofia Siest, Maurizio Simmaco, Marc Ansari, Mario Pazzagli, Chiara Di Resta, Ivan Brandslund, Matthias Schwab, Pieter Vermeersch, Jeantine E Lunshof, George Dedoussis, Christodoulos S Flordellis, Uwe Fuhr, Julia C Stingl, Ron HN van Schaik, Vangelis G Manolopoulos, Janja Marc
Published in: Pharmacogenomics, 20/9, 2019, Page(s) 643-657, ISSN 1462-2416
Publisher: Ashley Publications Ltd.
DOI: 10.2217/pgs-2019-0009

Ten years of Genome Medicine

Author(s): Charles Auffray, Julian L. Griffin, Muin J. Khoury, James R. Lupski, Matthias Schwab
Published in: Genome Medicine, 11/1, 2019, ISSN 1756-994X
Publisher: BioMed Central
DOI: 10.1186/s13073-019-0618-x

Comprehensive Evaluation of Organotypic and Microphysiological Liver Models for Prediction of Drug-Induced Liver Injury

Author(s): Yitian Zhou, Joanne X. Shen, Volker M. Lauschke
Published in: Frontiers in Pharmacology, 10, 2019, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2019.01093

Rates of complete nonadherence among atypical antipsychotic drugs: A study using blood samples from 13,217 outpatients with psychotic disorders.

Author(s): Smith RL, Tveito M, Kyllesø L, Jukic MM, Ingelman-Sundberg M, Andreassen OA, Molden E.
Published in: Schizophrenia research, 2021, ISSN 0920-9964
Publisher: Elsevier BV
DOI: 10.1016/j.schres.2020.11.025

Genotyping for HLA Risk Alleles to Prevent Drug Hypersensitivity Reactions: Impact Analysis.

Author(s): Manson LEN, van den Hout WB, Guchelaar HJ.
Published in: Pharmaceuticals (Basel, Switzerland), 2021, ISSN 1424-8247
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph15010004

Pharmacogenomics of anticancer drugs: Personalising the choice and dose to manage drug response.

Author(s): Carr DF, Turner RM, Pirmohamed M.
Published in: British journal of clinical pharmacology, 2021, ISSN 0306-5251
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/bcp.14407

Pharmacogenomic network analysis of the gene-drug interaction landscape underlying drug disposition

Author(s): Yitian Zhou, Volker M. Lauschke
Published in: Computational and Structural Biotechnology Journal, 18, 2020, Page(s) 52-58, ISSN 2001-0370
Publisher: Elsevier
DOI: 10.1016/j.csbj.2019.11.010

Technologies for Pharmacogenomics: A Review.

Author(s): van der Lee M, Kriek M, Guchelaar HJ, Swen JJ.
Published in: Genes, 2020, ISSN 2073-4425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes11121456

Physiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates

Author(s): Lukas Kovar, Christina Schräpel, Dominik Selzer, Yvonne Kohl, Robert Bals, Matthias Schwab, Thorsten Lehr
Published in: Pharmaceutics, 12/6, 2020, Page(s) 578, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12060578

Physiologically Based Precision Dosing Approach for Drug-Drug-Gene Interactions: A Simvastatin Network Analysis.

Author(s): Wojtyniak JG, Selzer D, Schwab M, Lehr T.
Published in: Clinical pharmacology and therapeutics, 2021, ISSN 0009-9236
Publisher: Nature Publishing Group
DOI: 10.1002/cpt.2111

Data Digitizing: Accurate and Precise Data Extraction for Quantitative Systems Pharmacology and Physiologically-Based Pharmacokinetic Modeling.

Author(s): Wojtyniak JG, Britz H, Selzer D, Schwab M, Lehr T.
Published in: CPT: pharmacometrics & systems pharmacology, 2020, ISSN 2163-8306
Publisher: Nature Publishing Group
DOI: 10.1002/psp4.12511

The Importance of Gene-Drug-Drug-Interactions in Pharmacogenomics Decision Support: An Analysis Based on Austrian Claims Data

Author(s): Kathrin Blagec, Wolfgang Kuch, Matthias Samwald
Published in: Studies in Health Technology and Informatics, 2017, Page(s) 121 - 127, ISSN 1879-8365
Publisher: IOS Press
DOI: 10.3233/978-1-61499-759-7-121

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