Deliverables
Therapeutic recommendations in Dutch Greek German Italian Slovene and Spanish
Report on ELSI education needsReport on design of future study employing one promising model
Overall report on ELSI aspects of U-PGx
Overall report on ELSI aspects of UPGx
Survey to evaluate the state of PGx knowledge in the 7 participating countriesReport on ethical issues, guidelines, governance model and principals for patients included in U-PGx
Report on ethical issues guidelines governance model and principals for patients included in UPGx
Establishment of PK models for prediction of DDI and genetic polymorphisms on drug exposure for candidate genes included in the U-PGx trialEstablishment of PK models for prediction of DDI and genetic polymorphisms on drug exposure for candidate genes included in the UPGx trial
Detection, assessment and evaluation of clinically relevant DDI in the U-PGx trialDetection assessment and evaluation of clinically relevant DDI in the UPGx trial
Report on detailed analysis of existing information infrastructures and requirements of implementation sitesReport on predictions from first model
Analysis of European regulatory requirements
Report on models identified to be developed
Policy recommendations on the pre-emptive use of U-PGx testing in routine clinical practice and uptake by health care systems
Policy recommendations on the preemptive use of UPGx testing in routine clinical practice and uptake by health care systems
Report on comparison of model predictions and observed data from WP4Critical re-evaluation and first implementation of revised DPWG guidelines by consideration of relevant DDI
Critical reevaluation and first implementation of revised DPWG guidelines by consideration of relevant DDI
Report on predictions from further modelsList of relevant genetic variants for pre-emptive PGx testing
List of relevant genetic variants for preemptive PGx testing
Report on the association of novel genomic variants and extreme phenotypesReport on finalization endpoint data extraction from clinical database into NONMEM dataset
Report on public events and societal activities in relation with U-PGx
Report on public events and societal activities in relation with UPGx
PGx-guidelines therapeutic recommendations and risk-assessments in EnglishPGxguidelines therapeutic recommendations and riskassessments in English
Published review paper based upon the current scientific and grey literature on ethics of PGxMidterm Review
Report on interoperability and development of a shared semantic model
Translated patient surveys for the web-based intensive monitoring system
Translated patient surveys for the webbased intensive monitoring system
Final report on decision support solutions at implementation sitesOrganization of a UPGx Personalized Medicine Day in France
Organization of the 1st patient/general public oriented PGx information eventsOrganization of the 1st patientgeneral public oriented PGx information events
Education programme for non-participantsEducation programme for nonparticipants
Organization of a U-PGx Personalized Medicine Day in GreeceOrganization of a UPGx Personalized Medicine Day in Greece
Organization of a U-PGx Personalized Medicine Day in the UKOrganization of a UPGx Personalized Medicine Day in the UK
Organization of the 3rd patient/general public-oriented PGx information eventOrganization of a UPGx Personalized Medicine Day in Germany
Organization of a major 4-day U-PGx Personalized Medicine Symposium in Leiden, NetherlandsOrganization of a major 4day UPGx Personalized Medicine Symposium in Leiden Netherlands
Summer school including ELSI topics (prepared by WP8) for medical and pharmacy studentsSummer school including ELSI topics prepared by WP8 for medical and pharmacy students
Organization of the 2nd patient/general public oriented PGx information eventsOrganization of the 2nd patientgeneral public oriented PGx information events
Organization of a U-PGx Personalized Medicine Day in SloveniaOrganization of a UPGx Personalized Medicine Day in Slovenia
Organization of a U-PGx Personalized Medicine Day in SwedenOrganization of a UPGx Personalized Medicine Day in Sweden
Organization of a U-PGx Personalized Medicine Day in SpainOrganization of a UPGx Personalized Medicine Day in Spain
Promotional video will be produced that visualises and promotes the idea of the idea of personalised medicine and pre-emptive PGx testingPromotional video will be produced that visualises and promotes the idea of the idea of personalised medicine and preemptive PGx testing
Workshop for participating healthcare professionalsOrganization of a U-PGx Personalized Medicine Day in Austria
Organization of a UPGx Personalized Medicine Day in Austria
1st version of the publicdomain webbased UPGx information portal
Delivery of decision support solutions including framework for digital infrastructure including secure cloud solutionsDedicated webpage with secured login access for investigators and study staff
3rd version of the public-domain web-based PGx information portal
3rd version of the publicdomain webbased PGx information portal
Standardized Electronic Case Record Form (eCRF)Standardized Electronic Case Record Form eCRF
A new model of cost-effectiveness analysis, taking into account the restriction of budgetA new model of costeffectiveness analysis taking into account the restriction of budget
Validated bioinformatics tool2nd version of the public-domain web-based PGx information portal
2nd version of the publicdomain webbased PGx information portal
A standard cost-effectiveness model to assess cost-effectiveness of PGx testing in each implementation siteA standard costeffectiveness model to assess costeffectiveness of PGx testing in each implementation site
Release of open-source software artefacts for decision support solutionsRelease of opensource software artefacts for decision support solutions
eLearning program for the train the trainers conceptRelease of opensource software artefacts describing semantic model
ELSI content for a summer school on PGx to be delivered by WP6set of specifications for the selected PGx assays
Publications
Author(s):
Zhou Y, Lauschke VM.
Published in:
Human genetics, 2021, ISSN 0340-6717
Publisher:
Springer Verlag
DOI:
10.1007/s00439-021-02385-x
Author(s):
Zanger UM, Momoi K, Hofmann U, Schwab M, Klein K.
Published in:
Clinical pharmacology and therapeutics, 2021, ISSN 0009-9236
Publisher:
Nature Publishing Group
DOI:
10.1002/cpt.2078
Author(s):
Abdullah-Koolmees H, van Keulen AM, Nijenhuis M, Deneer VHM.
Published in:
Frontiers in pharmacology, 2020, ISSN 1663-9812
Publisher:
Frontiers Media S.A.
DOI:
10.3389/fphar.2020.595219
Author(s):
Shefali Setia Verma, Thomas O. Bergmeijer, Li Gong, Jean‐Luc Reny, Joshua P. Lewis, Braxton D. Mitchell, Dimitrios Alexopoulos, Daniel Aradi, Russ B. Altman, Kevin Bliden, Yuki Bradford, Gianluca Campo, Kiyuk Chang, John H. Cleator, Jean‐Pierre Déry, Nadia P. Dridi, Israel Fernandez‐Cadenas, Pierre Fontana, Meinrad Gawaz, Tobias Geisler, Gian Franco Gensini, Betti Giusti, Paul A. Gurbel, Wi
Published in:
Clinical Pharmacology & Therapeutics, Issue 108/5, 2020, Page(s) 1067-1077, ISSN 0009-9236
Publisher:
Nature Publishing Group
DOI:
10.1002/cpt.1911
Author(s):
van der Lee M, Guchelaar HJ, Swen JJ.
Published in:
Pharmacogenomics, 2021, ISSN 1462-2416
Publisher:
Ashley Publications Ltd.
DOI:
10.2217/pgs-2021-0093
Author(s):
Delilah F.G. Hendriks, Sabine U. Vorrink, Tomas Smutny, Sarah C. Sim, Åsa Nordling, Shahid Ullah, Masaki Kumondai, Barry C. Jones, Inger Johansson, Tommy B. Andersson, Volker M. Lauschke, Magnus Ingelman‐Sundberg
Published in:
Clinical Pharmacology & Therapeutics, Issue 108/4, 2020, Page(s) 844-855, ISSN 0009-9236
Publisher:
Nature Publishing Group
DOI:
10.1002/cpt.1860
Author(s):
Maaike van der Lee; William G. Allard; Rolf H. A. M. Vossen; Renee Baak-Pablo; Roberta Menafra; Birgit A. L. M. Deiman; Maarten J. Deenen; Patrick Neven; Inger Johansson; Stefano Gastaldello; Magnus Ingelman-Sundberg; Henk-Jan Guchelaar; Jesse J. Swen; Seyed Yahya Anvar
Published in:
VOLUME=13;ISSUE=603;TITLE=Science Translational Medicine, Issue 6, 2021, ISSN 1946-6234
Publisher:
American Association for the Advancement of Science
DOI:
10.1126/scitranslmed.abf3637
Author(s):
Magnus Ingelman-Sundberg, Volker M. Lauschke
Published in:
Trends in Pharmacological Sciences, Issue 41/8, 2020, Page(s) 503-506, ISSN 0165-6147
Publisher:
Elsevier BV
DOI:
10.1016/j.tips.2020.05.007
Author(s):
Karamperis K, Koromina M, Papantoniou P, Skokou M, Kanellakis F, Mitropoulos K, Vozikis A, Müller DJ, Patrinos GP, Mitropoulou C.
Published in:
The pharmacogenomics journal, 2021, ISSN 1470-269X
Publisher:
Nature Publishing Group
DOI:
10.1038/s41397-021-00249-1
Author(s):
De Mattia E, Polesel J, Roncato R, Labriet A, Bignucolo A, Gagno S, Buonadonna A, D'Andrea M, Lévesque E, Jonker D, Couture F, Guillemette C, Cecchin E, Toffoli G.
Published in:
Cancers, 2021, ISSN 2072-6694
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/cancers13071705
Author(s):
Robert L Smith, Marit Tveito, Lennart Kyllesø, Marin M Jukic, Magnus Ingelman-Sundberg, Ole A Andreassen, Espen Molden
Published in:
European Neuropsychopharmacology, Issue 37, 2020, Page(s) 64-69, ISSN 0924-977X
Publisher:
Elsevier BV
DOI:
10.1016/j.euroneuro.2020.06.007
Author(s):
Matic M, Nijenhuis M, Soree B, de Boer-Veger NJ, Buunk AM, Houwink EJF, Mulder H, Rongen GAPJM, Weide JV, Wilffert B, Swen JJ, Guchelaar HJ, Deneer VHM, van Schaik RHN.
Published in:
European journal of human genetics : EJHG, 2021, ISSN 1018-4813
Publisher:
Natue Publishing Group
DOI:
10.1038/s41431-021-00920-y
Author(s):
Zhou Y, Arribas GH, Turku A, Jürgenson T, Mkrtchian S, Krebs K, Wang Y, Svobodova B, Milani L, Schulte G, Korabecny J, Gastaldello S, Lauschke VM.
Published in:
Science advances, 2021, ISSN 2375-2548
Publisher:
American Association for the Advancement of Science
DOI:
10.1126/sciadv.abi6856
Author(s):
Yitian Zhou, Kristi Krebs, Lili Milani, Volker M. Lauschke
Published in:
Clinical Pharmacology & Therapeutics, 2020, ISSN 0009-9236
Publisher:
Nature Publishing Group
DOI:
10.1002/cpt.1944
Author(s):
Lima JJ, Thomas CD, Barbarino J, Desta Z, Van Driest SL, El Rouby N, Johnson JA, Cavallari LH, Shakhnovich V, Thacker DL, Scott SA, Schwab M, Uppugunduri CRS, Formea CM, Franciosi JP, Sangkuhl K, Gaedigk A, Klein TE, Gammal RS, Furuta T.
Published in:
Clinical pharmacology and therapeutics, 2021, ISSN 0009-9236
Publisher:
Nature Publishing Group
DOI:
10.1002/cpt.2015
Author(s):
Langmia IM, Just KS, Yamoune S, Brockmöller J, Masimirembwa C, Stingl JC.
Published in:
Frontiers in genetics, 2021, ISSN 1664-8021
Publisher:
Frontiers Media
DOI:
10.3389/fgene.2021.692234
Author(s):
Brouwer JMJL, Nijenhuis M, Soree B, Guchelaar HJ, Swen JJ, van Schaik RHN, Weide JV, Rongen GAPJM, Buunk AM, de Boer-Veger NJ, Houwink EJF, van Westrhenen R, Wilffert B, Deneer VHM, Mulder H.
Published in:
European journal of human genetics : EJHG, 2021, ISSN 1018-4813
Publisher:
Natue Publishing Group
DOI:
10.1038/s41431-021-01004-7
Author(s):
Yitian Zhou, Carolina Dagli Hernandez, Volker M. Lauschke
Published in:
British Journal of Cancer, 2020, ISSN 0007-0920
Publisher:
Nature Publishing Group
DOI:
10.1038/s41416-020-01084-0
Author(s):
Katja S. Just; Harald Dormann; Mathias Freitag; Marlen Schurig; Miriam Böhme; Michael Steffens; Catharina Scholl; Thomas Seufferlein; Ingo Graeff; Matthias Schwab; Matthias Schwab; Matthias Schwab; Julia C. Stingl
Published in:
Frontiers in Pharmacology, Issue 9, 2021, ISSN 1663-9812
Publisher:
Frontiers Media S.A.
DOI:
10.3389/fphar.2021.624104
Author(s):
van der Lee M, Rowell WJ, Menafra R, Guchelaar HJ, Swen JJ, Anvar SY.
Published in:
The pharmacogenomics journal, 2022, ISSN 1470-269X
Publisher:
Nature Publishing Group
DOI:
10.1038/s41397-021-00259-z
Author(s):
Cathelijne H. van der Wouden, Stefan Böhringer, Erika Cecchin, Ka-Chun Cheung, Cristina Lucía Dávila-Fajardo, Vera H.M. Deneer, Vita Dolžan, Magnus Ingelman-Sundberg, Siv Jönsson, Mats O. Karlsson, Marjolein Kriek, Christina Mitropoulou, George P. Patrinos, Munir Pirmohamed, Emmanuelle Rial-Sebbag, Matthias Samwald, Matthias Schwab, Daniela Steinberger, Julia Stingl, Gere Sunder-Plassmann, Gi
Published in:
Pharmacogenetics and Genomics, Issue 30/6, 2020, Page(s) 131-144, ISSN 1744-6872
Publisher:
Lippincott Williams & Wilkins Ltd.
DOI:
10.1097/fpc.0000000000000405
Author(s):
Jukić MM, Smith RL, Molden E, Ingelman-Sundberg M.
Published in:
Clinical pharmacology and therapeutics, 2021, ISSN 0009-9236
Publisher:
Nature Publishing Group
DOI:
10.1002/cpt.2246
Author(s):
Turner RM, Newman WG, Bramon E, McNamee CJ, Wong WL, Misbah S, Hill S, Caulfield M, Pirmohamed M.
Published in:
Pharmacogenomics, 2020, ISSN 1462-2416
Publisher:
Ashley Publications Ltd.
DOI:
10.2217/pgs-2020-0091
Author(s):
Rollinson V, Turner R, Pirmohamed M.
Published in:
Genes, 2020, ISSN 2073-4425
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/genes11111337
Author(s):
iamoglou S, Koromina M, Hishinuma E, Yamazaki S, Tsermpini EE, Kordou Z, Fukunaga K, Chantratita W, Zhou Y, Lauschke VM, Mushiroda T, Hiratsuka M, Patrinos GP.
Published in:
Pharmacological research, 2021, ISSN 1043-6618
Publisher:
Academic Press
DOI:
10.1016/j.phrs.2021.105904
Author(s):
Lisanne E. N. Manson, Jesse J. Swen, Henk-Jan Guchelaar
Published in:
Frontiers in Pharmacology, Issue 11, 2020, ISSN 1663-9812
Publisher:
Frontiers Media S.A.
DOI:
10.3389/fphar.2020.567048
Author(s):
Sauter-Meyerhoff C, Bohnert R, Mazzola P, Stühler V, Kandabarau S, Büttner FA, Winter S, Herrmann L, Rausch S, Hennenlotter J, Fend F, Scharpf M, Stenzl A, Ossowski S, Bedke J, Schwab M, Schaeffeler E.
Published in:
Cancers, 2021, ISSN 2072-6694
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/cancers13246221
Author(s):
Line Skute Bråten; Tore Haslemo; Marin M. Jukic; Marin M. Jukic; Maxim Ivanov; Magnus Ingelman-Sundberg; Espen Molden; Marianne Kristiansen Kringen
Published in:
Clinical Pharmacology & Therapeutics, Issue 13, 2021, ISSN 0009-9236
Publisher:
Nature Publishing Group
DOI:
10.1002/cpt.2233
Author(s):
Taylor C, Crosby I, Yip V, Maguire P, Pirmohamed M, Turner RM.
Published in:
Genes, 2020, ISSN 2073-4425
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/genes11111295
Author(s):
Fendt R, Hofmann U, Schneider ARP, Schaeffeler E, Burghaus R, Yilmaz A, Blank LM, Kerb R, Lippert J, Schlender JF, Schwab M, Kuepfer L.
Published in:
CPT: pharmacometrics & systems pharmacology, 2021, ISSN 2163-8306
Publisher:
Nature Publishing Group
DOI:
10.1002/psp4.12646
Author(s):
Milosavljevic F, Bukvic N, Pavlovic Z, Miljevic C, Pešic V, Molden E, Ingelman-Sundberg M, Leucht S, Jukic MM.
Published in:
JAMA psychiatry, 2021, ISSN 2168-622X
Publisher:
American Medical Association
DOI:
10.1001/jamapsychiatry.2020.3643
Author(s):
Just KS, Scholl C, Boehme M, Kastenmüller K, Just JM, Bleckwenn M, Holdenrieder S, Meier F, Weckbecker K, Stingl JC.
Published in:
Pharmaceuticals (Basel, Switzerland), 2021, ISSN 1424-8247
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ph14101056
Author(s):
Anna Breit, Simon Ott, Asan Agibetov, Matthias Samwald
Published in:
Bioinformatics, Issue 36/13, 2020, Page(s) 4097-4098, ISSN 1367-4803
Publisher:
Oxford University Press
DOI:
10.1093/bioinformatics/btaa274
Author(s):
Minichmayr IK, Karlsson MO, Jönsson S.
Published in:
Pharmaceutical research, 2021, ISSN 0724-8741
Publisher:
Kluwer Academic/Plenum Publishers
DOI:
10.1007/s11095-021-03024-w
Author(s):
Smith RL, Tveito M, Kyllesø L, Jukic MM, Ingelman-Sundberg M, Andreassen OA, Molden E.
Published in:
Schizophrenia research, 2021, ISSN 0920-9964
Publisher:
Elsevier BV
DOI:
10.1016/j.schres.2020.11.025
Author(s):
Manson LEN, van den Hout WB, Guchelaar HJ.
Published in:
Pharmaceuticals (Basel, Switzerland), 2021, ISSN 1424-8247
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ph15010004
Author(s):
Carr DF, Turner RM, Pirmohamed M.
Published in:
British journal of clinical pharmacology, 2021, ISSN 0306-5251
Publisher:
Blackwell Publishing Inc.
DOI:
10.1111/bcp.14407
Author(s):
van der Lee M, Kriek M, Guchelaar HJ, Swen JJ.
Published in:
Genes, 2020, ISSN 2073-4425
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/genes11121456
Author(s):
Wojtyniak JG, Selzer D, Schwab M, Lehr T.
Published in:
Clinical pharmacology and therapeutics, 2021, ISSN 0009-9236
Publisher:
Nature Publishing Group
DOI:
10.1002/cpt.2111
Searching for OpenAIRE data...
There was an error trying to search data from OpenAIRE
No results available