Ubiquitous Pharmacogenomics (U-PGx): Making actionable pharmacogenomic data and effective treatment optimization accessible to every European citizen

Deliverables

Organization of a U-PGx Personalized Medicine Day in Germany

Summer school including ELSI topics (prepared by WP8) for medical and pharmacy students

Organization of the 2nd patient/general public oriented PGx information events

Organization of a U-PGx Personalized Medicine Day in Sweden

Organization of a U-PGx Personalized Medicine Day in Spain

Promotional video will be produced that visualises and promotes the idea of the idea of personalised medicine and pre-emptive PGx testing

Workshop for participating healthcare professionals

Organization of a U-PGx Personalized Medicine Day in Austria

1st version of the public-domain web-based U-PGx information portal

Delivery of decision support solutions including framework for digital infrastructure including secure cloud solutions

Dedicated webpage with secured login access for investigators and study staff

Standardized Electronic Case Record Form (eCRF)

Validated bioinformatics tool

2nd version of the public-domain web-based PGx information portal

A standard cost-effectiveness model to assess cost-effectiveness of PGx testing in each implementation site

Release of open-source software artefacts for decision support solutions

eLearning program for the train the trainers concept

updated version of DMP

first version of DMP

Release of open-source software artefacts describing semantic model

ELSI content for a summer school on PGx to be delivered by WP6

set of specifications for the selected PGx assays

Searching for OpenAIRE data...

Publications

Exploring public genomics data for population pharmacogenomics

Author(s): Kleanthi Lakiotaki, Alexandros Kanterakis, Evgenia Kartsaki, Theodora Katsila, George P. Patrinos, George Potamias
Published in: PLOS ONE, Issue 12/8, 2017, Page(s) e0182138, ISSN 1932-6203
DOI: 10.1371/journal.pone.0182138

Whole transcriptome analysis of human erythropoietic cells during ontogenesis suggests a role of VEGFA gene as modulator of fetal hemoglobin and pharmacogenomic biomarker of treatment response to hydroxyurea in β-type hemoglobinopathy patients

Author(s): Vasiliki Chondrou, Petros Kolovos, Argyro Sgourou, Alexandra Kourakli, Alexia Pavlidaki, Vlasia Kastrinou, Anne John, Argiris Symeonidis, Bassam R. Ali, Adamantia Papachatzopoulou, Theodora Katsila, George P. Patrinos
Published in: Human Genomics, Issue 11/1, 2017, ISSN 1479-7364
DOI: 10.1186/s40246-017-0120-8

Genetic variation in human drug-related genes

Author(s): Charlotta Pauline Irmgard Schärfe, Roman Tremmel, Matthias Schwab, Oliver Kohlbacher, Debora Susan Marks
Published in: Genome Medicine, Issue 9/1, 2017, ISSN 1756-994X
DOI: 10.1186/s13073-017-0502-5

Genomic variants in the FTO gene are associated with sporadic amyotrophic lateral sclerosis in Greek patients

Author(s): Konstantinos Mitropoulos, Eleni Merkouri Papadima, Georgia Xiromerisiou, Angeliki Balasopoulou, Kyriaki Charalampidou, Vasiliki Galani, Krystallia-Vassiliki Zafeiri, Efthymios Dardiotis, Styliani Ralli, Georgia Deretzi, Anne John, Kyriaki Kydonopoulou, Elpida Papadopoulou, Alba di Pardo, Fulya Akcimen, Annalisa Loizedda, Valerija Dobričić, Ivana Novaković, Vladimir S. Kostić, Clint Mizzi, Broc
Published in: Human Genomics, Issue 11/1, 2017, ISSN 1479-7364
DOI: 10.1186/s40246-017-0126-2

Incidence of Exposure of Patients in the United States to Multiple Drugs for Which Pharmacogenomic Guidelines Are Available

Author(s): Matthias Samwald, Hong Xu, Kathrin Blagec, Philip E. Empey, Daniel C. Malone, Seid Mussa Ahmed, Patrick Ryan, Sebastian Hofer, Richard D. Boyce
Published in: PLOS ONE, Issue 11/10, 2016, Page(s) e0164972, ISSN 1932-6203
DOI: 10.1371/journal.pone.0164972

Novel copy-number variations in pharmacogenes contribute to interindividual differences in drug pharmacokinetics

Author(s): María Santos, Mikko Niemi, Masahiro Hiratsuka, Masaki Kumondai, Magnus Ingelman-Sundberg, Volker M Lauschke, Cristina Rodríguez-Antona
Published in: Genetics in Medicine, Issue 20/6, 2017, Page(s) 622-629, ISSN 1098-3600
DOI: 10.1038/gim.2017.156

Measuring the Value of Pharmacogenomics Evidence

Author(s): GP Patrinos, C Mitropoulou
Published in: Clinical Pharmacology & Therapeutics, Issue 102/5, 2017, Page(s) 739-741, ISSN 0009-9236
DOI: 10.1002/cpt.743

Pharmacogenomic Biomarkers for Improved Drug Therapy—Recent Progress and Future Developments

Author(s): Volker M. Lauschke, Lili Milani, Magnus Ingelman-Sundberg
Published in: The AAPS Journal, Issue 20/1, 2018, ISSN 1550-7416
DOI: 10.1208/s12248-017-0161-x

Pharmacogenomics: an overview

Author(s): Rollinson V, Turner R, Pirmohamed M
Published in: Clinical Pharmacist, 2017, ISSN 2053-6178
DOI: 10.1211/CP.2017.20203640

Performance Ratio Based Resource Allocation Decision-Making in Genomic Medicine

Author(s): Vasilios Fragoulakis, Christina Mitropoulou, Daphne Katelidou, Ron H. van Schaik, Nikolaos Maniadakis, George P. Patrinos
Published in: OMICS: A Journal of Integrative Biology, Issue 21/2, 2017, Page(s) 67-73, ISSN 1536-2310
DOI: 10.1089/omi.2016.0161

Pitfalls and Opportunities for Epigenomic Analyses Focused on Disease Diagnosis, Prognosis, and Therapy

Author(s): Volker M. Lauschke, Maxim Ivanov, Magnus Ingelman-Sundberg
Published in: Trends in Pharmacological Sciences, Issue 38/9, 2017, Page(s) 765-770, ISSN 0165-6147
DOI: 10.1016/j.tips.2017.05.007

Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles

Author(s): Oliver Burk, Maria Kuzikov, Thales Kronenberger, Judith Jeske, Oliver Keminer, Wolfgang E. Thasler, Matthias Schwab, Carsten Wrenger, Björn Windshügel
Published in: Archives of Toxicology, Issue 92/4, 2018, Page(s) 1435-1451, ISSN 0340-5761
DOI: 10.1007/s00204-018-2165-4

Population pharmacogenomics: impact on public health and drug development

Author(s): George P Patrinos
Published in: Pharmacogenomics, Issue 19/1, 2018, Page(s) 3-6, ISSN 1462-2416
DOI: 10.2217/pgs-2017-0166

Pharmacoepigenetics and Toxicoepigenetics: Novel Mechanistic Insights and Therapeutic Opportunities

Author(s): Volker M. Lauschke, Isabel Barragan, Magnus Ingelman-Sundberg
Published in: Annual Review of Pharmacology and Toxicology, Issue 58/1, 2018, Page(s) 161-185, ISSN 0362-1642
DOI: 10.1146/annurev-pharmtox-010617-053021

Impact of CYP2C19 Genotype on Escitalopram Exposure and Therapeutic Failure: A Retrospective Study Based on 2,087 Patients

Author(s): Marin M. Jukić, Tore Haslemo, Espen Molden, Magnus Ingelman-Sundberg
Published in: American Journal of Psychiatry, Issue 175/5, 2018, Page(s) 463-470, ISSN 0002-953X
DOI: 10.1176/appi.ajp.2017.17050550

Implementing pharmacogenomics decision support across seven European countries: The Ubiquitous Pharmacogenomics (U-PGx) project

Author(s): Kathrin Blagec, Rudolf Koopmann, Mandy Crommentuijn – van Rhenen, Inge Holsappel, Cathelijne H van der Wouden, Lidija Konta, Hong Xu, Daniela Steinberger, Enrico Just, Jesse J Swen, Henk-Jan Guchelaar, Matthias Samwald
Published in: Journal of the American Medical Informatics Association, Issue 25/7, 2018, Page(s) 893-898, ISSN 1067-5027
DOI: 10.1093/jamia/ocy005

Systemic regulation of bilirubin homeostasis: Potential benefits of hyperbilirubinemia

Author(s): Ryoichi Fujiwara, Mathias Haag, Elke Schaeffeler, Anne T. Nies, Ulrich M. Zanger, Matthias Schwab
Published in: Hepatology, Issue 67/4, 2018, Page(s) 1609-1619, ISSN 0270-9139
DOI: 10.1002/hep.29599

Validation of a high-performance liquid chromatography method for thiopurine S-methyltransferase activity in whole blood using 6-mercaptopurine as substrate

Author(s): Hannah Rieger, Patrik Schmidt, Elke Schaeffeler, Manabu Abe, Mira Schiffhauer, Matthias Schwab, Nicolas von Ahsen, Gabriela Zurek, Hartmut Kirchherr, Maria Shipkova, Eberhard Wieland
Published in: Clinical Chemistry and Laboratory Medicine (CCLM), Issue 56/5, 2018, Page(s) 803-809, ISSN 1434-6621
DOI: 10.1515/cclm-2017-0670

Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points—Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC)

Author(s): Thomas O. Bergmeijer, Jean-Luc Reny, Ruth E. Pakyz, Li Gong, Joshua P. Lewis, Eun-Young Kim, Daniel Aradi, Israel Fernandez-Cadenas, Richard B. Horenstein, Ming Ta Michael Lee, Ryan M. Whaley, Joan Montaner, Gian Franco Gensini, John H. Cleator, Kiyuk Chang, Lene Holmvang, Willibald Hochholzer, Dan M. Roden, Stefan Winter, Russ B. Altman, Dimitrios Alexopoulos, Ho-Sook Kim, Jean-Pierre Déry, Mein
Published in: American Heart Journal, Issue 198, 2018, Page(s) 152-159, ISSN 0002-8703
DOI: 10.1016/j.ahj.2017.12.010

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and Tamoxifen Therapy

Author(s): Matthew P. Goetz, Katrin Sangkuhl, Henk-Jan Guchelaar, Matthias Schwab, Michael Province, Michelle Whirl-Carrillo, W. Fraser Symmans, Howard L. McLeod, Mark J. Ratain, Hitoshi Zembutsu, Andrea Gaedigk, Ron H. van Schaik, James N. Ingle, Kelly E. Caudle, Teri E. Klein
Published in: Clinical Pharmacology & Therapeutics, Issue 103/5, 2018, Page(s) 770-777, ISSN 0009-9236
DOI: 10.1002/cpt.1007

How to Consider Rare Genetic Variants in Personalized Drug Therapy

Author(s): Volker M. Lauschke, Magnus Ingelman-Sundberg
Published in: Clinical Pharmacology & Therapeutics, Issue 103/5, 2018, Page(s) 745-748, ISSN 0009-9236
DOI: 10.1002/cpt.976

Improving decision making on DPYD and UGT1A1*28 patients’ profiling with an innovative reimbursement strategy

Author(s): Rossana Roncato, Erika Cecchin, Giuseppe Toffoli
Published in: Pharmacogenomics, Issue 19/4, 2018, Page(s) 301-304, ISSN 1462-2416
DOI: 10.2217/pgs-2017-0303

Drinking Ethanol Has Few Acute Effects on CYP2C9, CYP2C19, NAT2, and P-Glycoprotein Activities but Somewhat Inhibits CYP1A2, CYP2D6, and Intestinal CYP3A: So What?

Author(s): Malaz Gazzaz, Martina Kinzig, Elke Schaeffeler, Martin Jübner, Chih-hsuan Hsin, Xia Li, Max Taubert, Christina Trueck, Juliane Iltgen-Breburda, Daria Kraus, Christian Queckenberg, Marc Stoffel, Matthias Schwab, Fritz Sörgel, Uwe Fuhr
Published in: Clinical Pharmacology & Therapeutics, Issue 104/6, 2018, Page(s) 1249-1259, ISSN 0009-9236
DOI: 10.1002/cpt.1083

Host genetic profiling to increase drug safety in colorectal cancer from discovery to implementation

Author(s): Erika Cecchin, Elena De Mattia, Fabrizio Ecca, Giuseppe Toffoli
Published in: Drug Resistance Updates, Issue 39, 2018, Page(s) 18-40, ISSN 1368-7646
DOI: 10.1016/j.drup.2018.07.001

From hype to reality: data science enabling personalized medicine

Author(s): Holger Fröhlich, Rudi Balling, Niko Beerenwinkel, Oliver Kohlbacher, Santosh Kumar, Thomas Lengauer, Marloes H. Maathuis, Yves Moreau, Susan A. Murphy, Teresa M. Przytycka, Michael Rebhan, Hannes Röst, Andreas Schuppert, Matthias Schwab, Rainer Spang, Daniel Stekhoven, Jimeng Sun, Andreas Weber, Daniel Ziemek, Blaz Zupan
Published in: BMC Medicine, Issue 16/1, 2018, ISSN 1741-7015
DOI: 10.1186/s12916-018-1122-7

Personalized laboratory medicine: a patient-centered future approach

Author(s): Irena Prodan Žitnik, Darko Černe, Irene Mancini, Lisa Simi, Mario Pazzagli, Chiara Di Resta, Helena Podgornik, Barbka Repič Lampret, Katarina Trebušak Podkrajšek, Csilla Sipeky, Ron van Schaik, Ivan Brandslund, Pieter Vermeersch, Matthias Schwab, Janja Marc
Published in: Clinical Chemistry and Laboratory Medicine (CCLM), Issue 56/12, 2018, Page(s) 1981-1991, ISSN 1434-6621
DOI: 10.1515/cclm-2018-0181

Genetic Variations Associated with Sleep Disorders in Patients with Schizophrenia: A Systematic Review

Author(s): Konstantinos Assimakopoulos, Katerina Karaivazoglou, Maria Skokou, Marina Kalogeropoulou, Panagiotis Kolios, Philippos Gourzis, George Patrinos, Evangelia Tsermpini
Published in: Medicines, Issue 5/2, 2018, Page(s) 27, ISSN 2305-6320
DOI: 10.3390/medicines5020027

Global genetic diversity of human apolipoproteins and effects on cardiovascular disease risk

Author(s): Yitian Zhou, Reedik Mägi, Lili Milani, Volker M. Lauschke
Published in: Journal of Lipid Research, Issue 59/10, 2018, Page(s) 1987-2000, ISSN 0022-2275
DOI: 10.1194/jlr.p086710

The New Age of -omics in Urothelial Cancer – Re-wording Its Diagnosis and Treatment

Author(s): Theodora Katsila, Michalis Liontos, George P. Patrinos, Aristotelis Bamias, Dimitrios Kardamakis
Published in: EBioMedicine, Issue 28, 2018, Page(s) 43-50, ISSN 2352-3964
DOI: 10.1016/j.ebiom.2018.01.044

Comprehensive overview of the pharmacogenetic diversity in Ashkenazi Jews

Author(s): Yitian Zhou, Volker M Lauschke
Published in: Journal of Medical Genetics, Issue 55/9, 2018, Page(s) 617-627, ISSN 0022-2593
DOI: 10.1136/jmedgenet-2018-105429

Pharmacogene Variation Consortium Gene Introduction: NUDT15

Author(s): Jun J. Yang, Michelle Whirl-Carrillo, Stuart A. Scott, Amy J. Turner, Matthias Schwab, Yoichi Tanaka, Guilherme Suarez-Kurtz, Elke Schaeffeler, Teri E. Klein, Neil A. Miller, Andrea Gaedigk
Published in: Clinical Pharmacology & Therapeutics, 2018, ISSN 0009-9236
DOI: 10.1002/cpt.1268

Integrating rare genetic variants into pharmacogenetic drug response predictions

Author(s): Magnus Ingelman-Sundberg, Souren Mkrtchian, Yitian Zhou, Volker M. Lauschke
Published in: Human Genomics, Issue 12/1, 2018, ISSN 1479-7364
DOI: 10.1186/s40246-018-0157-3

Clinical and Functional Relevance of the Monocarboxylate Transporter Family in Disease Pathophysiology and Drug Therapy

Author(s): Pascale Fisel, Elke Schaeffeler, Matthias Schwab
Published in: Clinical and Translational Science, Issue 11/4, 2018, Page(s) 352-364, ISSN 1752-8054
DOI: 10.1111/cts.12551

Searching for Clinically Relevant Biomarkers in Geriatric Oncology

Author(s): Theodora Katsila, George P. Patrinos, Dimitrios Kardamakis
Published in: BioMed Research International, Issue 2018, 2018, Page(s) 1-7, ISSN 2314-6133
DOI: 10.1155/2018/3793154

Functional characterization of CYP2D7 gene variants

Author(s): Marin M Jukic, Volker M Lauschke, Takahiro Saito, Masahiro Hiratsuka, Magnus Ingelman-Sundberg
Published in: Pharmacogenomics, Issue 19/12, 2018, Page(s) 931-936, ISSN 1462-2416
DOI: 10.2217/pgs-2018-0065

Impact of NUDT15 genetics on severe thiopurine-related hematotoxicity in patients with European ancestry

Author(s): Elke Schaeffeler, Simon U. Jaeger, Verena Klumpp, Jun J. Yang, Svitlana Igel, Laura Hinze, Martin Stanulla, Matthias Schwab
Published in: Genetics in Medicine, 2019, ISSN 1098-3600
DOI: 10.1038/s41436-019-0448-7

A Clinical-Genetic Score to Identify Surgically Resected Colorectal Cancer Patients Benefiting From an Adjuvant Fluoropyrimidine-Based Therapy

Author(s): Elena De Mattia, Eva Dreussi, Marcella Montico, Sara Gagno, Chiara Zanusso, Luca Quartuccio, Salvatore De Vita, Michela Guardascione, Angela Buonadonna, Mario D’Andrea, Nicoletta Pella, Adolfo Favaretto, Enrico Mini, Stefania Nobili, Loredana Romanato, Erika Cecchin, Giuseppe Toffoli
Published in: Frontiers in Pharmacology, Issue 9, 2018, ISSN 1663-9812
DOI: 10.3389/fphar.2018.01101

Population Pharmacokinetics of Mefloquine Intermittent Preventive Treatment for Malaria in Pregnancy in Gabon

Author(s): Michael Ramharter, Matthias Schwab, Ghyslain Mombo-Ngoma, Rella Zoleko Manego, Daisy Akerey-Diop, Arti Basra, Jean-Rodolphe Mackanga, Heike Würbel, Jan-Georg Wojtyniak, Raquel Gonzalez, Ute Hofmann, Mirjam Geditz, Pierre-Blaise Matsiegui, Peter G. Kremsner, Clara Menendez, Reinhold Kerb, Thorsten Lehr
Published in: Antimicrobial Agents and Chemotherapy, Issue 63/2, 2019, Page(s) e01113-18, ISSN 0066-4804
DOI: 10.1128/aac.01113-18

The Genotype for DPYD Risk Variants in Patients With Colorectal Cancer and the Related Toxicity Management Costs in Clinical Practice

Author(s): Giuseppe Toffoli, Federico Innocenti, Jerry Polesel, Elena De Mattia, Franca Sartor, Chiara Dalle Fratte, Fabrizio Ecca, Eva Dreussi, Elisa Palazzari, Michela Guardascione, Angela Buonadonna, Luisa Foltran, Marica Garziera, Alessia Bignucolo, Stefania Nobili, Enrico Mini, Adolfo Favaretto, Massimiliano Berretta, Mario D'Andrea, Antonino De Paoli, Rossana Roncato, Erika Cecchin
Published in: Clinical Pharmacology & Therapeutics, 2018, ISSN 0009-9236
DOI: 10.1002/cpt.1257

Significantly lower CYP2D6 metabolism measured as the O/N -desmethylvenlafaxine metabolic ratio in carriers of CYP2D6*41 versus CYP2D6*9 or CYP2D6*10 : a study on therapeutic drug monitoring data from 1003 genotyped Scandinavian patients

Author(s): Tore Haslemo, Erik Eliasson, Marin M. Jukić, Magnus Ingelman-Sundberg, Espen Molden
Published in: British Journal of Clinical Pharmacology, Issue 85/1, 2019, Page(s) 194-201, ISSN 0306-5251
DOI: 10.1111/bcp.13788

Computational Methods for the Pharmacogenetic Interpretation of Next Generation Sequencing Data

Author(s): Yitian Zhou, Kohei Fujikura, Souren Mkrtchian, Volker M. Lauschke
Published in: Frontiers in Pharmacology, Issue 9, 2018, ISSN 1663-9812
DOI: 10.3389/fphar.2018.01437

Genetic variability and population diversity of the human SLCO (OATP) transporter family

Author(s): Boyao Zhang, Volker M. Lauschke
Published in: Pharmacological Research, Issue 139, 2019, Page(s) 550-559, ISSN 1043-6618
DOI: 10.1016/j.phrs.2018.10.017

Fast and scalable neural embedding models for biomedical sentence classification

Author(s): Asan Agibetov, Kathrin Blagec, Hong Xu, Matthias Samwald
Published in: BMC Bioinformatics, Issue 19/1, 2018, ISSN 1471-2105
DOI: 10.1186/s12859-018-2496-4

An optimized prediction framework to assess the functional impact of pharmacogenetic variants

Author(s): Yitian Zhou, Souren Mkrtchian, Masaki Kumondai, Masahiro Hiratsuka, Volker M. Lauschke
Published in: The Pharmacogenomics Journal, 2018, ISSN 1470-269X
DOI: 10.1038/s41397-018-0044-2

A brighter future for the implementation of pharmacogenomic testing

Author(s): Cathelijne H van der Wouden, Jesse J Swen, Matthias Samwald, Christina Mitropoulou, Matthias Schwab, Henk-Jan Guchelaar
Published in: European Journal of Human Genetics, Issue 24/12, 2016, Page(s) 1658-1660, ISSN 1018-4813
DOI: 10.1038/ejhg.2016.116

Pharmacometabolomics Informs Viromics toward Precision Medicine

Author(s): Angeliki Balasopoulou, George P. Patrinos, Theodora Katsila
Published in: Frontiers in Pharmacology, Issue 7, 2016, ISSN 1663-9812
DOI: 10.3389/fphar.2016.00411

The Importance of Patient-Specific Factors for Hepatic Drug Response and Toxicity

Author(s): Volker Lauschke, Magnus Ingelman-Sundberg
Published in: International Journal of Molecular Sciences, Issue 17/10, 2016, Page(s) 1714, ISSN 1422-0067
DOI: 10.3390/ijms17101714

Pharmacogenomics education and research at the Department of Pharmacy, University of Patras, Greece

Author(s): George P Patrinos, Theodora Katsila
Published in: Pharmacogenomics, Issue 17/17, 2016, Page(s) 1865-1872, ISSN 1462-2416
DOI: 10.2217/pgs-2016-0142

Implementing Pharmacogenomics in Europe: Design and Implementation Strategy of the Ubiquitous Pharmacogenomics Consortium.

Author(s): van der Wouden CH, Cambon-Thomsen A, Cecchin E, Cheung KC, Dávila-Fajardo CL, Deneer VH, Dolžan V, Ingelman-Sundberg M, Jönsson S, Karlsson MO, Kriek M, Mitropoulou C, Patrinos GP, Pirmohamed M, Samwald M, Schaeffeler E, Schwab M, Steinberger D, Stingl J, Sunder-Plassmann G, Toffoli G, Turner RM, van Rhenen MH, Swen JJ, Guchelaar HJ; Ubiquitous Pharmacogenomics Consortium.
Published in: Clin Pharmacol Ther., 2017, ISSN 1532-6535
DOI: 10.1002/cpt.602

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 Genotype and Use of Ondansetron and Tropisetron.

Author(s): Bell GC, Caudle KE, Whirl-Carrillo M, Gordon RJ, Hikino K, Prows CA, Gaedigk A, Agundez JA, Sadhasivam S, Klein TE, Schwab M.
Published in: Clin Pharmacol Ther., 2016, ISSN 1532-6535
DOI: 10.1002/cpt.598

Impact of Membrane Drug Transporters on Resistance to Small-Molecule Tyrosine Kinase Inhibitors.

Author(s): Neul C, Schaeffeler E, Sparreboom A, Laufer S, Schwab M, Nies AT.
Published in: Trends Pharmacol Sci., 2016, ISSN 0165-6147
DOI: 10.1016/j.tips.2016.08.003

Structure and function of multidrug and toxin extrusion proteins (MATEs) and their relevance to drug therapy and personalized medicine.

Author(s): Nies AT, Damme K, Kruck S, Schaeffeler E, Schwab M.
Published in: Arch Toxicol., 2016, ISSN 0340-5761
DOI: 10.1007/s00204-016-1728-5

DNA Methylation of ADME Genes.

Author(s): Fisel P, Schaeffeler E, Schwab M.
Published in: Clin Pharmacol Ther., 2016, ISSN 1532-6535
DOI: 10.1002/cpt.343

The importance of drug transporter characterization to precision medicine.

Author(s): Fisel P, Nies AT, Schaeffeler E, Schwab M.
Published in: Expert Opin Drug Metab Toxicol., 2017, ISSN 1742-5255
DOI: 10.1080/17425255.2017.1290083

Polymorphic Variation in TPMT Is the Principal Determinant of TPMT Phenotype: A Meta-Analysis of Three Genome-Wide Association Studies

Author(s): R Tamm, R Mägi, R Tremmel, S Winter, E Mihailov, A Smid, A Möricke, K Klein, M Schrappe, M Stanulla, R Houlston, R Weinshilboum, Irena Mlinarič Raščan, A Metspalu, L Milani, M Schwab, E Schaeffeler
Published in: Clinical Pharmacology & Therapeutics, Issue 101/5, 2017, Page(s) 684-695, ISSN 0009-9236
DOI: 10.1002/cpt.540

Ubiquitous Pharmacogenomics (U-PGx): The time for implementation is now. An Horizon2020 program to drive pharmacogenomics into clinical practice.

Author(s): Cecchin E, Roncato R, Guchelaar HJ, Toffoli G, and for the Ubiquitous Pharmacogenomics Consortium.
Published in: Curr Pharm Biotechnol., Issue 18 (3); 2017, 2017, Page(s) 204-209, ISSN 1389-2010
DOI: 10.2174/1389201018666170103103619

Translational learning from clinical studies predicts drug pharmacokinetics across patient populations

Author(s): Markus Krauss, Ute Hofmann, Clemens Schafmayer, Svitlana Igel, Jan Schlender, Christian Mueller, Mario Brosch, Witigo von Schoenfels, Wiebke Erhart, Andreas Schuppert, Michael Block, Elke Schaeffeler, Gabriele Boehmer, Linus Goerlitz, Jan Hoecker, Joerg Lippert, Reinhold Kerb, Jochen Hampe, Lars Kuepfer, Matthias Schwab
Published in: npj Systems Biology and Applications, Issue 3/1, 2017, ISSN 2056-7189
DOI: 10.1038/s41540-017-0012-5

Worldwide Distribution of Cytochrome P450 Alleles: A Meta-analysis of Population-scale Sequencing Projects

Author(s): Y Zhou, M Ingelman-Sundberg, VM Lauschke
Published in: Clinical Pharmacology & Therapeutics, 2017, ISSN 0009-9236
DOI: 10.1002/cpt.690

Methyleugenol DNA adducts in human liver are associated with SULT1A1 copy number variations and expression levels

Author(s): Roman Tremmel, Kristin Herrmann, Wolfram Engst, Walter Meinl, Kathrin Klein, Hansruedi Glatt, Ulrich M. Zanger
Published in: Archives of Toxicology, 2017, ISSN 0340-5761
DOI: 10.1007/s00204-017-1955-4

Medical education in pharmacogenomics—results from a survey on pharmacogenetic knowledge in healthcare professionals within the European pharmacogenomics clinical implementation project Ubiquitous Pharmacogenomics (U-PGx)

Author(s): Katja Susanne Just, Michael Steffens, Jesse Joachim Swen, George P. Patrinos, Henk-Jan Guchelaar, Julia Carolin Stingl
Published in: European Journal of Clinical Pharmacology, 2017, ISSN 0031-6970
DOI: 10.1007/s00228-017-2292-5

The Ubiquitous Pharmacogenomics consortium: making effective treatment optimization accessible to every European citizen

Author(s): Lisanne EN Manson, Cathelijne H van der Wouden, Jesse J Swen, Henk-Jan Guchelaar
Published in: Pharmacogenomics, Issue 18/11, 2017, Page(s) 1041-1045, ISSN 1462-2416
DOI: 10.2217/pgs-2017-0093

Expanded national database collection and data coverage in the FINDbase worldwide database for clinically relevant genomic variation allele frequencies

Author(s): Emmanouil Viennas, Angeliki Komianou, Clint Mizzi, Maja Stojiljkovic, Christina Mitropoulou, Juha Muilu, Mauno Vihinen, Panagiota Grypioti, Styliani Papadaki, Cristiana Pavlidis, Branka Zukic, Theodora Katsila, Peter J. van der Spek, Sonja Pavlovic, Giannis Tzimas, George P. Patrinos
Published in: Nucleic Acids Research, Issue 45/D1, 2017, Page(s) D846-D853, ISSN 0305-1048
DOI: 10.1093/nar/gkw949

Exosomes: A Cancer Theranostics Road Map

Author(s): Angeliki Panagiotara, Athina Markou, Evi S. Lianidou, George P. Patrinos, Theodora Katsila
Published in: Public Health Genomics, 2017, ISSN 1662-4246
DOI: 10.1159/000478253

Application of the DruGeVar Database in Cancer Genomics and Pharmacogenomics

Author(s): Konstantinos Sarris, Angeliki Komianou, George P. Patrinos, Theodora Katsila
Published in: Public Health Genomics, 2017, ISSN 1662-4246
DOI: 10.1159/000478254

Pharmacometabolomics Informs Quantitative Radiomics for Glioblastoma Diagnostic Innovation

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