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Probing safety of nano-objects by defining immune responses of environmental organisms

Objective

PANDORA (Probing safety of nano-objects by defining immune responses of environmental organisms) shall assess the global impact of engineered nanoparticles (NP) on the immune responses of representative organisms covering all evolutionary stages and hierarchical levels from plants to invertebrates and vertebrates. Immunity is a major determinant of the survival and fitness of all living organisms, therefore immunosafety of engineered NP is a key element of environmental nanosafety. PANDORA will tackle the issue of global immunological nanosafety by comparing the impact of widely-used NP (e.g. iron, titanium and cerium oxide) on the human immune response with their effects in representative terrestrial and marine organisms. This comparison will focus on the conserved system of innate immunity/stress response/inflammation, aiming to identify common mechanisms and markers across immune defence evolution shared by plants (Arabidopsis), invertebrate (bivalves, echinoderms, earthworms), and vertebrate (human) species.
PANDORA’s objectives are: 1. To identify immunological mechanisms triggered by nano-objects, and predictive markers of risk vs. safety; 2. To do so by a collaborative cross-species comparison, from plants to human, of innate immune defence capacity, using selected, industrially-relevant NP; 3. To design predictive in vitro assays to measure the immuno-risk of NP to the environment and human health, as new approaches to industrial and environmental nanosafety testing.
PANDORA will train 11 PhD students in an overarching training programme involving training-by-research, joint courses of technical, scientific and transferrable skills, participation to public scientific events, and an intense intersectoral networking exchange plan. The PANDORA consortium encompasses academic institutions, research centres, and SMEs, all with proven experience in higher education and training, and state-of-the art scientific and technical expertise and infrastructures.

Coordinator

CONSIGLIO NAZIONALE DELLE RICERCHE
Net EU contribution
€ 516 122,64
Address
Piazzale Aldo Moro 7
00185 Roma
Italy

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Region
Centro (IT) Lazio Roma
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Participants (10)

PARIS-LODRON-UNIVERSITAT SALZBURG
Austria
Net EU contribution
€ 255 934,08
Address
Kapitelgasse 4-6
5020 Salzburg

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Region
Westösterreich Salzburg Salzburg und Umgebung
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITA DEGLI STUDI DI GENOVA
Italy
Net EU contribution
€ 258 061,32
Address
Via Balbi 5
16126 Genova

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Region
Nord-Ovest Liguria Genova
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
MIKROBIOLOGICKY USTAV AV CR V.V.I
Czechia
Net EU contribution
€ 232 422,48
Address
Videnska 1083
142 00 Praha 4

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Region
Praha Hlavní město Praha
Activity type
Research Organisations
Non-EU contribution
€ 0,00
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
Net EU contribution
€ 249 216,48
Address
Geschwister-scholl-platz
72074 Tuebingen

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Region
Baden-Württemberg Tübingen Tübingen, Landkreis
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERZA V LJUBLJANI
Slovenia
Net EU contribution
€ 234 997,56
Address
Kongresni Trg 12
1000 Ljubljana

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Region
Slovenija Zahodna Slovenija Osrednjeslovenska
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
CARDIFF UNIVERSITY
United Kingdom
Net EU contribution
€ 273 287,88
Address
Newport Road 30 36
CF24 0DE Cardiff

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Region
Wales East Wales Cardiff and Vale of Glamorgan
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNITED KINGDOM RESEARCH AND INNOVATION

Participation ended

United Kingdom
Net EU contribution
€ 113 869,95
Address
Polaris House North Star Avenue
SN2 1FL Swindon

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Region
South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Swindon
Activity type
Research Organisations
Non-EU contribution
€ 0,00
AvantiCell Science Ltd
United Kingdom
Net EU contribution
€ 273 287,88
Address
Gibbsyard Building
KA6 5HW Ayr

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Southern Scotland South Ayrshire
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA
Spain
Net EU contribution
€ 247 872,96
Address
Campus De La Uab Edifici Q Icn2
08193 Bellaterra (Barcelona)

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Non-EU contribution
€ 0,00
UK CENTRE FOR ECOLOGY & HYDROLOGY
United Kingdom
Net EU contribution
€ 159 417,93
Address
Maclean Building Benson Lane Crowmarsh Gifford
OX10 8BB Oxford

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Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Partners (1)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU
Italy
Net EU contribution
€ 0,00
Address
Via Fiorentina 151
53100 Siena

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Centro (IT) Toscana Siena
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00