Objective PANDORA (Probing safety of nano-objects by defining immune responses of environmental organisms) shall assess the global impact of engineered nanoparticles (NP) on the immune responses of representative organisms covering all evolutionary stages and hierarchical levels from plants to invertebrates and vertebrates. Immunity is a major determinant of the survival and fitness of all living organisms, therefore immunosafety of engineered NP is a key element of environmental nanosafety. PANDORA will tackle the issue of global immunological nanosafety by comparing the impact of widely-used NP (e.g. iron, titanium and cerium oxide) on the human immune response with their effects in representative terrestrial and marine organisms. This comparison will focus on the conserved system of innate immunity/stress response/inflammation, aiming to identify common mechanisms and markers across immune defence evolution shared by plants (Arabidopsis), invertebrate (bivalves, echinoderms, earthworms), and vertebrate (human) species. PANDORA’s objectives are: 1. To identify immunological mechanisms triggered by nano-objects, and predictive markers of risk vs. safety; 2. To do so by a collaborative cross-species comparison, from plants to human, of innate immune defence capacity, using selected, industrially-relevant NP; 3. To design predictive in vitro assays to measure the immuno-risk of NP to the environment and human health, as new approaches to industrial and environmental nanosafety testing. PANDORA will train 11 PhD students in an overarching training programme involving training-by-research, joint courses of technical, scientific and transferrable skills, participation to public scientific events, and an intense intersectoral networking exchange plan. The PANDORA consortium encompasses academic institutions, research centres, and SMEs, all with proven experience in higher education and training, and state-of-the art scientific and technical expertise and infrastructures. Fields of science medical and health sciencesbasic medicineimmunologymedical and health sciencesmedical biotechnologynanomedicineengineering and technologynanotechnologynano-materialsmedical and health sciencesbasic medicinetoxicologymedical and health sciencesbasic medicinephysiologyhomeostasis Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.1. - Fostering new skills by means of excellent initial training of researchers Topic(s) MSCA-ITN-2015-ETN - Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) Call for proposal H2020-MSCA-ITN-2015 See other projects for this call Funding Scheme MSCA-ITN-ETN - European Training Networks Coordinator CONSIGLIO NAZIONALE DELLE RICERCHE Net EU contribution € 516 122,64 Address Piazzale aldo moro 7 00185 Roma Italy See on map Region Centro (IT) Lazio Roma Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (10) Sort alphabetically Sort by Net EU contribution Expand all Collapse all PARIS-LODRON-UNIVERSITAT SALZBURG Austria Net EU contribution € 255 934,08 Address Kapitelgasse 4-6 5020 Salzburg See on map Region Westösterreich Salzburg Salzburg und Umgebung Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITA DEGLI STUDI DI GENOVA Italy Net EU contribution € 258 061,32 Address Via balbi 5 16126 Genova See on map Region Nord-Ovest Liguria Genova Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 MIKROBIOLOGICKY USTAV AV CR V.V.I Czechia Net EU contribution € 232 422,48 Address Videnska 1083 142 00 Praha 4 See on map Region Česko Praha Hlavní město Praha Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 EBERHARD KARLS UNIVERSITAET TUEBINGEN Germany Net EU contribution € 249 216,48 Address Geschwister-scholl-platz 72074 Tuebingen See on map Region Baden-Württemberg Tübingen Tübingen, Landkreis Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERZA V LJUBLJANI Slovenia Net EU contribution € 234 997,56 Address Kongresni trg 12 1000 Ljubljana See on map Region Slovenija Zahodna Slovenija Osrednjeslovenska Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 CARDIFF UNIVERSITY United Kingdom Net EU contribution € 273 287,88 Address Newport road 30 36 CF24 0DE Cardiff See on map Region Wales East Wales Cardiff and Vale of Glamorgan Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNITED KINGDOM RESEARCH AND INNOVATION Participation ended United Kingdom Net EU contribution € 113 869,95 Address Polaris house north star avenue SN2 1FL Swindon See on map Region South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Swindon Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 AvantiCell Science Ltd United Kingdom Net EU contribution € 273 287,88 Address Gibbsyard building KA6 5HW Ayr See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Scotland Southern Scotland South Ayrshire Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA Spain Net EU contribution € 247 872,96 Address Campus de la uab edifici q icn2 08193 Cerdanyola del valles See on map Region Este Cataluña Barcelona Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UK CENTRE FOR ECOLOGY & HYDROLOGY United Kingdom Net EU contribution € 159 417,93 Address Maclean building benson lane crowmarsh gifford OX10 8BB Oxford See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Partners (1) Sort alphabetically Sort by Net EU contribution Expand all Collapse all Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU Italy Net EU contribution € 0,00 Address Via fiorentina 151 53100 Siena See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Centro (IT) Toscana Siena Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
