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Probing safety of nano-objects by defining immune responses of environmental organisms

Obiettivo

PANDORA (Probing safety of nano-objects by defining immune responses of environmental organisms) shall assess the global impact of engineered nanoparticles (NP) on the immune responses of representative organisms covering all evolutionary stages and hierarchical levels from plants to invertebrates and vertebrates. Immunity is a major determinant of the survival and fitness of all living organisms, therefore immunosafety of engineered NP is a key element of environmental nanosafety. PANDORA will tackle the issue of global immunological nanosafety by comparing the impact of widely-used NP (e.g. iron, titanium and cerium oxide) on the human immune response with their effects in representative terrestrial and marine organisms. This comparison will focus on the conserved system of innate immunity/stress response/inflammation, aiming to identify common mechanisms and markers across immune defence evolution shared by plants (Arabidopsis), invertebrate (bivalves, echinoderms, earthworms), and vertebrate (human) species.
PANDORA’s objectives are: 1. To identify immunological mechanisms triggered by nano-objects, and predictive markers of risk vs. safety; 2. To do so by a collaborative cross-species comparison, from plants to human, of innate immune defence capacity, using selected, industrially-relevant NP; 3. To design predictive in vitro assays to measure the immuno-risk of NP to the environment and human health, as new approaches to industrial and environmental nanosafety testing.
PANDORA will train 11 PhD students in an overarching training programme involving training-by-research, joint courses of technical, scientific and transferrable skills, participation to public scientific events, and an intense intersectoral networking exchange plan. The PANDORA consortium encompasses academic institutions, research centres, and SMEs, all with proven experience in higher education and training, and state-of-the art scientific and technical expertise and infrastructures.

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H2020-MSCA-ITN-2015
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Coordinatore

CONSIGLIO NAZIONALE DELLE RICERCHE
Indirizzo
Piazzale Aldo Moro 7
00185 Roma
Italia

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Tipo di attività
Research Organisations
Contributo UE
€ 516 122,64

Partecipanti (10)

PARIS-LODRON-UNIVERSITAT SALZBURG
Austria
Contributo UE
€ 255 934,08
Indirizzo
Kapitelgasse 4-6
5020 Salzburg

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Tipo di attività
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI GENOVA
Italia
Contributo UE
€ 258 061,32
Indirizzo
Via Balbi 5
16126 Genova

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Tipo di attività
Higher or Secondary Education Establishments
MIKROBIOLOGICKY USTAV AV CR V.V.I
Cechia
Contributo UE
€ 232 422,48
Indirizzo
Videnska 1083
142 00 Praha 4

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Tipo di attività
Research Organisations
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germania
Contributo UE
€ 249 216,48
Indirizzo
Geschwister-scholl-platz
72074 Tuebingen

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Tipo di attività
Higher or Secondary Education Establishments
UNIVERZA V LJUBLJANI
Slovenia
Contributo UE
€ 234 997,56
Indirizzo
Kongresni Trg 12
1000 Ljubljana

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Tipo di attività
Higher or Secondary Education Establishments
CARDIFF UNIVERSITY
United Kingdom
Contributo UE
€ 273 287,88
Indirizzo
Newport Road 30 36
CF24 0DE Cardiff

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Tipo di attività
Higher or Secondary Education Establishments
UNITED KINGDOM RESEARCH AND INNOVATION

Partecipazione conclusa

United Kingdom
Contributo UE
€ 113 869,95
Indirizzo
Polaris House North Star Avenue
SN2 1FL Swindon

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Tipo di attività
Research Organisations
AvantiCell Science Ltd
United Kingdom
Contributo UE
€ 273 287,88
Indirizzo
Gibbsyard Building
KA6 5HW Ayr

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Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA
Spagna
Contributo UE
€ 247 872,96
Indirizzo
Campus De La Uab Edifici Q Icn2
08193 Bellaterra (Barcelona)

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Tipo di attività
Research Organisations
UK CENTRE FOR ECOLOGY & HYDROLOGY
United Kingdom
Contributo UE
€ 159 417,93
Indirizzo
Maclean Building Benson Lane Crowmarsh Gifford
OX10 8BB Oxford

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Tipo di attività
Research Organisations

Partner (1)

ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU
Italia
Indirizzo
Via Fiorentina 151
53100 Siena

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Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)