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Probing safety of nano-objects by defining immune responses of environmental organisms


NP interaction with innate immune cells/receptors

Report encompassing the joint results of individual projects 1, 2, 3, 5, 10, 11.

Industrial outreach

Reports on industrial outreach activities Multiple delivery dates Months 18 30 42

Local training

Reports on local training activities. Multiple delivery dates: Months 18, 30, 42.


Reports on secondments Multiple delivery dates Months 25 43

Setting up immuno-risk predictive cell-based in vitro assays

Report encompassing the joint results of individual projects 1, 2, 3, 9, 11.

Virtual outreach

Reports on virtual outreach activities. Multiple delivery dates: Months 18, 30, 42.

Defining biomarkers of environmental immuno-risk

Report encompassing the joint results of individual projects 1-11.

Academic outreach

Reports on academic outreach activities. Multiple delivery dates: Months 18, 30, 42.


Reports on dissemination activities. Multiple delivery dates: Months 12, 24, 36, 48.

Individual CDP

Preparation of individual Career Development Plans.

Modulation of immune-pathogen interaction by NP

Report encompassing the joint results of individual projects 1, 2, 3, 5, 6, 7, 8, 10.

PhD thesis

PhD thesis for all ESR.

SSC activities

Organisation of Short Scientific Courses. Multiple delivery dates: Months 10, 22, 34.


Report on the recruitment process, including publication of call, CV evaluation, interview outcome, final decision on the fellows.

SCT activities

Organisation of Short Courses of Transferrable training (SCT). Multiple delivery dates: Months 16, 28, 40.

Scientific meetings

Scientific meetings organisation. Multiple delivery dates: Months 10, 22, 34.

Final Workshop

Final Workshop organisation.


Probing safety of nanoparticles by outlining sea urchin sensing and signaling cascades

Author(s): Andi Alijagic, Annalisa Pinsino
Published in: Ecotoxicology and Environmental Safety, Issue 144, 2017, Page(s) 416-421, ISSN 0147-6513
Publisher: Academic Press
DOI: 10.1016/j.ecoenv.2017.06.060

Formation of the Protein Corona: The Interface between Nanoparticles and the Immune System

Author(s): Francesco Barbero, Lorenzo Russo, Michele Vitali, Jordi Piella, Ignacio Salvo, Mireya L. Borrajo, Marti Busquets-Fité, Rita Grandori, Neus G. Bastús, Eudald Casals, Victor Puntes
Published in: Seminars in Immunology, Issue 34, 2017, Page(s) 52-60, ISSN 1044-5323
Publisher: Academic Press
DOI: 10.1016/j.smim.2017.10.001

Sea Urchin Extracellular Proteins Design a Complex Protein Corona on Titanium Dioxide Nanoparticle Surface Influencing Immune Cell Behavior

Author(s): Andi Alijagic, Oldřich Benada, Olga Kofroňová, Diego Cigna, Annalisa Pinsino
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
Publisher: -
DOI: 10.3389/fimmu.2019.02261

Effects of nanosilver on Mytilus galloprovincialis hemocytes and early embryo development

Author(s): M. Auguste, C. Ciacci, T. Balbi, A. Brunelli, V. Caratto, A. Marcomini, R. Cuppini, L. Canesi
Published in: Aquatic Toxicology, Issue 203, 2018, Page(s) 107-116, ISSN 0166-445X
Publisher: Elsevier BV
DOI: 10.1016/j.aquatox.2018.08.005

In vivo immunomodulatory and antioxidant properties of nanoceria (nCeO2) in the marine mussel Mytilus galloprovincialis

Author(s): M. Auguste, T. Balbi, M. Montagna, R. Fabbri, M. Sendra, J. Blasco, L. Canesi
Published in: Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, Issue 219, 2019, Page(s) 95-102, ISSN 1532-0456
Publisher: Elsevier BV
DOI: 10.1016/j.cbpc.2019.02.006

Exposure to TiO2 nanoparticles induces shifts in the microbiota composition of Mytilus galloprovincialis hemolymph

Author(s): Manon Auguste, Aide Lasa, Alberto Pallavicini, Stefano Gualdi, Luigi Vezzulli, Laura Canesi
Published in: Science of The Total Environment, Issue 670, 2019, Page(s) 129-137, ISSN 0048-9697
Publisher: Elsevier BV
DOI: 10.1016/j.scitotenv.2019.03.133

Interaction of engineered nanomaterials with the immune system: Health-related safety and possible benefits

Author(s): Diana Boraschi, Benjamin J. Swartzwelter, Paola Italiani
Published in: Current Opinion in Toxicology, Issue 10, 2018, Page(s) 74-83, ISSN 2468-2020
Publisher: -
DOI: 10.1016/j.cotox.2018.02.002

IL-1β induces expression of costimulatory molecules and cytokines but not immune feedback regulators in dendritic cells

Author(s): Sara Michelini, Muamera Sarajlic, Albert Duschl, Jutta Horejs-Hoeck
Published in: Human Immunology, Issue 79/8, 2018, Page(s) 610-615, ISSN 0198-8859
Publisher: Elsevier BV
DOI: 10.1016/j.humimm.2018.06.002

Sea urchin Paracentrotus lividus immune cells in culture: formulation of the appropriate harvesting and culture media and maintenance conditions

Author(s): Annalisa Pinsino, Andi Alijagic
Published in: Biology Open, Issue 8/3, 2019, Page(s) bio039289, ISSN 2046-6390
Publisher: -
DOI: 10.1242/bio.039289

First person – Annalisa Pinsino and Andi Alijagic

Author(s): A. Pinsino, and A. Alijagic
Published in: Biology Open, Issue 8/3, 2019, Page(s) bio042242, ISSN 2046-6390
Publisher: -
DOI: 10.1242/bio.042242

Developmental and Immune Role of a Novel Multiple Cysteine Cluster TLR From Eisenia andrei Earthworms

Author(s): Petra Prochazkova, Radka Roubalova, Frantisek Skanta, Jiri Dvorak, Natividad Isabel Navarro Pacheco, Miroslav Kolarik, Martin Bilej
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
Publisher: -
DOI: 10.3389/fimmu.2019.01277

Titanium dioxide nanoparticles temporarily influence the sea urchin immunological state suppressing inflammatory-relate gene transcription and boosting antioxidant metabolic activity

Author(s): Andi Alijagic, Daniela Gaglio, Elisabetta Napodano, Roberta Russo, Caterina Costa, Oldřich Benada, Olga Kofroňová, Annalisa Pinsino
Published in: Journal of Hazardous Materials, Issue 384, 2020, Page(s) 121389, ISSN 0304-3894
Publisher: Elsevier BV
DOI: 10.1016/j.jhazmat.2019.121389

Pattern recognition receptors in annelids

Author(s): P. Prochazkova, R. Roubalova, J. Dvorak, N.I. Navarro Pacheco, M. Bilej
Published in: Developmental & Comparative Immunology, Issue 102, 2020, Page(s) 103493, ISSN 0145-305X
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.dci.2019.103493

Shift in Immune Parameters After Repeated Exposure to Nanoplastics in the Marine Bivalve Mytilus

Author(s): Manon Auguste, Teresa Balbi, Caterina Ciacci, Barbara Canonico, Stefano Papa, Alessio Borello, Luigi Vezzulli, Laura Canesi
Published in: Frontiers in Immunology, Issue 11, 2020, Page(s) 426, ISSN 1664-3224
Publisher: -
DOI: 10.3389/fimmu.2020.00426

Dynamic Equilibrium in the Cetyltrimethylammonium Bromide–Au Nanoparticle Bilayer, and the Consequent Impact on the Formation of the Nanoparticle Protein Corona

Author(s): Francesco Barbero, Oscar H. Moriones, Neus G. Bastús, Victor Puntes
Published in: Bioconjugate Chemistry, Issue 30/11, 2019, Page(s) 2917-2930, ISSN 1043-1802
Publisher: American Chemical Society
DOI: 10.1021/acs.bioconjchem.9b00624

Surface Exposure of PEG and Amines on Biodegradable Nanoparticles as a Strategy to Tune Their Interaction with Protein-Rich Biological Media

Author(s): Claudia Conte, Giovanni Dal Poggetto, Benjamin J. Swartzwelter, Diletta Esposito, Francesca Ungaro, Paola Laurienzo, Diana Boraschi, Fabiana Quaglia
Published in: Nanomaterials, Issue 9/10, 2019, Page(s) 1354, ISSN 2079-4991
Publisher: -
DOI: 10.3390/nano9101354

Addressing Nanomaterial Immunosafety by Evaluating Innate Immunity across Living Species

Author(s): Diana Boraschi, Andi Alijagic, Manon Auguste, Francesco Barbero, Eleonora Ferrari, Szabolcs Hernadi, Craig Mayall, Sara Michelini, Natividad I. Navarro Pacheco, Alessandra Prinelli, Elmer Swart, Benjamin J. Swartzwelter, Neus G. Bastús, Laura Canesi, Damjana Drobne, Albert Duschl, Marie‐Ann Ewart, Jutta Horejs‐Hoeck, Paola Italiani, Birgit Kemmerling, Peter Kille, Petra Prochazkova, Victor F.
Published in: Small, Issue 16/21, 2020, Page(s) 2000598, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202000598

Mechanisms of particles in sensitization, effector function and therapy of allergic disease.

Author(s): A.I. Joubert, M. Geppert, L. Johnson, R. Mills-Goodlet, S. Michelini, E. Korotchenko, A. Duschl, R. Weiss, J. Horejs-Höck and M. Himly
Published in: Front. Immunol, Issue 11, 2020, Page(s) 1334
Publisher: -
DOI: 10.3389/fimmu.2020.01334

Gold Nanoparticles Modulate BCG-Induced Innate Immune Memory in Human Monocytes by Shifting the Memory Response towards Tolerance

Author(s): Benjamin J. Swartzwelter, Francesco Barbero, Alessandro Verde, Maria Mangini, Marinella Pirozzi, Anna Chiara De Luca, Victor F. Puntes, Luciana C. C. Leite, Paola Italiani, Diana Boraschi
Published in: Cells, Issue 9/2, 2020, Page(s) 284, ISSN 2073-4409
Publisher: -
DOI: 10.3390/cells9020284

The Effects of in Vivo Exposure to Copper Oxide Nanoparticles on the Gut Microbiome, Host Immunity and Susceptibility to a Bacterial Infection in Earthworms

Author(s): Elmer Swart, Jiri Dvorak, Szabolcs Hernádi, Tim Goodall, Peter Kille, David Spurgeon, Claus Svendsen and Petra Prochazkova
Published in: Nanomaterials, Issue 10, 2020, Page(s) 1337
Publisher: -
DOI: 10.3390/nano10071337

Annelida: Environmental Interactions and Ecotoxicity in Relation to the Earthworm Immune System

Author(s): Radka Roubalová, Barbara Płytycz, Petra Procházková, Natividad Isabel Navarro Pacheco, Martin Bilej
Published in: Advances in Comparative Immunology, 2018, Page(s) 933-951, ISBN 978-3-319-76767-3
Publisher: Springer International Publishing
DOI: 10.1007/978-3-319-76768-0_27

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