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Probing safety of nano-objects by defining immune responses of environmental organisms

Ziel

PANDORA (Probing safety of nano-objects by defining immune responses of environmental organisms) shall assess the global impact of engineered nanoparticles (NP) on the immune responses of representative organisms covering all evolutionary stages and hierarchical levels from plants to invertebrates and vertebrates. Immunity is a major determinant of the survival and fitness of all living organisms, therefore immunosafety of engineered NP is a key element of environmental nanosafety. PANDORA will tackle the issue of global immunological nanosafety by comparing the impact of widely-used NP (e.g. iron, titanium and cerium oxide) on the human immune response with their effects in representative terrestrial and marine organisms. This comparison will focus on the conserved system of innate immunity/stress response/inflammation, aiming to identify common mechanisms and markers across immune defence evolution shared by plants (Arabidopsis), invertebrate (bivalves, echinoderms, earthworms), and vertebrate (human) species.
PANDORA’s objectives are: 1. To identify immunological mechanisms triggered by nano-objects, and predictive markers of risk vs. safety; 2. To do so by a collaborative cross-species comparison, from plants to human, of innate immune defence capacity, using selected, industrially-relevant NP; 3. To design predictive in vitro assays to measure the immuno-risk of NP to the environment and human health, as new approaches to industrial and environmental nanosafety testing.
PANDORA will train 11 PhD students in an overarching training programme involving training-by-research, joint courses of technical, scientific and transferrable skills, participation to public scientific events, and an intense intersectoral networking exchange plan. The PANDORA consortium encompasses academic institutions, research centres, and SMEs, all with proven experience in higher education and training, and state-of-the art scientific and technical expertise and infrastructures.

Aufforderung zur Vorschlagseinreichung

H2020-MSCA-ITN-2015
Andere Projekte für diesen Aufruf anzeigen

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Koordinator

CONSIGLIO NAZIONALE DELLE RICERCHE
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Piazzale Aldo Moro 7
00185 Roma
Italien
Aktivitätstyp
Research Organisations
EU-Beitrag
€ 516 122,64

Beteiligte (10)

PARIS-LODRON-UNIVERSITAT SALZBURG
Österreich
EU-Beitrag
€ 255 934,08
Adresse
Kapitelgasse 4-6
5020 Salzburg
Aktivitätstyp
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI GENOVA
Italien
EU-Beitrag
€ 258 061,32
Adresse
Via Balbi 5
16126 Genova
Aktivitätstyp
Higher or Secondary Education Establishments
MIKROBIOLOGICKY USTAV AV CR V.V.I
Tschechien
EU-Beitrag
€ 232 422,48
Adresse
Videnska 1083
142 00 Praha 4
Aktivitätstyp
Research Organisations
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Deutschland
EU-Beitrag
€ 249 216,48
Adresse
Geschwister-scholl-platz
72074 Tuebingen
Aktivitätstyp
Higher or Secondary Education Establishments
UNIVERZA V LJUBLJANI
Slowenien
EU-Beitrag
€ 234 997,56
Adresse
Kongresni Trg 12
1000 Ljubljana
Aktivitätstyp
Higher or Secondary Education Establishments
CARDIFF UNIVERSITY
United Kingdom
EU-Beitrag
€ 273 287,88
Adresse
Newport Road 30 36
CF24 0DE Cardiff
Aktivitätstyp
Higher or Secondary Education Establishments
UNITED KINGDOM RESEARCH AND INNOVATION

Beteiligung beendet

United Kingdom
EU-Beitrag
€ 113 869,95
Adresse
Polaris House North Star Avenue
SN2 1FL Swindon
Aktivitätstyp
Research Organisations
AvantiCell Science Ltd
United Kingdom
EU-Beitrag
€ 273 287,88
Adresse
Gibbsyard Building
KA6 5HW Ayr
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA
Spanien
EU-Beitrag
€ 247 872,96
Adresse
Campus De La Uab Edifici Q Icn2
08193 Bellaterra (Barcelona)
Aktivitätstyp
Research Organisations
UK CENTRE FOR ECOLOGY & HYDROLOGY
United Kingdom
EU-Beitrag
€ 159 417,93
Adresse
Maclean Building Benson Lane Crowmarsh Gifford
OX10 8BB Oxford
Aktivitätstyp
Research Organisations

Partner (1)

ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU
Italien
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Via Fiorentina 151
53100 Siena
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Private for-profit entities (excluding Higher or Secondary Education Establishments)