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Probing safety of nano-objects by defining immune responses of environmental organisms

Risultati finali

NP interaction with innate immune cells/receptors

Report encompassing the joint results of individual projects 1, 2, 3, 5, 10, 11.

Industrial outreach

Reports on industrial outreach activities Multiple delivery dates Months 18 30 42

Local training

Reports on local training activities. Multiple delivery dates: Months 18, 30, 42.

Secondments

Reports on secondments Multiple delivery dates Months 25 43

Setting up immuno-risk predictive cell-based in vitro assays

Report encompassing the joint results of individual projects 1, 2, 3, 9, 11.

Virtual outreach

Reports on virtual outreach activities. Multiple delivery dates: Months 18, 30, 42.

Defining biomarkers of environmental immuno-risk

Report encompassing the joint results of individual projects 1-11.

Academic outreach

Reports on academic outreach activities. Multiple delivery dates: Months 18, 30, 42.

Dissemination

Reports on dissemination activities. Multiple delivery dates: Months 12, 24, 36, 48.

Individual CDP

Preparation of individual Career Development Plans.

Modulation of immune-pathogen interaction by NP

Report encompassing the joint results of individual projects 1, 2, 3, 5, 6, 7, 8, 10.

PhD thesis

PhD thesis for all ESR.

SSC activities

Organisation of Short Scientific Courses. Multiple delivery dates: Months 10, 22, 34.

Recruitment

Report on the recruitment process, including publication of call, CV evaluation, interview outcome, final decision on the fellows.

SCT activities

Organisation of Short Courses of Transferrable training (SCT). Multiple delivery dates: Months 16, 28, 40.

Website

Development of the project website.

Scientific meetings

Scientific meetings organisation. Multiple delivery dates: Months 10, 22, 34.

Final Workshop

Final Workshop organisation.

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Pubblicazioni

Probing safety of nanoparticles by outlining sea urchin sensing and signaling cascades

Autori: Andi Alijagic, Annalisa Pinsino
Pubblicato in: Ecotoxicology and Environmental Safety, 144, 2017, Page(s) 416-421, ISSN 0147-6513
Editore: Academic Press
DOI: 10.1016/j.ecoenv.2017.06.060

Formation of the Protein Corona: The Interface between Nanoparticles and the Immune System

Autori: Francesco Barbero, Lorenzo Russo, Michele Vitali, Jordi Piella, Ignacio Salvo, Mireya L. Borrajo, Marti Busquets-Fité, Rita Grandori, Neus G. Bastús, Eudald Casals, Victor Puntes
Pubblicato in: Seminars in Immunology, 34, 2017, Page(s) 52-60, ISSN 1044-5323
Editore: Academic Press
DOI: 10.1016/j.smim.2017.10.001

Sea Urchin Extracellular Proteins Design a Complex Protein Corona on Titanium Dioxide Nanoparticle Surface Influencing Immune Cell Behavior

Autori: Andi Alijagic, Oldřich Benada, Olga Kofroňová, Diego Cigna, Annalisa Pinsino
Pubblicato in: Frontiers in Immunology, 10, 2019, ISSN 1664-3224
Editore: -
DOI: 10.3389/fimmu.2019.02261

Effects of nanosilver on Mytilus galloprovincialis hemocytes and early embryo development

Autori: M. Auguste, C. Ciacci, T. Balbi, A. Brunelli, V. Caratto, A. Marcomini, R. Cuppini, L. Canesi
Pubblicato in: Aquatic Toxicology, 203, 2018, Page(s) 107-116, ISSN 0166-445X
Editore: Elsevier BV
DOI: 10.1016/j.aquatox.2018.08.005

In vivo immunomodulatory and antioxidant properties of nanoceria (nCeO2) in the marine mussel Mytilus galloprovincialis

Autori: M. Auguste, T. Balbi, M. Montagna, R. Fabbri, M. Sendra, J. Blasco, L. Canesi
Pubblicato in: Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 219, 2019, Page(s) 95-102, ISSN 1532-0456
Editore: Elsevier BV
DOI: 10.1016/j.cbpc.2019.02.006

Exposure to TiO2 nanoparticles induces shifts in the microbiota composition of Mytilus galloprovincialis hemolymph

Autori: Manon Auguste, Aide Lasa, Alberto Pallavicini, Stefano Gualdi, Luigi Vezzulli, Laura Canesi
Pubblicato in: Science of The Total Environment, 670, 2019, Page(s) 129-137, ISSN 0048-9697
Editore: Elsevier BV
DOI: 10.1016/j.scitotenv.2019.03.133

Interaction of engineered nanomaterials with the immune system: Health-related safety and possible benefits

Autori: Diana Boraschi, Benjamin J. Swartzwelter, Paola Italiani
Pubblicato in: Current Opinion in Toxicology, 10, 2018, Page(s) 74-83, ISSN 2468-2020
Editore: -
DOI: 10.1016/j.cotox.2018.02.002

IL-1β induces expression of costimulatory molecules and cytokines but not immune feedback regulators in dendritic cells

Autori: Sara Michelini, Muamera Sarajlic, Albert Duschl, Jutta Horejs-Hoeck
Pubblicato in: Human Immunology, 79/8, 2018, Page(s) 610-615, ISSN 0198-8859
Editore: Elsevier BV
DOI: 10.1016/j.humimm.2018.06.002

Sea urchin Paracentrotus lividus immune cells in culture: formulation of the appropriate harvesting and culture media and maintenance conditions

Autori: Annalisa Pinsino, Andi Alijagic
Pubblicato in: Biology Open, 8/3, 2019, Page(s) bio039289, ISSN 2046-6390
Editore: -
DOI: 10.1242/bio.039289

First person – Annalisa Pinsino and Andi Alijagic

Autori: A. Pinsino, and A. Alijagic
Pubblicato in: Biology Open, 8/3, 2019, Page(s) bio042242, ISSN 2046-6390
Editore: -
DOI: 10.1242/bio.042242

Developmental and Immune Role of a Novel Multiple Cysteine Cluster TLR From Eisenia andrei Earthworms

Autori: Petra Prochazkova, Radka Roubalova, Frantisek Skanta, Jiri Dvorak, Natividad Isabel Navarro Pacheco, Miroslav Kolarik, Martin Bilej
Pubblicato in: Frontiers in Immunology, 10, 2019, ISSN 1664-3224
Editore: -
DOI: 10.3389/fimmu.2019.01277

Titanium dioxide nanoparticles temporarily influence the sea urchin immunological state suppressing inflammatory-relate gene transcription and boosting antioxidant metabolic activity

Autori: Andi Alijagic, Daniela Gaglio, Elisabetta Napodano, Roberta Russo, Caterina Costa, Oldřich Benada, Olga Kofroňová, Annalisa Pinsino
Pubblicato in: Journal of Hazardous Materials, 384, 2020, Page(s) 121389, ISSN 0304-3894
Editore: Elsevier BV
DOI: 10.1016/j.jhazmat.2019.121389

Pattern recognition receptors in annelids

Autori: P. Prochazkova, R. Roubalova, J. Dvorak, N.I. Navarro Pacheco, M. Bilej
Pubblicato in: Developmental & Comparative Immunology, 102, 2020, Page(s) 103493, ISSN 0145-305X
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.dci.2019.103493

Shift in Immune Parameters After Repeated Exposure to Nanoplastics in the Marine Bivalve Mytilus

Autori: Manon Auguste, Teresa Balbi, Caterina Ciacci, Barbara Canonico, Stefano Papa, Alessio Borello, Luigi Vezzulli, Laura Canesi
Pubblicato in: Frontiers in Immunology, 11, 2020, Page(s) 426, ISSN 1664-3224
Editore: -
DOI: 10.3389/fimmu.2020.00426

Dynamic Equilibrium in the Cetyltrimethylammonium Bromide–Au Nanoparticle Bilayer, and the Consequent Impact on the Formation of the Nanoparticle Protein Corona

Autori: Francesco Barbero, Oscar H. Moriones, Neus G. Bastús, Victor Puntes
Pubblicato in: Bioconjugate Chemistry, 30/11, 2019, Page(s) 2917-2930, ISSN 1043-1802
Editore: American Chemical Society
DOI: 10.1021/acs.bioconjchem.9b00624

Surface Exposure of PEG and Amines on Biodegradable Nanoparticles as a Strategy to Tune Their Interaction with Protein-Rich Biological Media

Autori: Claudia Conte, Giovanni Dal Poggetto, Benjamin J. Swartzwelter, Diletta Esposito, Francesca Ungaro, Paola Laurienzo, Diana Boraschi, Fabiana Quaglia
Pubblicato in: Nanomaterials, 9/10, 2019, Page(s) 1354, ISSN 2079-4991
Editore: -
DOI: 10.3390/nano9101354

Addressing Nanomaterial Immunosafety by Evaluating Innate Immunity across Living Species

Autori: Diana Boraschi, Andi Alijagic, Manon Auguste, Francesco Barbero, Eleonora Ferrari, Szabolcs Hernadi, Craig Mayall, Sara Michelini, Natividad I. Navarro Pacheco, Alessandra Prinelli, Elmer Swart, Benjamin J. Swartzwelter, Neus G. Bastús, Laura Canesi, Damjana Drobne, Albert Duschl, Marie‐Ann Ewart, Jutta Horejs‐Hoeck, Paola Italiani, Birgit Kemmerling, Peter Kille, Petra Prochazkova, Victor F.
Pubblicato in: Small, 16/21, 2020, Page(s) 2000598, ISSN 1613-6810
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202000598

Mechanisms of particles in sensitization, effector function and therapy of allergic disease.

Autori: A.I. Joubert, M. Geppert, L. Johnson, R. Mills-Goodlet, S. Michelini, E. Korotchenko, A. Duschl, R. Weiss, J. Horejs-Höck and M. Himly
Pubblicato in: Front. Immunol, 11, 2020, Page(s) 1334
Editore: -
DOI: 10.3389/fimmu.2020.01334

Gold Nanoparticles Modulate BCG-Induced Innate Immune Memory in Human Monocytes by Shifting the Memory Response towards Tolerance

Autori: Benjamin J. Swartzwelter, Francesco Barbero, Alessandro Verde, Maria Mangini, Marinella Pirozzi, Anna Chiara De Luca, Victor F. Puntes, Luciana C. C. Leite, Paola Italiani, Diana Boraschi
Pubblicato in: Cells, 9/2, 2020, Page(s) 284, ISSN 2073-4409
Editore: -
DOI: 10.3390/cells9020284

The Effects of in Vivo Exposure to Copper Oxide Nanoparticles on the Gut Microbiome, Host Immunity and Susceptibility to a Bacterial Infection in Earthworms

Autori: Elmer Swart, Jiri Dvorak, Szabolcs Hernádi, Tim Goodall, Peter Kille, David Spurgeon, Claus Svendsen and Petra Prochazkova
Pubblicato in: Nanomaterials, 10, 2020, Page(s) 1337
Editore: -
DOI: 10.3390/nano10071337

Annelida: Environmental Interactions and Ecotoxicity in Relation to the Earthworm Immune System

Autori: Radka Roubalová, Barbara Płytycz, Petra Procházková, Natividad Isabel Navarro Pacheco, Martin Bilej
Pubblicato in: Advances in Comparative Immunology, 2018, Page(s) 933-951, ISBN 978-3-319-76767-3
Editore: Springer International Publishing
DOI: 10.1007/978-3-319-76768-0_27