Probing safety of nano-objects by defining immune responses of environmental organisms

Informations projet

PANDORA

N° de convention de subvention: 671881

DOI

10.3030/671881

Projet clôturé

Date de signature de la CE 10 Août 2015

Date de début 1 Janvier 2016

Date de fin 31 Decembre 2019

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total

€ 2 814 491,16

Contribution de l’UE

€ 2 814 491,16

Coordonné par

CONSIGLIO NAZIONALE DELLE RICERCHE
Italy

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (15)

NP interaction with innate immune cells/receptors

Report encompassing the joint results of individual projects 1, 2, 3, 5, 10, 11.

Industrial outreach

Reports on industrial outreach activities Multiple delivery dates Months 18 30 42

Local training

Reports on local training activities. Multiple delivery dates: Months 18, 30, 42.

Secondments

Reports on secondments Multiple delivery dates Months 25 43

Setting up immuno-risk predictive cell-based in vitro assays

Report encompassing the joint results of individual projects 1, 2, 3, 9, 11.

Virtual outreach

Reports on virtual outreach activities. Multiple delivery dates: Months 18, 30, 42.

Defining biomarkers of environmental immuno-risk

Report encompassing the joint results of individual projects 1-11.

Academic outreach

Reports on academic outreach activities. Multiple delivery dates: Months 18, 30, 42.

Dissemination

Reports on dissemination activities. Multiple delivery dates: Months 12, 24, 36, 48.

Individual CDP

Preparation of individual Career Development Plans.

Modulation of immune-pathogen interaction by NP

Report encompassing the joint results of individual projects 1, 2, 3, 5, 6, 7, 8, 10.

PhD thesis

PhD thesis for all ESR.

SSC activities

Organisation of Short Scientific Courses. Multiple delivery dates: Months 10, 22, 34.

Recruitment

Report on the recruitment process, including publication of call, CV evaluation, interview outcome, final decision on the fellows.

SCT activities

Organisation of Short Courses of Transferrable training (SCT). Multiple delivery dates: Months 16, 28, 40.

Websites, patent fillings, videos etc. (1)

Website

Development of the project website.

Other (2)

Scientific meetings

Scientific meetings organisation. Multiple delivery dates: Months 10, 22, 34.

Final Workshop

Final Workshop organisation.

Publications

Peer reviewed articles (20)

Probing safety of nanoparticles by outlining sea urchin sensing and signaling cascades

Auteurs: Andi Alijagic, Annalisa Pinsino
Publié dans: Ecotoxicology and Environmental Safety, Numéro 144, 2017, Page(s) 416-421, ISSN 0147-6513
Éditeur: Academic Press
DOI: 10.1016/j.ecoenv.2017.06.060

Formation of the Protein Corona: The Interface between Nanoparticles and the Immune System

Auteurs: Francesco Barbero, Lorenzo Russo, Michele Vitali, Jordi Piella, Ignacio Salvo, Mireya L. Borrajo, Marti Busquets-Fité, Rita Grandori, Neus G. Bastús, Eudald Casals, Victor Puntes
Publié dans: Seminars in Immunology, Numéro 34, 2017, Page(s) 52-60, ISSN 1044-5323
Éditeur: Academic Press
DOI: 10.1016/j.smim.2017.10.001

Sea Urchin Extracellular Proteins Design a Complex Protein Corona on Titanium Dioxide Nanoparticle Surface Influencing Immune Cell Behavior

Auteurs: Andi Alijagic, Oldřich Benada, Olga Kofroňová, Diego Cigna, Annalisa Pinsino
Publié dans: Frontiers in Immunology, Numéro 10, 2019, ISSN 1664-3224
Éditeur: -
DOI: 10.3389/fimmu.2019.02261

Effects of nanosilver on Mytilus galloprovincialis hemocytes and early embryo development

Auteurs: M. Auguste, C. Ciacci, T. Balbi, A. Brunelli, V. Caratto, A. Marcomini, R. Cuppini, L. Canesi
Publié dans: Aquatic Toxicology, Numéro 203, 2018, Page(s) 107-116, ISSN 0166-445X
Éditeur: Elsevier BV
DOI: 10.1016/j.aquatox.2018.08.005

In vivo immunomodulatory and antioxidant properties of nanoceria (nCeO2) in the marine mussel Mytilus galloprovincialis

Auteurs: M. Auguste, T. Balbi, M. Montagna, R. Fabbri, M. Sendra, J. Blasco, L. Canesi
Publié dans: Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, Numéro 219, 2019, Page(s) 95-102, ISSN 1532-0456
Éditeur: Elsevier BV
DOI: 10.1016/j.cbpc.2019.02.006

Exposure to TiO2 nanoparticles induces shifts in the microbiota composition of Mytilus galloprovincialis hemolymph

Auteurs: Manon Auguste, Aide Lasa, Alberto Pallavicini, Stefano Gualdi, Luigi Vezzulli, Laura Canesi
Publié dans: Science of The Total Environment, Numéro 670, 2019, Page(s) 129-137, ISSN 0048-9697
Éditeur: Elsevier BV
DOI: 10.1016/j.scitotenv.2019.03.133

Interaction of engineered nanomaterials with the immune system: Health-related safety and possible benefits

Auteurs: Diana Boraschi, Benjamin J. Swartzwelter, Paola Italiani
Publié dans: Current Opinion in Toxicology, Numéro 10, 2018, Page(s) 74-83, ISSN 2468-2020
Éditeur: -
DOI: 10.1016/j.cotox.2018.02.002

IL-1β induces expression of costimulatory molecules and cytokines but not immune feedback regulators in dendritic cells

Auteurs: Sara Michelini, Muamera Sarajlic, Albert Duschl, Jutta Horejs-Hoeck
Publié dans: Human Immunology, Numéro 79/8, 2018, Page(s) 610-615, ISSN 0198-8859
Éditeur: Elsevier BV
DOI: 10.1016/j.humimm.2018.06.002

Sea urchin Paracentrotus lividus immune cells in culture: formulation of the appropriate harvesting and culture media and maintenance conditions

Auteurs: Annalisa Pinsino, Andi Alijagic
Publié dans: Biology Open, Numéro 8/3, 2019, Page(s) bio039289, ISSN 2046-6390
Éditeur: -
DOI: 10.1242/bio.039289

First person – Annalisa Pinsino and Andi Alijagic

Auteurs: A. Pinsino, and A. Alijagic
Publié dans: Biology Open, Numéro 8/3, 2019, Page(s) bio042242, ISSN 2046-6390
Éditeur: -
DOI: 10.1242/bio.042242

Developmental and Immune Role of a Novel Multiple Cysteine Cluster TLR From Eisenia andrei Earthworms

Auteurs: Petra Prochazkova, Radka Roubalova, Frantisek Skanta, Jiri Dvorak, Natividad Isabel Navarro Pacheco, Miroslav Kolarik, Martin Bilej
Publié dans: Frontiers in Immunology, Numéro 10, 2019, ISSN 1664-3224
Éditeur: -
DOI: 10.3389/fimmu.2019.01277

Titanium dioxide nanoparticles temporarily influence the sea urchin immunological state suppressing inflammatory-relate gene transcription and boosting antioxidant metabolic activity

Auteurs: Andi Alijagic, Daniela Gaglio, Elisabetta Napodano, Roberta Russo, Caterina Costa, Oldřich Benada, Olga Kofroňová, Annalisa Pinsino
Publié dans: Journal of Hazardous Materials, Numéro 384, 2020, Page(s) 121389, ISSN 0304-3894
Éditeur: Elsevier BV
DOI: 10.1016/j.jhazmat.2019.121389

Pattern recognition receptors in annelids

Auteurs: P. Prochazkova, R. Roubalova, J. Dvorak, N.I. Navarro Pacheco, M. Bilej
Publié dans: Developmental & Comparative Immunology, Numéro 102, 2020, Page(s) 103493, ISSN 0145-305X
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.dci.2019.103493

Shift in Immune Parameters After Repeated Exposure to Nanoplastics in the Marine Bivalve Mytilus

Auteurs: Manon Auguste, Teresa Balbi, Caterina Ciacci, Barbara Canonico, Stefano Papa, Alessio Borello, Luigi Vezzulli, Laura Canesi
Publié dans: Frontiers in Immunology, Numéro 11, 2020, Page(s) 426, ISSN 1664-3224
Éditeur: -
DOI: 10.3389/fimmu.2020.00426

Dynamic Equilibrium in the Cetyltrimethylammonium Bromide–Au Nanoparticle Bilayer, and the Consequent Impact on the Formation of the Nanoparticle Protein Corona

Auteurs: Francesco Barbero, Oscar H. Moriones, Neus G. Bastús, Victor Puntes
Publié dans: Bioconjugate Chemistry, Numéro 30/11, 2019, Page(s) 2917-2930, ISSN 1043-1802
Éditeur: American Chemical Society
DOI: 10.1021/acs.bioconjchem.9b00624

Surface Exposure of PEG and Amines on Biodegradable Nanoparticles as a Strategy to Tune Their Interaction with Protein-Rich Biological Media

Auteurs: Claudia Conte, Giovanni Dal Poggetto, Benjamin J. Swartzwelter, Diletta Esposito, Francesca Ungaro, Paola Laurienzo, Diana Boraschi, Fabiana Quaglia
Publié dans: Nanomaterials, Numéro 9/10, 2019, Page(s) 1354, ISSN 2079-4991
Éditeur: -
DOI: 10.3390/nano9101354

Addressing Nanomaterial Immunosafety by Evaluating Innate Immunity across Living Species

Auteurs: Diana Boraschi, Andi Alijagic, Manon Auguste, Francesco Barbero, Eleonora Ferrari, Szabolcs Hernadi, Craig Mayall, Sara Michelini, Natividad I. Navarro Pacheco, Alessandra Prinelli, Elmer Swart, Benjamin J. Swartzwelter, Neus G. Bastús, Laura Canesi, Damjana Drobne, Albert Duschl, Marie‐Ann Ewart, Jutta Horejs‐Hoeck, Paola Italiani, Birgit Kemmerling, Peter Kille, Petra Prochazkova, Victor F.
Publié dans: Small, Numéro 16/21, 2020, Page(s) 2000598, ISSN 1613-6810
Éditeur: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202000598

Mechanisms of particles in sensitization, effector function and therapy of allergic disease.

Auteurs: A.I. Joubert, M. Geppert, L. Johnson, R. Mills-Goodlet, S. Michelini, E. Korotchenko, A. Duschl, R. Weiss, J. Horejs-Höck and M. Himly
Publié dans: Front. Immunol, Numéro 11, 2020, Page(s) 1334
Éditeur: -
DOI: 10.3389/fimmu.2020.01334

Gold Nanoparticles Modulate BCG-Induced Innate Immune Memory in Human Monocytes by Shifting the Memory Response towards Tolerance

Auteurs: Benjamin J. Swartzwelter, Francesco Barbero, Alessandro Verde, Maria Mangini, Marinella Pirozzi, Anna Chiara De Luca, Victor F. Puntes, Luciana C. C. Leite, Paola Italiani, Diana Boraschi
Publié dans: Cells, Numéro 9/2, 2020, Page(s) 284, ISSN 2073-4409
Éditeur: -
DOI: 10.3390/cells9020284

The Effects of in Vivo Exposure to Copper Oxide Nanoparticles on the Gut Microbiome, Host Immunity and Susceptibility to a Bacterial Infection in Earthworms

Auteurs: Elmer Swart, Jiri Dvorak, Szabolcs Hernádi, Tim Goodall, Peter Kille, David Spurgeon, Claus Svendsen and Petra Prochazkova
Publié dans: Nanomaterials, Numéro 10, 2020, Page(s) 1337
Éditeur: -
DOI: 10.3390/nano10071337

Book chapters (1)

Annelida: Environmental Interactions and Ecotoxicity in Relation to the Earthworm Immune System

Auteurs: Radka Roubalová, Barbara Płytycz, Petra Procházková, Natividad Isabel Navarro Pacheco, Martin Bilej
Publié dans: Advances in Comparative Immunology, 2018, Page(s) 933-951, ISBN 978-3-319-76767-3
Éditeur: Springer International Publishing
DOI: 10.1007/978-3-319-76768-0_27