Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility
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Autori:
Ana Angulo-Urarte, Pedro Casado, Sandra D. Castillo, Piotr Kobialka, Maria Paraskevi Kotini, Ana M. Figueiredo, Pau Castel, Vinothini Rajeeve, Maria Milà-Guasch, Jaime Millan, Cora Wiesner, Helena Serra, Laia Muixi, Oriol Casanovas, Francesc Viñals, Markus Affolter, Holger Gerhardt, Stephan Huveneers, Heinz-Georg Belting, Pedro R. Cutillas, Mariona Graupera
Pubblicato in:
Nature Communications, Numero 9/1, 2018, ISSN 2041-1723
Editore:
Nature Publishing Group
DOI:
10.1038/s41467-018-07172-3
5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology
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Autori:
Florent Beaufils, Natasa Cmiljanovic, Vladimir Cmiljanovic, Thomas Bohnacker, Anna Melone, Romina Marone, Eileen Jackson, Xuxiao Zhang, Alexander Sele, Chiara Borsari, Jürgen Mestan, Paul Hebeisen, Petra Hillmann, Bernd Giese, Marketa Zvelebil, Doriano Fabbro, Roger L. Williams, Denise Rageot, Matthias P. Wymann
Pubblicato in:
Journal of Medicinal Chemistry, Numero 60/17, 2017, Pagina/e 7524-7538, ISSN 0022-2623
Editore:
American Chemical Society
DOI:
10.1021/acs.jmedchem.7b00930
The role of metabolic adaptation to nutrient stress in pancreatic cancer
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Autori:
Abhishek Derle, Maria Chiara De Santis, Luca Gozzelino, Edoardo Ratto, Miriam Martini
Pubblicato in:
Cell Stress, Numero 2/12, 2018, Pagina/e 332-339, ISSN 2523-0204
Editore:
Shared Science Publishers
DOI:
10.15698/cst2018.12.166
Signal-Targeted Therapies and Resistance Mechanisms in Pancreatic Cancer: Future Developments Reside in Proteomics
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Autori:
Célia Cintas, Thibaut Douché, Nicole Therville, Silvia Arcucci, Fernanda Ramos-Delgado, Céline Basset, Benoît Thibault, Julie Guillermet-Guibert
Pubblicato in:
Cancers, Numero 10/6, 2018, Pagina/e 174, ISSN 2072-6694
Editore:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/cancers10060174
Experimental pancreatic cancer develops in soft pancreas: novel leads for an individualized diagnosis by ultrafast elasticity imaging
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Autori:
Nicole Therville, Silvia Arcucci, Aurélie Vertut, Fernanda Ramos-Delgado, Dina Ferreira Da Mota, Marlène Dufresne, Céline Basset, Julie Guillermet-Guibert
Pubblicato in:
Theranostics, Numero 9/22, 2019, Pagina/e 6369-6379, ISSN 1838-7640
Editore:
Ivyspring International Publisher
DOI:
10.7150/thno.34066
