Deliverables Documents, reports (20) Validation of the array used for whole blood leukocyte DNA analyses Techniques used include in vivo and in vitro models of sepsis and immunosuppression; leukocyte purification and functional assays; FACS analysis; ELISA; molecular biology; microscopy. Assessment of sequential trial versus a more standard clinical trial Assessment of sequential trial versus a more standard clinical trial Assessment of epigenetic signatures and DNA methylation marks in sepsis Assessment of epigenetic signatures and DNA methylation marks in sepsis Signed PCDPs ESR's PCDP's Analysis of markers such as PTX3marker, TIR8 and MSF as markers for the anti inflammatory phase of sepsis Analysis of markers such as PTX3marker, TIR8 and MSF as markers for the anti inflammatory phase of sepsis Identification of potential utility of therapies (by confirmation of reversibility) directed towards mitochondrial protection, or stimulation of mitochondrial turnover Identification of potential utility of therapies (by confirmation of reversibility) directed towards mitochondrial protection, or stimulation of mitochondrial turnover Design of a fully integrated molecular tool to manage sepsis patients based on their immune status: a proof of concept Design of a fully integrated molecular tool to manage sepsis patients based on their immune status: a proof of concept ESR training certificates granted to ESRs ESR training certificates granted to ESRs Further caracterisation of MDSC subpopulations Further caracterisation of MDSC subpopulations Data on patient flows and sepsis provided by partners for development of computer model. Data on patient flows and sepsis provided by partners for development of computer model. Report of studies with PTX3, TIR8 and IRAK-M targeted mice in murine models of sepsis Report of studies with PTX3, TIR8 and IRAK-M targeted mice in murine models of sepsis Technology set up for the of DNA methylation probes of isolated cell fractions which can be used as prognostic markers in sepsis patients Technology set up for the of DNA methylation probes of isolated cell fractions which can be used as prognostic markers in sepsis patients Impact of putative therapies on reversing immune dysfunction in white cells Impact of putative therapies on reversing immune dysfunction in white cells Validation of the primers and setup the Fluidigm technology for analysing MDSC Validation of the primers and setup the Fluidigm technology for analysing MDSC Proof of principle on testing therapeutic potential of PTX3 and IRAK-M modulation and potential identification of early biomarkers of immune dysfunction Proof of principle on testing therapeutic potential of PTX3 and IRAK-M modulation and potential identification of early biomarkers of immune dysfunction Comparison of data from cell- and in vivo models to data obtained from human sepsis samples and confirmation of a relationship (both temporal and severity) between immune and mitochondrial function in white cell subsets Comparison of data from cell- and in vivo models to data obtained from human sepsis samples and confirmation of a relationship (both temporal and severity) between immune and mitochondrial function in white cell subsets Validation of DNA methylation probes of isolated cell fractions Validation of DNA methylation probes of isolated cell fractions Temporal comparison of immune and bioenergetic function in models of sepsis Temporal comparison of immune and bioenergetic function in models of sepsis Characterisation of the involvement of factors such as IRAK-M, PTX3 and TIR8 in sepsis-induced immunosuppression Partner ICH is in the lead for the characterisation of involvement of factors such as IRAK-M, PTX3 and TIR8 in sepsis-induced immunosuppression. AMC is the other partner involved. Validation of PTX3, TIR8 and MSF as novel biomarkers of sepsis, to be translated to the clinic Validation of PTX3, TIR8 and MSF as novel biomarkers of sepsis, to be translated to the clinic Websites, patent fillings, videos etc. (1) First online version of network public multi modality website First online version of network public website (with multimodality options) Publications Peer reviewed articles (26) Host cystathionine-γ lyase derived hydrogen sulfide protects against Pseudomonas aeruginosa sepsis. Author(s): Georgios Renieris; Dionysia-Eirini Droggiti; Konstantina Katrini; Panagiotis Koufargyris; Theologia Gkavogianni; Eleni Karakike; Nikolaos Antonakos; Georgia Damoraki; Athanasios Karageorgos; Labros Sabracos; Antonia Katsouda; Elisa Jentho; Sebastian Weis; Rui Wang; Michael Bauer; Csaba Szabo; Kalliopi Platoni; Vasilios Kouloulias; Andreas Papapetropoulos; Evangelos J. Giamarellos-Bourboulis Published in: PLoS Pathogens, Issue 5, 2021, ISSN 1553-7366 Publisher: Public Library of Science DOI: 10.1371/journal.ppat.1009473 Pulmonary and intestinal microbiota dynamics during Gram-negative pneumonia-derived sepsis Author(s): Wolff, Nora S.; Jacobs, Max C.; Wiersinga, W. Joost; Hugenholtz, Floor Published in: Intensive Care Medicine Experimental, Vol 9, Iss 1, Pp 1-14 (2021), Issue 21, 2021, ISSN 2197-425X Publisher: Springer Open DOI: 10.1186/s40635-021-00398-4 ICU capacity management during the COVID-19 pandemic using a process simulation. Author(s): Alban, Andres; Chick, Stephen E.; Dongelmans, Dave A.; Vlaar, Alexander P. J.; Sent, Danielle; van der Sluijs, Alexander F.; Wiersinga, W. Joost Published in: Intensive care medicine, 46(8), 1624 - 1626. Springer Verlag, Issue 27, 2020, ISSN 0342-4642 Publisher: Springer Verlag DOI: 10.1007/s00134-020-06066-7 Staphylococcus Aureus Osteomyelitis as an Inducer of Tolerance to Escherichia Coli Pyelonephritis: an Experimental Study Author(s): Stavros Goumenos; Olga D. Savvidou; George Renieris; Theologia Gkavogianni; Panayiotis J. Papagelopoulos; Evangelos J. Giamarellos-Bourboulis Published in: Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020), Issue 30, 2020, ISSN 2045-2322 Publisher: Nature Publishing Group DOI: 10.1038/s41598-020-58420-w Source of Circulating Pentraxin 3 in Septic Shock Patients. Author(s): Chloé Albert Vega; Chloé Albert Vega; Marine Mommert; Marine Mommert; Mathilde Boccard; Mathilde Boccard; Thomas Rimmelé; Thomas Rimmelé; Fabienne Venet; Fabienne Venet; Alexandre Pachot; Veronique Leray; Guillaume Monneret; Guillaume Monneret; Benjamin Delwarde; Karen Brengel-Pesce; Karen Brengel-Pesce; François Mallet; François Mallet; François Mallet; Sophie Trouillet-Assant; Sophie Trou Published in: Frontiers in Immunology, Issue 4, 2019, ISSN 1664-3224 Publisher: Frontiers media SA DOI: 10.3389/fimmu.2018.03048 Immune Profiling Panel: a proof of concept study of a new multiplex molecular tool to assess the immune status of critically-ill patients Author(s): Tawfik, Dina M.; Vachot, Laurence; Bocquet, Adeline; Venet, Fabienne; Rimmelé, Thomas; Monneret, Guillaume; Blein, Sophie; Montogomery, Jesse L.; Hemmert, Andrew C.; Pachot, Alexandre; Moucadel, Virginie; Marcos, Javier Yugueros; Brengel-Pesce, Karen; Mallet, François; Textoris, Julien Published in: The Journal of Infectious Diseases, Issue 19, 2020, ISSN 1537-6613 Publisher: Oxford University press DOI: 10.1093/infdis/jiaa248 Melioidosis Author(s): W. Joost Wiersinga, Harjeet S. Virk, Alfredo G. Torres, Bart J. Currie, Sharon J. Peacock, David A. B. Dance, Direk Limmathurotsakul Published in: Nature Reviews Disease Primers, Issue 4, 2018, Page(s) 17107, ISSN 2056-676X Publisher: Nature reviews DOI: 10.1038/nrdp.2017.107 The emerging role of the microbiota in the ICU Author(s): Nora Suzanne Wolff, Floor Hugenholtz, Willem Joost Wiersinga Published in: Critical Care, Issue 22/1, 2018, ISSN 1364-8535 Publisher: BioMed Central- Springer nature DOI: 10.1186/s13054-018-1999-8 Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection Author(s): Eleonora Ciarlo, Tytti Heinonen, Charlotte Théroude, Jacobus Herderschee, Matteo Mombelli, Jérôme Lugrin, Marc Pfefferlé, Beatrice Tyrrell, Sarah Lensch, Hans Acha-Orbea, Didier Le Roy, Johan Auwerx, Thierry Roger Published in: Frontiers in Immunology, Issue 8, 2017, ISSN 1664-3224 Publisher: Frontiers in Immunology DOI: 10.3389/fimmu.2017.01037 Immune Functional Assays, From Custom to Standardized Tests for Precision Medicine Author(s): Chloé Albert-Vega, Dina M. Tawfik, Sophie Trouillet-Assant, Laurence Vachot, François Mallet, Julien Textoris Published in: Frontiers in Immunology, Issue 9, 2018, Page(s) 1-9, ISSN 1664-3224 Publisher: Frontiers DOI: 10.3389/fimmu.2018.02367 Sirtuin 5 Deficiency Does Not Compromise Innate Immune Responses to Bacterial Infections Author(s): Tytti Heinonen, Eleonora Ciarlo, Charlotte Théroude, Aimilia Pelekanou, Jacobus Herderschee, Didier Le Roy, Thierry Roger Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224 Publisher: Frontiers DOI: 10.3389/fimmu.2018.02675 Late Peaks of HMGB1 and Sepsis Outcome Author(s): Eleni Karakike, Maria-Evangelia Adami, Malvina Lada, Theologia Gkavogianni, Ioannis M. Koutelidakis, Michael Bauer, Evangelos J. Giamarellos-Bourboulis, Iraklis Tsangaris Published in: SHOCK, 2019, Page(s) 1, ISSN 1073-2322 Publisher: Lippincott Williams & Wilkins Ltd. DOI: 10.1097/shk.0000000000001265 Myeloid-Derived Suppressor Cells in Sepsis Author(s): Irene T. Schrijver, Charlotte Théroude, Thierry Roger Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224 Publisher: Frontiers Media SA DOI: 10.3389/fimmu.2019.00327 Macrophage Activation-Like Syndrome: A Distinct Entity Leading to Early Death in Sepsis Author(s): Eleni Karakike, Evangelos J. Giamarellos-Bourboulis Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224 Publisher: Frontiers Media SA DOI: 10.3389/fimmu.2019.00055 Trained immunity confers broad-spectrum protection against bacterial infections Author(s): Eleonora Ciarlo, Tytti Heinonen, Charlotte Théroude, Fatemeh Asgari, Didier Le Roy, Mihai G Netea, Thierry Roger Published in: The Journal of Infectious Diseases, 2019, ISSN 0022-1899 Publisher: University of Chicago Press DOI: 10.1093/infdis/jiz692 The early change of SOFA score as a prognostic marker of 28-day sepsis mortality: analysis through a derivation and a validation cohort Author(s): Eleni Karakike, Evdoxia Kyriazopoulou, Iraklis Tsangaris, Christina Routsi, Jean-Louis Vincent, Evangelos J. Giamarellos-Bourboulis Published in: Critical Care, Issue 23/1, 2019, ISSN 1364-8535 Publisher: Springer Nature DOI: 10.1186/s13054-019-2665-5 Daptomycin as adjunctive treatment for experimental infection by Acinetobacter baumannii with resistance to colistin Author(s): Garyfallia Poulakou, Georgios Renieris, Labros Sabrakos, Olympia Zarkotou, Katherine Themeli-Digalaki, Efstathia Perivolioti, Eleni Kraniotaki, Evangelos J. Giamarellos-Bourboulis, Nikolaos Zavras Published in: International Journal of Antimicrobial Agents, Issue 53/2, 2019, Page(s) 190-194, ISSN 0924-8579 Publisher: Elsevier BV DOI: 10.1016/j.ijantimicag.2018.10.024 Early increase of VEGF-A is associated with resolution of ventilator-associated pneumonia: Clinical and experimental evidence Author(s): Ioannis Strouvalis, Christina Routsi, Maria Adamopoulou, Maria Raftogiannis, George Renieris, Stylianos E. Orfanos, Anastasia Kotanidou, Labros Sabracos, Evangelos J. Giamarellos-Bourboulis Published in: Respirology, Issue 23/10, 2018, Page(s) 942-949, ISSN 1323-7799 Publisher: Blackwell Publishing Inc. DOI: 10.1111/resp.13320 Staphylococcus Aureus Osteomyelitis as an Inducer of Tolerance to Escherichia Coli Pyelonephritis: an Experimental Study Author(s): Stavros Goumenos, Olga Savvidou, George Renieris, Theologia Gkavogianni, Panayiotis J. Papagelopoulos, Evangelos J. Giamarellos-Bourboulis Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322 Publisher: Nature Publishing Group DOI: 10.1038/s41598-020-58420-w The Long Pentraxin PTX3 as a Humoral Innate Immunity Functional Player and Biomarker of Infections and Sepsis Author(s): Rémi Porte, Sadaf Davoudian, Fatemeh Asgari, Raffaella Parente, Alberto Mantovani, Cecilia Garlanda, Barbara Bottazzi Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224 Publisher: Europa PMC DOI: 10.3389/fimmu.2019.00794 Association of modulation of pro‐inflammatory responses by dectin‐2 with preterm delivery: An experimental model Author(s): Aspasia Liassidou, Georgios Renieris, Dionysia‐Irene Droggiti, Theologia Gkavogianni, Christakis Liassides, Labros Sabracos, Evangelos J. Giamarellos‐Bourboulis, Charalampos S. Siristatidis Published in: American Journal of Reproductive Immunology, Issue 83/3, 2019, ISSN 1046-7408 Publisher: Blackwell Publishing Inc. DOI: 10.1111/aji.13216 Impact of antimicrobial therapy on the gut microbiome Author(s): Amira A Bhalodi, Tjitske S R van Engelen, Harjeet S Virk, W Joost Wiersinga Published in: Journal of Antimicrobial Chemotherapy, Issue 74/Supplement_1, 2019, Page(s) i6-i15, ISSN 0305-7453 Publisher: Oxford University Press DOI: 10.1093/jac/dky530 Global burden of melioidosis in 2015: a systematic review and data synthesis Author(s): Emma Birnie, Harjeet S Virk, Jelmer Savelkoel, Rene Spijker, Eric Bertherat, David A B Dance, Direk Limmathurotsakul, Brecht Devleesschauwer, Juanita A Haagsma, W Joost Wiersinga Published in: The Lancet Infectious Diseases, Issue 19/8, 2019, Page(s) 892-902, ISSN 1473-3099 Publisher: The Lancet Publishing Group DOI: 10.1016/s1473-3099(19)30157-4 Macrophage migration inhibitory factor promotes the migration of dendritic cells through CD74 and the activation of the Src/PI3K/myosin II pathway. Author(s): Annette Ives; Didier Le Roy; Charlotte Théroude; Jürgen Bernhagen; Thierry Roger; Thierry Calandra Published in: Crossref, Issue 37, 2021, ISSN 0892-6638 Publisher: Federation of American Societies for Experimental Biology DOI: 10.1096/fj.202001605r Vendor effects on murine gut microbiota and its influence on lipopolysaccharide-induced lung inflammation and Gram-negative pneumonia Author(s): Nora S. Wolff; Max C. Jacobs; Bastiaan W. Haak; Joris J. T. H. Roelofs; Alex F. de Vos; Floor Hugenholtz; W. Joost Wiersinga Published in: Intensive Care Medicine Experimental volume, Issue 8, 47, 2020, ISSN 2197-425X Publisher: Springer open DOI: 10.1186/s40635-020-00336-w The Long Pentraxin PTX3 Controls Klebsiella Pneumoniae Severe Infection Author(s): Fatemeh Asgari; Fatemeh Asgari; Domenico Supino; Raffaella Parente; Nadia Polentarutti; Matteo Stravalaci; Matteo Stravalaci; Remi Porte; Fabio Pasqualini; Fabio Pasqualini; Marialuisa Barbagallo; Chiara Perucchini; Camilla Recordati; Elena Magrini; Andrea Mariancini; Federica Riva; Alessia Giordano; Sadaf Davoudian; Sadaf Davoudian; Thierry Roger; Cornelis van’t Veer; Sebastien Jaillon; Sebasti Published in: Frontiers in immunology, vol. 12, pp. 666198, Issue 34, 2021, ISSN 1664-3224 Publisher: Frontiers Media SA DOI: 10.3389/fimmu.2021.666198 Monographic books (1) Cancer Immunology - A Translational Medicine Context Author(s): Rezaei N. Authors. Tamara Gulic, Rita Silva-Gomes, Sadaf Davoudian, Marina Sironi, Paola Allavena, Alberto Mantovani, Barbara Bottazzi. Published in: 2020, ISBN 978-3-030-30845-2 Publisher: Springer, Cham DOI: 10.1007/978-3-030-30845-2 Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available
