European Sepsis Academy: towards new biomarkers to improve sepsis management

Livrables

Validation of the array used for whole blood leukocyte DNA analyses

Techniques used include in vivo and in vitro models of sepsis and immunosuppression; leukocyte purification and functional assays; FACS analysis; ELISA; molecular biology; microscopy.

Assessment of sequential trial versus a more standard clinical trial
Assessment of epigenetic signatures and DNA methylation marks in sepsis
Signed PCDPs

ESR's PCDP's

Analysis of markers such as PTX3marker, TIR8 and MSF as markers for the anti inflammatory phase of sepsis
Identification of potential utility of therapies (by confirmation of reversibility) directed towards mitochondrial protection, or stimulation of mitochondrial turnover
Design of a fully integrated molecular tool to manage sepsis patients based on their immune status: a proof of concept
ESR training certificates granted to ESRs
Further caracterisation of MDSC subpopulations
Data on patient flows and sepsis provided by partners for development of computer model.
Report of studies with PTX3, TIR8 and IRAK-M targeted mice in murine models of sepsis
Technology set up for the of DNA methylation probes of isolated cell fractions which can be used as prognostic markers in sepsis patients
Impact of putative therapies on reversing immune dysfunction in white cells
Validation of the primers and setup the Fluidigm technology for analysing MDSC
Proof of principle on testing therapeutic potential of PTX3 and IRAK-M modulation and potential identification of early biomarkers of immune dysfunction
Comparison of data from cell- and in vivo models to data obtained from human sepsis samples and confirmation of a relationship (both temporal and severity) between immune and mitochondrial function in white cell subsets
Validation of DNA methylation probes of isolated cell fractions
Temporal comparison of immune and bioenergetic function in models of sepsis
Characterisation of the involvement of factors such as IRAK-M, PTX3 and TIR8 in sepsis-induced immunosuppression

Partner ICH is in the lead for the characterisation of involvement of factors such as IRAK-M, PTX3 and TIR8 in sepsis-induced immunosuppression. AMC is the other partner involved.

Validation of PTX3, TIR8 and MSF as novel biomarkers of sepsis, to be translated to the clinic

First online version of network public multi modality website

First online version of network public website (with multimodality options)

Publications

Host cystathionine-γ lyase derived hydrogen sulfide protects against Pseudomonas aeruginosa sepsis.

Auteurs: Georgios Renieris; Dionysia-Eirini Droggiti; Konstantina Katrini; Panagiotis Koufargyris; Theologia Gkavogianni; Eleni Karakike; Nikolaos Antonakos; Georgia Damoraki; Athanasios Karageorgos; Labros Sabracos; Antonia Katsouda; Elisa Jentho; Sebastian Weis; Rui Wang; Michael Bauer; Csaba Szabo; Kalliopi Platoni; Vasilios Kouloulias; Andreas Papapetropoulos; Evangelos J. Giamarellos-Bourboulis
Publié dans: PLoS Pathogens, Numéro 5, 2021, ISSN 1553-7366
Éditeur: Public Library of Science
DOI: 10.1371/journal.ppat.1009473

Pulmonary and intestinal microbiota dynamics during Gram-negative pneumonia-derived sepsis

Auteurs: Wolff, Nora S.; Jacobs, Max C.; Wiersinga, W. Joost; Hugenholtz, Floor
Publié dans: Intensive Care Medicine Experimental, Vol 9, Iss 1, Pp 1-14 (2021), Numéro 21, 2021, ISSN 2197-425X
Éditeur: Springer Open
DOI: 10.1186/s40635-021-00398-4

ICU capacity management during the COVID-19 pandemic using a process simulation.

Auteurs: Alban, Andres; Chick, Stephen E.; Dongelmans, Dave A.; Vlaar, Alexander P. J.; Sent, Danielle; van der Sluijs, Alexander F.; Wiersinga, W. Joost
Publié dans: Intensive care medicine, 46(8), 1624 - 1626. Springer Verlag, Numéro 27, 2020, ISSN 0342-4642
Éditeur: Springer Verlag
DOI: 10.1007/s00134-020-06066-7

Staphylococcus Aureus Osteomyelitis as an Inducer of Tolerance to Escherichia Coli Pyelonephritis: an Experimental Study

Auteurs: Stavros Goumenos; Olga D. Savvidou; George Renieris; Theologia Gkavogianni; Panayiotis J. Papagelopoulos; Evangelos J. Giamarellos-Bourboulis
Publié dans: Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020), Numéro 30, 2020, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-020-58420-w

Source of Circulating Pentraxin 3 in Septic Shock Patients.

Auteurs: Chloé Albert Vega; Chloé Albert Vega; Marine Mommert; Marine Mommert; Mathilde Boccard; Mathilde Boccard; Thomas Rimmelé; Thomas Rimmelé; Fabienne Venet; Fabienne Venet; Alexandre Pachot; Veronique Leray; Guillaume Monneret; Guillaume Monneret; Benjamin Delwarde; Karen Brengel-Pesce; Karen Brengel-Pesce; François Mallet; François Mallet; François Mallet; Sophie Trouillet-Assant; Sophie Trou
Publié dans: Frontiers in Immunology, Numéro 4, 2019, ISSN 1664-3224
Éditeur: Frontiers media SA
DOI: 10.3389/fimmu.2018.03048

Immune Profiling Panel: a proof of concept study of a new multiplex molecular tool to assess the immune status of critically-ill patients

Auteurs: Tawfik, Dina M.; Vachot, Laurence; Bocquet, Adeline; Venet, Fabienne; Rimmelé, Thomas; Monneret, Guillaume; Blein, Sophie; Montogomery, Jesse L.; Hemmert, Andrew C.; Pachot, Alexandre; Moucadel, Virginie; Marcos, Javier Yugueros; Brengel-Pesce, Karen; Mallet, François; Textoris, Julien
Publié dans: The Journal of Infectious Diseases, Numéro 19, 2020, ISSN 1537-6613
Éditeur: Oxford University press
DOI: 10.1093/infdis/jiaa248

Melioidosis

Auteurs: W. Joost Wiersinga, Harjeet S. Virk, Alfredo G. Torres, Bart J. Currie, Sharon J. Peacock, David A. B. Dance, Direk Limmathurotsakul
Publié dans: Nature Reviews Disease Primers, Numéro 4, 2018, Page(s) 17107, ISSN 2056-676X
Éditeur: Nature reviews
DOI: 10.1038/nrdp.2017.107

The emerging role of the microbiota in the ICU

Auteurs: Nora Suzanne Wolff, Floor Hugenholtz, Willem Joost Wiersinga
Publié dans: Critical Care, Numéro 22/1, 2018, ISSN 1364-8535
Éditeur: BioMed Central- Springer nature
DOI: 10.1186/s13054-018-1999-8

Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection

Auteurs: Eleonora Ciarlo, Tytti Heinonen, Charlotte Théroude, Jacobus Herderschee, Matteo Mombelli, Jérôme Lugrin, Marc Pfefferlé, Beatrice Tyrrell, Sarah Lensch, Hans Acha-Orbea, Didier Le Roy, Johan Auwerx, Thierry Roger
Publié dans: Frontiers in Immunology, Numéro 8, 2017, ISSN 1664-3224
Éditeur: Frontiers in Immunology
DOI: 10.3389/fimmu.2017.01037

Immune Functional Assays, From Custom to Standardized Tests for Precision Medicine

Auteurs: Chloé Albert-Vega, Dina M. Tawfik, Sophie Trouillet-Assant, Laurence Vachot, François Mallet, Julien Textoris
Publié dans: Frontiers in Immunology, Numéro 9, 2018, Page(s) 1-9, ISSN 1664-3224
Éditeur: Frontiers
DOI: 10.3389/fimmu.2018.02367

Sirtuin 5 Deficiency Does Not Compromise Innate Immune Responses to Bacterial Infections

Auteurs: Tytti Heinonen, Eleonora Ciarlo, Charlotte Théroude, Aimilia Pelekanou, Jacobus Herderschee, Didier Le Roy, Thierry Roger
Publié dans: Frontiers in Immunology, Numéro 9, 2018, ISSN 1664-3224
Éditeur: Frontiers
DOI: 10.3389/fimmu.2018.02675

Late Peaks of HMGB1 and Sepsis Outcome

Auteurs: Eleni Karakike, Maria-Evangelia Adami, Malvina Lada, Theologia Gkavogianni, Ioannis M. Koutelidakis, Michael Bauer, Evangelos J. Giamarellos-Bourboulis, Iraklis Tsangaris
Publié dans: SHOCK, 2019, Page(s) 1, ISSN 1073-2322
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/shk.0000000000001265

Myeloid-Derived Suppressor Cells in Sepsis

Auteurs: Irene T. Schrijver, Charlotte Théroude, Thierry Roger
Publié dans: Frontiers in Immunology, Numéro 10, 2019, ISSN 1664-3224
Éditeur: Frontiers Media SA
DOI: 10.3389/fimmu.2019.00327

Macrophage Activation-Like Syndrome: A Distinct Entity Leading to Early Death in Sepsis

Auteurs: Eleni Karakike, Evangelos J. Giamarellos-Bourboulis
Publié dans: Frontiers in Immunology, Numéro 10, 2019, ISSN 1664-3224
Éditeur: Frontiers Media SA
DOI: 10.3389/fimmu.2019.00055

Trained immunity confers broad-spectrum protection against bacterial infections

Auteurs: Eleonora Ciarlo, Tytti Heinonen, Charlotte Théroude, Fatemeh Asgari, Didier Le Roy, Mihai G Netea, Thierry Roger
Publié dans: The Journal of Infectious Diseases, 2019, ISSN 0022-1899
Éditeur: University of Chicago Press
DOI: 10.1093/infdis/jiz692

The early change of SOFA score as a prognostic marker of 28-day sepsis mortality: analysis through a derivation and a validation cohort

Auteurs: Eleni Karakike, Evdoxia Kyriazopoulou, Iraklis Tsangaris, Christina Routsi, Jean-Louis Vincent, Evangelos J. Giamarellos-Bourboulis
Publié dans: Critical Care, Numéro 23/1, 2019, ISSN 1364-8535
Éditeur: Springer Nature
DOI: 10.1186/s13054-019-2665-5

Daptomycin as adjunctive treatment for experimental infection by Acinetobacter baumannii with resistance to colistin

Auteurs: Garyfallia Poulakou, Georgios Renieris, Labros Sabrakos, Olympia Zarkotou, Katherine Themeli-Digalaki, Efstathia Perivolioti, Eleni Kraniotaki, Evangelos J. Giamarellos-Bourboulis, Nikolaos Zavras
Publié dans: International Journal of Antimicrobial Agents, Numéro 53/2, 2019, Page(s) 190-194, ISSN 0924-8579
Éditeur: Elsevier BV
DOI: 10.1016/j.ijantimicag.2018.10.024

Early increase of VEGF-A is associated with resolution of ventilator-associated pneumonia: Clinical and experimental evidence

Auteurs: Ioannis Strouvalis, Christina Routsi, Maria Adamopoulou, Maria Raftogiannis, George Renieris, Stylianos E. Orfanos, Anastasia Kotanidou, Labros Sabracos, Evangelos J. Giamarellos-Bourboulis
Publié dans: Respirology, Numéro 23/10, 2018, Page(s) 942-949, ISSN 1323-7799
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/resp.13320

Staphylococcus Aureus Osteomyelitis as an Inducer of Tolerance to Escherichia Coli Pyelonephritis: an Experimental Study

Auteurs: Stavros Goumenos, Olga Savvidou, George Renieris, Theologia Gkavogianni, Panayiotis J. Papagelopoulos, Evangelos J. Giamarellos-Bourboulis
Publié dans: Scientific Reports, Numéro 10/1, 2020, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-020-58420-w

The Long Pentraxin PTX3 as a Humoral Innate Immunity Functional Player and Biomarker of Infections and Sepsis

Auteurs: Rémi Porte, Sadaf Davoudian, Fatemeh Asgari, Raffaella Parente, Alberto Mantovani, Cecilia Garlanda, Barbara Bottazzi
Publié dans: Frontiers in Immunology, Numéro 10, 2019, ISSN 1664-3224
Éditeur: Europa PMC
DOI: 10.3389/fimmu.2019.00794

Association of modulation of pro‐inflammatory responses by dectin‐2 with preterm delivery: An experimental model

Auteurs: Aspasia Liassidou, Georgios Renieris, Dionysia‐Irene Droggiti, Theologia Gkavogianni, Christakis Liassides, Labros Sabracos, Evangelos J. Giamarellos‐Bourboulis, Charalampos S. Siristatidis
Publié dans: American Journal of Reproductive Immunology, Numéro 83/3, 2019, ISSN 1046-7408
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/aji.13216

Impact of antimicrobial therapy on the gut microbiome

Auteurs: Amira A Bhalodi, Tjitske S R van Engelen, Harjeet S Virk, W Joost Wiersinga
Publié dans: Journal of Antimicrobial Chemotherapy, Numéro 74/Supplement_1, 2019, Page(s) i6-i15, ISSN 0305-7453
Éditeur: Oxford University Press
DOI: 10.1093/jac/dky530

Global burden of melioidosis in 2015: a systematic review and data synthesis

Auteurs: Emma Birnie, Harjeet S Virk, Jelmer Savelkoel, Rene Spijker, Eric Bertherat, David A B Dance, Direk Limmathurotsakul, Brecht Devleesschauwer, Juanita A Haagsma, W Joost Wiersinga
Publié dans: The Lancet Infectious Diseases, Numéro 19/8, 2019, Page(s) 892-902, ISSN 1473-3099
Éditeur: The Lancet Publishing Group
DOI: 10.1016/s1473-3099(19)30157-4

Macrophage migration inhibitory factor promotes the migration of dendritic cells through CD74 and the activation of the Src/PI3K/myosin II pathway.

Auteurs: Annette Ives; Didier Le Roy; Charlotte Théroude; Jürgen Bernhagen; Thierry Roger; Thierry Calandra
Publié dans: Crossref, Numéro 37, 2021, ISSN 0892-6638
Éditeur: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202001605r

Vendor effects on murine gut microbiota and its influence on lipopolysaccharide-induced lung inflammation and Gram-negative pneumonia

Auteurs: Nora S. Wolff; Max C. Jacobs; Bastiaan W. Haak; Joris J. T. H. Roelofs; Alex F. de Vos; Floor Hugenholtz; W. Joost Wiersinga
Publié dans: Intensive Care Medicine Experimental volume, Numéro 8, 47, 2020, ISSN 2197-425X
Éditeur: Springer open
DOI: 10.1186/s40635-020-00336-w

The Long Pentraxin PTX3 Controls Klebsiella Pneumoniae Severe Infection

Auteurs: Fatemeh Asgari; Fatemeh Asgari; Domenico Supino; Raffaella Parente; Nadia Polentarutti; Matteo Stravalaci; Matteo Stravalaci; Remi Porte; Fabio Pasqualini; Fabio Pasqualini; Marialuisa Barbagallo; Chiara Perucchini; Camilla Recordati; Elena Magrini; Andrea Mariancini; Federica Riva; Alessia Giordano; Sadaf Davoudian; Sadaf Davoudian; Thierry Roger; Cornelis van’t Veer; Sebastien Jaillon; Sebasti
Publié dans: Frontiers in immunology, vol. 12, pp. 666198, Numéro 34, 2021, ISSN 1664-3224
Éditeur: Frontiers Media SA
DOI: 10.3389/fimmu.2021.666198

Cancer Immunology - A Translational Medicine Context

Auteurs: Rezaei N. Authors. Tamara Gulic, Rita Silva-Gomes, Sadaf Davoudian, Marina Sironi, Paola Allavena, Alberto Mantovani, Barbara Bottazzi.
Publié dans: 2020, ISBN 978-3-030-30845-2
Éditeur: Springer, Cham
DOI: 10.1007/978-3-030-30845-2

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