Rezultaty
Techniques used include in vivo and in vitro models of sepsis and immunosuppression; leukocyte purification and functional assays; FACS analysis; ELISA; molecular biology; microscopy.
Assessment of sequential trial versus a more standard clinical trialAssessment of epigenetic signatures and DNA methylation marks in sepsis
Signed PCDPs
ESR's PCDP's
Analysis of markers such as PTX3marker, TIR8 and MSF as markers for the anti inflammatory phase of sepsisIdentification of potential utility of therapies (by confirmation of reversibility) directed towards mitochondrial protection, or stimulation of mitochondrial turnover
Design of a fully integrated molecular tool to manage sepsis patients based on their immune status: a proof of concept
ESR training certificates granted to ESRs
Further caracterisation of MDSC subpopulations
Data on patient flows and sepsis provided by partners for development of computer model.
Report of studies with PTX3, TIR8 and IRAK-M targeted mice in murine models of sepsis
Technology set up for the of DNA methylation probes of isolated cell fractions which can be used as prognostic markers in sepsis patients
Impact of putative therapies on reversing immune dysfunction in white cells
Validation of the primers and setup the Fluidigm technology for analysing MDSC
Proof of principle on testing therapeutic potential of PTX3 and IRAK-M modulation and potential identification of early biomarkers of immune dysfunction
Comparison of data from cell- and in vivo models to data obtained from human sepsis samples and confirmation of a relationship (both temporal and severity) between immune and mitochondrial function in white cell subsets
Validation of DNA methylation probes of isolated cell fractions
Temporal comparison of immune and bioenergetic function in models of sepsis
Characterisation of the involvement of factors such as IRAK-M, PTX3 and TIR8 in sepsis-induced immunosuppression
Partner ICH is in the lead for the characterisation of involvement of factors such as IRAK-M, PTX3 and TIR8 in sepsis-induced immunosuppression. AMC is the other partner involved.
Validation of PTX3, TIR8 and MSF as novel biomarkers of sepsis, to be translated to the clinicFirst online version of network public website (with multimodality options)
Publikacje
Autorzy:
Georgios Renieris; Dionysia-Eirini Droggiti; Konstantina Katrini; Panagiotis Koufargyris; Theologia Gkavogianni; Eleni Karakike; Nikolaos Antonakos; Georgia Damoraki; Athanasios Karageorgos; Labros Sabracos; Antonia Katsouda; Elisa Jentho; Sebastian Weis; Rui Wang; Michael Bauer; Csaba Szabo; Kalliopi Platoni; Vasilios Kouloulias; Andreas Papapetropoulos; Evangelos J. Giamarellos-Bourboulis
Opublikowane w:
PLoS Pathogens, Numer 5, 2021, ISSN 1553-7366
Wydawca:
Public Library of Science
DOI:
10.1371/journal.ppat.1009473
Autorzy:
Wolff, Nora S.; Jacobs, Max C.; Wiersinga, W. Joost; Hugenholtz, Floor
Opublikowane w:
Intensive Care Medicine Experimental, Vol 9, Iss 1, Pp 1-14 (2021), Numer 21, 2021, ISSN 2197-425X
Wydawca:
Springer Open
DOI:
10.1186/s40635-021-00398-4
Autorzy:
Alban, Andres; Chick, Stephen E.; Dongelmans, Dave A.; Vlaar, Alexander P. J.; Sent, Danielle; van der Sluijs, Alexander F.; Wiersinga, W. Joost
Opublikowane w:
Intensive care medicine, 46(8), 1624 - 1626. Springer Verlag, Numer 27, 2020, ISSN 0342-4642
Wydawca:
Springer Verlag
DOI:
10.1007/s00134-020-06066-7
Autorzy:
Stavros Goumenos; Olga D. Savvidou; George Renieris; Theologia Gkavogianni; Panayiotis J. Papagelopoulos; Evangelos J. Giamarellos-Bourboulis
Opublikowane w:
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020), Numer 30, 2020, ISSN 2045-2322
Wydawca:
Nature Publishing Group
DOI:
10.1038/s41598-020-58420-w
Autorzy:
Chloé Albert Vega; Chloé Albert Vega; Marine Mommert; Marine Mommert; Mathilde Boccard; Mathilde Boccard; Thomas Rimmelé; Thomas Rimmelé; Fabienne Venet; Fabienne Venet; Alexandre Pachot; Veronique Leray; Guillaume Monneret; Guillaume Monneret; Benjamin Delwarde; Karen Brengel-Pesce; Karen Brengel-Pesce; François Mallet; François Mallet; François Mallet; Sophie Trouillet-Assant; Sophie Trou
Opublikowane w:
Frontiers in Immunology, Numer 4, 2019, ISSN 1664-3224
Wydawca:
Frontiers media SA
DOI:
10.3389/fimmu.2018.03048
Autorzy:
Tawfik, Dina M.; Vachot, Laurence; Bocquet, Adeline; Venet, Fabienne; Rimmelé, Thomas; Monneret, Guillaume; Blein, Sophie; Montogomery, Jesse L.; Hemmert, Andrew C.; Pachot, Alexandre; Moucadel, Virginie; Marcos, Javier Yugueros; Brengel-Pesce, Karen; Mallet, François; Textoris, Julien
Opublikowane w:
The Journal of Infectious Diseases, Numer 19, 2020, ISSN 1537-6613
Wydawca:
Oxford University press
DOI:
10.1093/infdis/jiaa248
Autorzy:
W. Joost Wiersinga, Harjeet S. Virk, Alfredo G. Torres, Bart J. Currie, Sharon J. Peacock, David A. B. Dance, Direk Limmathurotsakul
Opublikowane w:
Nature Reviews Disease Primers, Numer 4, 2018, Strona(/y) 17107, ISSN 2056-676X
Wydawca:
Nature reviews
DOI:
10.1038/nrdp.2017.107
Autorzy:
Nora Suzanne Wolff, Floor Hugenholtz, Willem Joost Wiersinga
Opublikowane w:
Critical Care, Numer 22/1, 2018, ISSN 1364-8535
Wydawca:
BioMed Central- Springer nature
DOI:
10.1186/s13054-018-1999-8
Autorzy:
Eleonora Ciarlo, Tytti Heinonen, Charlotte Théroude, Jacobus Herderschee, Matteo Mombelli, Jérôme Lugrin, Marc Pfefferlé, Beatrice Tyrrell, Sarah Lensch, Hans Acha-Orbea, Didier Le Roy, Johan Auwerx, Thierry Roger
Opublikowane w:
Frontiers in Immunology, Numer 8, 2017, ISSN 1664-3224
Wydawca:
Frontiers in Immunology
DOI:
10.3389/fimmu.2017.01037
Autorzy:
Chloé Albert-Vega, Dina M. Tawfik, Sophie Trouillet-Assant, Laurence Vachot, François Mallet, Julien Textoris
Opublikowane w:
Frontiers in Immunology, Numer 9, 2018, Strona(/y) 1-9, ISSN 1664-3224
Wydawca:
Frontiers
DOI:
10.3389/fimmu.2018.02367
Autorzy:
Tytti Heinonen, Eleonora Ciarlo, Charlotte Théroude, Aimilia Pelekanou, Jacobus Herderschee, Didier Le Roy, Thierry Roger
Opublikowane w:
Frontiers in Immunology, Numer 9, 2018, ISSN 1664-3224
Wydawca:
Frontiers
DOI:
10.3389/fimmu.2018.02675
Autorzy:
Eleni Karakike, Maria-Evangelia Adami, Malvina Lada, Theologia Gkavogianni, Ioannis M. Koutelidakis, Michael Bauer, Evangelos J. Giamarellos-Bourboulis, Iraklis Tsangaris
Opublikowane w:
SHOCK, 2019, Strona(/y) 1, ISSN 1073-2322
Wydawca:
Lippincott Williams & Wilkins Ltd.
DOI:
10.1097/shk.0000000000001265
Autorzy:
Irene T. Schrijver, Charlotte Théroude, Thierry Roger
Opublikowane w:
Frontiers in Immunology, Numer 10, 2019, ISSN 1664-3224
Wydawca:
Frontiers Media SA
DOI:
10.3389/fimmu.2019.00327
Autorzy:
Eleni Karakike, Evangelos J. Giamarellos-Bourboulis
Opublikowane w:
Frontiers in Immunology, Numer 10, 2019, ISSN 1664-3224
Wydawca:
Frontiers Media SA
DOI:
10.3389/fimmu.2019.00055
Autorzy:
Eleonora Ciarlo, Tytti Heinonen, Charlotte Théroude, Fatemeh Asgari, Didier Le Roy, Mihai G Netea, Thierry Roger
Opublikowane w:
The Journal of Infectious Diseases, 2019, ISSN 0022-1899
Wydawca:
University of Chicago Press
DOI:
10.1093/infdis/jiz692
Autorzy:
Eleni Karakike, Evdoxia Kyriazopoulou, Iraklis Tsangaris, Christina Routsi, Jean-Louis Vincent, Evangelos J. Giamarellos-Bourboulis
Opublikowane w:
Critical Care, Numer 23/1, 2019, ISSN 1364-8535
Wydawca:
Springer Nature
DOI:
10.1186/s13054-019-2665-5
Autorzy:
Garyfallia Poulakou, Georgios Renieris, Labros Sabrakos, Olympia Zarkotou, Katherine Themeli-Digalaki, Efstathia Perivolioti, Eleni Kraniotaki, Evangelos J. Giamarellos-Bourboulis, Nikolaos Zavras
Opublikowane w:
International Journal of Antimicrobial Agents, Numer 53/2, 2019, Strona(/y) 190-194, ISSN 0924-8579
Wydawca:
Elsevier BV
DOI:
10.1016/j.ijantimicag.2018.10.024
Autorzy:
Ioannis Strouvalis, Christina Routsi, Maria Adamopoulou, Maria Raftogiannis, George Renieris, Stylianos E. Orfanos, Anastasia Kotanidou, Labros Sabracos, Evangelos J. Giamarellos-Bourboulis
Opublikowane w:
Respirology, Numer 23/10, 2018, Strona(/y) 942-949, ISSN 1323-7799
Wydawca:
Blackwell Publishing Inc.
DOI:
10.1111/resp.13320
Autorzy:
Stavros Goumenos, Olga Savvidou, George Renieris, Theologia Gkavogianni, Panayiotis J. Papagelopoulos, Evangelos J. Giamarellos-Bourboulis
Opublikowane w:
Scientific Reports, Numer 10/1, 2020, ISSN 2045-2322
Wydawca:
Nature Publishing Group
DOI:
10.1038/s41598-020-58420-w
Autorzy:
Rémi Porte, Sadaf Davoudian, Fatemeh Asgari, Raffaella Parente, Alberto Mantovani, Cecilia Garlanda, Barbara Bottazzi
Opublikowane w:
Frontiers in Immunology, Numer 10, 2019, ISSN 1664-3224
Wydawca:
Europa PMC
DOI:
10.3389/fimmu.2019.00794
Autorzy:
Aspasia Liassidou, Georgios Renieris, Dionysia‐Irene Droggiti, Theologia Gkavogianni, Christakis Liassides, Labros Sabracos, Evangelos J. Giamarellos‐Bourboulis, Charalampos S. Siristatidis
Opublikowane w:
American Journal of Reproductive Immunology, Numer 83/3, 2019, ISSN 1046-7408
Wydawca:
Blackwell Publishing Inc.
DOI:
10.1111/aji.13216
Autorzy:
Amira A Bhalodi, Tjitske S R van Engelen, Harjeet S Virk, W Joost Wiersinga
Opublikowane w:
Journal of Antimicrobial Chemotherapy, Numer 74/Supplement_1, 2019, Strona(/y) i6-i15, ISSN 0305-7453
Wydawca:
Oxford University Press
DOI:
10.1093/jac/dky530
Autorzy:
Emma Birnie, Harjeet S Virk, Jelmer Savelkoel, Rene Spijker, Eric Bertherat, David A B Dance, Direk Limmathurotsakul, Brecht Devleesschauwer, Juanita A Haagsma, W Joost Wiersinga
Opublikowane w:
The Lancet Infectious Diseases, Numer 19/8, 2019, Strona(/y) 892-902, ISSN 1473-3099
Wydawca:
The Lancet Publishing Group
DOI:
10.1016/s1473-3099(19)30157-4
Autorzy:
Annette Ives; Didier Le Roy; Charlotte Théroude; Jürgen Bernhagen; Thierry Roger; Thierry Calandra
Opublikowane w:
Crossref, Numer 37, 2021, ISSN 0892-6638
Wydawca:
Federation of American Societies for Experimental Biology
DOI:
10.1096/fj.202001605r
Autorzy:
Nora S. Wolff; Max C. Jacobs; Bastiaan W. Haak; Joris J. T. H. Roelofs; Alex F. de Vos; Floor Hugenholtz; W. Joost Wiersinga
Opublikowane w:
Intensive Care Medicine Experimental volume, Numer 8, 47, 2020, ISSN 2197-425X
Wydawca:
Springer open
DOI:
10.1186/s40635-020-00336-w
Autorzy:
Fatemeh Asgari; Fatemeh Asgari; Domenico Supino; Raffaella Parente; Nadia Polentarutti; Matteo Stravalaci; Matteo Stravalaci; Remi Porte; Fabio Pasqualini; Fabio Pasqualini; Marialuisa Barbagallo; Chiara Perucchini; Camilla Recordati; Elena Magrini; Andrea Mariancini; Federica Riva; Alessia Giordano; Sadaf Davoudian; Sadaf Davoudian; Thierry Roger; Cornelis van’t Veer; Sebastien Jaillon; Sebasti
Opublikowane w:
Frontiers in immunology, vol. 12, pp. 666198, Numer 34, 2021, ISSN 1664-3224
Wydawca:
Frontiers Media SA
DOI:
10.3389/fimmu.2021.666198
Autorzy:
Rezaei N. Authors. Tamara Gulic, Rita Silva-Gomes, Sadaf Davoudian, Marina Sironi, Paola Allavena, Alberto Mantovani, Barbara Bottazzi.
Opublikowane w:
2020, ISBN 978-3-030-30845-2
Wydawca:
Springer, Cham
DOI:
10.1007/978-3-030-30845-2
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