Engineering in vitro microenvironments for translation of cell-based therapies for tendon repair

Resultado final

To protect intellectual property, three patents strengthening European innovation in cell-based therapy development will be filed: i) methods to differentiate dermal fibroblasts (DFs) and stem cells (BMSCs) towards tenogenic lineage; ii) methods to maintain tendon-specific function in vitro; and iii) the final tendon substitute products.

Digital media dissemination

Led by NUI Galway, digital media dissemination will include the Tendon Therapy website and dedicated project accounts on social media including twitter and linked-in. All press releases will also be issued electronically.

Supervisory Board of the Network

supervisory agreement

Ethics

provide documents linked to the ethics issues

Progress report

progress report

Draft Periodic Report

periodic report

Mid Term review meeting

mid term review meeting

Publicaciones

Natural Architectures for Tissue Engineering and Regenerative Medicine

Autores: Floris Honig, Steven Vermeulen, Amir A. Zadpoor, Jan de Boer, Lidy E. Fratila-Apachitei
Publicado en: Journal of Functional Biomaterials, Edición 11/3, 2020, Página(s) 47, ISSN 2079-4983
Editor: MDPI
DOI: 10.3390/jfb11030047

Screening as a strategy to drive regenerative medicine research

Autores: Steven Vermeulen, Jan de Boer
Publicado en: Methods, 2020, ISSN 1046-2023
Editor: Academic Press
DOI: 10.1016/j.ymeth.2020.04.004

Mechanotransduction is a context-dependent activator of TGF-β signaling in mesenchymal stem cells

Autores: Steven Vermeulen, Nadia Roumans, Floris Honig, Aurélie Carlier, Dennie G.A.J. Hebels, Aysegul Dede Eren, Peter ten Dijke, Aliaksei Vasilevich, Jan de Boer
Publicado en: Biomaterials, Edición 259, 2020, Página(s) 120331, ISSN 0142-9612
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.120331

Advancements and Challenges in Multidomain Multicargo Delivery Vehicles

Autores: Eugenia Pugliese, João Q. Coentro, Dimitrios I. Zeugolis
Publicado en: Advanced Materials, Edición 30/13, 2018, Página(s) 1704324, ISSN 0935-9648
Editor: United Nations Industrial Developement Organization
DOI: 10.1002/adma.201704324

Biophysics Rules the Cell Culture but Has Yet to Reach the Clinic

Autores: Salomé Guillaumin, Ignacio Sallent, Dimitrios I. Zeugolis
Publicado en: Journal of the American Academy of Orthopaedic Surgeons, Edición 25/7, 2017, Página(s) e144-e147, ISSN 1067-151X
Editor: American Academy of Orthopaedic Surgeons
DOI: 10.5435/JAAOS-D-17-00324

Micro-Topographies Promote Late Chondrogenic Differentiation Markers in the ATDC5 Cell Line

Autores: Bach Q. Le, Aliaksei Vasilevich, Steven Vermeulen, Frits Hulshof, Dimitrios F. Stamatialis, Clemens A. van Blitterswijk, Jan de Boer
Publicado en: Tissue Engineering Part A, Edición 23/9-10, 2017, Página(s) 458-469, ISSN 1937-3341
Editor: Mary Ann Liebert Inc.
DOI: 10.1089/ten.TEA.2016.0421

Identification of topographical architectures supporting the phenotype of rat tenocytes

Autores: Steven Vermeulen, Aliaksei Vasilevich, Dimitrios Tsiapalis, Nadia Roumans, Pascal Vroemen, Nick R.M. Beijer, Aysegul Dede Eren, Dimitrios Zeugolis, Jan de Boer
Publicado en: Acta Biomaterialia, Edición 83, 2019, Página(s) 277-290, ISSN 1742-7061
Editor: Elsevier BV
DOI: 10.1016/j.actbio.2018.10.041

Current and upcoming therapies to modulate skin scarring and fibrosis

Autores: João Q. Coentro, Eugenia Pugliese, Geoffrey Hanley, Michael Raghunath, Dimitrios I. Zeugolis
Publicado en: Advanced Drug Delivery Reviews, Edición Theme issue format, 2018, Página(s) digital, ISSN 0169-409X
Editor: Elsevier BV
DOI: 10.1016/j.addr.2018.08.009

Wound healing and scar wars

Autores: Eugenia Pugliese, João Q. Coentro, Michael Raghunath, Dimitrios I. Zeugolis
Publicado en: Advanced Drug Delivery Reviews, Edición 129, 2018, Página(s) 1-3, ISSN 0169-409X
Editor: Elsevier BV
DOI: 10.1016/j.addr.2018.05.010

Shaping Cell Fate: Influence of Topographical Substratum Properties on Embryonic Stem Cells

Autores: Sarita Kumari, Steven Vermeulen, Ben van der Veer, Aurélie Carlier, Jan de Boer, Deepa Subramanyam
Publicado en: Tissue Engineering Part B: Reviews, Edición 24/4, 2018, Página(s) 255-266, ISSN 1937-3368
Editor: Mary Ann Liebert Inc.
DOI: 10.1089/ten.teb.2017.0468

Joint academic and industrial efforts towards innovative and efficient solutions for clinical needs

Autores: Andrea De Pieri, Sofia Ribeiro, Dimitrios Tsiapalis, David Eglin, Marc Bohner, Peter Dubruel, Philip Procter, Dimitrios I. Zeugolis, Yves Bayon
Publicado en: Journal of Materials Science: Materials in Medicine, Edición 29/8, 2018, ISSN 0957-4530
Editor: Kluwer Academic Publishers
DOI: 10.1007/s10856-018-6136-3

The Collagen Suprafamily: From Biosynthesis to Advanced Biomaterial Development

Autores: Anna Sorushanova, Luis M. Delgado, Zhuning Wu, Naledi Shologu, Aniket Kshirsagar, Rufus Raghunath, Anne M. Mullen, Yves Bayon, Abhay Pandit, Michael Raghunath, Dimitrios I. Zeugolis
Publicado en: Advanced Materials, Edición 31/1, 2019, Página(s) 1801651, ISSN 0935-9648
Editor: United Nations Industrial Developement Organization
DOI: 10.1002/adma.201801651

Evaluation of tenogenic differentiation potential of selected subpopulations of human adipose‐derived stem cells

Autores: Ana I. Gonçalves, Dominika Berdecka, Márcia T. Rodrigues, Aysegul Dede Eren, Jan Boer, Rui L. Reis, Manuela E. Gomes
Publicado en: Journal of Tissue Engineering and Regenerative Medicine, Edición 13/12, 2019, Página(s) 2204-2217, ISSN 1932-6254
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/term.2967

Decellularized Porcine Achilles tendon induces anti-inflammatory macrophage phenotype in Vitro and tendon repair in vivo

Autores: Aysegul Dede Eren, Ravi Sinha, Egemen Deniz Eren, Yuan Huipin, Sultan Gulce-Iz, Henriette Valster, Lorenzo Moroni, Jasper Foolen, Jan de Boer
Publicado en: Journal of Immunology and Regenerative Medicine, Edición 8, 2020, Página(s) 100027, ISSN 2468-4988
Editor: Elsevier
DOI: 10.1016/j.regen.2020.100027

The synergistic effect of low oxygen tension and macromolecular crowding in the development of extracellular matrix-rich tendon equivalents

Autores: Dimitrios Tsiapalis, Andrea De Pieri, Kyriakos Spanoudes, Ignacio Sallent, Stephen Kearns, Jack L Kelly, Michael Raghunath, Dimitrios I Zeugolis
Publicado en: Biofabrication, Edición 12/2, 2020, Página(s) 025018, ISSN 1758-5090
Editor: IOP Publishing
DOI: 10.1088/1758-5090/ab6412

Hypoxia Preconditioning of Bone Marrow Mesenchymal Stem Cells Before Implantation in Orthopaedics

Autores: Dimitrios Tsiapalis, Dimitrios I. Zeugolis
Publicado en: Journal of the American Academy of Orthopaedic Surgeons, Edición 27/23, 2019, Página(s) e1040-e1042, ISSN 1067-151X
Editor: American Academy of Orthopaedic Surgeons
DOI: 10.5435/jaaos-d-19-00044

The cytokine secretion profile of mesenchymal stromal cells is determined by surface structure of the microenvironment

Autores: Daniëlle G. Leuning, Nick R. M. Beijer, Nadia A. du Fossé, Steven Vermeulen, Ellen Lievers, Cees van Kooten, Ton J. Rabelink, Jan de Boer
Publicado en: Scientific Reports, Edición 8/1, 2018, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-018-25700-5

Translational Research Symposium—collaborative efforts as driving forces of healthcare innovation

Autores: João Q. Coentro, Andrea De Pieri, Diana Gaspar, Dimitrios Tsiapalis, Dimitrios I. Zeugolis, Yves Bayon
Publicado en: Journal of Materials Science: Materials in Medicine, Edición 30/12, 2019, ISSN 0957-4530
Editor: Kluwer Academic Publishers
DOI: 10.1007/s10856-019-6339-2

ISEV2018 abstract book

Autores: Clotilde Théry, Kenneth Witwer
Publicado en: Journal of Extracellular Vesicles, Edición 7/sup1, 2018, Página(s) 1461450, ISSN 2001-3078
Editor: US
DOI: 10.1080/20013078.2018.1461450

Local pharmacological induction of angiogenesis: Drugs for cells and cells as drugs

Autores: Diana Gaspar, Rita Peixoto, Andrea De Pieri, Britta Striegl, Dimitrios I. Zeugolis, Michael Raghunath
Publicado en: Advanced Drug Delivery Reviews, Edición 146, 2019, Página(s) 126-154, ISSN 0169-409X
Editor: Elsevier BV
DOI: 10.1016/j.addr.2019.06.002

British Society for Matrix Biology Spring 2019 Meeting: “Stroma, Niche, Repair”

Autores: Gifford. V., et. at.,
Publicado en: International Journal of Experimental Pathology, Edición 100/4, 2019, ISSN 0959-9673
Editor: Blackwell Publishing Inc.
DOI: 10.1111/iep.12332

Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation

Autores: Vassey, Matthew J.; Figueredo, Grazziela P.; Scurr, David; Vasilevich, Aliaksei S.; Vermeulen, Steven; Carlier, Aurélie; Luckett, Jeni; Beijer, Nick R.M.; Williams, Paul; Winkler, Dave; de Boer, Jan; Ghaemmaghami, Amir M.; Alexander, Morgan R.
Publicado en: Advanced Science, 2020, ISSN 2198-3844
Editor: Wiley
DOI: 10.1002/advs.201903392

Seaweed polysaccharides as macromolecular crowding agents

Autores: Andrea De Pieri, Shubhasmin Rana, Stefanie Korntner, Dimitrios I. Zeugolis
Publicado en: International Journal of Biological Macromolecules, Edición 164, 2020, Página(s) 434-446, ISSN 0141-8130
Editor: Elsevier BV
DOI: 10.1016/j.ijbiomac.2020.07.087

Bioreactors for Tendon Tissue Engineering

Autores: Ana I. Gonçalves
Publicado en: Bioreactors for Stem Cell Expansion and Differentiation, 2018, Página(s) 269-300, ISBN 9780-429453144
Editor: CRC Press
DOI: 10.1201/9780429453144-10

Preparation and Characterization of Tissue Surrogates Rich in Extracellular Matrix Using the Principles of Macromolecular Crowding

Autores: Adrian Djalali-Cuevas, Sergio Garnica-Galvez, Andrea Rampin, Diana Gaspar, Ioannis Skoufos, Athina Tzora, Nikitas Prassinos, Nikolaos Diakakis, Dimitrios I. Zeugolis
Publicado en: The Extracellular Matrix - Methods and Protocols, Edición 1952, 2019, Página(s) 245-259, ISBN 978-1-4939-9132-7
Editor: Springer New York
DOI: 10.1007/978-1-4939-9133-4_20

Designing Microenvironments for Optimal Outcomes in Tissue Engineering and Regenerative Medicine: From Biopolymers to Culturing Conditions

Autores: Dimitrios Tsiapalis, Sofia Ribeiro, Andrea De Pieri, Ignacio Sallent, Salomé Guillaumin, Diana Gaspar, Stefanie Korntner, Yves Bayon, Manuela E. Gomes, Rui L. Reis, Dimitrios I. Zeugolis
Publicado en: Reference Module in Biomedical Sciences, 2019, ISBN 9780-128012383
Editor: Elsevier
DOI: 10.1016/b978-0-12-801238-3.11140-7

Scaffolds for tendon tissue engineering

Autores: Héctor Capella-Monsonís, Salomé Guillaumin, Sofia Ribeiro, Stefanie Korntner, Yves Bayon, Dimitrios I. Zeugolis
Publicado en: Handbook of Tissue Engineering Scaffolds: Volume One, 2019, Página(s) 259-298, ISBN 9780-081025635
Editor: Elsevier
DOI: 10.1016/b978-0-08-102563-5.00013-7

The effect of aligned electrospun fibers and macromolecular crowding in tenocyte culture

Autores: Dimitrios Tsiapalis, Shubhasmin Rana, Meletios Doulgkeroglou, Stephen Kearns, Jack Kelly, Yves Bayon, Dimitrios I. Zeugolis
Publicado en: Methods in Cell Biology, 2019
Editor: Elsevier
DOI: 10.1016/bs.mcb.2019.11.003

Production and Characterization of Chemically Cross-Linked Collagen Scaffolds

Autores: Ignacio Sallent, Héctor Capella-Monsonís, Dimitrios I. Zeugolis
Publicado en: Collagen - Methods and Protocols, Edición 1944, 2019, Página(s) 23-38, ISBN 978-1-4939-9094-8
Editor: Springer New York
DOI: 10.1007/978-1-4939-9095-5_3

Concept Design of a New Portable Medical Device for Lymphedema Monitoring: A EIT Health ClinMed Summer School Project

Autores: Jordi Tisaire, Elena Rodrigo, Sofia Ribeiro, Mariachiara Ricci, Juan Cuellar, Dimitrios Zeugolis, Yves Bayon, Isabel Rocha
Publicado en: Proceedings of the 12th International Joint Conference on Biomedical Engineering Systems and Technologies, 2019, Página(s) 611-620, ISBN 978-989-758-353-7
Editor: SCITEPRESS - Science and Technology Publications
DOI: 10.5220/0007696706110620

Design and Characterization of Synthetic Biodegradable Films for Soft Tissue Engineering

Autores: Ribeiro, S.; Fernandes, E.; Gomes, M.; Reis, R.; Bayon, Y. and Zeugolis, D.
Publicado en: Doctoral Consortium - Volume 1: DCBIOSTEC, 2019, Página(s) 28-32
Editor: DCBIOSTEC

Empowering Translation of New Ideas - A EIT Health ClinMed Summer School Overview

Autores: Sofia Ribeiro, Mariachiara Ricci, Albert Von Der Lieth, Yves Bayon, Dimitrios Zeugolis, Sylvia Pelayo, Isabelle Marque, Lionel Pazart
Publicado en: Proceedings of the 12th International Joint Conference on Biomedical Engineering Systems and Technologies, 2019, Página(s) 603-610, ISBN 978-989-758-353-7
Editor: SCITEPRESS - Science and Technology Publications
DOI: 10.5220/0007696606030610

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