Engineering in vitro microenvironments for translation of cell-based therapies for tendon repair

Livrables

To protect intellectual property, three patents strengthening European innovation in cell-based therapy development will be filed: i) methods to differentiate dermal fibroblasts (DFs) and stem cells (BMSCs) towards tenogenic lineage; ii) methods to maintain tendon-specific function in vitro; and iii) the final tendon substitute products.

Digital media dissemination

Led by NUI Galway, digital media dissemination will include the Tendon Therapy website and dedicated project accounts on social media including twitter and linked-in. All press releases will also be issued electronically.

Supervisory Board of the Network

supervisory agreement

Ethics

provide documents linked to the ethics issues

Progress report

progress report

Draft Periodic Report

periodic report

Mid Term review meeting

mid term review meeting

Publications

Natural Architectures for Tissue Engineering and Regenerative Medicine

Auteurs: Floris Honig, Steven Vermeulen, Amir A. Zadpoor, Jan de Boer, Lidy E. Fratila-Apachitei
Publié dans: Journal of Functional Biomaterials, Numéro 11/3, 2020, Page(s) 47, ISSN 2079-4983
Éditeur: MDPI
DOI: 10.3390/jfb11030047

Screening as a strategy to drive regenerative medicine research

Auteurs: Steven Vermeulen, Jan de Boer
Publié dans: Methods, 2020, ISSN 1046-2023
Éditeur: Academic Press
DOI: 10.1016/j.ymeth.2020.04.004

Mechanotransduction is a context-dependent activator of TGF-β signaling in mesenchymal stem cells

Auteurs: Steven Vermeulen, Nadia Roumans, Floris Honig, Aurélie Carlier, Dennie G.A.J. Hebels, Aysegul Dede Eren, Peter ten Dijke, Aliaksei Vasilevich, Jan de Boer
Publié dans: Biomaterials, Numéro 259, 2020, Page(s) 120331, ISSN 0142-9612
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.120331

Advancements and Challenges in Multidomain Multicargo Delivery Vehicles

Auteurs: Eugenia Pugliese, João Q. Coentro, Dimitrios I. Zeugolis
Publié dans: Advanced Materials, Numéro 30/13, 2018, Page(s) 1704324, ISSN 0935-9648
Éditeur: United Nations Industrial Developement Organization
DOI: 10.1002/adma.201704324

Biophysics Rules the Cell Culture but Has Yet to Reach the Clinic

Auteurs: Salomé Guillaumin, Ignacio Sallent, Dimitrios I. Zeugolis
Publié dans: Journal of the American Academy of Orthopaedic Surgeons, Numéro 25/7, 2017, Page(s) e144-e147, ISSN 1067-151X
Éditeur: American Academy of Orthopaedic Surgeons
DOI: 10.5435/JAAOS-D-17-00324

Micro-Topographies Promote Late Chondrogenic Differentiation Markers in the ATDC5 Cell Line

Auteurs: Bach Q. Le, Aliaksei Vasilevich, Steven Vermeulen, Frits Hulshof, Dimitrios F. Stamatialis, Clemens A. van Blitterswijk, Jan de Boer
Publié dans: Tissue Engineering Part A, Numéro 23/9-10, 2017, Page(s) 458-469, ISSN 1937-3341
Éditeur: Mary Ann Liebert Inc.
DOI: 10.1089/ten.TEA.2016.0421

Identification of topographical architectures supporting the phenotype of rat tenocytes

Auteurs: Steven Vermeulen, Aliaksei Vasilevich, Dimitrios Tsiapalis, Nadia Roumans, Pascal Vroemen, Nick R.M. Beijer, Aysegul Dede Eren, Dimitrios Zeugolis, Jan de Boer
Publié dans: Acta Biomaterialia, Numéro 83, 2019, Page(s) 277-290, ISSN 1742-7061
Éditeur: Elsevier BV
DOI: 10.1016/j.actbio.2018.10.041

Current and upcoming therapies to modulate skin scarring and fibrosis

Auteurs: João Q. Coentro, Eugenia Pugliese, Geoffrey Hanley, Michael Raghunath, Dimitrios I. Zeugolis
Publié dans: Advanced Drug Delivery Reviews, Numéro Theme issue format, 2018, Page(s) digital, ISSN 0169-409X
Éditeur: Elsevier BV
DOI: 10.1016/j.addr.2018.08.009

Wound healing and scar wars

Auteurs: Eugenia Pugliese, João Q. Coentro, Michael Raghunath, Dimitrios I. Zeugolis
Publié dans: Advanced Drug Delivery Reviews, Numéro 129, 2018, Page(s) 1-3, ISSN 0169-409X
Éditeur: Elsevier BV
DOI: 10.1016/j.addr.2018.05.010

Shaping Cell Fate: Influence of Topographical Substratum Properties on Embryonic Stem Cells

Auteurs: Sarita Kumari, Steven Vermeulen, Ben van der Veer, Aurélie Carlier, Jan de Boer, Deepa Subramanyam
Publié dans: Tissue Engineering Part B: Reviews, Numéro 24/4, 2018, Page(s) 255-266, ISSN 1937-3368
Éditeur: Mary Ann Liebert Inc.
DOI: 10.1089/ten.teb.2017.0468

Joint academic and industrial efforts towards innovative and efficient solutions for clinical needs

Auteurs: Andrea De Pieri, Sofia Ribeiro, Dimitrios Tsiapalis, David Eglin, Marc Bohner, Peter Dubruel, Philip Procter, Dimitrios I. Zeugolis, Yves Bayon
Publié dans: Journal of Materials Science: Materials in Medicine, Numéro 29/8, 2018, ISSN 0957-4530
Éditeur: Kluwer Academic Publishers
DOI: 10.1007/s10856-018-6136-3

The Collagen Suprafamily: From Biosynthesis to Advanced Biomaterial Development

Auteurs: Anna Sorushanova, Luis M. Delgado, Zhuning Wu, Naledi Shologu, Aniket Kshirsagar, Rufus Raghunath, Anne M. Mullen, Yves Bayon, Abhay Pandit, Michael Raghunath, Dimitrios I. Zeugolis
Publié dans: Advanced Materials, Numéro 31/1, 2019, Page(s) 1801651, ISSN 0935-9648
Éditeur: United Nations Industrial Developement Organization
DOI: 10.1002/adma.201801651

Evaluation of tenogenic differentiation potential of selected subpopulations of human adipose‐derived stem cells

Auteurs: Ana I. Gonçalves, Dominika Berdecka, Márcia T. Rodrigues, Aysegul Dede Eren, Jan Boer, Rui L. Reis, Manuela E. Gomes
Publié dans: Journal of Tissue Engineering and Regenerative Medicine, Numéro 13/12, 2019, Page(s) 2204-2217, ISSN 1932-6254
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/term.2967

Decellularized Porcine Achilles tendon induces anti-inflammatory macrophage phenotype in Vitro and tendon repair in vivo

Auteurs: Aysegul Dede Eren, Ravi Sinha, Egemen Deniz Eren, Yuan Huipin, Sultan Gulce-Iz, Henriette Valster, Lorenzo Moroni, Jasper Foolen, Jan de Boer
Publié dans: Journal of Immunology and Regenerative Medicine, Numéro 8, 2020, Page(s) 100027, ISSN 2468-4988
Éditeur: Elsevier
DOI: 10.1016/j.regen.2020.100027

The synergistic effect of low oxygen tension and macromolecular crowding in the development of extracellular matrix-rich tendon equivalents

Auteurs: Dimitrios Tsiapalis, Andrea De Pieri, Kyriakos Spanoudes, Ignacio Sallent, Stephen Kearns, Jack L Kelly, Michael Raghunath, Dimitrios I Zeugolis
Publié dans: Biofabrication, Numéro 12/2, 2020, Page(s) 025018, ISSN 1758-5090
Éditeur: IOP Publishing
DOI: 10.1088/1758-5090/ab6412

Hypoxia Preconditioning of Bone Marrow Mesenchymal Stem Cells Before Implantation in Orthopaedics

Auteurs: Dimitrios Tsiapalis, Dimitrios I. Zeugolis
Publié dans: Journal of the American Academy of Orthopaedic Surgeons, Numéro 27/23, 2019, Page(s) e1040-e1042, ISSN 1067-151X
Éditeur: American Academy of Orthopaedic Surgeons
DOI: 10.5435/jaaos-d-19-00044

The cytokine secretion profile of mesenchymal stromal cells is determined by surface structure of the microenvironment

Auteurs: Daniëlle G. Leuning, Nick R. M. Beijer, Nadia A. du Fossé, Steven Vermeulen, Ellen Lievers, Cees van Kooten, Ton J. Rabelink, Jan de Boer
Publié dans: Scientific Reports, Numéro 8/1, 2018, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-018-25700-5

Translational Research Symposium—collaborative efforts as driving forces of healthcare innovation

Auteurs: João Q. Coentro, Andrea De Pieri, Diana Gaspar, Dimitrios Tsiapalis, Dimitrios I. Zeugolis, Yves Bayon
Publié dans: Journal of Materials Science: Materials in Medicine, Numéro 30/12, 2019, ISSN 0957-4530
Éditeur: Kluwer Academic Publishers
DOI: 10.1007/s10856-019-6339-2

ISEV2018 abstract book

Auteurs: Clotilde Théry, Kenneth Witwer
Publié dans: Journal of Extracellular Vesicles, Numéro 7/sup1, 2018, Page(s) 1461450, ISSN 2001-3078
Éditeur: US
DOI: 10.1080/20013078.2018.1461450

Local pharmacological induction of angiogenesis: Drugs for cells and cells as drugs

Auteurs: Diana Gaspar, Rita Peixoto, Andrea De Pieri, Britta Striegl, Dimitrios I. Zeugolis, Michael Raghunath
Publié dans: Advanced Drug Delivery Reviews, Numéro 146, 2019, Page(s) 126-154, ISSN 0169-409X
Éditeur: Elsevier BV
DOI: 10.1016/j.addr.2019.06.002

British Society for Matrix Biology Spring 2019 Meeting: “Stroma, Niche, Repair”

Auteurs: Gifford. V., et. at.,
Publié dans: International Journal of Experimental Pathology, Numéro 100/4, 2019, ISSN 0959-9673
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/iep.12332

Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation

Auteurs: Vassey, Matthew J.; Figueredo, Grazziela P.; Scurr, David; Vasilevich, Aliaksei S.; Vermeulen, Steven; Carlier, Aurélie; Luckett, Jeni; Beijer, Nick R.M.; Williams, Paul; Winkler, Dave; de Boer, Jan; Ghaemmaghami, Amir M.; Alexander, Morgan R.
Publié dans: Advanced Science, 2020, ISSN 2198-3844
Éditeur: Wiley
DOI: 10.1002/advs.201903392

Seaweed polysaccharides as macromolecular crowding agents

Auteurs: Andrea De Pieri, Shubhasmin Rana, Stefanie Korntner, Dimitrios I. Zeugolis
Publié dans: International Journal of Biological Macromolecules, Numéro 164, 2020, Page(s) 434-446, ISSN 0141-8130
Éditeur: Elsevier BV
DOI: 10.1016/j.ijbiomac.2020.07.087

Bioreactors for Tendon Tissue Engineering

Auteurs: Ana I. Gonçalves
Publié dans: Bioreactors for Stem Cell Expansion and Differentiation, 2018, Page(s) 269-300, ISBN 9780-429453144
Éditeur: CRC Press
DOI: 10.1201/9780429453144-10

Preparation and Characterization of Tissue Surrogates Rich in Extracellular Matrix Using the Principles of Macromolecular Crowding

Auteurs: Adrian Djalali-Cuevas, Sergio Garnica-Galvez, Andrea Rampin, Diana Gaspar, Ioannis Skoufos, Athina Tzora, Nikitas Prassinos, Nikolaos Diakakis, Dimitrios I. Zeugolis
Publié dans: The Extracellular Matrix - Methods and Protocols, Numéro 1952, 2019, Page(s) 245-259, ISBN 978-1-4939-9132-7
Éditeur: Springer New York
DOI: 10.1007/978-1-4939-9133-4_20

Designing Microenvironments for Optimal Outcomes in Tissue Engineering and Regenerative Medicine: From Biopolymers to Culturing Conditions

Auteurs: Dimitrios Tsiapalis, Sofia Ribeiro, Andrea De Pieri, Ignacio Sallent, Salomé Guillaumin, Diana Gaspar, Stefanie Korntner, Yves Bayon, Manuela E. Gomes, Rui L. Reis, Dimitrios I. Zeugolis
Publié dans: Reference Module in Biomedical Sciences, 2019, ISBN 9780-128012383
Éditeur: Elsevier
DOI: 10.1016/b978-0-12-801238-3.11140-7

Scaffolds for tendon tissue engineering

Auteurs: Héctor Capella-Monsonís, Salomé Guillaumin, Sofia Ribeiro, Stefanie Korntner, Yves Bayon, Dimitrios I. Zeugolis
Publié dans: Handbook of Tissue Engineering Scaffolds: Volume One, 2019, Page(s) 259-298, ISBN 9780-081025635
Éditeur: Elsevier
DOI: 10.1016/b978-0-08-102563-5.00013-7

The effect of aligned electrospun fibers and macromolecular crowding in tenocyte culture

Auteurs: Dimitrios Tsiapalis, Shubhasmin Rana, Meletios Doulgkeroglou, Stephen Kearns, Jack Kelly, Yves Bayon, Dimitrios I. Zeugolis
Publié dans: Methods in Cell Biology, 2019
Éditeur: Elsevier
DOI: 10.1016/bs.mcb.2019.11.003

Production and Characterization of Chemically Cross-Linked Collagen Scaffolds

Auteurs: Ignacio Sallent, Héctor Capella-Monsonís, Dimitrios I. Zeugolis
Publié dans: Collagen - Methods and Protocols, Numéro 1944, 2019, Page(s) 23-38, ISBN 978-1-4939-9094-8
Éditeur: Springer New York
DOI: 10.1007/978-1-4939-9095-5_3

Concept Design of a New Portable Medical Device for Lymphedema Monitoring: A EIT Health ClinMed Summer School Project

Auteurs: Jordi Tisaire, Elena Rodrigo, Sofia Ribeiro, Mariachiara Ricci, Juan Cuellar, Dimitrios Zeugolis, Yves Bayon, Isabel Rocha
Publié dans: Proceedings of the 12th International Joint Conference on Biomedical Engineering Systems and Technologies, 2019, Page(s) 611-620, ISBN 978-989-758-353-7
Éditeur: SCITEPRESS - Science and Technology Publications
DOI: 10.5220/0007696706110620

Design and Characterization of Synthetic Biodegradable Films for Soft Tissue Engineering

Auteurs: Ribeiro, S.; Fernandes, E.; Gomes, M.; Reis, R.; Bayon, Y. and Zeugolis, D.
Publié dans: Doctoral Consortium - Volume 1: DCBIOSTEC, 2019, Page(s) 28-32
Éditeur: DCBIOSTEC

Empowering Translation of New Ideas - A EIT Health ClinMed Summer School Overview

Auteurs: Sofia Ribeiro, Mariachiara Ricci, Albert Von Der Lieth, Yves Bayon, Dimitrios Zeugolis, Sylvia Pelayo, Isabelle Marque, Lionel Pazart
Publié dans: Proceedings of the 12th International Joint Conference on Biomedical Engineering Systems and Technologies, 2019, Page(s) 603-610, ISBN 978-989-758-353-7
Éditeur: SCITEPRESS - Science and Technology Publications
DOI: 10.5220/0007696606030610

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